Role of ion flux in the control of c-fos expression.

abstract：:Protein chains coil into alpha-helices and beta-sheet structures. Knowing the timescales and mechanism of formation of these basic structural elements is essential for understanding how proteins fold. For the past 40 years, alpha-helix formation has been extensively investigated in synthetic and natural peptides, incl...

journal_title：Nature

authors： Muñoz V,Thompson PA,Hofrichter J,Eaton WA

更新日期：1997-11-13 00:00:00

abstract：:It has been suggested that the initiation step in mouse skin carcinogenesis involves an alteration in epidermal-differentiation, as mouse basal keratinocytes exposed to initiators resist the arrest of cell growth that is normally associated with the induction of terminal differentiation by calcium ions. The growth of ...

journal_title：Nature

authors： Yuspa SH,Kilkenny AE,Stanley J,Lichti U

更新日期：1985-04-04 00:00:00

abstract：:Deposition of amyoid-beta peptide in the central nervous system is a hallmark of Alzheimer's disease and a possible cause of neurodegeneration. The factors that initiate or promote deposition of amyloid-beta peptide are not known. The transforming growth factor TGF-beta1 plays a central role in the response of the bra...

journal_title：Nature

authors： Wyss-Coray T,Masliah E,Mallory M,McConlogue L,Johnson-Wood K,Lin C,Mucke L

更新日期：1997-10-09 00:00:00

abstract：:The behaviour of electrons in solids is well described by Landau's Fermi-liquid theory, which predicts that although electrons in a metal interact, they can still be treated as well defined fermions, which are called 'quasiparticles'. At low temperatures, the ability of quasiparticles to transport heat is given strict...

journal_title：Nature

authors： Hill RW,Proust C,Taillefer L,Fournier P,Greene RL

更新日期：2001-12-13 00:00:00

abstract：:Insulin stimulates glucose uptake in muscle and adipocytes by signalling the translocation of GLUT4 glucose transporters from intracellular membranes to the cell surface. The translocation of GLUT4 may involve signalling pathways that are both independent of and dependent on phosphatidylinositol-3-OH kinase (PI(3)K). ...

journal_title：Nature

authors： Bose A,Guilherme A,Robida SI,Nicoloro SM,Zhou QL,Jiang ZY,Pomerleau DP,Czech MP

更新日期：2002-12-19 00:00:00

abstract：:The ability to excise (repair) UV-induced pyrimidine dimers in Escherichia coli is not related to its ability to remove N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced O6-methylguanine (O6-MeG) from DNA. It was therefore surprising that certain xeroderma pigmentosum cell lines, deficient in dimer excision, were al...

journal_title：Nature

authors： Sklar R,Strauss B

更新日期：1981-01-29 00:00:00

abstract：:For unknown reasons, autoimmune diseases such as type 1 diabetes develop after prolonged periods of inflammation of mononuclear cells in target tissues. Here we show that progression of pancreatic islet inflammation to overt diabetes in nonobese diabetic (NOD) mice is driven by the 'avidity maturation' of a prevailing...

journal_title：Nature

authors： Amrani A,Verdaguer J,Serra P,Tafuro S,Tan R,Santamaria P

更新日期：2000-08-17 00:00:00

abstract：:There is increasing evidence for the process of sympatric speciation, in which reproductive isolation of species occurs without physical isolation. Theoretical models have focused on disruptive natural selection as the crucial pressure for splitting a species. Here we report the theoretical finding that sympatric spec...

journal_title：Nature

authors： Higashi M,Takimoto G,Yamamura N

更新日期：1999-12-02 00:00:00

abstract：:Observations of galaxies and primordial radiation suggest that the Universe is made mostly of non-luminous dark matter1,2. Several new types of fundamental particle have been proposed as candidates for dark matter3, such as weakly interacting massive particles (WIMPs)4,5. These particles would be expected to interact ...

journal_title：Nature

authors： COSINE-100 Collaboration.

更新日期：2018-12-01 00:00:00

abstract：:The extent to which evolution is reversible has long fascinated biologists. Most previous work on the reversibility of morphological and life-history evolution has been indecisive, because of uncertainty and bias in the methods used to infer ancestral states for such characters. Further, despite theoretical work on th...

journal_title：Nature

authors： Bridgham JT,Ortlund EA,Thornton JW

更新日期：2009-09-24 00:00:00

abstract：:'Identifier' or ID sequences are present in 62% of the RNA polymerase II and III transcripts made in vitro from brain nuclei but in fewer than 4% of the transcripts made from the nuclei of other tissues. An homologous 160-nucleotide cytoplasmic poly(A)+ RNA species, BC1, and a smaller species, BC2, are located in vivo...

journal_title：Nature

authors： Sutcliffe JG,Milner RJ,Gottesfeld JM,Lerner RA

更新日期：1984-03-15 00:00:00

abstract：:Recent work demonstrates that stochastic fluctuations in molecular populations have consequences for gene regulation. Previous experiments focused on noise sources or noise propagation through gene networks by measuring noise magnitudes. However, in theoretical analysis, we showed that noise frequency content is deter...

journal_title：Nature

authors： Austin DW,Allen MS,McCollum JM,Dar RD,Wilgus JR,Sayler GS,Samatova NF,Cox CD,Simpson ML

更新日期：2006-02-02 00:00:00

abstract：:Proximal spinal muscular atrophies represent the second most common fatal, autosomal recessive disorder after cystic fibrosis. The childhood form is classically subdivided into three groups: acute Werdnig-Hoffmann (type I), intermediate Werdnig-Hoffmann disease (type II) and Kugelberg-Welander disease (type III). Thes...

journal_title：Nature

authors： Melki J,Abdelhak S,Sheth P,Bachelot MF,Burlet P,Marcadet A,Aicardi J,Barois A,Carriere JP,Fardeau M

更新日期：1990-04-19 00:00:00

abstract：:Most species live in species-rich food webs; yet, for a century, most mathematical models for population dynamics have included only one or two species. We ask whether such models are relevant to the real world. Two-species population models of an interacting consumer and resource collapse to one-species dynamics when...

journal_title：Nature

authors： Murdoch WW,Kendall BE,Nisbet RM,Briggs CJ,McCauley E,Bolser R

更新日期：2002-05-30 00:00:00

abstract：:Because monoclonal antibodies can recognize and bind to specific groups of atoms such as tumour antigens, they have promise for use in vivo as carriers of radionuclides, drugs or other appended molecules for diagnosis and treatment of disease. Attachment of metal ions to antibodies by means of bifunctional chelating a...

journal_title：Nature

authors： Reardan DT,Meares CF,Goodwin DA,McTigue M,David GS,Stone MR,Leung JP,Bartholomew RM,Frincke JM

更新日期：1985-07-18 00:00:00

abstract：:Classical population-genetics theory suggests that reproductive isolation will evolve fastest in small isolated populations. In contrast, recent theory suggests that divergence should occur fastest in larger allopatric populations. The rationale behind this is that sexual conflict, potentially the strongest driver of ...

journal_title：Nature

authors： Martin OY,Hosken DJ

更新日期：2003-06-26 00:00:00

abstract：:The perception of yellow has played a central role in distinguishing two main theories of colour vision. Hering proposed that yellow results from the activation of a distinct retinal-neural mechanism, whereas according to the Young-Helmholtz-Maxwell view, yellow results from the combined activation of red and green co...

journal_title：Nature

authors： Nijhawan R

更新日期：1997-03-06 00:00:00

abstract：:Asexual reproduction by free-living invertebrate larvae is a rare and enigmatic phenomenon and, although it is known to occur in sea stars and brittle stars, it has not been detected in other echinoderms despite more than a century of intensive study. Here we describe spontaneous larval cloning in three species from t...

journal_title：Nature

authors： Eaves AA,Palmer AR

更新日期：2003-09-11 00:00:00

abstract：:The development of cancer is contingent on the emergence of at least one clone of transformed cells. One method used to investigate whether human tumours are monoclonal depends on the mosaicism in the normal tissues of women heterozygous for the two forms of the enzyme glucose-6-phosphate dehydrogenase (G-6-PD). This ...

journal_title：Nature

authors： Woodruff MF,Ansell JD,Forbes GM,Gordon JC,Burton DI,Micklem HS

更新日期：1982-10-28 00:00:00

abstract：:The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory1,2. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-se...

journal_title：Nature

authors： Zhong S,Ding W,Sun L,Lu Y,Dong H,Fan X,Liu Z,Chen R,Zhang S,Ma Q,Tang F,Wu Q,Wang X

更新日期：2020-01-01 00:00:00

abstract：:Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-1 persists in a stable latent reservoir, primarily in resting memory CD4(+) T cells. This reservoir presents a major barrier to the cure of HIV-1 infection. To purge the reservoir, pharmacological reactivation of latent HIV-1 has been proposed an...

journal_title：Nature

authors： Deng K,Pertea M,Rongvaux A,Wang L,Durand CM,Ghiaur G,Lai J,McHugh HL,Hao H,Zhang H,Margolick JB,Gurer C,Murphy AJ,Valenzuela DM,Yancopoulos GD,Deeks SG,Strowig T,Kumar P,Siliciano JD,Salzberg SL,Flavell RA,Shan

更新日期：2015-01-15 00:00:00

abstract：:A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement tha...

journal_title：Nature

authors： Martin-Zanca D,Hughes SH,Barbacid M

更新日期：1986-02-27 00:00:00

abstract：:Single-stranded DNA can fold into well-defined sequence-dependent tertiary structures that specifically bind a variety of target molecules, raising the possibility that some folded single-stranded DNAs might exhibit catalytic activities similar to those of ribozymes and protein enzymes. Derivatives of the hammerhead r...

journal_title：Nature

authors： Cuenoud B,Szostak JW

更新日期：1995-06-15 00:00:00

abstract：:Cosmid, yeast artificial chromosome (YAC), P1 and complementary DNA (cDNA) libraries are distributed on high-density filters to the scientific community and experimental results are stored in a common object-based database accessible through the Internet. ...

journal_title：Nature

authors： Zehetner G,Lehrach H

更新日期：1994-02-03 00:00:00

abstract：:On infection of their host, temperate viruses that infect bacteria (bacteriophages; hereafter referred to as phages) enter either a lytic or a lysogenic cycle. The former results in lysis of bacterial cells and phage release (resulting in horizontal transmission), whereas lysogeny is characterized by the integration o...

journal_title：Nature

authors： Rollie C,Chevallereau A,Watson BNJ,Chyou TY,Fradet O,McLeod I,Fineran PC,Brown CM,Gandon S,Westra ER

更新日期：2020-02-01 00:00:00

abstract：:The Pax-6 transcription-factor gene, containing a paired domain and a paired-type homeodomain, is conserved in structure and ubiquitously present among Metazoa. It is required for development of the central nervous system, and is mutated in human aniridia, mouse and rat small eye and Drosophila eyeless. We identified ...

journal_title：Nature

authors： Zhang Y,Emmons SW

更新日期：1995-09-07 00:00:00

abstract：:Carbon exchange between the terrestrial biosphere and the atmosphere is one of the key processes that need to be assessed in the context of the Kyoto Protocol. Several studies suggest that the terrestrial biosphere is gaining carbon, but these estimates are obtained primarily by indirect methods, and the factors that ...

journal_title：Nature

authors： Valentini R,Matteucci G,Dolman AJ,Schulze ED,Rebmann C,Moors EJ,Granier A,Gross P,Jensen NO,Pilegaard K,Lindroth A,Grelle A,Bernhofer C,Grünwald T,Aubinet M,Ceulemans R,Kowalski AS,Vesala T,Rannik U,Berbigier P,Lo

更新日期：2000-04-20 00:00:00

abstract：:Antigenic variation in the haemagglutinin (HA) glycoprotein of influenza virus is associated with recurrent epidemics of respiratory disease in man (for review see ref. 1). We have examined the size of structural changes necessary to alter the antigenicity of HA by determining the three-dimensional structure of the HA...

journal_title：Nature

authors： Knossow M,Daniels RS,Douglas AR,Skehel JJ,Wiley DC

更新日期：1984-10-18 00:00:00

abstract：:The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteom...

journal_title：Nature

authors： Zhang G,Fang X,Guo X,Li L,Luo R,Xu F,Yang P,Zhang L,Wang X,Qi H,Xiong Z,Que H,Xie Y,Holland PW,Paps J,Zhu Y,Wu F,Chen Y,Wang J,Peng C,Meng J,Yang L,Liu J,Wen B,Zhang N,Huang Z,Zhu Q,Feng Y,Mount A

更新日期：2012-10-04 00:00:00

abstract：:Although lunar crystalline rocks are essentially devoid of nitrogen, the same is not true of the lunar regolith. The nitrogen contents of individual regolith samples (which can be as high as 0.012% by mass) correlate strongly with abundances of noble gases known to be implanted in the lunar surface by solar radiation,...

journal_title：Nature

authors： Kim JS,Kim Y,Marti K,Kerridge JF

更新日期：1995-06-01 00:00:00