Abstract:
:It has long been known that the 5' to 3' polarity of DNA synthesis results in both a leading and lagging strand at all replication forks. Until now, however, there has been no evidence that leading or lagging strands are spatially organized in any way within a cell. Here we show that chromosome segregation in Escherichia coli is not random but is driven in a manner that results in the leading and lagging strands being addressed to particular cellular destinations. These destinations are consistent with the known patterns of chromosome segregation. Our work demonstrates a new level of organization relating to the replication and segregation of the E. coli chromosome.
journal_name
Naturejournal_title
Natureauthors
White MA,Eykelenboom JK,Lopez-Vernaza MA,Wilson E,Leach DRdoi
10.1038/nature07282subject
Has Abstractpub_date
2008-10-30 00:00:00pages
1248-50issue
7217eissn
0028-0836issn
1476-4687pii
nature07282journal_volume
455pub_type
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