Origin of a 'Southern Hemisphere' geochemical signature in the Arctic upper mantle.

abstract：:Replication of multipotential stem cells in long-term murine bone marrow cell culture is known to depend on the development of an adherent stromal cell layer. In these conditions, restricted haematopoietic progenitor cells have also been generated for up to several months1-3. However, maturation is observed only in th...

journal_title：Nature

authors： Wendling F,Shreeve MM,McLeod DL,Axelrad AA

更新日期：1983-10-13 00:00:00

abstract：:The making and breaking of atomic bonds are essential processes in chemical reactions. Although the ultrafast dynamics of bond breaking have been studied intensively using time-resolved techniques, it is very difficult to study the structural dynamics of bond making, mainly because of its bimolecular nature. It is esp...

journal_title：Nature

authors： Kim KH,Kim JG,Nozawa S,Sato T,Oang KY,Kim TW,Ki H,Jo J,Park S,Song C,Sato T,Ogawa K,Togashi T,Tono K,Yabashi M,Ishikawa T,Kim J,Ryoo R,Kim J,Ihee H,Adachi S

更新日期：2015-02-19 00:00:00

abstract：:The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific...

journal_title：Nature

authors： Graves BJ,Crowther RL,Chandran C,Rumberger JM,Li S,Huang KS,Presky DH,Familletti PC,Wolitzky BA,Burns DK

更新日期：1994-02-10 00:00:00

abstract：:A hybrid gene was constructed between the beta-lactamase gene of plasmid pBR322 and the cloned coding sequence for rat growth hormone. This gene is expressed in bacteria and growth hormone sequences are detectable by immunological methods. ...

journal_title：Nature

authors： Seeburg PH,Shine J,Martial JA,Ivarie RD,Morris JA,Ullrich A,Baxter JD,Goodman HM

更新日期：1978-12-21 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory and immunomodulatory cytokine implicated in inflammatory conditions such as rheumatoid arthritis, Crohn's disease, multiple sclerosis and the cachexia associated with cancer or human immunodeficiency virus infection. TNF-alpha is initially expressed...

journal_title：Nature

authors： Gearing AJ,Beckett P,Christodoulou M,Churchill M,Clements J,Davidson AH,Drummond AH,Galloway WA,Gilbert R,Gordon JL

更新日期：1994-08-18 00:00:00

abstract：:The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneous...

journal_title：Nature

authors： Hilbert P,Lindpaintner K,Beckmann JS,Serikawa T,Soubrier F,Dubay C,Cartwright P,De Gouyon B,Julier C,Takahasi S

更新日期：1991-10-10 00:00:00

abstract：:Over the past decade, ice loss from the Greenland Ice Sheet increased as a result of both increased surface melting and ice discharge to the ocean. The latter is controlled by the acceleration of ice flow and subsequent thinning of fast-flowing marine-terminating outlet glaciers. Quantifying the future dynamic contrib...

journal_title：Nature

authors： Nick FM,Vieli A,Andersen ML,Joughin I,Payne A,Edwards TL,Pattyn F,van de Wal RS

更新日期：2013-05-09 00:00:00

abstract：:There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the Drosophila melanogaster antenna called t...

journal_title：Nature

authors： Kain P,Boyle SM,Tharadra SK,Guda T,Pham C,Dahanukar A,Ray A

更新日期：2013-10-24 00:00:00

abstract：:In mammals, one of the most pronounced consequences of viral infection is the induction of type I interferons, cytokines with potent antiviral activity. Schlafen (Slfn) genes are a subset of interferon-stimulated early response genes (ISGs) that are also induced directly by pathogens via the interferon regulatory fact...

journal_title：Nature

authors： Li M,Kao E,Gao X,Sandig H,Limmer K,Pavon-Eternod M,Jones TE,Landry S,Pan T,Weitzman MD,David M

更新日期：2012-11-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Goodman SN

更新日期：2018-12-01 00:00:00

abstract：:It is currently debated whether segmentation in different animal phyla has a common origin and shares a common genetic mechanism. The apparent use of different genetic networks in arthropods and vertebrates has become a strong argument against a common origin of segmentation. Our knowledge of arthropod segmentation is...

journal_title：Nature

authors： Stollewerk A,Schoppmeier M,Damen WG

更新日期：2003-06-19 00:00:00

abstract：:Many tissues including blood, skin, gut and germ cells are continuously maintained by tissue stem cells. Under certain conditions, however, other organs can undergo repair using stem-cell-like progenitors generated by cell de-differentiation. Cell fates have been broadened experimentally, but mechanisms allowing de-di...

journal_title：Nature

authors： Kai T,Spradling A

更新日期：2004-04-01 00:00:00

abstract：:Piwi-associated RNAs (piRNAs), a specific class of 24- to 30-nucleotide-long RNAs produced by the Piwi-type of Argonaute proteins, have a specific germline function in repressing transposable elements. This repression is thought to involve heterochromatin formation and transcriptional and post-transcriptional silencin...

journal_title：Nature

authors： Rouget C,Papin C,Boureux A,Meunier AC,Franco B,Robine N,Lai EC,Pelisson A,Simonelig M

更新日期：2010-10-28 00:00:00

abstract：:Octopamine is highly concentrated in neurones of several invertebrate species. Unlike in mammals, octopaminergic neurones in invertebrates are spatially separated from catecholaminergic neurons. In identified nerve cells of Aplysia, however, this amine coexists with other putative neurotransmitters. Octopamine is synt...

journal_title：Nature

authors： Axelrod J,Saavedra JM

更新日期：1977-02-10 00:00:00

abstract：:The retinoblastoma tumour-suppressor protein Rb inhibits cell proliferation by repressing a subset of genes that are controlled by the E2F family of transcription factors and which are involved in progression from the G1 to the S phase of the cell cycle. Rb, which is recruited to target promoters by E2F1, represses tr...

journal_title：Nature

authors： Magnaghi-Jaulin L,Groisman R,Naguibneva I,Robin P,Lorain S,Le Villain JP,Troalen F,Trouche D,Harel-Bellan A

更新日期：1998-02-05 00:00:00

abstract：:Type Ia supernovae have been used empirically as 'standard candles' to demonstrate the acceleration of the expansion of the Universe even though fundamental details, such as the nature of their progenitor systems and how the stars explode, remain a mystery. There is consensus that a white dwarf star explodes after acc...

journal_title：Nature

authors： Nugent PE,Sullivan M,Cenko SB,Thomas RC,Kasen D,Howell DA,Bersier D,Bloom JS,Kulkarni SR,Kandrashoff MT,Filippenko AV,Silverman JM,Marcy GW,Howard AW,Isaacson HT,Maguire K,Suzuki N,Tarlton JE,Pan YC,Bildsten L,Ful

更新日期：2011-12-14 00:00:00

abstract：:Multiple sulphatase deficiency disease is an unusual autosomal recessive disorder characterised biochemically by a deficiency of several sulphohydrolase activities. The laboratory diagnosis of this combined neurological connective tissue disorder is made on the basis of decreased activities of the lysosomal enzymes, a...

journal_title：Nature

authors： Fiddler MB,Vine D,Shapira E,Nadler HL

更新日期：1979-11-01 00:00:00

abstract：:Quantum cryptography exploits the fundamental laws of quantum mechanics to provide a secure way to exchange private information. Such an exchange requires a common random bit sequence, called a key, to be shared secretly between the sender and the receiver. The basic idea behind quantum key distribution (QKD) has wide...

journal_title：Nature

authors： Sasaki T,Yamamoto Y,Koashi M

更新日期：2014-05-22 00:00:00

abstract：:The human T-cell leukaemia and differentiation antigen HTA 1 is defined by the monoclonal antibody NA1/34 (ref. 1) and also recognized by the monoclonal antibody OKT6. Like class I products of the human major histocompatibility complex, it has a glycosylated heavy (alpha) chain of approximately 45-50,000 molecular wei...

journal_title：Nature

authors： Kefford RF,Calabi F,Fearnley IM,Burrone OR,Milstein C

更新日期：1984-04-12 00:00:00

abstract：:The pseudogap is a partial gap in the electronic density of states that opens in the normal (non-superconducting) state of cuprate superconductors and whose origin is a long-standing puzzle. Its connection to the Mott insulator phase at low doping (hole concentration, p) remains ambiguous and its relation to the charg...

journal_title：Nature

authors： Badoux S,Tabis W,Laliberté F,Grissonnanche G,Vignolle B,Vignolles D,Béard J,Bonn DA,Hardy WN,Liang R,Doiron-Leyraud N,Taillefer L,Proust C

更新日期：2016-03-10 00:00:00

abstract：:An optimal search theory, the so-called Lévy-flight foraging hypothesis, predicts that predators should adopt search strategies known as Lévy flights where prey is sparse and distributed unpredictably, but that Brownian movement is sufficiently efficient for locating abundant prey. Empirical studies have generated con...

journal_title：Nature

authors： Humphries NE,Queiroz N,Dyer JR,Pade NG,Musyl MK,Schaefer KM,Fuller DW,Brunnschweiler JM,Doyle TK,Houghton JD,Hays GC,Jones CS,Noble LR,Wearmouth VJ,Southall EJ,Sims DW

更新日期：2010-06-24 00:00:00

abstract：:Leks have traditionally been considered as arenas where males compete to attract females and secure matings. Thus, direct fitness benefits mediated through competition between males to fertilize females have been considered to be the primary force driving the evolution of lekking behaviour. Inclusive fitness benefits ...

journal_title：Nature

authors： Shorey L,Piertney S,Stone J,Höglund J

更新日期：2000-11-16 00:00:00

abstract：:Although stars form from clouds of gas and dust, there are insignificant amounts of gas around ordinary (Sun-like) stars. This suggests that hydrogen and helium, the primary constituents of planets such as Jupiter and Saturn, are not easily retained in orbit as a star matures. The gas-giant planets in the Solar System...

journal_title：Nature

authors： Zuckerman B,Forveille T,Kastner JH

更新日期：1995-02-09 00:00:00

abstract：:The biological importance of DNA methylation for gene expression in eukaryotes is becoming increasingly evident, and a direct role of methylation in gene expression has been suggested by an analysis of the infectivity of integrated retroviral genomes in a transfection assay. These studies, however, did not address whe...

journal_title：Nature

authors： Simon D,Stuhlmann H,Jähner D,Wagner H,Werner E,Jaenisch R

更新日期：1983-07-21 00:00:00

abstract：:The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies,...

journal_title：Nature

authors： Wang JH,Yan YW,Garrett TP,Liu JH,Rodgers DW,Garlick RL,Tarr GE,Husain Y,Reinherz EL,Harrison SC

更新日期：1990-11-29 00:00:00

abstract：:Piezoelectric materials, which convert mechanical to electrical energy (and vice versa), are crucial in medical imaging, telecommunication and ultrasonic devices. A new generation of single-crystal materials, such as Pb(Zn1/3Nb2/3)O3-PbTiO3 (PZN-PT) and Pb(Mg1/3Nb2/3)O3-PbTiO3 (PMN-PT), exhibit a piezoelectric effect ...

journal_title：Nature

authors： Fu H,Cohen RE

更新日期：2000-01-20 00:00:00

abstract：:The tumour suppressor p53 is required to induce programmed cell death (apoptosis) by DNA-damaging agents. As p53 is a transcriptional activator that mediates gene induction after DNA damage, it has been proposed to be a genetic switch that activates apoptosis-mediator genes. Here we evaluate the role of p53 in DNA-dam...

journal_title：Nature

authors： Caelles C,Helmberg A,Karin M

更新日期：1994-07-21 00:00:00

abstract：:A DNA probe from a human Y chromosome-derived cosmid detects a single-copy genomic DNA fragment which can appear in different allelic forms shared by both sex chromosomes. Variants at this DNA locus show an autosomal pattern of inheritance, undergo recombination with sexual phenotype and can therefore be described as ...

journal_title：Nature

authors： Simmler MC,Rouyer F,Vergnaud G,Nyström-Lahti M,Ngo KY,de la Chapelle A,Weissenbach J

更新日期：1985-10-24 00:00:00

abstract：:Visible-light absorption and transport of the resultant electronic excitations to a reaction centre through Förster resonance energy transfer1-3 (FRET) are critical to the operation of biological light-harvesting systems4, and are used in various artificial systems made of synthetic dyes5, polymers6 or nanodots7,8. Th...

journal_title：Nature

authors： Lau JA,Chen L,Choudhury A,Schwarzer D,Verma VB,Wodtke AM

更新日期：2021-01-01 00:00:00

abstract：:Transposable elements from prokaryotic and eukaryotic organisms are discrete DNA segments bounded by inverted or directly repeated sequences that insert into non-homologous DNA in a reaction that is independent of the general recombination functions of the host. The mechanisms proposed generally involve a staggered do...

journal_title：Nature

authors： Murphy E,Löfdahl S

更新日期：1984-01-19 00:00:00