Abstract:
:Homoiotherms, for example mammals, regulate their body temperature with physiological responses such as a change of metabolic rate and sweating. In contrast, the body temperature of poikilotherms, for example Drosophila, is the result of heat exchange with the surrounding environment as a result of the large ratio of surface area to volume of their bodies. Accordingly, these animals must instinctively move to places with an environmental temperature as close as possible to their genetically determined desired temperature. The temperature that Drosophila instinctively prefers has a function equivalent to the 'set point' temperature in mammals. Although various temperature-gated TRP channels have been discovered, molecular and cellular components in Drosophila brain responsible for determining the desired temperature remain unknown. We identified these components by performing a large-scale genetic screen of temperature preference behaviour (TPB) in Drosophila. In parallel, we mapped areas of the Drosophila brain controlling TPB by targeted inactivation of neurons with tetanus toxin and a potassium channel (Kir2.1) driven with various brain-specific GAL4s. Here we show that mushroom bodies (MBs) and the cyclic AMP-cAMP-dependent protein kinase A (cAMP-PKA) pathway are essential for controlling TPB. Furthermore, targeted expression of cAMP-PKA pathway components in only the MB was sufficient to rescue abnormal TPB of the corresponding mutants. Preferred temperatures were affected by the level of cAMP and PKA activity in the MBs in various PKA pathway mutants.
journal_name
Naturejournal_title
Natureauthors
Hong ST,Bang S,Hyun S,Kang J,Jeong K,Paik D,Chung J,Kim Jdoi
10.1038/nature07090subject
Has Abstractpub_date
2008-08-07 00:00:00pages
771-5issue
7205eissn
0028-0836issn
1476-4687pii
nature07090journal_volume
454pub_type
杂志文章相关文献
NATURE文献大全abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07109-2
更新日期:2018-10-01 00:00:00
abstract::The existence of prostate stem cells (PSCs) was first postulated from the observation that normal prostate regeneration can occur after repeated cycles of androgen deprivation and replacement in rodents. Given the critical role of PSCs in maintaining prostate tissue integrity and their potential involvement in prostat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07427
更新日期:2008-12-11 00:00:00
abstract::Nanomachines of the future will require molecular-scale motors that can perform work and collectively induce controlled motion of much larger objects. We have designed a synthetic, light-driven molecular motor that is embedded in a liquid-crystal film and can rotate objects placed on the film that exceed the size of t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/440163a
更新日期:2006-03-09 00:00:00
abstract::Abscisic acid (ABA) is a vital phytohormone that regulates mainly stomatal aperture and seed development, but ABA receptors involved in these processes have yet to be determined. We previously identified from broad bean an ABA-binding protein (ABAR) potentially involved in stomatal signalling, the gene for which encod...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05176
更新日期:2006-10-19 00:00:00
abstract::Transient receptor potential (TRP) channels are sensors for a wide range of cellular and environmental signals, but elucidating how these channels respond to physical and chemical stimuli has been hampered by a lack of detailed structural information. Here we exploit advances in electron cryo-microscopy to determine t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12822
更新日期:2013-12-05 00:00:00
abstract::Mice of the C57BL/6 strain are resistant to the development of skin squamous carcinomas (SCCs) induced by an activated Ras oncogene, whereas FVB/N mice are highly susceptible. The genetic basis of this difference in phenotype is unknown. Here we show that susceptibility to SCC is under the control of a carboxy-termina...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05489
更新日期:2007-02-15 00:00:00
abstract::Whether or not the Large Hadron Collider reveals the long-awaited Higgs particle, it is likely to lead to discoveries that add to, or challenge, the standard model of particle physics. Data produced will be pored over for any evidence of supersymmetric partners for the existing denizens of the particle 'zoo' and for t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06079
更新日期:2007-07-19 00:00:00
abstract::Interleukin (IL)-17-producing T helper cells (T(H)17) are a recently identified CD4(+) T cell subset distinct from T helper type 1 (T(H)1) and T helper type 2 (T(H)2) cells. T(H)17 cells can drive antigen-specific autoimmune diseases and are considered the main population of pathogenic T cells driving experimental aut...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10228
更新日期:2011-07-17 00:00:00
abstract::Nuclear pore complexes reside in the nuclear envelope of eukaryotic cells and mediate the nucleocytoplasmic exchange of macromolecules. Traffic is regulated by mobile transport receptors that target their cargo to the central translocation channel, where phenylalanine-glycine-rich repeats serve as binding sites. The s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06170
更新日期:2007-10-04 00:00:00
abstract::Dense plexuses of neurones containing immunoreactive vasoactive intestinal peptide (VIP) have been found in discrete areas of the central nervous system and in peripheral organs, including the gastrointestinal tract, pancreas and urogenital system. In many of these locations VIP is concentrated in nerve endings, where...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/281574a0
更新日期:1979-10-18 00:00:00
abstract::Approximately 2% of colorectal cancer is linked to pre-existing inflammation known as colitis-associated cancer, but most develops in patients without underlying inflammatory bowel disease. Colorectal cancer often follows a genetic pathway whereby loss of the adenomatous polyposis coli (APC) tumour suppressor and acti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11465
更新日期:2012-11-08 00:00:00
abstract::It is commonly assumed that certain features are so elementary to the visual system that they require no attentional resources to be perceived. Such 'preattentive' features are traditionally identified by visual search performance, in which the reaction time for detecting a feature difference against a set of distract...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/42940
更新日期:1997-06-19 00:00:00
abstract::Atrial natriuretic peptide (ANP) is a polypeptide hormone whose effects include the induction of diuresis, natriuresis and vasorelaxation. One of the earliest events following binding of ANP to receptors on target cells is an increase in cyclic GMP concentration, indicating that this nucleotide might act as a mediator...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338078a0
更新日期:1989-03-02 00:00:00
abstract::Lake Victoria, together with its satellite lakes, harbours roughly 200 endemic forms of cichlid fishes that are classified as 'haplochromines' and yet the lake system is less than a million years old. This 'flock' has attracted attention because of the possibility that it evolved within the lake from one ancestral spe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347550a0
更新日期:1990-10-11 00:00:00
abstract::Functioning and processing of membrane proteins critically depend on the way their transmembrane segments are embedded in the membrane. Sphingolipids are structural components of membranes and can also act as intracellular second messengers. Not much is known of sphingolipids binding to transmembrane domains (TMDs) of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10742
更新日期:2012-01-09 00:00:00
abstract::Nerve growth factor (NGF) activity was not detected by bioassay in irides killed immediately after excision but NGF appeared within 24 h in living irides placed in culture or grafted to a host eye. Furthermore, sensory and, although less effective, sympathetic denervation of irides in situ led within 10 days to the ap...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/286025a0
更新日期:1980-07-03 00:00:00
abstract::Gamma-ray bursts (GRBs) are most probably powered by collimated relativistic outflows (jets) from accreting black holes at cosmological distances. Bright afterglows are produced when the outflow collides with the ambient medium. Afterglow polarization directly probes the magnetic properties of the jet when measured mi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13237
更新日期:2014-05-08 00:00:00
abstract::The ability to pattern surfaces on a microscopic length scale is of importance for technological applications such as the fabrication of microelectronic circuits and digital storage media. Devices fabricated entirely from polymers are now available, opening up the possibility of adapting polymer processing technologie...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35006597
更新日期:2000-03-30 00:00:00
abstract::The injection of Rous sarcoma virus (RSV) into the wing web of newly hatched chicks causes a rapidly growing sarcomatous tumour which is palpable within 1 week of inoculation; and cultures of fibroblasts derived from chick embryos (CEF) and infected with RSV become rapidly transformed. Genetic studies have determined ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/309552a0
更新日期:1984-06-07 00:00:00
abstract::To cause diseases in plants, pathogenic microorganisms have evolved mechanisms to deliver proteins directly into plant cells, where they suppress plant defences and facilitate tissue invasion. How plant pathogenic fungi, which cause many of the world's most serious plant diseases, deliver proteins during plant infecti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04567
更新日期:2006-03-23 00:00:00
abstract::Mammalian circadian clocks consist of complex integrated feedback loops that cannot be elucidated without comprehensive measurement of system dynamics and determination of network structures. To dissect such a complicated system, we took a systems-biological approach based on genomic, molecular and cell biological tec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00906
更新日期:2002-08-01 00:00:00
abstract::Hereditary persistance of fetal haemoglobin (HPFH) is a benign condition characterized by the production in adulthood of more than 1% fetal haemoglobin (HbF, alpha 2 gamma 2) in the absence of erythropoietic stress. Several genetic types have been discerned based on the level of HbF produced, the relative contribution...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/313325a0
更新日期:1985-01-24 00:00:00
abstract::Decision making in an uncertain environment poses a conflict between the opposing demands of gathering and exploiting information. In a classic illustration of this 'exploration-exploitation' dilemma, a gambler choosing between multiple slot machines balances the desire to select what seems, on the basis of accumulate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04766
更新日期:2006-06-15 00:00:00
abstract::Distinctive acute brain damage involving limbic and related brain regions develops in adult rats following sustained limbic seizures induced by systemic administration of kainic acid or dipiperidinoethane (DPE) or by intra-amygdaloid injection of kainic acid or folic acid. This seizure-brain damage (S-BD) syndrome is ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/301520a0
更新日期:1983-02-10 00:00:00
abstract::Global efforts to mitigate climate change are guided by projections of future temperatures. But the eventual equilibrium global mean temperature associated with a given stabilization level of atmospheric greenhouse gas concentrations remains uncertain, complicating the setting of stabilization targets to avoid potenti...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature08019
更新日期:2009-04-30 00:00:00
abstract::Change history: In this Letter, the received date should be 20 December 2017, instead of 27 April 2018. This has been corrected online. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0314-9
更新日期:2018-10-01 00:00:00
abstract::In mammalian somatic-cell cycles, progression through the G1-phase restriction point and initiation of DNA replication are controlled by the ability of the retinoblastoma tumour-suppressor protein (pRb) family to regulate the E2F/DP transcription factors. Continuing transcription of E2F target genes beyond the G1/S tr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/44611
更新日期:1999-10-21 00:00:00
abstract::DNA winds about itself in a right-handed or left-handed fashion at several structural levels. The double helix is generally right-handed and is given a (+) sign by convention, whereas supercoiling of the helix axis is always (-) in the cell. The winding in higher -order forms such as knots and catenanes is unknown, an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304559a0
更新日期:1983-08-11 00:00:00
abstract::The giant polytene chromosomes of Drosophila melanogaster have long been of interest to the geneticist because of the visible map of the genome provided by their characteristic banding patterns. An issue in the understanding of the molecular basis of chromosome banding has been whether the chromosomal DNA is replicate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307176a0
更新日期:1984-01-12 00:00:00
abstract::ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP occurs in the mitochondrial matrix, ATP is exported into the cytoplasm while ADP is imported into the matrix. The exchange is accomplished by...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02056
更新日期:2003-11-06 00:00:00