Atrial natriuretic peptide inhibits angiotensin-stimulated proximal tubular sodium and water reabsorption.

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains recalcitrant to all forms of cancer treatment and carries a five-year survival rate of only 8%1. Inhibition of oncogenic KRAS (hereafter KRAS*), the earliest lesion in disease development that is present in more than 90% of PDACs, and its signalling surrogates has yielde...

journal_title：Nature

authors： Yao W,Rose JL,Wang W,Seth S,Jiang H,Taguchi A,Liu J,Yan L,Kapoor A,Hou P,Chen Z,Wang Q,Nezi L,Xu Z,Yao J,Hu B,Pettazzoni PF,Ho IL,Feng N,Ramamoorthy V,Jiang S,Deng P,Ma GJ,Den P,Tan Z,Zhang SX,Wang H,

更新日期：2019-04-01 00:00:00

abstract：:Courtship rituals serve to reinforce reproductive barriers between closely related species. Drosophila melanogaster and Drosophila simulans exhibit reproductive isolation, owing in part to the fact that D. melanogaster females produce 7,11-heptacosadiene, a pheromone that promotes courtship in D. melanogaster males bu...

journal_title：Nature

authors： Seeholzer LF,Seppo M,Stern DL,Ruta V

更新日期：2018-07-01 00:00:00

abstract：:Abscisic acid (ABA) is a vital phytohormone that regulates mainly stomatal aperture and seed development, but ABA receptors involved in these processes have yet to be determined. We previously identified from broad bean an ABA-binding protein (ABAR) potentially involved in stomatal signalling, the gene for which encod...

journal_title：Nature

authors： Shen YY,Wang XF,Wu FQ,Du SY,Cao Z,Shang Y,Wang XL,Peng CC,Yu XC,Zhu SY,Fan RC,Xu YH,Zhang DP

更新日期：2006-10-19 00:00:00

abstract：:Studies of the actin-based motility of the intracellular pathogens Listeria monocytogenes and Shigella flexneri have provided important insight into the events occurring at the leading edges of motile cells. Like the bacteria Listeria and Shigella, vaccinia virus, a relative of the causative agent of smallpox, uses ac...

journal_title：Nature

authors： Frischknecht F,Moreau V,Röttger S,Gonfloni S,Reckmann I,Superti-Furga G,Way M

更新日期：1999-10-28 00:00:00

abstract：:X chromosomes evolve differently from autosomes, but general governing principles have not emerged. For example, genes with male-biased expression are under-represented on the X chromosome of D. melanogaster, but are randomly distributed in the genome of Anopheles gambiae. In direct global profiling experiments using ...

journal_title：Nature

authors： Sturgill D,Zhang Y,Parisi M,Oliver B

更新日期：2007-11-08 00:00:00

abstract：:The recently emerged fields of metamaterials and transformation optics promise a family of exciting applications such as invisibility, optical imaging with deeply subwavelength resolution and nanophotonics with the potential for much faster information processing. The possibility of creating optical negative-index met...

journal_title：Nature

authors： Xiao S,Drachev VP,Kildishev AV,Ni X,Chettiar UK,Yuan HK,Shalaev VM

更新日期：2010-08-05 00:00:00

abstract：:Yeast phosphatidylinositol transfer protein (Sec14p) is required for the production of secretory vesicles from the Golgi. This requirement can be relieved by inactivation of the cytosine 5'-diphosphate (CDP)-choline pathway for phosphatidylcholine biosynthesis, indicating that Sec14p is an essential component of a reg...

journal_title：Nature

authors： Kearns BG,McGee TP,Mayinger P,Gedvilaite A,Phillips SE,Kagiwada S,Bankaitis VA

更新日期：1997-05-01 00:00:00

abstract：:White dwarfs represent the endpoint of stellar evolution for stars with initial masses between approximately 0.07 and 8-10, where is the mass of the Sun (more massive stars end their life as either black holes or neutron stars). The theory of stellar evolution predicts that the majority of white dwarfs have a core mad...

journal_title：Nature

authors： Dufour P,Liebert J,Fontaine G,Behara N

更新日期：2007-11-22 00:00:00

abstract：:Chemokines are chemotactic cytokines that activate and direct the migration of leukocytes. There are two subfamilies, the CXC and the CC chemokines. We recently found that the CXC-chemokine stromal cell-derived factor-1 (SDF-1) is a highly efficacious lymphocyte chemoattractant. Chemokines act on responsive leukocyte ...

journal_title：Nature

authors： Bleul CC,Farzan M,Choe H,Parolin C,Clark-Lewis I,Sodroski J,Springer TA

更新日期：1996-08-29 00:00:00

abstract：:For cells of the innate immune system to mount a host defence response to infection, they must recognize products of microbial pathogens such as lipopolysaccharide (LPS), the endotoxin secreted by Gram-negative bacteria. These cellular responses require intracellular signalling pathways, such as the four MAP kinase (M...

journal_title：Nature

authors： Han J,Jiang Y,Li Z,Kravchenko VV,Ulevitch RJ

更新日期：1997-03-20 00:00:00

abstract：:The mir-34/449 family consists of six homologous miRNAs at three genomic loci. Redundancy of miR-34/449 miRNAs and their dominant expression in multiciliated epithelia suggest a functional significance in ciliogenesis. Here we report that mice deficient for all miR-34/449 miRNAs exhibited postnatal mortality, infertil...

journal_title：Nature

authors： Song R,Walentek P,Sponer N,Klimke A,Lee JS,Dixon G,Harland R,Wan Y,Lishko P,Lize M,Kessel M,He L

更新日期：2014-06-05 00:00:00

abstract：:The epidermal growth factor receptor (EGFR)-directed tyrosine kinase inhibitors (TKIs) gefitinib, erlotinib and afatinib are approved treatments for non-small cell lung cancers harbouring activating mutations in the EGFR kinase, but resistance arises rapidly, most frequently owing to the secondary T790M mutation withi...

journal_title：Nature

authors： Jia Y,Yun CH,Park E,Ercan D,Manuia M,Juarez J,Xu C,Rhee K,Chen T,Zhang H,Palakurthi S,Jang J,Lelais G,DiDonato M,Bursulaya B,Michellys PY,Epple R,Marsilje TH,McNeill M,Lu W,Harris J,Bender S,Wong KK,Jänne PA

更新日期：2016-06-02 00:00:00

abstract：:The high-resolution seismic imaging of subducted oceanic slabs has become a powerful tool for reconstructing palaeogeography. The images can now be interpreted quantitatively by comparison with models of the general circulation of the Earth's mantle. Here we use a three-dimensional spherical computer model of mantle c...

journal_title：Nature

authors： Bunge HP,Grand SP

更新日期：2000-05-18 00:00:00

abstract：:In mammals, enlargement of the heart during embryonic development is primarily dependent on the increase in cardiomyocyte numbers. Shortly after birth, however, cardiomyocytes stop proliferating and further growth of the myocardium occurs through hypertrophic enlargement of the existing myocytes. As a consequence of t...

journal_title：Nature

authors： Eulalio A,Mano M,Dal Ferro M,Zentilin L,Sinagra G,Zacchigna S,Giacca M

更新日期：2012-12-20 00:00:00

abstract：:The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis methods to identify somatic variants across thousands of tumours. Here we present data and analytical results for point mutations and small insertions/deletions from 3,281 tumours across 12 tumour types as part of the TCGA Pan-Cancer effort. We...

journal_title：Nature

authors： Kandoth C,McLellan MD,Vandin F,Ye K,Niu B,Lu C,Xie M,Zhang Q,McMichael JF,Wyczalkowski MA,Leiserson MDM,Miller CA,Welch JS,Walter MJ,Wendl MC,Ley TJ,Wilson RK,Raphael BJ,Ding L

更新日期：2013-10-17 00:00:00

abstract：:Constructing agents with planning capabilities has long been one of the main challenges in the pursuit of artificial intelligence. Tree-based planning methods have enjoyed huge success in challenging domains, such as chess1 and Go2, where a perfect simulator is available. However, in real-world problems, the dynamics ...

journal_title：Nature

authors： Schrittwieser J,Antonoglou I,Hubert T,Simonyan K,Sifre L,Schmitt S,Guez A,Lockhart E,Hassabis D,Graepel T,Lillicrap T,Silver D

更新日期：2020-12-01 00:00:00

abstract：:Many natural products that contain basic nitrogen atoms--for example alkaloids like morphine and quinine-have the potential to treat a broad range of human diseases. However, the presence of a nitrogen atom in a target molecule can complicate its chemical synthesis because of the basicity of nitrogen atoms and their s...

journal_title：Nature

authors： Mercado-Marin EV,Garcia-Reynaga P,Romminger S,Pimenta EF,Romney DK,Lodewyk MW,Williams DE,Andersen RJ,Miller SJ,Tantillo DJ,Berlinck RGS,Sarpong R

更新日期：2014-05-15 00:00:00

abstract：:Transcriptional activator proteins (activators) function, at least in part, by increasing preinitiation complex assembly (for reviews see refs 1-4). Previous studies have shown that an acidic activator forms a contact with the general transcription factor TFIIB (refs 5-7) and recruits it into the preinitiation complex...

journal_title：Nature

authors： Roberts SG,Green MR

更新日期：1994-10-20 00:00:00

abstract：:Susceptibility to some human diseases is linked, albeit weakly, to major transplantation antigens (HLA) encoded by the major histocompatibility gene complex (MHC). Here we have studied MHC/disease association in inbred strains of mice after intracerebral (i.c.) injection of lymphocytic choriomeningitis virus (LCMV). T...

journal_title：Nature

authors： Zinkernagel RM,Pfau CJ,Hengartner H,Althage A

更新日期：1985-08-29 00:00:00

abstract：:Sex in mammals is determined in the fetal gonad by the presence or absence of the Y chromosome gene Sry, which controls whether bipotential precursor cells differentiate into testicular Sertoli cells or ovarian granulosa cells. This pivotal decision in a single gonadal cell type ultimately controls sexual differentiat...

journal_title：Nature

authors： Matson CK,Murphy MW,Sarver AL,Griswold MD,Bardwell VJ,Zarkower D

更新日期：2011-07-20 00:00:00

abstract：:A membrane receptor protein for asialoglycoproteins induces voltage-dependent increases in ion conductance across a lipid bilayer, probably reflecting penetration of the protein into the bilayer towards an electrically positive pole. In the presence of specific ligand for the receptor, this penetration leads to a 'tra...

journal_title：Nature

authors： Blumenthal R,Klausner RD,Weinstein JN

更新日期：1980-11-27 00:00:00

abstract：:The bmi-1 proto-oncogene can be activated by Moloney murine leukaemia proviral insertions in E mu-myc transgenic mice. It encodes a highly conserved nuclear protein of 324 amino acids which belongs to a family of proteins containing a putative new zinc-finger. Another closely related member of this family is the mouse...

journal_title：Nature

authors： van Lohuizen M,Frasch M,Wientjens E,Berns A

更新日期：1991-09-26 00:00:00

abstract：:The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization ...

journal_title：Nature

authors： Pellegrini L,Tan S,Richmond TJ

更新日期：1995-08-10 00:00:00

abstract：:Deep neural networks have achieved impressive successes in fields ranging from object recognition to complex games such as Go1,2. Navigation, however, remains a substantial challenge for artificial agents, with deep neural networks trained by reinforcement learning3-5 failing to rival the proficiency of mammalian spat...

journal_title：Nature

authors： Banino A,Barry C,Uria B,Blundell C,Lillicrap T,Mirowski P,Pritzel A,Chadwick MJ,Degris T,Modayil J,Wayne G,Soyer H,Viola F,Zhang B,Goroshin R,Rabinowitz N,Pascanu R,Beattie C,Petersen S,Sadik A,Gaffney S,King H

更新日期：2018-05-01 00:00:00

abstract：:Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis of neurons. These events are mediated by NGF as a result of binding to its two cell-surface receptors, TrkA and p75. TrkA is a receptor with tyrosine kinase ac...

journal_title：Nature

authors： Wiesmann C,Ultsch MH,Bass SH,de Vos AM

更新日期：1999-09-09 00:00:00

abstract：:Patterning matter on the nanometre scale is an important objective of current materials chemistry and physics. It is driven by both the need to further miniaturize electronic components and the fact that at the nanometre scale, materials properties are strongly size-dependent and thus can be tuned sensitively. In nano...

journal_title：Nature

authors： Alivisatos AP,Johnsson KP,Peng X,Wilson TE,Loweth CJ,Bruchez MP Jr,Schultz PG

更新日期：1996-08-15 00:00:00

abstract：:It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia. We find that a p...

journal_title：Nature

authors： Kuhlwilm M,Gronau I,Hubisz MJ,de Filippo C,Prado-Martinez J,Kircher M,Fu Q,Burbano HA,Lalueza-Fox C,de la Rasilla M,Rosas A,Rudan P,Brajkovic D,Kucan Ž,Gušic I,Marques-Bonet T,Andrés AM,Viola B,Pääbo S,Meyer M,Sie

更新日期：2016-02-25 00:00:00

abstract：:Topoisomerases relieve the torsional strain in DNA that is built up during replication and transcription. They are vital for cell proliferation and are a target for poisoning by anti-cancer drugs. Type IB topoisomerase (TopIB) forms a protein clamp around the DNA duplex and creates a transient nick that permits remova...

journal_title：Nature

authors： Koster DA,Croquette V,Dekker C,Shuman S,Dekker NH

更新日期：2005-03-31 00:00:00

abstract：:In mammalian somatic-cell cycles, progression through the G1-phase restriction point and initiation of DNA replication are controlled by the ability of the retinoblastoma tumour-suppressor protein (pRb) family to regulate the E2F/DP transcription factors. Continuing transcription of E2F target genes beyond the G1/S tr...

journal_title：Nature

authors： Lukas C,Sørensen CS,Kramer E,Santoni-Rugiu E,Lindeneg C,Peters JM,Bartek J,Lukas J

更新日期：1999-10-21 00:00:00

abstract：:Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription ...

journal_title：Nature

authors： Anneser L,Alcantara IC,Gemmer A,Mirkes K,Ryu S,Schuman EM

更新日期：2020-12-01 00:00:00