Abstract：
:In mammalian tissues the C-terminal amide structure has been found to occur only in neuroactive or hormonally-active peptides. About half known neuropeptide and peptide hormones have this unique chemical feature. Using a chemical detection method, a search for previously unknown peptides that possess the C-terminal amide structure in extracts of brain and intestine was carried out and a number of novel neuropeptides and hormonal peptides, designated neuropeptide Y, PHI, peptide YY, galanin and neuropeptide K were isolated. We recently performed a similar search in porcine pancreas and found a high concentration of a peptide having a glycine amide at its C-terminus. Here we report the isolation, primary structure and biological activity of this novel peptide. The 49-residue peptide strongly inhibits glucose-induced insulin release from the isolated perfused pancreas and was therefore named pancreastatin. It may be important in the regulation of insulin secretion and in the pathogenesis and treatment of diabetes mellitus.
journal_name
Naturejournal_title
Natureauthors
Tatemoto K,Efendić S,Mutt V,Makk G,Feistner GJ,Barchas JDdoi
10.1038/324476a0subject
Has Abstractpub_date
1986-12-04 00:00:00pages
476-8issue
6096eissn
0028-0836issn
1476-4687journal_volume
324pub_type
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