Snapshots of nuclear pore complexes in action captured by cryo-electron tomography.

abstract：:Monoclonal antibodies can now be genetically engineered and endowed with new properties. In the future, gene technology could enable antigen-binding fragments to be made by exploiting repertoires of variable domain genes derived from immunized animals and expressed in bacteria. How readily can this approach be extende...

journal_title：Nature

authors： Winter G,Milstein C

更新日期：1991-01-24 00:00:00

abstract：:Early sensory experience instructs the maturation of neural circuitry in the cortex. This has been studied extensively in the primary visual cortex, in which loss of vision to one eye permanently degrades cortical responsiveness to that eye, a phenomenon known as ocular dominance plasticity (ODP). Cortical inhibition ...

journal_title：Nature

authors： Kuhlman SJ,Olivas ND,Tring E,Ikrar T,Xu X,Trachtenberg JT

更新日期：2013-09-26 00:00:00

abstract：:The ras proto-oncogene, found in all eukaryotes so far examined, encode s a protein with guanine nucleotide-binding and GTPase activity. Gene disruption experiments in yeast indicate that ras is essential for cell growth. Anit-sense mutagenesis approaches suggest that this is also true for Dictyostelium. Most mutation...

journal_title：Nature

authors： Reymond CD,Gomer RH,Nellen W,Theibert A,Devreotes P,Firtel RA

更新日期：1986-09-25 00:00:00

abstract：:The DNA of telomeres--the terminal DNA-protein complexes of chromosomes--differs notably from other DNA sequences in both structure and function. Recent work has highlighted its remarkable mode of synthesis by the ribonucleoprotein reverse transcriptase, telomerase, as well as its ability to form unusual structures in...

journal_title：Nature

authors： Blackburn EH

更新日期：1991-04-18 00:00:00

abstract：:Supersolids are exotic materials combining the frictionless flow of a superfluid with the crystal-like periodic density modulation of a solid. The supersolid phase of matter was predicted 50 years ago1-3 for solid helium4-8. Ultracold quantum gases have recently been made to exhibit periodic order typical of a crystal...

journal_title：Nature

authors： Tanzi L,Roccuzzo SM,Lucioni E,Famà F,Fioretti A,Gabbanini C,Modugno G,Recati A,Stringari S

更新日期：2019-10-01 00:00:00

abstract：:The editing of RNA in trypanosomatid mitochondria involves the insertion and occasional deletion of uridine residues within coding regions of maxicircle messenger RNA transcripts. The extent to which the transcripts of homologous genes undergo editing differs in different species. In some, entire genes are edited (pan...

journal_title：Nature

authors： Maslov DA,Avila HA,Lake JA,Simpson L

更新日期：1994-03-24 00:00:00

abstract：:One simple, widely accepted mechanism for generating an aberrant chromosome number, or aneuploidy, is through nondisjunction--a chromosome distribution error that occurs during mitosis when both copies of a duplicated chromosome are deposited into one daughter cell and none into the other. Shi and King challenge this ...

journal_title：Nature

authors： Weaver BA,Silk AD,Cleveland DW

更新日期：2006-08-17 00:00:00

abstract：:Tobacco smoking causes lung cancer1-3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented6-10, but equivalent data for normal bronchial cells are lacking. Here we sequence...

journal_title：Nature

authors： Yoshida K,Gowers KHC,Lee-Six H,Chandrasekharan DP,Coorens T,Maughan EF,Beal K,Menzies A,Millar FR,Anderson E,Clarke SE,Pennycuick A,Thakrar RM,Butler CR,Kakiuchi N,Hirano T,Hynds RE,Stratton MR,Martincorena I,Janes

更新日期：2020-02-01 00:00:00

abstract：:High pressure is known to influence electronic structure and crystal packing, and can in some cases even induce compound formation between elements that do not bond under ambient conditions. Here we present a computational study showing that high pressure fundamentally alters the reactivity of the light elements lithi...

journal_title：Nature

authors： Feng J,Hennig RG,Ashcroft NW,Hoffmann R

更新日期：2008-01-24 00:00:00

abstract：:Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a compl...

journal_title：Nature

authors： Perry JR,Day F,Elks CE,Sulem P,Thompson DJ,Ferreira T,He C,Chasman DI,Esko T,Thorleifsson G,Albrecht E,Ang WQ,Corre T,Cousminer DL,Feenstra B,Franceschini N,Ganna A,Johnson AD,Kjellqvist S,Lunetta KL,McMahon G,N

更新日期：2014-10-02 00:00:00

abstract：:Sudden cardiac death is the leading cause of death in the industrialized world, with the majority of such tragedies being due to ventricular fibrillation. Ventricular fibrillation is a frenzied and irregular disturbance of the heart rhythm that quickly renders the heart incapable of sustaining life. Rotors, electrophy...

journal_title：Nature

authors： Witkowski FX,Leon LJ,Penkoske PA,Giles WR,Spano ML,Ditto WL,Winfree AT

更新日期：1998-03-05 00:00:00

abstract：:Nitrogen (N) limits the productivity of many ecosystems worldwide, thereby restricting the ability of terrestrial ecosystems to offset the effects of rising atmospheric CO(2) emissions naturally. Understanding input pathways of bioavailable N is therefore paramount for predicting carbon (C) storage on land, particular...

journal_title：Nature

authors： Morford SL,Houlton BZ,Dahlgren RA

更新日期：2011-08-31 00:00:00

abstract：:The molecular and cellular basis of T-lymphocyte activation remains a central question in immunology. The growth of already proliferating T cells is known to depend on T-cell growth factor (TCGF), a physiological mitogen. Noncycling T lymphocytes, however, are not sensitive to TCGF. They require a short contact with m...

journal_title：Nature

authors： Larsson EL,Iscove NN,Coutinho A

更新日期：1980-02-14 00:00:00

abstract：:The best spectrographs are limited in stability by their calibration light source. Laser frequency combs are the ideal calibrators for astronomical spectrographs. They emit a spectrum of lines that are equally spaced in frequency and that are as accurate and stable as the atomic clock relative to which the comb is sta...

journal_title：Nature

authors： Wilken T,Curto GL,Probst RA,Steinmetz T,Manescau A,Pasquini L,González Hernández JI,Rebolo R,Hänsch TW,Udem T,Holzwarth R

更新日期：2012-05-30 00:00:00

abstract：:Why infer evolution when you can watch it happen in real time? This is the basic premise of using populations of fast-replicating microorganisms in test tubes to study evolution. The approach, known as experimental evolution, has provided a way of testing many of the key hypotheses that arose from the modern evolution...

journal_title：Nature

authors： Buckling A,Craig Maclean R,Brockhurst MA,Colegrave N

更新日期：2009-02-12 00:00:00

abstract：:The autosomal dominant hyper-IgE syndrome (HIES, 'Job's syndrome') is characterized by recurrent and often severe pulmonary infections, pneumatoceles, eczema, staphylococcal abscesses, mucocutaneous candidiasis, and abnormalities of bone and connective tissue. Mutations presumed to underlie HIES have recently been ide...

journal_title：Nature

authors： Milner JD,Brenchley JM,Laurence A,Freeman AF,Hill BJ,Elias KM,Kanno Y,Spalding C,Elloumi HZ,Paulson ML,Davis J,Hsu A,Asher AI,O'Shea J,Holland SM,Paul WE,Douek DC

更新日期：2008-04-10 00:00:00

abstract：:In Fig. 6a of this Article, the two dots corresponding to Cidea and S100b were erroneously moved to the top left of the volcano plot; this figure has been corrected online.An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Zeng X,Ye M,Resch JM,Jedrychowski MP,Hu B,Lowell BB,Ginty DD,Spiegelman BM

更新日期：2019-06-01 00:00:00

abstract：:Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural...

journal_title：Nature

authors： Jones EY,Stuart DI,Walker NP

更新日期：1989-03-16 00:00:00

abstract：:The TGF-beta/activin/BMP superfamily of growth factors signals through heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. The signal originated by TGF-beta-like molecules appears to be transduced by a set of evolutionarily conserved proteins known as SMADs, which upon activation di...

journal_title：Nature

authors： Lagna G,Hata A,Hemmati-Brivanlou A,Massagué J

更新日期：1996-10-31 00:00:00

abstract：:The insulins of New World hystricomorph rodents exhibit many novel amino acid changes in primary structure when compared with other mammalian insulins. These changes give rise to unusual properties (low potency, failure to self-associate) not shared by other naturally-occurring insulins. We report here on the primary ...

journal_title：Nature

authors： Horuk R,Blundell TL,Lazarus NR,Neville RW,Stone D,Wollmer A

更新日期：1980-08-21 00:00:00

abstract：:Paired-associate learning is often used to examine episodic memory in humans. Animal models include the recall of food-cache locations by scrub jays and sequential memory. Here we report a model in which rats encode, during successive sample trials, two paired associates (flavours of food and their spatial locations) ...

journal_title：Nature

authors： Day M,Langston R,Morris RG

更新日期：2003-07-10 00:00:00

abstract：:All living organisms use ion channels to regulate the transport of ions across cellular membranes. Certain ion channels are classed as voltage-dependent because they have a voltage-sensing structure that induces their pores to open in response to changes in the cell membrane voltage. Until recently, the voltage-depend...

journal_title：Nature

authors： Ruta V,Jiang Y,Lee A,Chen J,MacKinnon R

更新日期：2003-03-13 00:00:00

abstract：:Human activities are causing Earth's sixth major extinction event-an accelerating decline of the world's stocks of biological diversity at rates 100 to 1,000 times pre-human levels. Historically, low-impact intrusion into species habitats arose from local demands for food, fuel and living space. However, in today's in...

journal_title：Nature

authors： Lenzen M,Moran D,Kanemoto K,Foran B,Lobefaro L,Geschke A

更新日期：2012-06-06 00:00:00

abstract：:CDKN2A (INK4a/ARF) is frequently disrupted in various types of human cancer, and germline mutations of this locus can confer susceptibility to melanoma and other tumours. However, because CDKN2A encodes two distinct cell cycle inhibitory proteins, p16INK4a and p14ARF (p19Arf in mice), the mechanism of tumour suppressi...

journal_title：Nature

authors： Krimpenfort P,Quon KC,Mooi WJ,Loonstra A,Berns A

更新日期：2001-09-06 00:00:00

abstract：:Metazoan gene regulation often involves the pausing of RNA polymerase II (Pol II) in the promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation factor (NELF). Here we report the cryo-electron microscopy structure of a paused transcr...

journal_title：Nature

authors： Vos SM,Farnung L,Urlaub H,Cramer P

更新日期：2018-08-01 00:00:00

abstract：:The structure of poly(dA).poly(dT) currently arouses great interest, mainly because dAn.dTn stretches are associated with considerable DNA bending. Until recently the heteronomous DNA described by Arnott et al., with the poly(dA) and poly(dT) chains in A and B conformations respectively, was the only detailed model of...

journal_title：Nature

authors： Alexeev DG,Lipanov AA,Skuratovskii IYa

更新日期：1987-02-26 00:00:00

abstract：:Traditionally, entanglement was considered to be a quirk of microscopic objects that defied a common-sense explanation. Now, however, entanglement is recognized to be ubiquitous and robust. With the realization that entanglement can occur in macroscopic systems - and with the development of experiments aimed at exploi...

journal_title：Nature

authors： Vedral V

更新日期：2008-06-19 00:00:00

abstract：:Interest in mapping the global distribution of malaria is motivated by a need to define populations at risk for appropriate resource allocation and to provide a robust framework for evaluating its global economic impact. Comparison of older and more recent malaria maps shows how the disease has been geographically res...

journal_title：Nature

authors： Snow RW,Guerra CA,Noor AM,Myint HY,Hay SI

更新日期：2005-03-10 00:00:00

abstract：:The beta, gamma-crystallins form a class of homologous proteins in the eye lens. Each gamma-crystallin comprises four topologically equivalent, Greek key motifs; pairs of motifs are organized around a local dyad to give domains and two similar domains are in turn related by a further local dyad. Sequence comparisons a...

journal_title：Nature

authors： Bax B,Lapatto R,Nalini V,Driessen H,Lindley PF,Mahadevan D,Blundell TL,Slingsby C

更新日期：1990-10-25 00:00:00

abstract：:Templates are widely used to arrange molecular components so they can be covalently linked into complex molecules that are not readily accessible by classical synthetic methods. Nature uses sophisticated templates such as the ribosome, whereas chemists use simple ions or small molecules. But as we tackle the synthesis...

journal_title：Nature

authors： O'Sullivan MC,Sprafke JK,Kondratuk DV,Rinfray C,Claridge TD,Saywell A,Blunt MO,O'Shea JN,Beton PH,Malfois M,Anderson HL

更新日期：2011-01-06 00:00:00