Abstract:
:A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.
journal_name
Naturejournal_title
Natureauthors
Martin-Zanca D,Hughes SH,Barbacid Mdoi
10.1038/319743a0subject
Has Abstractpub_date
1986-02-27 00:00:00pages
743-8issue
6056eissn
0028-0836issn
1476-4687journal_volume
319pub_type
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