Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3.

abstract：:During the fission yeast cell cycle, the rate of polyadenylated messenger RNA synthesis doubles when the cell reaches a critical size. This size-related control maintains average mRNA content in balance with total cell mass during exponential growth, even in cells growing at different absolute growth rates per cell. ...

journal_title：Nature

authors： Fraser RS,Nurse P

更新日期：1978-02-23 00:00:00

abstract：:When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure. This is especially relevant to proteins for which lipids have both structural and regulatory roles. Here we demonstrat...

journal_title：Nature

authors： Gao Y,Cao E,Julius D,Cheng Y

更新日期：2016-06-16 00:00:00

abstract：:Recent studies have suggested a critical role of specific gene loss in several embryonic tumours and certain adult cancers. In retinoblastoma, hemizygosity or homozygosity of a recessive mutant allele results in the loss of normal gene product, and this seems to cause the manifestation of the disorder. Familial polypo...

journal_title：Nature

authors： Okamoto M,Sasaki M,Sugio K,Sato C,Iwama T,Ikeuchi T,Tonomura A,Sasazuki T,Miyaki M

更新日期：1988-01-21 00:00:00

abstract：:In the chick embryo hindbrain, morphological segmentation into rhombomeres is matched by metameric patterns of early neuronal differentiation and axonogenesis. Boundaries between rhombomeres coincide with boundaries of expression of murine regulatory genes. By clonal analysis using intracellular marking, we show here ...

journal_title：Nature

authors： Fraser S,Keynes R,Lumsden A

更新日期：1990-03-29 00:00:00

abstract：:Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways1. Cleavage of human and mouse RIPK1 after residues D324 and D325, respectively, by caspase-8 separates the RIPK1 kinase domain from the intermediate and death domains. The D325A mutation in mouse RIPK1 leads to embryonic lethali...

journal_title：Nature

authors： Tao P,Sun J,Wu Z,Wang S,Wang J,Li W,Pan H,Bai R,Zhang J,Wang Y,Lee PY,Ying W,Zhou Q,Hou J,Wang W,Sun B,Yang M,Liu D,Fang R,Han H,Yang Z,Huang X,Li H,Deuitch N,Zhang Y,Dissanayake D,Haude K,McWalter K

更新日期：2020-01-01 00:00:00

abstract：:Over the last twenty years classical views of how compound eyes work optically have undergone a series of overhauls. Exner's central concept of an optically inhomogeneous lens cylinder has survived, and such devices are now made commercially. He was wrong, however, about some crustacean eyes. They produce images by a ...

journal_title：Nature

authors： Land MF

更新日期：1980-10-23 00:00:00

abstract：:Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's syndrome (trisomy 21) and may be involved in the pathogenesis of Alzheimer's disease. Recent molecular genetic studies have indicated that amyl...

journal_title：Nature

authors： Tanzi RE,McClatchey AI,Lamperti ED,Villa-Komaroff L,Gusella JF,Neve RL

更新日期：1988-02-11 00:00:00

abstract：:A temperature sensitive mutant has been isolated for the first time from a replication defective acute leukaemia virus, AEV. In vivo, at 41 degrees C, the mutant shows a reduced leukaemogenic potential. In vitro, in erythroblasts transformed at 35 degrees C, haemoglobin synthesis can be induced by a shift to 41 degree...

journal_title：Nature

authors： Graf T,Ade N,Beug H

更新日期：1978-10-12 00:00:00

abstract：:Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2. Because previously described cyt...

journal_title：Nature

authors： Mok BY,de Moraes MH,Zeng J,Bosch DE,Kotrys AV,Raguram A,Hsu F,Radey MC,Peterson SB,Mootha VK,Mougous JD,Liu DR

更新日期：2020-07-01 00:00:00

abstract：:The Gakkel ridge, which extends under the Arctic ice cap for approximately 1,800 km, is the slowest spreading ocean ridge on Earth. Its spreading created the Eurasian basin, which is isolated from the rest of the oceanic mantle by North America, Eurasia and the Lomonosov ridge. The Gakkel ridge thus provides unique op...

journal_title：Nature

authors： Goldstein SL,Soffer G,Langmuir CH,Lehnert KA,Graham DW,Michael PJ

更新日期：2008-05-01 00:00:00

abstract：:In multinucleated heterokaryons formed from the fusion of differentiated muscle cells to either hepatocytes or fibroblasts, muscle-specific gene expression is activated, liver-specific gene expression is repressed, and there are changes in the location of the Golgi apparatus. An understanding of the regulatory mechani...

journal_title：Nature

authors： Schäfer BW,Blakely BT,Darlington GJ,Blau HM

更新日期：1990-03-29 00:00:00

abstract：:We have attempted to reproduce the findings of Benveniste and co-workers, who reported in 1988 that degranulation of human basophil leukocytes is triggered by very dilute (10(2)-10(120)) antiserum against IgE. The results were contrary to conventional scientific theory and were not satisfactorily explained. Following ...

journal_title：Nature

authors： Hirst SJ,Hayes NA,Burridge J,Pearce FL,Foreman JC

更新日期：1993-12-09 00:00:00

abstract：:It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light thr...

journal_title：Nature

authors： Sonnenburg JL,Bäckhed F

更新日期：2016-07-07 00:00:00

abstract：: ...

journal_title：Nature

authors： Payne D

更新日期：2018-11-01 00:00:00

abstract：:In addition to acting as template for protein synthesis, messenger RNA (mRNA) often contains sensory sequence elements that regulate this process. Here we report a new mechanism that limits the number of complete protein molecules that can be synthesized from a single mRNA molecule of the human AMD1 gene encoding aden...

journal_title：Nature

authors： Yordanova MM,Loughran G,Zhdanov AV,Mariotti M,Kiniry SJ,O'Connor PBF,Andreev DE,Tzani I,Saffert P,Michel AM,Gladyshev VN,Papkovsky DB,Atkins JF,Baranov PV

更新日期：2018-01-18 00:00:00

abstract：:Shiga toxin and some other protein toxins that act on targets in the cytosol have previously been shown to enter the trans-Golgi network. Transport by this route may be necessary for translocation of the toxin to the cytosol and for intoxication, but it is not known whether the enzymatically active part of the toxins ...

journal_title：Nature

authors： Sandvig K,Garred O,Prydz K,Kozlov JV,Hansen SH,van Deurs B

更新日期：1992-08-06 00:00:00

abstract：:Recognition of sweet, bitter and umami tastes requires the non-vesicular release from taste bud cells of ATP, which acts as a neurotransmitter to activate afferent neural gustatory pathways. However, how ATP is released to fulfil this function is not fully understood. Here we show that calcium homeostasis modulator 1 ...

journal_title：Nature

authors： Taruno A,Vingtdeux V,Ohmoto M,Ma Z,Dvoryanchikov G,Li A,Adrien L,Zhao H,Leung S,Abernethy M,Koppel J,Davies P,Civan MM,Chaudhari N,Matsumoto I,Hellekant G,Tordoff MG,Marambaud P,Foskett JK

更新日期：2013-03-14 00:00:00

abstract：:Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified, despite analysis of more than 9,000 cases. Here, using low-coverag...

journal_title：Nature

authors： CONVERGE consortium.

更新日期：2015-07-30 00:00:00

abstract：:For more than four decades, transistors have been shrinking exponentially in size, and therefore the number of transistors in a single microelectronic chip has been increasing exponentially. Such an increase in packing density was made possible by continually shrinking the metal-oxide-semiconductor field-effect transi...

journal_title：Nature

authors： Ferain I,Colinge CA,Colinge JP

更新日期：2011-11-16 00:00:00

abstract：:A major component of the large genomes of higher plants and vertebrates comprises transposable elements and their derivatives, which potentially reduce the stability of the genome. It has been proposed that methylation of cytosine residues may suppress transposition, but experimental evidence for this has been limited...

journal_title：Nature

authors： Miura A,Yonebayashi S,Watanabe K,Toyama T,Shimada H,Kakutani T

更新日期：2001-05-10 00:00:00

abstract：:Galactose oxidase is an extracellular enzyme secreted by the fungus Dactylium dendroides. It is monomeric, with a relative molecular mass of 68,000, catalyses the stereospecific oxidation of a broad range of primary alcohol substrates and possesses a unique mononuclear copper site essential for catalysing a two-electr...

journal_title：Nature

authors： Ito N,Phillips SE,Stevens C,Ogel ZB,McPherson MJ,Keen JN,Yadav KD,Knowles PF

更新日期：1991-03-07 00:00:00

abstract：:The superposition principle is a fundamental tenet of quantum mechanics. It allows a quantum system to be 'in two places at the same time', because the quantum state of a physical system can simultaneously include measurably different physical states. The preparation and use of such superposed states forms the basis o...

journal_title：Nature

authors： Hofheinz M,Wang H,Ansmann M,Bialczak RC,Lucero E,Neeley M,O'Connell AD,Sank D,Wenner J,Martinis JM,Cleland AN

更新日期：2009-05-28 00:00:00

abstract：:The growth of plants depends on continuous function of the meristems. Shoot meristems are responsible for all the post-embryonic aerial organs, such as leaves, stems and flowers. It has been assumed that the phytohormone cytokinin has a positive role in shoot meristem function. A severe reduction in the size of merist...

journal_title：Nature

authors： Kurakawa T,Ueda N,Maekawa M,Kobayashi K,Kojima M,Nagato Y,Sakakibara H,Kyozuka J

更新日期：2007-02-08 00:00:00

abstract：:Recent advances in understanding the molecular basis of human X-linked muscular dystrophies have come from the identification of dystrophin, a cytoskeletal protein associated with the surface membrane. Although there is little or virtually no dystrophin in affected individuals, it is not known how this causes muscle d...

journal_title：Nature

authors： Franco A Jr,Lansman JB

更新日期：1990-04-12 00:00:00

abstract：:Dense plexuses of neurones containing immunoreactive vasoactive intestinal peptide (VIP) have been found in discrete areas of the central nervous system and in peripheral organs, including the gastrointestinal tract, pancreas and urogenital system. In many of these locations VIP is concentrated in nerve endings, where...

journal_title：Nature

authors： Giachetti A,Said SI

更新日期：1979-10-18 00:00:00

abstract：:Cysticercosis caused by larval tapeworms is a major public health problem and a cause of substantial economic losses in the farm-animal industries. Taenia ovis in sheep is a particularly important example. Immunity to reinfection with the larvae has a central role in regulating natural transmission of the parasites, a...

journal_title：Nature

authors： Johnson KS,Harrison GB,Lightowlers MW,O'Hoy KL,Cougle WG,Dempster RP,Lawrence SB,Vinton JG,Heath DD,Rickard MD

更新日期：1989-04-13 00:00:00

abstract：:Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per a...

journal_title：Nature

authors： Marouli E,Graff M,Medina-Gomez C,Lo KS,Wood AR,Kjaer TR,Fine RS,Lu Y,Schurmann C,Highland HM,Rüeger S,Thorleifsson G,Justice AE,Lamparter D,Stirrups KE,Turcot V,Young KL,Winkler TW,Esko T,Karaderi T,Locke AE,Mas

更新日期：2017-02-09 00:00:00

abstract：:When chemical reactions whose rate increases with the concentration of a product species are carried out in imperfectly mixed systems, a variety of complex behaviours can occur. These phenomena, which have relevance for biological processes as well, include chaotic and stochastic behaviour and selection of one final s...

journal_title：Nature

authors： Epstein IR

更新日期：1995-03-23 00:00:00

abstract：:A pathological hallmark of Alzheimer's disease is the deposition of amyloid fibrils in the brain. The principal component of amyloid fibrils is beta/A4 amyloid protein, which can be generated by the aberrant processing of a large membrane-bound glycoprotein, the beta/A4 amyloid protein precursor (APP)3. To test whethe...

journal_title：Nature

authors： Yoshikawa K,Aizawa T,Hayashi Y

更新日期：1992-09-03 00:00:00

abstract：:Large seasonal and hemispheric asymmetries in the martian climate system are generally ascribed to variations in solar heating associated with orbital eccentricity. As the orbital elements slowly change (over a period of >104 years), characteristics of the climate such as dustiness and the vigour of atmospheric circul...

journal_title：Nature

authors： Richardson MI,Wilson RJ

更新日期：2002-03-21 00:00:00