Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex.

abstract：:Most of the 470-million-year history of plants on land belongs to bryophytes, pteridophytes and gymnosperms, which eventually yielded to the ecological dominance by angiosperms 90 Myr ago. Our knowledge of angiosperm phylogeny, particularly the branching order of the earliest lineages, has recently been increased by t...

journal_title：Nature

authors： Pryer KM,Schneider H,Smith AR,Cranfill R,Wolf PG,Hunt JS,Sipes SD

更新日期：2001-02-01 00:00:00

abstract：:At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength. Rapid frequency-dependent changes in synaptic strength have key roles in sensory adaptation, gain control and many other neural computations. However, some auditory, vestibular and cerebellar synapses maintain constant streng...

journal_title：Nature

authors： Turecek J,Jackman SL,Regehr WG

更新日期：2017-11-23 00:00:00

abstract：:T-cell factor (TCF), a high-mobility-group domain protein, is the transcription factor activated by Wnt/Wingless signalling. When signalling occurs, TCF binds to its coactivator, beta-catenin/Armadillo, and stimulates the transcription of the target genes of Wnt/Wingless by binding to TCF-responsive enhancers. Inappro...

journal_title：Nature

authors： Waltzer L,Bienz M

更新日期：1998-10-01 00:00:00

abstract：:Spontaneous mutations are the source of genetic variation required for evolutionary change, and are therefore important for many aspects of evolutionary biology. For example, the divergence between taxa at neutrally evolving sites in the genome is proportional to the per nucleotide mutation rate, u (ref. 1), and this ...

journal_title：Nature

authors： Haag-Liautard C,Dorris M,Maside X,Macaskill S,Halligan DL,Houle D,Charlesworth B,Keightley PD

更新日期：2007-01-04 00:00:00

abstract：:Thyroid hormones and retinoic acid function through nuclear receptors that belong to the steroid/thyroid-hormone receptor superfamily. Thyroid hormone receptors (TRs) and retinoic acid receptors (RARs) require auxiliary nuclear proteins for efficient DNA binding. Here we report that retinoid X receptors RXR alpha is o...

journal_title：Nature

authors： Zhang XK,Hoffmann B,Tran PB,Graupner G,Pfahl M

更新日期：1992-01-30 00:00:00

abstract：:Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular mechanisms involved in disease pathogenesis and enable the discovery of therapeutic targets, ...

journal_title：Nature

authors： Ramachandran P,Dobie R,Wilson-Kanamori JR,Dora EF,Henderson BEP,Luu NT,Portman JR,Matchett KP,Brice M,Marwick JA,Taylor RS,Efremova M,Vento-Tormo R,Carragher NO,Kendall TJ,Fallowfield JA,Harrison EM,Mole DJ,Wigmore SJ

更新日期：2019-11-01 00:00:00

abstract：:Medawar has suggested that the major histocompatibility gene complex (MHC) might be involved in the contact inhibition of movement shown by fibroblasts and epithelia. Contact inhibition of movement is that reaction of cells which stops the movement of one cell over another and thus leads to monolayering and other feat...

journal_title：Nature

authors： Curtis AS,Rooney P

更新日期：1979-09-20 00:00:00

abstract：:Carbon exchange between the terrestrial biosphere and the atmosphere is one of the key processes that need to be assessed in the context of the Kyoto Protocol. Several studies suggest that the terrestrial biosphere is gaining carbon, but these estimates are obtained primarily by indirect methods, and the factors that ...

journal_title：Nature

authors： Valentini R,Matteucci G,Dolman AJ,Schulze ED,Rebmann C,Moors EJ,Granier A,Gross P,Jensen NO,Pilegaard K,Lindroth A,Grelle A,Bernhofer C,Grünwald T,Aubinet M,Ceulemans R,Kowalski AS,Vesala T,Rannik U,Berbigier P,Lo

更新日期：2000-04-20 00:00:00

abstract：:Ubiquitin (Ub) has important roles in a wide range of intracellular signalling pathways. In the conventional view, ubiquitin alters the signalling activity of the target protein through covalent modification, but accumulating evidence points to the emerging role of non-covalent interaction between ubiquitin and the ta...

journal_title：Nature

authors： Peisley A,Wu B,Xu H,Chen ZJ,Hur S

更新日期：2014-05-01 00:00:00

abstract：:Digital organisms are computer programs that self-replicate, mutate and adapt by natural selection. They offer an opportunity to test generalizations about living systems that may extend beyond the organic life that biologists usually study. Here we have generated two classes of digital organism: simple programs selec...

journal_title：Nature

authors： Lenski RE,Ofria C,Collier TC,Adami C

更新日期：1999-08-12 00:00:00

abstract：:Large parts of the Antarctic ice sheet lying on bedrock below sea level may be vulnerable to marine-ice-sheet instability (MISI), a self-sustaining retreat of the grounding line triggered by oceanic or atmospheric changes. There is growing evidence that MISI may be underway throughout the Amundsen Sea embayment (ASE),...

journal_title：Nature

authors： Ritz C,Edwards TL,Durand G,Payne AJ,Peyaud V,Hindmarsh RC

更新日期：2015-12-03 00:00:00

abstract：:We have previously identified a structurally abnormal insulin in the serum and pancreas of a middle-aged man with diabetes mellitus which arose from a leucine for phenylalanine substitution at position 24 or 25 of the insulin B chain; further analysis of the patient's leukocyte DNA showed that one of the patient's ins...

journal_title：Nature

authors： Shoelson S,Haneda M,Blix P,Nanjo A,Sanke T,Inouye K,Steiner D,Rubenstein A,Tager H

更新日期：1983-04-07 00:00:00

abstract：:Despite decades of research, the identity of the cells generating the first haematopoietic cells in mammalian embryos is unknown. Indeed, whether blood cells arise from mesodermal cells, mesenchymal progenitors, bipotent endothelial-haematopoietic precursors or haemogenic endothelial cells remains controversial. Proxi...

journal_title：Nature

authors： Eilken HM,Nishikawa S,Schroeder T

更新日期：2009-02-12 00:00:00

abstract：:The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete. In the nucleus of eukaryotic cells, interphase chromosomes occupy distinct chromosome territories, and numerous models have been proposed...

journal_title：Nature

authors： Dixon JR,Selvaraj S,Yue F,Kim A,Li Y,Shen Y,Hu M,Liu JS,Ren B

更新日期：2012-04-11 00:00:00

abstract：:In the originally published version of this Article, the sequenced axolotl strain (the homozygous white mutant) was denoted as 'D/D' rather than 'd/d' in Fig. 1a and the accompanying legend, the main text and the Methods section. The original Article has been corrected online. ...

journal_title：Nature

authors： Nowoshilow S,Schloissnig S,Fei JF,Dahl A,Pang AWC,Pippel M,Winkler S,Hastie AR,Young G,Roscito JG,Falcon F,Knapp D,Powell S,Cruz A,Cao H,Habermann B,Hiller M,Tanaka EM,Myers EW

更新日期：2018-07-01 00:00:00

abstract：:Transposable elements of DNA that are structurally defined and genetically discrete units seem to have an important role in the evolution of bacterial plasmids. Recombination occurring at the termini of such elements can result in the joining together of unrelated DNA segments that lack extensive nucleotide sequence h...

journal_title：Nature

authors： Cohen SN

更新日期：1976-10-28 00:00:00

abstract：:Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross...

journal_title：Nature

authors： Maser RS,Choudhury B,Campbell PJ,Feng B,Wong KK,Protopopov A,O'Neil J,Gutierrez A,Ivanova E,Perna I,Lin E,Mani V,Jiang S,McNamara K,Zaghlul S,Edkins S,Stevens C,Brennan C,Martin ES,Wiedemeyer R,Kabbarah O,Noguei

更新日期：2007-06-21 00:00:00

abstract：:An unusual feature of the cerebellar cortex is that its output neurons, Purkinje cells, release GABA (γ-aminobutyric acid). Their high intrinsic firing rates (50 Hz) and extensive convergence predict that their target neurons in the cerebellar nuclei would be largely inhibited unless Purkinje cells pause their spiking...

journal_title：Nature

authors： Person AL,Raman IM

更新日期：2011-12-25 00:00:00

abstract：:Mutations in the Schizosaccharomyces pombe cdc8 gene impair cytokinesis. Here we clone cdc8+ and find that it encodes a novel tropomyosin. Gene disruption results in lethal arrest of the cell cycle, but spore germination, cell growth, DNA replication and mitosis are all unaffected. Haploid cdc8 gene disruptants are re...

journal_title：Nature

authors： Balasubramanian MK,Helfman DM,Hemmingsen SM

更新日期：1992-11-05 00:00:00

abstract：:The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) and tricyclic antidepressants (TCAs). Because eukaryotic BATs...

journal_title：Nature

authors： Wang H,Goehring A,Wang KH,Penmatsa A,Ressler R,Gouaux E

更新日期：2013-11-07 00:00:00

abstract：:Resolving current concerns about the role of biodiversity on ecosystems calls for understanding the separate roles of changes in species numbers and of composition. Recent work shows that primary productivity often, but not always, saturates with species richness within single trophic levels. However, any interpretati...

journal_title：Nature

authors： Downing AL,Leibold MA

更新日期：2002-04-25 00:00:00

abstract：:Simple mathematical models of the transmission dynamics of HIV that incorporate demographic and epidemiological processes to assess the potential impact of AIDS on human population growth and structure in developing countries suggest that AIDS is capable of changing population growth rates from positive to negative va...

journal_title：Nature

authors： Anderson RM,May RM,McLean AR

更新日期：1988-03-17 00:00:00

abstract：:Bivalve molluscs, the primary vectors of paralytic shellfish poisoning (PSP) in humans, show marked inter-species variation in their capacity to accumulate PSP toxins (PSTs) which has a neural basis. PSTs cause human fatalities by blocking sodium conductance in nerve fibres. Here we identify a molecular basis for inte...

journal_title：Nature

authors： Bricelj VM,Connell L,Konoki K,Macquarrie SP,Scheuer T,Catterall WA,Trainer VL

更新日期：2005-04-07 00:00:00

abstract：:The observation of the superfluid to Mott insulator phase transition of ultracold atoms in optical lattices was an enabling discovery in experimental many-body physics, providing the first tangible example of a quantum phase transition (one that occurs even at zero temperature) in an ultracold atomic gas. For a trappe...

journal_title：Nature

authors： Gemelke N,Zhang X,Hung CL,Chin C

更新日期：2009-08-20 00:00:00

abstract：:Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two hormones, FGF23 and osteocalcin, which regulate kidney function and glucose homeostasis, respectively. These findings have raised the question of whether other bone-derived hormones exist and what their potential functions are. Here ...

journal_title：Nature

authors： Mosialou I,Shikhel S,Liu JM,Maurizi A,Luo N,He Z,Huang Y,Zong H,Friedman RA,Barasch J,Lanzano P,Deng L,Leibel RL,Rubin M,Nickolas T,Chung W,Zeltser LM,Williams KW,Pessin JE,Kousteni S

更新日期：2017-03-16 00:00:00

abstract：:Activation of oncogenes by mechanisms other than genetic aberrations such as mutations, translocations, or amplifications is largely undefined. Here we report a novel isoform of the anaplastic lymphoma kinase (ALK) that is expressed in ∼11% of melanomas and sporadically in other human cancer types, but not in normal t...

journal_title：Nature

authors： Wiesner T,Lee W,Obenauf AC,Ran L,Murali R,Zhang QF,Wong EW,Hu W,Scott SN,Shah RH,Landa I,Button J,Lailler N,Sboner A,Gao D,Murphy DA,Cao Z,Shukla S,Hollmann TJ,Wang L,Borsu L,Merghoub T,Schwartz GK,Postow MA

更新日期：2015-10-15 00:00:00

abstract：:A mutant form of the alpha-isoform of protein kinase C (PKC) was recently isolated from an ultraviolet radiation-induced murine fibrosarcoma cell line and reported to transform mouse BALB/c 3T3 fibroblasts on transfection. Four point mutations in the regulatory domain were assumed to be responsible for its oncogenicit...

journal_title：Nature

authors： Borner C,Filipuzzi I,Weinstein IB,Imber R

更新日期：1991-09-05 00:00:00

abstract：:Complex I is the first enzyme of the respiratory chain and has a central role in cellular energy production, coupling electron transfer between NADH and quinone to proton translocation by an unknown mechanism. Dysfunction of complex I has been implicated in many human neurodegenerative diseases. We have determined the...

journal_title：Nature

authors： Efremov RG,Baradaran R,Sazanov LA

更新日期：2010-05-27 00:00:00

abstract：:In legumes, root nodule organogenesis is activated in response to morphogenic lipochitin oligosaccharides that are synthesized by bacteria, commonly known as rhizobia. Successful symbiotic interaction results in the formation of highly specialized organs called root nodules, which provide a unique environment for symb...

journal_title：Nature

authors： Krusell L,Madsen LH,Sato S,Aubert G,Genua A,Szczyglowski K,Duc G,Kaneko T,Tabata S,de Bruijn F,Pajuelo E,Sandal N,Stougaard J

更新日期：2002-11-28 00:00:00

abstract：:Mineralocorticoid secretion is predominantly controlled by the octapeptide angiotensin II, which exerts trophic actions on the adrenal glomerulosa and acute regulatory effects on aldosterone biosynthesis. The trophic actions include stimulation of angiotensin II receptors and enzymes of the aldosterone biosynthetic pa...

journal_title：Nature

authors： Aguilera G,Schirar A,Baukal A,Catt KJ

更新日期：1981-02-05 00:00:00