相关文献
NATURE文献大全abstract::The folding of newly synthesized proteins to the native state is a major challenge within the crowded cellular environment, as non-productive interactions can lead to misfolding, aggregation and degradation1. Cells cope with this challenge by coupling synthesis with polypeptide folding and by using molecular chaperone...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0462-y
更新日期:2018-09-01 00:00:00
abstract::Volatile anaesthetics have historically been considered to act in a nonspecific manner on the central nervous system. More recent studies, however, have revealed that the receptors for inhibitory neurotransmitters such as gamma-aminobutyric acid (GABA) and glycine are sensitive to clinically relevant concentrations of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/38738
更新日期:1997-09-25 00:00:00
abstract::The gut microbiota influences development1-3 and homeostasis4-7 of the mammalian immune system, and is associated with human inflammatory8 and immune diseases9,10 as well as responses to immunotherapy11-14. Nevertheless, our understanding of how gut bacteria modulate the immune system remains limited, particularly in ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2971-8
更新日期:2020-12-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 面试
doi:10.1038/d41586-018-07047-z
更新日期:2018-10-01 00:00:00
abstract::Various mechanisms have been proposed for beta-adrenergically mediated relaxation of smooth muscle. All theories suggest the involvement of cyclic AMP as a second messenger: beta-agonists stimulate adenylate cyclase which converts ATP to cyclic AMP and protein kinase, activated by cyclic AMP, is then thought to cataly...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/281682a0
更新日期:1979-10-25 00:00:00
abstract::Silicon dominates contemporary solar cell technologies1. But when absorbing photons, silicon (like other semiconductors) wastes energy in excess of its bandgap2. Reducing these thermalization losses and enabling better sensitivity to light is possible by sensitizing the silicon solar cell using singlet exciton fission...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1339-4
更新日期:2019-07-01 00:00:00
abstract::Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haem...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25168
更新日期:2018-01-11 00:00:00
abstract::Biochemical and genetic studies suggest the existence of mediators that work between the activation domains (ADs) of regulatory proteins and the basic transcriptional machinery. We have previously shown genetically that Sug1 interacts with the AD of the yeast activator Ga14. Here we provide evidence that the Sug1 prot...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/374088a0
更新日期:1995-03-02 00:00:00
abstract::During the past ten years, coupled quantum wells have emerged as a promising system for experiments on Bose condensation of excitons, with numerous theoretical and experimental studies aimed at the demonstration of this effect. One of the issues driving these studies is the possibility of long-range coherent transport...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00940
更新日期:2002-08-15 00:00:00
abstract::Major histocompatibility complex class II molecules and their peptide ligands show unusual interaction kinetics, with slow association and dissociation rates that yield an apparent equilibrium constant of approximately 10(-6)-10(-8) M (refs 1-5). However, there is evidence for a specific, rapidly formed, short-lived c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/370647a0
更新日期:1994-08-25 00:00:00
abstract::DEET (N,N-diethyl-meta-toluamide) is a synthetic chemical identified by the US Department of Agriculture in 1946 in a screen for repellents to protect soldiers from mosquito-borne diseases1,2. Since its discovery, DEET has become the world's most widely used arthropod repellent and is effective against invertebrates s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0546-8
更新日期:2018-10-01 00:00:00
abstract::Electric-field-induced charge separation (polarization) is the most fundamental manifestation of the interaction of light with matter and a phenomenon of great technological relevance. Nonlinear optical polarization produces coherent radiation in spectral ranges inaccessible by lasers and constitutes the key to ultima...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17650
更新日期:2016-06-02 00:00:00
abstract::Sea-level histories during the two most recent deglacial-interglacial intervals show substantial differences1-3 despite both periods undergoing similar changes in global mean temperature4,5 and forcing from greenhouse gases6. Although the last interglaciation (LIG) experienced stronger boreal summer insolation forcing...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/s41586-020-1931-7
更新日期:2020-01-01 00:00:00
abstract::Cyclosporin A, a cyclic undecapeptide, is a potent immunosuppressant that binds to a peptidyl-prolyl cis-trans isomerase of 165 amino acids, cyclophilin. The cyclosporin A/cyclophilin complex inhibits the calcium- and calmodulin-dependent phosphatase, calcineurin, resulting in a failure to activate genes encoding inte...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/361088a0
更新日期:1993-01-07 00:00:00
abstract::The repressor of phage 434 binds to six operator sites on the phage chromosome. A comparison of the sequences of these 14-base-pair (bp) operator sites reveals a striking pattern: at five of the six sites, the symmetrically arrayed outer eight base pairs (four in each half-site) are identical and the remaining site di...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326886a0
更新日期:1987-04-30 00:00:00
abstract::Proteomics, the large-scale analysis of proteins, will contribute greatly to our understanding of gene function in the post-genomic era. Proteomics can be divided into three main areas: (1) protein micro-characterization for large-scale identification of proteins and their post-translational modifications; (2) 'differ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/35015709
更新日期:2000-06-15 00:00:00
abstract::The site of action of the antispastic drug baclofen has long been considered to reside in the spinal cord although supraspinal effects have also been reported. This beta-chlorophenyl derivative of the neurotransmitter gamma-aminobutyric acid (GABA) depresses both monosynaptic and polysynaptic transmission in the cord ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307071a0
更新日期:1984-01-05 00:00:00
abstract::Fresnel lenses allow almost perfect imaging in widely different circumstances, but their focus is perfect only for a single wavelength. Wang et al. have shown how the effective bandpass may be widened for X-ray microscopy by using a compound diffractive/refractive lens near to an absorption edge. A compound lens has a...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/426245b
更新日期:2003-11-20 00:00:00
abstract::Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells (CSCs), which co-opt stem cell properties. For most tumours, the cellular origin of these CSCs and regulatory pathways essential for sus...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06835
更新日期:2008-04-03 00:00:00
abstract::The detection of horizontal disparities between the right and left retinal images is accepted as an important component in the visual perception of depth. It has occasionally been pointed out that a disparity will also occur in the vertical when a target is nearer to one eye than the other and could be used as a secon...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307632a0
更新日期:1984-02-16 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07480-0
更新日期:2018-11-01 00:00:00
abstract::Climate strongly affects the production of sediment from mountain catchments as well as its transport and deposition within adjacent sedimentary basins. However, identifying climatic influences on basin stratigraphy is complicated by nonlinearities, feedback loops, lag times, buffering and convergence among processes ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature11513
更新日期:2012-11-01 00:00:00
abstract::During cell division, chromosomes are segregated to nascent daughter cells by attaching to the microtubules of the mitotic spindle through the kinetochore. Kinetochores are assembled on a specialized chromatin domain called the centromere, which is characterized by the replacement of nucleosomal histone H3 with the hi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10379
更新日期:2011-08-28 00:00:00
abstract::The current need for novel antibiotics is especially acute for drug-resistant Gram-negative pathogens1,2. These microorganisms have a highly restrictive permeability barrier, which limits the penetration of most compounds3,4. As a result, the last class of antibiotics that acted against Gram-negative bacteria was deve...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1791-1
更新日期:2019-12-01 00:00:00
abstract::A fundamental tenet of cerebellar learning theories asserts that climbing fibre afferents from the inferior olive provide a teaching signal that promotes the gradual adaptation of movements. Data from several forms of motor learning provide support for this tenet. In pavlovian eyelid conditioning, for example, where a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416330a
更新日期:2002-03-21 00:00:00
abstract::The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor po...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/316701a0
更新日期:1985-08-22 00:00:00
abstract::Multiple sclerosis is thought to be an autoimmune disease of the central nervous system mediated by T cells specific for a myelin antigen. Myelin basic protein has been studied as a potential autoantigen in the disease because of its role as an encephalitogen in experimental autoimmune encephalomyelitis and post-viral...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/346183a0
更新日期:1990-07-12 00:00:00
abstract::Mutations of the presenilin-1 gene are a major cause of familial early-onset Alzheimer's disease. Presenilin-1 can associate with members of the catenin family of signalling proteins, but the significance of this association is unknown. Here we show that presenilin-1 forms a complex with beta-catenin in vivo that incr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/27208
更新日期:1998-10-15 00:00:00
abstract::(S)-2-hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear non-haem-iron-dependent enzyme responsible for the final step in the biosynthesis of the clinically useful antibiotic fosfomycin. Enzymes of this class typically catalyse oxygenation reactions that proceed via the formation of substrate radic...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11998
更新日期:2013-04-04 00:00:00
abstract::The distribution of fitness effects of protein mutations is still unknown. Of particular interest is whether accumulating deleterious mutations interact, and how the resulting epistatic effects shape the protein's fitness landscape. Here we apply a model system in which bacterial fitness correlates with the enzymatic ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05385
更新日期:2006-12-14 00:00:00