Evolution of RNA editing in kinetoplastid protozoa.

abstract：:China is the world's most populous country and a major emitter of greenhouse gases. Consequently, much research has focused on China's influence on climate change but somewhat less has been written about the impact of climate change on China. China experienced explosive economic growth in recent decades, but with only...

journal_title：Nature

authors： Piao S,Ciais P,Huang Y,Shen Z,Peng S,Li J,Zhou L,Liu H,Ma Y,Ding Y,Friedlingstein P,Liu C,Tan K,Yu Y,Zhang T,Fang J

更新日期：2010-09-02 00:00:00

abstract：:Magnetic fields play a part in almost all stages of stellar evolution. Most low-mass stars, including the Sun, show surface fields that are generated by dynamo processes in their convective envelopes. Intermediate-mass stars do not have deep convective envelopes, although 10 per cent exhibit strong surface fields that...

journal_title：Nature

authors： Stello D,Cantiello M,Fuller J,Huber D,García RA,Bedding TR,Bildsten L,Aguirre VS

更新日期：2016-01-21 00:00:00

abstract：:In mammals, enlargement of the heart during embryonic development is primarily dependent on the increase in cardiomyocyte numbers. Shortly after birth, however, cardiomyocytes stop proliferating and further growth of the myocardium occurs through hypertrophic enlargement of the existing myocytes. As a consequence of t...

journal_title：Nature

authors： Eulalio A,Mano M,Dal Ferro M,Zentilin L,Sinagra G,Zacchigna S,Giacca M

更新日期：2012-12-20 00:00:00

abstract：:In associative learning, the activated neurones undergo a variety of concomitant functional alterations--increases or decreases of firing activity and modifications of membrane potential or resistance and of synaptic responsiveness. Synaptic transmission which can be strengthened only when there is paired activity in ...

journal_title：Nature

authors： Baranyi A,Fehér O

更新日期：1981-04-02 00:00:00

abstract：:The efficiency of generating electricity from heat using concentrated solar power plants (which use mirrors or lenses to concentrate sunlight in order to drive heat engines, usually involving turbines) may be appreciably increased by operating with higher turbine inlet temperatures, but this would require improved hea...

journal_title：Nature

authors： Caccia M,Tabandeh-Khorshid M,Itskos G,Strayer AR,Caldwell AS,Pidaparti S,Singnisai S,Rohskopf AD,Schroeder AM,Jarrahbashi D,Kang T,Sahoo S,Kadasala NR,Marquez-Rossy A,Anderson MH,Lara-Curzio E,Ranjan D,Henry A,Sandhag

更新日期：2018-10-01 00:00:00

abstract：:In the few species of birds in which males form display partnerships to attract females, one male secures most or all of the copulations. This leads to the question of why subordinate males help in the absence of observable reproductive benefits. Hamilton's concept of kin selection, whereby individuals can benefit ind...

journal_title：Nature

authors： Krakauer AH

更新日期：2005-03-03 00:00:00

abstract：:Plants encounter a myriad of microorganisms, particularly at the root-soil interface, that can invade with detrimental or beneficial outcomes. Prevalent beneficial associations between plants and microorganisms include those that promote plant growth by facilitating the acquisition of limiting nutrients such as nitrog...

journal_title：Nature

authors： Zipfel C,Oldroyd GE

更新日期：2017-03-15 00:00:00

abstract：:Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1% of the human population. It is generally accepted that genetic factors have an important pathogenic role in a substantial portion of schizophrenia cases; however, despite decades of family studies, there is no agreed-upon mode...

journal_title：Nature

authors： Kennedy JL,Giuffra LA,Moises HW,Cavalli-Sforza LL,Pakstis AJ,Kidd JR,Castiglione CM,Sjogren B,Wetterberg L,Kidd KK

更新日期：1988-11-10 00:00:00

abstract：:The stable isotope ratios of atmospheric CO(2) ((18)O/(16)O and (13)C/(12)C) have been monitored since 1977 to improve our understanding of the global carbon cycle, because biosphere-atmosphere exchange fluxes affect the different atomic masses in a measurable way. Interpreting the (18)O/(16)O variability has proved d...

journal_title：Nature

authors： Welp LR,Keeling RF,Meijer HA,Bollenbacher AF,Piper SC,Yoshimura K,Francey RJ,Allison CE,Wahlen M

更新日期：2011-09-28 00:00:00

abstract：:The behaviour of electrons in solids is well described by Landau's Fermi-liquid theory, which predicts that although electrons in a metal interact, they can still be treated as well defined fermions, which are called 'quasiparticles'. At low temperatures, the ability of quasiparticles to transport heat is given strict...

journal_title：Nature

authors： Hill RW,Proust C,Taillefer L,Fournier P,Greene RL

更新日期：2001-12-13 00:00:00

abstract：:Zika virus (ZIKV) is a flavivirus that is responsible for the current epidemic in Brazil and the Americas. ZIKV has been causally associated with fetal microcephaly, intrauterine growth restriction, and other birth defects in both humans and mice. The rapid development of a safe and effective ZIKV vaccine is a global ...

journal_title：Nature

authors： Larocca RA,Abbink P,Peron JP,Zanotto PM,Iampietro MJ,Badamchi-Zadeh A,Boyd M,Ng'ang'a D,Kirilova M,Nityanandam R,Mercado NB,Li Z,Moseley ET,Bricault CA,Borducchi EN,Giglio PB,Jetton D,Neubauer G,Nkolola JP,Maxfield

更新日期：2016-08-25 00:00:00

abstract：:For the past couple of centuries the penchant for prediction has been prevalent at century turns. How much have evaluations of scientific discovery and predictions for future advancement changed since those of the science commentators at the end of the last century? ...

journal_title：Nature

authors： Heilbron JL,Bynum WF

更新日期：1999-12-02 00:00:00

abstract：:A fascinating question in biology is how molecular changes in developmental pathways lead to macroevolutionary changes in morphology. Mutations in homeotic (Hox) genes have long been suggested as potential causes of morphological evolution, and there is abundant evidence that some changes in Hox expression patterns co...

journal_title：Nature

authors： Ronshaugen M,McGinnis N,McGinnis W

更新日期：2002-02-21 00:00:00

abstract：:Mammal-like reptiles of the order Therapsida document the emergence of mammals from more primitive synapsids and are of unique zoological and palaeontological interest on that account. Therapsids, first appearing in the Early Permian, were thought to become extinct in the Middle Jurassic, soon after the Late Triassic ...

journal_title：Nature

authors： Fox RC,Youzwyshyn GP,Krause DW

更新日期：1992-07-16 00:00:00

abstract：:Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self. In the settings of infection and cancer, microbes and tumours can exploit DCs to evade immunity, but DCs also can generate resistance, a capacity that is readily enhanced with...

journal_title：Nature

authors： Steinman RM,Banchereau J

更新日期：2007-09-27 00:00:00

abstract：:The epiblast (EPI) is the origin of all somatic and germ cells in mammals, and of pluripotent stem cells in vitro. To explore the ontogeny of human and primate pluripotency, here we perform comprehensive single-cell RNA sequencing for pre- and post-implantation EPI development in cynomolgus monkeys (Macaca fasciculari...

journal_title：Nature

authors： Nakamura T,Okamoto I,Sasaki K,Yabuta Y,Iwatani C,Tsuchiya H,Seita Y,Nakamura S,Yamamoto T,Saitou M

更新日期：2016-09-01 00:00:00

abstract：:Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription ...

journal_title：Nature

authors： Anneser L,Alcantara IC,Gemmer A,Mirkes K,Ryu S,Schuman EM

更新日期：2020-12-01 00:00:00

abstract：:Introns are removed from nuclear messenger RNA precursors through two sequential phospho-transesterification reactions in a dynamic RNA-protein complex called the spliceosome. But whether splicing is catalysed by small nuclear RNAs in the spliceosome is unresolved. As the spliceosome is a metalloenzyme, it is importan...

journal_title：Nature

authors： Yean SL,Wuenschell G,Termini J,Lin RJ

更新日期：2000-12-14 00:00:00

abstract：:Plasticity in neural circuits can result from alterations in synaptic strength or connectivity, as well as from changes in the excitability of the neurons themselves. To better understand the role of plasticity in the brain, we need to establish how brain circuits work and the kinds of computations that different circ...

journal_title：Nature

authors： Destexhe A,Marder E

更新日期：2004-10-14 00:00:00

abstract：:To understand the processes that regulate the abundance and persistence of wild populations is a fundamental goal of ecology and a prerequisite for the management of living resources. Variable abundance data, however, make the demonstration of regulation processes challenging. A previously overlooked aspect in underst...

journal_title：Nature

authors： Minto C,Myers RA,Blanchard W

更新日期：2008-03-20 00:00:00

abstract：:The colorectal adenoma-carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal expansions that lead to cancer1. However, our understanding of the earliest phases of colorectal neoplastic changes-which may occur in morphologically normal ti...

journal_title：Nature

authors： Lee-Six H,Olafsson S,Ellis P,Osborne RJ,Sanders MA,Moore L,Georgakopoulos N,Torrente F,Noorani A,Goddard M,Robinson P,Coorens THH,O'Neill L,Alder C,Wang J,Fitzgerald RC,Zilbauer M,Coleman N,Saeb-Parsy K,Martincorena

更新日期：2019-10-01 00:00:00

abstract：:In mammalian tissues the C-terminal amide structure has been found to occur only in neuroactive or hormonally-active peptides. About half known neuropeptide and peptide hormones have this unique chemical feature. Using a chemical detection method, a search for previously unknown peptides that possess the C-terminal am...

journal_title：Nature

authors： Tatemoto K,Efendić S,Mutt V,Makk G,Feistner GJ,Barchas JD

更新日期：1986-12-04 00:00:00

abstract：:How to image objects that are hidden from a camera's view is a problem of fundamental importance to many fields of research, with applications in robotic vision, defence, remote sensing, medical imaging and autonomous vehicles. Non-line-of-sight (NLOS) imaging at macroscopic scales has been demonstrated by scanning a ...

journal_title：Nature

authors： O'Toole M,Lindell DB,Wetzstein G

更新日期：2018-03-15 00:00:00

abstract：:CRISPR-Cas genome-editing nucleases hold substantial promise for developing human therapeutic applications1-6 but identifying unwanted off-target mutations is important for clinical translation7. A well-validated method that can reliably identify off-targets in vivo has not been described to date, which means it is cu...

journal_title：Nature

authors： Akcakaya P,Bobbin ML,Guo JA,Malagon-Lopez J,Clement K,Garcia SP,Fellows MD,Porritt MJ,Firth MA,Carreras A,Baccega T,Seeliger F,Bjursell M,Tsai SQ,Nguyen NT,Nitsch R,Mayr LM,Pinello L,Bohlooly-Y M,Aryee MJ,Maresca

更新日期：2018-09-01 00:00:00

abstract：:Rivers sourced in the Himalayan mountain range carry some of the largest sediment loads on the planet, yet coarse gravel in these rivers vanishes within approximately 10-40 kilometres on entering the Ganga Plain (the part of the North Indian River Plain containing the Ganges River). Understanding the fate of gravel is...

journal_title：Nature

authors： Dingle EH,Attal M,Sinclair HD

更新日期：2017-04-26 00:00:00

abstract：:The cortex organizes sensory information to enable discrimination and generalization1-4. As systematic representations of chemical odour space have not yet been described in the olfactory cortex, it remains unclear how odour relationships are encoded to place chemically distinct but similar odours, such as lemon and o...

journal_title：Nature

authors： Pashkovski SL,Iurilli G,Brann D,Chicharro D,Drummey K,Franks KM,Panzeri S,Datta SR

更新日期：2020-07-01 00:00:00

abstract：:Multiple sulphatase deficiency disease is an unusual autosomal recessive disorder characterised biochemically by a deficiency of several sulphohydrolase activities. The laboratory diagnosis of this combined neurological connective tissue disorder is made on the basis of decreased activities of the lysosomal enzymes, a...

journal_title：Nature

authors： Fiddler MB,Vine D,Shapira E,Nadler HL

更新日期：1979-11-01 00:00:00

abstract：:Measuring the completeness of the fossil record is essential to understanding evolution over long timescales, particularly when comparing evolutionary patterns among biological groups with different preservational properties. Completeness measures have been presented for various groups based on gaps in the stratigraph...

journal_title：Nature

authors： Foote M,Sepkoski JJ Jr

更新日期：1999-04-01 00:00:00

abstract：:There is increasing evidence for the process of sympatric speciation, in which reproductive isolation of species occurs without physical isolation. Theoretical models have focused on disruptive natural selection as the crucial pressure for splitting a species. Here we report the theoretical finding that sympatric spec...

journal_title：Nature

authors： Higashi M,Takimoto G,Yamamura N

更新日期：1999-12-02 00:00:00

abstract：:Interleukin-2 (IL-2) is a regulatory peptide important for the growth and differentiation of antigen-specific T lymphocytes and large granular lymphocytes. Interaction of IL-2 with its specific receptor results in the promotion of S-phase progression as well as, in certain circumstances, the production and release of ...

journal_title：Nature

authors： Farrar WL,Anderson WB

更新日期：1985-05-16 00:00:00