An amino-acid substitution involved in phenylketonuria is in linkage disequilibrium with DNA haplotype 2.

abstract：:Increasing human populations around the global coastline have caused extensive loss, degradation and fragmentation of coastal ecosystems, threatening the delivery of important ecosystem services1. As a result, alarming losses of mangrove, coral reef, seagrass, kelp forest and coastal marsh ecosystems have occurred1-6....

journal_title：Nature

authors： Murray NJ,Phinn SR,DeWitt M,Ferrari R,Johnston R,Lyons MB,Clinton N,Thau D,Fuller RA

更新日期：2019-01-01 00:00:00

abstract：:Silbo Gomero is a whistled language that is a rare and endangered surrogate of Spanish, used by shepherds on the island of La Gomera in the Canary Islands for communication over long distances on difficult terrain. Here we show that areas of the brain normally associated with spoken-language function are also activate...

journal_title：Nature

authors： Carreiras M,Lopez J,Rivero F,Corina D

更新日期：2005-01-06 00:00:00

abstract：:The shape of the human erythrocyte depends on intracellular ATP content and echinocytic erythrocyte ghosts obtained in the presence of Mg-ATP acquire a diskocytic shape after incubation at 37 degrees C; however, agreement is lacking about the molecular basis of the shape changes. The suggestion that phosphorylation of...

journal_title：Nature

authors： Jinbu Y,Sato S,Nakao M

更新日期：1984-01-26 00:00:00

abstract：:Cell-free DNA in the blood provides a non-invasive diagnostic avenue for patients with cancer1. However, characteristics of the origins and molecular features of cell-free DNA are poorly understood. Here we developed an approach to evaluate fragmentation patterns of cell-free DNA across the genome, and found that prof...

journal_title：Nature

authors： Cristiano S,Leal A,Phallen J,Fiksel J,Adleff V,Bruhm DC,Jensen SØ,Medina JE,Hruban C,White JR,Palsgrove DN,Niknafs N,Anagnostou V,Forde P,Naidoo J,Marrone K,Brahmer J,Woodward BD,Husain H,van Rooijen KL,Ørntoft MW

更新日期：2019-06-01 00:00:00

abstract：:The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific...

journal_title：Nature

authors： Graves BJ,Crowther RL,Chandran C,Rumberger JM,Li S,Huang KS,Presky DH,Familletti PC,Wolitzky BA,Burns DK

更新日期：1994-02-10 00:00:00

abstract：:(S)-2-hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear non-haem-iron-dependent enzyme responsible for the final step in the biosynthesis of the clinically useful antibiotic fosfomycin. Enzymes of this class typically catalyse oxygenation reactions that proceed via the formation of substrate radic...

journal_title：Nature

authors： Chang WC,Dey M,Liu P,Mansoorabadi SO,Moon SJ,Zhao ZK,Drennan CL,Liu HW

更新日期：2013-04-04 00:00:00

abstract：:Susceptibility to some human diseases is linked, albeit weakly, to major transplantation antigens (HLA) encoded by the major histocompatibility gene complex (MHC). Here we have studied MHC/disease association in inbred strains of mice after intracerebral (i.c.) injection of lymphocytic choriomeningitis virus (LCMV). T...

journal_title：Nature

authors： Zinkernagel RM,Pfau CJ,Hengartner H,Althage A

更新日期：1985-08-29 00:00:00

abstract：:The axial relationship between the collagen and mineral componetns in calcified turkey leg tendon was investigated using low-angle X-ray and neutron diffraction. The results indicate that the mineral is arranged with the same axial periodicity as the collagen and occupies the gap region of the collagen structure. ...

journal_title：Nature

authors： White SW,Hulmes DJ,Miller A,Timmins PA

更新日期：1977-03-31 00:00:00

abstract：:Phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II is believed to control the transition from transcription initiation to elongation. The general transcription factor IIH (TFIIH) contains a kinase activity capable of phosphorylating this domain. Factors that promote the associat...

journal_title：Nature

authors： Lu H,Zawel L,Fisher L,Egly JM,Reinberg D

更新日期：1992-08-20 00:00:00

abstract：:The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate perceptions and higher brain functions. Here we describe a large-scale screen to create an atlas of CNS gene expression at the cellular level, and to provide a libra...

journal_title：Nature

authors： Gong S,Zheng C,Doughty ML,Losos K,Didkovsky N,Schambra UB,Nowak NJ,Joyner A,Leblanc G,Hatten ME,Heintz N

更新日期：2003-10-30 00:00:00

abstract：:In addition to acting as template for protein synthesis, messenger RNA (mRNA) often contains sensory sequence elements that regulate this process. Here we report a new mechanism that limits the number of complete protein molecules that can be synthesized from a single mRNA molecule of the human AMD1 gene encoding aden...

journal_title：Nature

authors： Yordanova MM,Loughran G,Zhdanov AV,Mariotti M,Kiniry SJ,O'Connor PBF,Andreev DE,Tzani I,Saffert P,Michel AM,Gladyshev VN,Papkovsky DB,Atkins JF,Baranov PV

更新日期：2018-01-18 00:00:00

abstract：:In multinucleated heterokaryons formed from the fusion of differentiated muscle cells to either hepatocytes or fibroblasts, muscle-specific gene expression is activated, liver-specific gene expression is repressed, and there are changes in the location of the Golgi apparatus. An understanding of the regulatory mechani...

journal_title：Nature

authors： Schäfer BW,Blakely BT,Darlington GJ,Blau HM

更新日期：1990-03-29 00:00:00

abstract：:The growth cycle in nutrient-rich, aquatic environments starts with a diatom bloom that ends in mass sinking of ungrazed cells and phytodetritus. The low grazing pressure on these blooms has been attributed to the inability of overwintering copepod populations to track them temporally. We tested an alternative explana...

journal_title：Nature

authors： Ianora A,Miralto A,Poulet SA,Carotenuto Y,Buttino I,Romano G,Casotti R,Pohnert G,Wichard T,Colucci-D'Amato L,Terrazzano G,Smetacek V

更新日期：2004-05-27 00:00:00

abstract：:The ability to generate patient-specific human induced pluripotent stem cells (iPSCs) offers a new paradigm for modelling human disease and for individualizing drug testing. Congenital long QT syndrome (LQTS) is a familial arrhythmogenic syndrome characterized by abnormal ion channel function and sudden cardiac death....

journal_title：Nature

authors： Itzhaki I,Maizels L,Huber I,Zwi-Dantsis L,Caspi O,Winterstern A,Feldman O,Gepstein A,Arbel G,Hammerman H,Boulos M,Gepstein L

更新日期：2011-03-10 00:00:00

abstract：: ...

journal_title：Nature

authors： Segal M

更新日期：2018-11-01 00:00:00

abstract：:The rod and cone transducins are specific G proteins originally thought to be present only in photoreceptor cells of the vertebrate retina. Transducins convert light stimulation of photoreceptor opsins into activation of cyclic GMP phosphodiesterase (reviewed in refs. 5-7). A transducin-like G protein, gustducin, has ...

journal_title：Nature

authors： Ruiz-Avila L,McLaughlin SK,Wildman D,McKinnon PJ,Robichon A,Spickofsky N,Margolskee RF

更新日期：1995-07-06 00:00:00

abstract：:How does the human visual system 'bind' different fragments in the visual scene to create enduring representations of objects? A visual illusion known as 'metacontrast' or backward masking provides compelling evidence that perception is not instantaneous and that it occurs sequentially in distinct stages. If a solid w...

journal_title：Nature

authors： Ramachandran VS,Cobb S

更新日期：1995-01-05 00:00:00

abstract：:During cell division, sister chromosomes segregate from each other on a microtubule-based structure called the mitotic spindle. Proteins bind to the centromere, a region of chromosomal DNA, to form the kinetochore, which mediates chromosome attachment to the mitotic spindle microtubules. In the budding yeast Saccharom...

journal_title：Nature

authors： Hyman AA,Middleton K,Centola M,Mitchison TJ,Carbon J

更新日期：1992-10-08 00:00:00

abstract：:Understanding how ecological communities are organized and how they change through time is critical to predicting the effects of climate change. Recent work documenting the co-occurrence structure of modern communities found that most significant species pairs co-occur less frequently than would be expected by chance....

journal_title：Nature

authors： Lyons SK,Amatangelo KL,Behrensmeyer AK,Bercovici A,Blois JL,Davis M,DiMichele WA,Du A,Eronen JT,Faith JT,Graves GR,Jud N,Labandeira C,Looy CV,McGill B,Miller JH,Patterson D,Pineda-Munoz S,Potts R,Riddle B,Terry R

更新日期：2016-01-07 00:00:00

abstract：:In this Letter, owing to a copying error in Illustrator, the two centre panels in Extended Data Fig. 7a were identical. This error has been corrected online. The old, incorrect Extended Data Fig. 7 is shown in the Supplementary Information to this Amendment for transparency. Some typos ('occurence') in Figs. 1, 2 and ...

journal_title：Nature

authors： Andersen TG,Naseer S,Ursache R,Wybouw B,Smet W,De Rybel B,Vermeer JEM,Geldner N

更新日期：2018-07-01 00:00:00

abstract：:During platelet activation there is a major reorganization in the platelet cytoskeleton that accompanies a rapid change in platelet shape. Many of the events associated with activation are attributed to a rise in calcium concentration within the platelet cytoplasm. One direct consequence of the elevated calcium is the...

journal_title：Nature

authors： O'Halloran T,Beckerle MC,Burridge K

更新日期：1985-10-03 00:00:00

abstract：:The microtubule cytoskeleton is essential to cell morphogenesis. Growing microtubule plus ends have emerged as dynamic regulatory sites in which specialized proteins, called plus-end-binding proteins (+TIPs), bind and regulate the proper functioning of microtubules. However, the molecular mechanism of plus-end associa...

journal_title：Nature

authors： Bieling P,Laan L,Schek H,Munteanu EL,Sandblad L,Dogterom M,Brunner D,Surrey T

更新日期：2007-12-13 00:00:00

abstract：:Human cooperation in social dilemmas challenges researchers from various disciplines. Here we combine advances in experimental economics and evolutionary biology that separately have shown that costly punishment and reputation formation, respectively, induce cooperation in social dilemmas. The mechanisms of punishment...

journal_title：Nature

authors： Rockenbach B,Milinski M

更新日期：2006-12-07 00:00:00

abstract：:Quantum criticality is associated with a system composed of a nearly infinite number of interacting quantum degrees of freedom at zero temperature, and it implies that the system looks on average the same regardless of the time- and length scale on which it is observed. Electrons on the atomic scale do not exhibit suc...

journal_title：Nature

authors： van der Marel D,Molegraaf HJ,Zaanen J,Nussinov Z,Carbone F,Damascelli A,Eisaki H,Greven M,Kes PH,Li M

更新日期：2003-09-18 00:00:00

abstract：:Hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both heart and brain. All four family members contain both a core transmembrane segment domain, homologous to the S1-S6 regions of voltage-gated K+ channels, and a carboxy-terminal 120 amino-acid cyclic nu...

journal_title：Nature

authors： Wainger BJ,DeGennaro M,Santoro B,Siegelbaum SA,Tibbs GR

更新日期：2001-06-14 00:00:00

abstract：:In vast areas of the ocean, the scarcity of iron controls the growth and productivity of phytoplankton. Although most dissolved iron in the marine environment is complexed with organic molecules, picomolar amounts of labile inorganic iron species (labile iron) are maintained within the euphotic zone and serve as an im...

journal_title：Nature

authors： McQuaid JB,Kustka AB,Oborník M,Horák A,McCrow JP,Karas BJ,Zheng H,Kindeberg T,Andersson AJ,Barbeau KA,Allen AE

更新日期：2018-03-22 00:00:00

abstract：:A major problem in the elucidation of the molecular mechanisms governing development is the distinction between direct and indirect regulatory interactions among developmental control genes. In vivo studies have indicated that the Drosophila segmentation gene fushi tarazu (ftz) directly or indirectly autoregulates its...

journal_title：Nature

authors： Schier AF,Gehring WJ

更新日期：1992-04-30 00:00:00

abstract：:Alphabeta T lymphocytes are able to detect even a single peptide-major histocompatibility complex (MHC) on the surface of an antigen-presenting cell. This is despite clear evidence, at least with CD4+ T cells, that monomeric ligands are not stimulatory. In an effort to understand how this remarkable sensitivity is ach...

journal_title：Nature

authors： Krogsgaard M,Li QJ,Sumen C,Huppa JB,Huse M,Davis MM

更新日期：2005-03-10 00:00:00

abstract：:In associative learning, the activated neurones undergo a variety of concomitant functional alterations--increases or decreases of firing activity and modifications of membrane potential or resistance and of synaptic responsiveness. Synaptic transmission which can be strengthened only when there is paired activity in ...

journal_title：Nature

authors： Baranyi A,Fehér O

更新日期：1981-04-02 00:00:00

abstract：:How the brain selects appropriate sensory inputs and suppresses distractors is unknown. Given the well-established role of the prefrontal cortex (PFC) in executive function, its interactions with sensory cortical areas during attention have been hypothesized to control sensory selection. To test this idea and, more ge...

journal_title：Nature

authors： Wimmer RD,Schmitt LI,Davidson TJ,Nakajima M,Deisseroth K,Halassa MM

更新日期：2015-10-29 00:00:00