Abstract：
:The shape of the human erythrocyte depends on intracellular ATP content and echinocytic erythrocyte ghosts obtained in the presence of Mg-ATP acquire a diskocytic shape after incubation at 37 degrees C; however, agreement is lacking about the molecular basis of the shape changes. The suggestion that phosphorylation of cytoskeletal structures underlying the membrane is involved has been disputed and alternative explanations based on lipid bilayer theory and metabolism of phospholipid have been proposed. Recently, we re-examined the effect of ATP on the shape of ghosts and found that it consists of two distinct steps. We have, therefore, now examined the effect of physiological concentrations of Ca2+ and ATP on the cytoskeleton of the erythrocyte membrane directly using Triton-treated ghosts which had lost this permeability barrier. Our findings suggest that a noncovalent effect of ATP on the cytoskeleton is a prerequisite for shape change.
journal_name
Naturejournal_title
Natureauthors
Jinbu Y,Sato S,Nakao Mdoi
10.1038/307376a0subject
Has Abstractpub_date
1984-01-26 00:00:00pages
376-8issue
5949eissn
0028-0836issn
1476-4687journal_volume
307pub_type
杂志文章相关文献
NATURE文献大全abstract：:Protein synthesis takes place on the ribosome, where genetic information carried by messenger RNA is translated into a sequence of amino acids. This process is terminated when a stop codon moves into the ribosomal decoding centre (DC) and is recognized by a class-1 release factor (RF). RFs have a conserved GGQ amino-a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01224
更新日期：2003-01-02 00:00:00
abstract：:The heterotrimeric G proteins mediate a variety of cellular processes by coupling transmembrane receptors to different effector molecules, including adenylyl cyclases and inositol-phospholipid-specific phospholipase C (PLC)1-3. Activation of adenylyl cyclases results in the production of cyclic AMP and activation of c...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/382083a0
更新日期：1996-07-04 00:00:00
abstract：:Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2. Because previously described cyt...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2477-4
更新日期：2020-07-01 00:00:00
abstract：:Unmethylated CpG dinucleotides are more frequent in the genomes of bacteria and viruses than of vertebrates. We report here that bacterial DNA and synthetic oligodeoxynucleotides containing unmethylated CpG dinucleotides induce murine B cells to proliferate and secrete immunoglobulin in vitro and in vivo. This activat...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/374546a0
更新日期：1995-04-06 00:00:00
abstract：:The effect of anthropogenic aerosols on cloud droplet concentrations and radiative properties is the source of one of the largest uncertainties in the radiative forcing of climate over the industrial period. This uncertainty affects our ability to estimate how sensitive the climate is to greenhouse gas emissions. Here...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature12674
更新日期：2013-11-07 00:00:00
abstract：:Whether or not the Large Hadron Collider reveals the long-awaited Higgs particle, it is likely to lead to discoveries that add to, or challenge, the standard model of particle physics. Data produced will be pored over for any evidence of supersymmetric partners for the existing denizens of the particle 'zoo' and for t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06079
更新日期：2007-07-19 00:00:00
abstract：:Alternative splicing of pre-messenger RNAs diversifies gene products in eukaryotes and is guided by factors that enable spliceosomes to recognize particular splice sites. Here we report that alternative splicing of Saccharomyces cerevisiae SRC1 pre-mRNA is promoted by the conserved ubiquitin-like protein Hub1. Structu...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10143
更新日期：2011-05-25 00:00:00
abstract：:In multinucleated heterokaryons formed from the fusion of differentiated muscle cells to either hepatocytes or fibroblasts, muscle-specific gene expression is activated, liver-specific gene expression is repressed, and there are changes in the location of the Golgi apparatus. An understanding of the regulatory mechani...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/344454a0
更新日期：1990-03-29 00:00:00
abstract：:Demethylation at distinct lysine residues in histone H3 by lysine-specific demethylase 1 (LSD1) causes either gene repression or activation. As a component of co-repressor complexes, LSD1 contributes to target gene repression by removing mono- and dimethyl marks from lysine 4 of histone H3 (H3K4). In contrast, during ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08839
更新日期：2010-04-01 00:00:00
abstract：:Measuring the completeness of the fossil record is essential to understanding evolution over long timescales, particularly when comparing evolutionary patterns among biological groups with different preservational properties. Completeness measures have been presented for various groups based on gaps in the stratigraph...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/18872
更新日期：1999-04-01 00:00:00
abstract：:Homoiotherms, for example mammals, regulate their body temperature with physiological responses such as a change of metabolic rate and sweating. In contrast, the body temperature of poikilotherms, for example Drosophila, is the result of heat exchange with the surrounding environment as a result of the large ratio of ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07090
更新日期：2008-08-07 00:00:00
abstract：:Maize smut caused by the fungus Ustilago maydis is a widespread disease characterized by the development of large plant tumours. U. maydis is a biotrophic pathogen that requires living plant tissue for its development and establishes an intimate interaction zone between fungal hyphae and the plant plasma membrane. U. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10454
更新日期：2011-10-05 00:00:00
abstract：:The most severe excursions in the Earth's climatic history are thought to be associated with Proterozoic glaciations. According to the 'Snowball Earth' hypothesis, the Marinoan glaciation, which ended about 635 million years ago, involved global or nearly global ice cover. At the termination of this glacial period, ra...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03176
更新日期：2005-01-13 00:00:00
abstract：:DNA sequences containing the 5'-flanking regions of the insulin and chymotrypsin genes were linked to the coding sequence of the chloramphenicol acetyltransferase (CAT) gene. The insulin gene recombinant elicits preferential expression of CAT activity when introduced into cells producing insulin; similarly, the chymot...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/306557a0
更新日期：1983-12-08 00:00:00
abstract：:Intraplate magmatic provinces found away from plate boundaries provide direct sampling of the composition and heterogeneity of the Earth's mantle. The chemical heterogeneities that have been observed in the mantle are usually attributed to recycling during subduction1-3, which allows for the addition of volatiles and ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1183-6
更新日期：2019-05-01 00:00:00
abstract：:Levels of gene expression underpin organismal phenotypes1,2, but the nature of selection that acts on gene expression and its role in adaptive evolution remain unknown1,2. Here we assayed gene expression in rice (Oryza sativa)3, and used phenotypic selection analysis to estimate the type and strength of selection on t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-1997-2
更新日期：2020-02-01 00:00:00
abstract：:The horizontal separation of the eyes means that objects nearer or farther than the fixation point project to different locations on the two retinae, differing principally in their horizontal coordinates (horizontal binocular disparity). Disparity-selective neurons have generally been studied with disparities applied ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature00909
更新日期：2002-08-08 00:00:00
abstract：:A long-standing problem in managing the behaviour of a collection of solid grains concerns the nature of the grain packing, a property that is typically controlled by how the grains are poured or shaken. Here we show that a systematic and controllable increase in granular packing can be induced by simply raising and t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/442257a
更新日期：2006-07-20 00:00:00
abstract：:A magnetic field penetrates a superconductor through an array of 'vortices', each of which carries one quantum of flux that is surrounded by a circulating supercurrent. In this vortex state, the resistivity is determined by the dynamical properties of the vortex 'matter'. For the high-temperature copper oxide supercon...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35078016
更新日期：2001-05-24 00:00:00
abstract：:Non-ribosomal peptide synthetase (NRPS) mega-enzyme complexes are modular assembly lines that are involved in the biosynthesis of numerous peptide metabolites independently of the ribosome. The multiple interactions between catalytic domains within the NRPS machinery are further complemented by additional interactions...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14141
更新日期：2015-05-07 00:00:00
abstract：:In somatic cells, entry into mitosis depends on the completion of DNA synthesis. This dependency is established by S-phase feedback controls that arrest cell division when damaged or unreplicated DNA is present. In the fission yeast Schizosaccharomyces pombe, mutations that interfere with the phosphorylation of tyrosi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/355365a0
更新日期：1992-01-23 00:00:00
abstract：:In vast areas of the ocean, the scarcity of iron controls the growth and productivity of phytoplankton. Although most dissolved iron in the marine environment is complexed with organic molecules, picomolar amounts of labile inorganic iron species (labile iron) are maintained within the euphotic zone and serve as an im...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature25982
更新日期：2018-03-22 00:00:00
abstract：:It has long been known that the 5' to 3' polarity of DNA synthesis results in both a leading and lagging strand at all replication forks. Until now, however, there has been no evidence that leading or lagging strands are spatially organized in any way within a cell. Here we show that chromosome segregation in Escheric...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07282
更新日期：2008-10-30 00:00:00
abstract：:Compared with atoms, molecules have a rich internal structure that offers many opportunities for technological and scientific advancement. The study of this structure could yield critical insights into quantum chemistry, new methods for manipulating quantum information, and improved tests of discrete symmetry violatio...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11937
更新日期：2013-03-28 00:00:00
abstract：:As key executers of biological functions, the activity and abundance of proteins are subjected to extensive regulation. Deciphering the genetic architecture underlying this regulation is critical for understanding cellular signalling events and responses to environmental cues. Using random mutagenesis in haploid human...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature22376
更新日期：2017-06-08 00:00:00
abstract：:'Hot Jupiter' extrasolar planets are expected to be tidally locked because they are close (<0.05 astronomical units, where 1 au is the average Sun-Earth distance) to their parent stars, resulting in permanent daysides and nightsides. By observing systems where the planet and star periodically eclipse each other, sever...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05782
更新日期：2007-05-10 00:00:00
abstract：:Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellula...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/341619a0
更新日期：1989-10-19 00:00:00
abstract：:This corrects the article DOI: 10.1038/nature22062. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature24276
更新日期：2017-10-26 00:00:00
abstract：:Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding sites are widely distributed in the promoters and enhancers of the globin gene family, and of other erythroid-specific genes. Aberrant binding of the human factor...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/343092a0
更新日期：1990-01-04 00:00:00
abstract：:The presence of papillomaviruses in epithelial-derived cancers from several animal species has led to the speculation that these viruses may also have a pathogenic role in the development of certain human carcinomas, particularly those associated with the anogenital tract. Recently, human papillomavirus (HPV) DNA has ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/300771a0
更新日期：1982-12-23 00:00:00
