Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes.

abstract：:Milankovitch proposed that summer insolation at mid-latitudes in the Northern Hemisphere directly causes the ice-age climate cycles. This would imply that times of ice-sheet collapse should correspond to peaks in Northern Hemisphere June insolation. But the penultimate deglaciation has proved controversial because Jun...

journal_title：Nature

authors： Henderson GM,Slowey NC

更新日期：2000-03-02 00:00:00

abstract：:Two large-scale yeast two-hybrid screens were undertaken to identify protein-protein interactions between full-length open reading frames predicted from the Saccharomyces cerevisiae genome sequence. In one approach, we constructed a protein array of about 6,000 yeast transformants, with each transformant expressing on...

journal_title：Nature

authors： Uetz P,Giot L,Cagney G,Mansfield TA,Judson RS,Knight JR,Lockshon D,Narayan V,Srinivasan M,Pochart P,Qureshi-Emili A,Li Y,Godwin B,Conover D,Kalbfleisch T,Vijayadamodar G,Yang M,Johnston M,Fields S,Rothberg JM

更新日期：2000-02-10 00:00:00

abstract：:There is ample evidence that the secretion of follicle stimulating hormone (FSH) by the pituitary gland is regulated by a nonsteroidal hormone of gonadal origin, termed inhibin. In several species, testicular extracts, gonadal lymph and seminal plasma have been shown to contain proteins which inhibit FSH release; lack...

journal_title：Nature

authors： Scott RS,Burger HG

更新日期：1980-05-22 00:00:00

abstract：:The NMDA (N-methyl-D-aspartate) receptor transduces the binding of glutamate and glycine, coupling it to the opening of a calcium-permeable ion channel 1 . Owing to the lack of high-resolution structural studies of the NMDA receptor, the mechanism by which ion-channel blockers occlude ion permeation is not well unders...

journal_title：Nature

authors： Song X,Jensen MØ,Jogini V,Stein RA,Lee CH,Mchaourab HS,Shaw DE,Gouaux E

更新日期：2018-04-01 00:00:00

abstract：:Estimates of the effect of increasing atmospheric CO2 concentrations on future global plant production rely on the physiological response of individual plants or plant communities when exposed to high CO2 (refs 1-6). Plant populations may adapt to the changing atmosphere, however, such that the evolved plant communiti...

journal_title：Nature

authors： Collins S,Bell G

更新日期：2004-09-30 00:00:00

abstract：:A key step in the elimination of pathogens from the body is the covalent binding of complement proteins C3 and C4 to their surfaces. Proteolytic activation of these proteins results in a conformational change, and an internal thioester is exposed which reacts with amino or hydroxyl groups on the target surface to form...

journal_title：Nature

authors： Dodds AW,Ren XD,Willis AC,Law SK

更新日期：1996-01-11 00:00:00

abstract：:Natural products containing phosphorus-carbon bonds have found widespread use in medicine and agriculture. One such compound, phosphinothricin tripeptide, contains the unusual amino acid phosphinothricin attached to two alanine residues. Synthetic phosphinothricin (glufosinate) is a component of two top-selling herbic...

journal_title：Nature

authors： Cicchillo RM,Zhang H,Blodgett JA,Whitteck JT,Li G,Nair SK,van der Donk WA,Metcalf WW

更新日期：2009-06-11 00:00:00

abstract：:The biological importance of DNA methylation for gene expression in eukaryotes is becoming increasingly evident, and a direct role of methylation in gene expression has been suggested by an analysis of the infectivity of integrated retroviral genomes in a transfection assay. These studies, however, did not address whe...

journal_title：Nature

authors： Simon D,Stuhlmann H,Jähner D,Wagner H,Werner E,Jaenisch R

更新日期：1983-07-21 00:00:00

abstract：:How long does it take a random walker to reach a given target point? This quantity, known as a first-passage time (FPT), has led to a growing number of theoretical investigations over the past decade. The importance of FPTs originates from the crucial role played by first encounter properties in various real situation...

journal_title：Nature

authors： Condamin S,Bénichou O,Tejedor V,Voituriez R,Klafter J

更新日期：2007-11-01 00:00:00

abstract：:A large number of cis-regulatory sequences have been annotated in the human genome, but defining their target genes remains a challenge. One strategy is to identify the long-range looping interactions at these elements with the use of chromosome conformation capture (3C)-based techniques. However, previous studies lac...

journal_title：Nature

authors： Jin F,Li Y,Dixon JR,Selvaraj S,Ye Z,Lee AY,Yen CA,Schmitt AD,Espinoza CA,Ren B

更新日期：2013-11-14 00:00:00

abstract：:A rapid decrease in shear velocity in the suboceanic mantle is used to infer the thickness of the lithosphere. It is proposed that new and highly precise group velocity data constrain the solutions and imply a thickness near 70 km. ...

journal_title：Nature

authors： Kanamori H,Press F

更新日期：1970-04-25 00:00:00

abstract：:Microbes comprise the majority of extant organisms, yet much remains to be learned about the nature and driving forces of microbial diversification. Our understanding of how microorganisms adapt and evolve can be advanced by genome-wide documentation of the patterns of genetic exchange, particularly if analyses target...

journal_title：Nature

authors： Lo I,Denef VJ,Verberkmoes NC,Shah MB,Goltsman D,DiBartolo G,Tyson GW,Allen EE,Ram RJ,Detter JC,Richardson P,Thelen MP,Hettich RL,Banfield JF

更新日期：2007-03-29 00:00:00

abstract：:Zika virus (ZIKV) remained obscure until the recent explosive outbreaks in French Polynesia (2013-2014) and South America (2015-2016). Phylogenetic studies have shown that ZIKV has evolved into African and Asian lineages. The Asian lineage of ZIKV was responsible for the recent epidemics in the Americas. However, the ...

journal_title：Nature

authors： Liu Y,Liu J,Du S,Shan C,Nie K,Zhang R,Li XF,Zhang R,Wang T,Qin CF,Wang P,Shi PY,Cheng G

更新日期：2017-05-25 00:00:00

abstract：: ...

journal_title：Nature

authors： Masood E

更新日期：2018-11-01 00:00:00

abstract：:The origin of cooperation is a central challenge to our understanding of evolution. The fact that microbial interactions can be manipulated in ways that animal interactions cannot has led to a growing interest in microbial models of cooperation and competition. For the budding yeast Saccharomyces cerevisiae to grow on...

journal_title：Nature

authors： Gore J,Youk H,van Oudenaarden A

更新日期：2009-05-14 00:00:00

abstract：:Remodelling its shape, or morphogenesis, is a fundamental property of living tissue. It underlies much of embryonic development and numerous pathologies. Convergent extension (CE) of the axial mesoderm of vertebrates is an intensively studied model for morphogenetic processes that rely on cell rearrangement. It involv...

journal_title：Nature

authors： Ninomiya H,Elinson RP,Winklbauer R

更新日期：2004-07-15 00:00:00

abstract：:Many planktonic organisms produce 'resting' stages when the environmental conditions deteriorate. Like seeds, resting stages can survive unfavourable conditions. The crustacean Daphnia normally reproduces by means of parthenogenetically produced normal, not resting, eggs-but occasionally switches to bisexual reproduct...

journal_title：Nature

authors： Alekseev V,Lampert W

更新日期：2001-12-20 00:00:00

abstract：:One way of accounting for lowered atmospheric carbon dioxide concentrations during Pleistocene glacial periods is by invoking the Antarctic stratification hypothesis, which links the reduction in CO2 to greater stratification of ocean surface waters around Antarctica. As discussed by Sigman and Boyle, this hypothesis ...

journal_title：Nature

authors： Keeling RF,Visbeck M

更新日期：2001-08-09 00:00:00

abstract：:In budding yeast many genes are expressed under cell-cycle control in late G1. These include a large group of DNA synthesis genes, the HO gene involved in mating-type switching, CTS1 (chitinase) and also CLN1 and CLN2 (ref. 4) encoding G1 cyclins. Two factors, encoded by the SWI4 and SWI6 genes, are required for HO (r...

journal_title：Nature

authors： Lowndes NF,Johnson AL,Breeden L,Johnston LH

更新日期：1992-06-11 00:00:00

abstract：:Approximately 2% of colorectal cancer is linked to pre-existing inflammation known as colitis-associated cancer, but most develops in patients without underlying inflammatory bowel disease. Colorectal cancer often follows a genetic pathway whereby loss of the adenomatous polyposis coli (APC) tumour suppressor and acti...

journal_title：Nature

authors： Grivennikov SI,Wang K,Mucida D,Stewart CA,Schnabl B,Jauch D,Taniguchi K,Yu GY,Osterreicher CH,Hung KE,Datz C,Feng Y,Fearon ER,Oukka M,Tessarollo L,Coppola V,Yarovinsky F,Cheroutre H,Eckmann L,Trinchieri G,Karin M

更新日期：2012-11-08 00:00:00

abstract：: ...

journal_title：Nature

authors： Measey J

更新日期：2018-10-01 00:00:00

abstract：:The epiblast (EPI) is the origin of all somatic and germ cells in mammals, and of pluripotent stem cells in vitro. To explore the ontogeny of human and primate pluripotency, here we perform comprehensive single-cell RNA sequencing for pre- and post-implantation EPI development in cynomolgus monkeys (Macaca fasciculari...

journal_title：Nature

authors： Nakamura T,Okamoto I,Sasaki K,Yabuta Y,Iwatani C,Tsuchiya H,Seita Y,Nakamura S,Yamamoto T,Saitou M

更新日期：2016-09-01 00:00:00

abstract：:Materials are said to show a shape-memory effect if they can be deformed and fixed into a temporary shape, and recover their original, permanent shape only on exposure to an external stimulus. Shape-memory polymers have received increasing attention because of their scientific and technological significance. In princi...

journal_title：Nature

authors： Lendlein A,Jiang H,Jünger O,Langer R

更新日期：2005-04-14 00:00:00

abstract：:The discovery that atrial extracts have potent diuretic and natriuretic properties revealed a possible endocrine function of the heart in the regulation of extracellular fluid volume. Since that first report intense research activity has been directed towards determining the mechanism of action of the active atrial na...

journal_title：Nature

authors： Harris PJ,Thomas D,Morgan TO

更新日期：1987-04-16 00:00:00

abstract：:Lung epithelial cells can influence immune responses to airway allergens. Airway epithelial cells also undergo apoptosis after encountering environmental allergens; yet, relatively little is known about how these are cleared, and their effect on airway inflammation. Here we show that airway epithelial cells efficientl...

journal_title：Nature

authors： Juncadella IJ,Kadl A,Sharma AK,Shim YM,Hochreiter-Hufford A,Borish L,Ravichandran KS

更新日期：2013-01-24 00:00:00

abstract：:Individual mammals have the capacity to express at least one million distinct antigen binding specificities, implying a high degree of structural heterogeneity in the variable heavy and light chain (VH and VL) portions of the antibody molecules. Studies of higher vertebrate species suggest that this heterogeneity is c...

journal_title：Nature

authors： Mäkelä O,Litman GW

更新日期：1980-10-16 00:00:00

abstract：:Apoptosis (programmed cell death), an essential process in the development and homeostasis of metazoans, is carried out by caspases. The mitochondrial protein Smac/DIABLO performs a critical function in apoptosis by eliminating the inhibitory effect of IAPs (inhibitor of apoptosis proteins) on caspases. Here we show t...

journal_title：Nature

authors： Chai J,Du C,Wu JW,Kyin S,Wang X,Shi Y

更新日期：2000-08-24 00:00:00

abstract：:Since the discovery of superconductivity in the high-transition-temperature (high-T(c)) copper oxides two decades ago, it has been firmly established that the CuO(2) plane is essential for superconductivity and gives rise to a host of other very unusual properties. A new family of superconductors with the general comp...

journal_title：Nature

authors： Chen TY,Tesanovic Z,Liu RH,Chen XH,Chien CL

更新日期：2008-06-26 00:00:00

abstract：:Phelan-McDermid syndrome (PMDS) is a complex neurodevelopmental disorder characterized by global developmental delay, severely impaired speech, intellectual disability, and an increased risk of autism spectrum disorders (ASDs). PMDS is caused by heterozygous deletions of chromosome 22q13.3. Among the genes in the dele...

journal_title：Nature

authors： Shcheglovitov A,Shcheglovitova O,Yazawa M,Portmann T,Shu R,Sebastiano V,Krawisz A,Froehlich W,Bernstein JA,Hallmayer JF,Dolmetsch RE

更新日期：2013-11-14 00:00:00

abstract：:Signals elicited by binding of the T-cell antigen receptor and the CD4/CD8 co-receptor to major histocompatibility complex (MHC) molecules control the generation of CD4+ (helper) or CD8+ (cytotoxic) T cells from thymic precursors that initially express both co-receptor proteins. These precursors have unique, clonally ...

journal_title：Nature

authors： Yasutomo K,Doyle C,Miele L,Fuchs C,Germain RN

更新日期：2000-03-30 00:00:00