Abstract:
:Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals transmitted from the T-cell antigen receptor to the LFA-1 adhesion molecule. The increase in avidity is rapid and transient, providing a dynamic mechanism for antigen-specific regulation of lymphocyte adhesion and de-adhesion.
journal_name
Naturejournal_title
Natureauthors
Dustin ML,Springer TAdoi
10.1038/341619a0subject
Has Abstractpub_date
1989-10-19 00:00:00pages
619-24issue
6243eissn
0028-0836issn
1476-4687journal_volume
341pub_type
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