The evolution of reproductive isolation through sexual conflict.

abstract：:Bird songs frequently contain trilling sounds that demand extremely fast vocalization control. Here we show that doves control their syrinx, a vocal organ that is unique to birds, by using superfast muscles. These muscles, which are similar to those that operate highly specialist acoustic organs such as the rattle of ...

journal_title：Nature

authors： Elemans CP,Spierts IL,Müller UK,Van Leeuwen JL,Goller F

更新日期：2004-09-09 00:00:00

abstract：:Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the maintenance of neurological function. In the embryo, the genetic mechanisms that underlie the specification of macroglial precursors in vivo appear strikingly similar to those that regul...

journal_title：Nature

authors： Rowitch DH,Kriegstein AR

更新日期：2010-11-11 00:00:00

abstract：:Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for growth, development and the control of metabolism in vertebrates1,2. Hormone synthesis from TG occurs in the thyroid gland via the iodination and coupling of pairs of tyrosines, and is completed by TG proteolysis3. Tyrosine proxim...

journal_title：Nature

authors： Coscia F,Taler-Verčič A,Chang VT,Sinn L,O'Reilly FJ,Izoré T,Renko M,Berger I,Rappsilber J,Turk D,Löwe J

更新日期：2020-02-01 00:00:00

abstract：:A combination of biochemistry in animal cell-free systems and genetics in yeast is revealing the molecular machinery of the secretory pathway of eukaryotes. Transporting vesicles have a simple coat structure and employ a general mechanism for fusion that is conserved in evolution. ...

journal_title：Nature

authors： Rothman JE,Orci L

更新日期：1992-01-30 00:00:00

abstract：:N-glycosylation of proteins in the endoplasmic reticulum (ER) has a central role in protein quality control. Here we report that N-glycan serves as a signal for degradation by the Skp1-Cullin1-Fbx2-Roc1 (SCF(Fbx2)) ubiquitin ligase complex. The F-box protein Fbx2 (ref. 4) binds specifically to proteins attached to N-l...

journal_title：Nature

authors： Yoshida Y,Chiba T,Tokunaga F,Kawasaki H,Iwai K,Suzuki T,Ito Y,Matsuoka K,Yoshida M,Tanaka K,Tai T

更新日期：2002-07-25 00:00:00

abstract：:Wetlands are the largest natural source of atmospheric methane, the second most important greenhouse gas. Methane flux to the atmosphere depends strongly on the climate; however, by far the largest part of the methane formed in wetland ecosystems is recycled and does not reach the atmosphere. The biogeochemical contro...

journal_title：Nature

authors： Raghoebarsing AA,Smolders AJ,Schmid MC,Rijpstra WI,Wolters-Arts M,Derksen J,Jetten MS,Schouten S,Sinninghe Damsté JS,Lamers LP,Roelofs JG,Op den Camp HJ,Strous M

更新日期：2005-08-25 00:00:00

abstract：:A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identif...

journal_title：Nature

authors： Beroukhim R,Mermel CH,Porter D,Wei G,Raychaudhuri S,Donovan J,Barretina J,Boehm JS,Dobson J,Urashima M,Mc Henry KT,Pinchback RM,Ligon AH,Cho YJ,Haery L,Greulich H,Reich M,Winckler W,Lawrence MS,Weir BA,Tanaka KE,

更新日期：2010-02-18 00:00:00

abstract：:During lymphocyte development, cellular proliferation and positive and negative selection events ensure the production of T and B lymphocytes bearing highly diverse, but self-tolerant, repertoires of antigen receptors. These processes are initiated when engagement of growth-factor receptors, or the T and B lymphocyte ...

journal_title：Nature

authors： Fischer KD,Zmuldzinas A,Gardner S,Barbacid M,Bernstein A,Guidos C

更新日期：1995-03-30 00:00:00

abstract：:Titan, the largest moon of Saturn, is the only satellite in the Solar System with a substantial atmosphere. The atmosphere is poorly understood and obscures the surface, leading to intense speculation about Titan's nature. Here we present observations of Titan from the imaging science experiment onboard the Cassini sp...

journal_title：Nature

authors： Porco CC,Baker E,Barbara J,Beurle K,Brahic A,Burns JA,Charnoz S,Cooper N,Dawson DD,Del Genio AD,Denk T,Dones L,Dyudina U,Evans MW,Fussner S,Giese B,Grazier K,Helfenstein P,Ingersoll AP,Jacobson RA,Johnson TV,McE

更新日期：2005-03-10 00:00:00

abstract：:The role of magnetic domains (and the walls between domains) in determining the electrical properties of ferromagnetic materials has been investigated in great detail for many years, not least because control over domains offers a means of manipulating electron spin to control charge transport in 'spintronic' devices....

journal_title：Nature

authors： Kummamuru RK,Soh YA

更新日期：2008-04-17 00:00:00

abstract：:The mammalian microbiome has many important roles in health and disease, and genetic engineering is enabling the development of microbial therapeutics and diagnostics. A key determinant of the activity of both natural and engineered microorganisms in vivo is their location within the host organism. However, existing m...

journal_title：Nature

authors： Bourdeau RW,Lee-Gosselin A,Lakshmanan A,Farhadi A,Kumar SR,Nety SP,Shapiro MG

更新日期：2018-01-03 00:00:00

abstract：:A new system has been developed for measuring the forces produced by a small number (less than 5-150) of myosin molecules interacting with a single actin filament in vitro. The technique can resolve forces of less than a piconewton and has a time resolution in the submillisecond range. It can thus detect fluctuations ...

journal_title：Nature

authors： Ishijima A,Doi T,Sakurada K,Yanagida T

更新日期：1991-07-25 00:00:00

abstract：:Understanding the physical mechanisms behind the generation of ocean waves by wind has been a longstanding challenge. Previous studies have assumed that ocean waves induce fluctuations in velocity and pressure of the overlying air that are synchronized with the waves, and numerical models have supported this assumptio...

journal_title：Nature

authors： Hristov TS,Miller SD,Friehe CA

更新日期：2003-03-06 00:00:00

abstract：:In this Article, in Fig. 1a, the 5' and 3' labels were reversed in the DNA sequence, and Fig. 4 was missing panel labels a-e. These errors have been corrected online. ...

journal_title：Nature

authors： Matsumoto S,Cavadini S,Bunker RD,Grand RS,Potenza A,Rabl J,Yamamoto J,Schenk AD,Schübeler D,Iwai S,Sugasawa K,Kurumizaka H,Thomä NH

更新日期：2019-07-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Smallman M

更新日期：2019-03-01 00:00:00

abstract：:Coherent light sources can be used to manipulate the outcome of light-matter interactions by exploiting interference phenomena in the time and frequency domain. A powerful tool in this emerging field of 'quantum control' is the adaptive shaping of femtosecond laser pulses, resulting, for instance, in selective molecul...

journal_title：Nature

authors： Brixner T,Damrauer NH,Niklaus P,Gerber G

更新日期：2001-11-01 00:00:00

abstract：:Phenylketonuria (PKU) is an autosomal recessive human genetic disorder caused by a deficiency of hepatic phenylalanine hydroxylase (PAH, phenylalanine 4-monooxygenase, EC 1.14.16.1). PKU is a common inborn error of amino-acid metabolism in caucasian populations and approximately 1 in 50 individuals are carriers of a P...

journal_title：Nature

authors： DiLella AG,Marvit J,Brayton K,Woo SL

更新日期：1987-05-28 00:00:00

abstract：:Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppre...

journal_title：Nature

authors： Png KJ,Halberg N,Yoshida M,Tavazoie SF

更新日期：2011-12-14 00:00:00

abstract：:Mineralocorticoid secretion is predominantly controlled by the octapeptide angiotensin II, which exerts trophic actions on the adrenal glomerulosa and acute regulatory effects on aldosterone biosynthesis. The trophic actions include stimulation of angiotensin II receptors and enzymes of the aldosterone biosynthetic pa...

journal_title：Nature

authors： Aguilera G,Schirar A,Baukal A,Catt KJ

更新日期：1981-02-05 00:00:00

abstract：:L-glutamate, the neurotransmitter of the majority of excitatory synapses in the brain, acts on three classes of ionotropic receptors: NMDA (N-methyl-D-aspartate), AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) and kainate receptors. Little is known about the physiological role of kainate receptors be...

journal_title：Nature

authors： Mulle C,Sailer A,Pérez-Otaño I,Dickinson-Anson H,Castillo PE,Bureau I,Maron C,Gage FH,Mann JR,Bettler B,Heinemann SF

更新日期：1998-04-09 00:00:00

abstract：:Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative analyses. Here we present a large-scale evolutionary study of lnc...

journal_title：Nature

authors： Necsulea A,Soumillon M,Warnefors M,Liechti A,Daish T,Zeller U,Baker JC,Grützner F,Kaessmann H

更新日期：2014-01-30 00:00:00

abstract：:Folding of two monomeric enzymes mediated by groE has been reconstituted in vitro. The groEL protein stabilizes the polypeptides in a conformation resembling the 'molten globule' state. Mg-ATP and groES then promote the acquisition of ordered tertiary structure at the surface of groEL. Folding requires the hydrolysis ...

journal_title：Nature

authors： Martin J,Langer T,Boteva R,Schramel A,Horwich AL,Hartl FU

更新日期：1991-07-04 00:00:00

abstract：:There is still no universally accepted theory of high-temperature superconductivity. Most models assume that doping creates 'holes' in the valence band of an insulating, antiferromagnetic 'parent' compound, and that antiferromagnetism and high-temperature superconductivity are intimately related. If their respective e...

journal_title：Nature

authors： Bozovic I,Logvenov G,Verhoeven MA,Caputo P,Goldobin E,Geballe TH

更新日期：2003-04-24 00:00:00

abstract：:Numerous studies have suggested that biodiversity reduces variability in ecosystem productivity through compensatory effects; that is, a species increases in its abundance in response to the reduction of another in a fluctuating environment. But this view has been challenged on several grounds. Because most studies ha...

journal_title：Nature

authors： Bai Y,Han X,Wu J,Chen Z,Li L

更新日期：2004-09-09 00:00:00

abstract：:Nuclear pore complexes (NPCs) fuse the inner and outer membranes of the nuclear envelope. They comprise hundreds of nucleoporins (Nups) that assemble into multiple subcomplexes and form large central channels for nucleocytoplasmic exchange1,2. How this architecture facilitates messenger RNA export, NPC biogenesis and ...

journal_title：Nature

authors： Allegretti M,Zimmerli CE,Rantos V,Wilfling F,Ronchi P,Fung HKH,Lee CW,Hagen W,Turoňová B,Karius K,Börmel M,Zhang X,Müller CW,Schwab Y,Mahamid J,Pfander B,Kosinski J,Beck M

更新日期：2020-10-01 00:00:00

abstract：:The main asteroid belt lies between the orbits of Mars and Jupiter, but the region is not uniformly filled with asteroids. There are gaps, known as the Kirkwood gaps, in distinct locations that are associated with orbital resonances with the giant planets; asteroids placed in these locations will follow chaotic orbits...

journal_title：Nature

authors： Minton DA,Malhotra R

更新日期：2009-02-26 00:00:00

abstract：:It is of fundamental importance to establish whether there is a limit to how thin a superconducting wire can be, while retaining its superconducting character--and if there is a limit, to determine what sets it. This issue may also be of practical importance in defining the limit to miniaturization of superconducting ...

journal_title：Nature

authors： Bezryadin A,Lau CN,Tinkham M

更新日期：2000-04-27 00:00:00

abstract：:Chick embryo fibroblasts (CEF) infected with avian sarcoma virus become rapidly transformed as a result of expression of the viral src gene in the form of a single polypeptide of molecular weight 60,000 (pp60src) with protein kinase activity and suggested preferential association with the plasma membrane. Studies with...

journal_title：Nature

authors： Witt DP,Gordon JA

更新日期：1980-09-18 00:00:00

abstract：:Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels disp...

journal_title：Nature

authors： Berridge MJ

更新日期：1993-01-28 00:00:00

abstract：:Diatoms dominate the biomass of phytoplankton in nutrient-rich conditions and form the basis of some of the world's most productive marine food webs. The diatom nuclear genome contains genes with bacterial and plastid origins as well as genes of the secondary endosymbiotic host (the exosymbiont), yet little is known a...

journal_title：Nature

authors： Allen AE,Dupont CL,Oborník M,Horák A,Nunes-Nesi A,McCrow JP,Zheng H,Johnson DA,Hu H,Fernie AR,Bowler C

更新日期：2011-05-12 00:00:00