TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.

abstract：:Soft machines are a promising design paradigm for human-centric devices1,2 and systems required to interact gently with their environment3,4. To enable soft machines to respond intelligently to their surroundings, compliant sensory feedback mechanisms are needed. Specifically, soft alternatives to strain gauges-with h...

journal_title：Nature

authors： Araromi OA,Graule MA,Dorsey KL,Castellanos S,Foster JR,Hsu WH,Passy AE,Vlassak JJ,Weaver JC,Walsh CJ,Wood RJ

更新日期：2020-11-01 00:00:00

abstract：:During the evolution of sea urchins, a transfer RNA gene lost its tRNA function and became part of a protein-coding gene. This functional loss of a tRNA with specificity for one group of leucine codons (CUN, where N is any base) was accompanied by the gain of a new tRNA with that specificity. The new tRNA gene for CUN...

journal_title：Nature

authors： Cantatore P,Gadaleta MN,Roberti M,Saccone C,Wilson AC

更新日期：1987-10-29 00:00:00

abstract：:To artists, the face is a mirror of the soul. To biologists, the face reflects remarkable structural diversity--think of bulldogs and wolfhounds or galapagos finches. How do such variations in skeletal form arise? Do the same mechanisms control skeletogenesis elsewhere in the body? The answers lie in the molecular mac...

journal_title：Nature

authors： Helms JA,Schneider RA

更新日期：2003-05-15 00:00:00

abstract：:The peptide GsMTx4, isolated from the venom of the tarantula Grammostola spatulata, is a selective inhibitor of stretch-activated cation channels (SACs). The mechanism of inhibition remains unknown; but both GsMTx4 and its enantiomer, enGsMTx4, modify the gating of SACs, thus violating a trademark of the traditional l...

journal_title：Nature

authors： Suchyna TM,Tape SE,Koeppe RE 2nd,Andersen OS,Sachs F,Gottlieb PA

更新日期：2004-07-08 00:00:00

abstract：:Surgical, pharmacological and genetic lesion studies have revealed distinct anatomical sites involved with different forms of learning. Studies of patients with localized brain damage and work in rodent model systems, for example, have shown that the hippocampal formation participates in acquisition of declarative tas...

journal_title：Nature

authors： Dubnau J,Grady L,Kitamoto T,Tully T

更新日期：2001-05-24 00:00:00

abstract：:Lung diseases such as chronic obstructive pulmonary disease and pulmonary fibrosis involve the progressive and inexorable destruction of oxygen exchange surfaces and airways, and have emerged as a leading cause of death worldwide. Mitigating therapies, aside from impractical organ transplantation, remain limited and t...

journal_title：Nature

authors： Zuo W,Zhang T,Wu DZ,Guan SP,Liew AA,Yamamoto Y,Wang X,Lim SJ,Vincent M,Lessard M,Crum CP,Xian W,McKeon F

更新日期：2015-01-29 00:00:00

abstract：:Intracellular signalling following mitogenic stimulation of quiescent cells involves the initiation of a phosphorylation cascade that leads to the rapid and reversible activation of the mitogen-activated protein (MAP) kinases ERK1 and ERK2. MAP kinase activation is mediated by dual phosphorylation within the motif Thr...

journal_title：Nature

authors： Ward Y,Gupta S,Jensen P,Wartmann M,Davis RJ,Kelly K

更新日期：1994-02-17 00:00:00

abstract：:Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neovascularisation (CNV). Here we show that the eosinophil/mast cell chemokine receptor CCR3 is specifically expres...

journal_title：Nature

authors： Takeda A,Baffi JZ,Kleinman ME,Cho WG,Nozaki M,Yamada K,Kaneko H,Albuquerque RJ,Dridi S,Saito K,Raisler BJ,Budd SJ,Geisen P,Munitz A,Ambati BK,Green MG,Ishibashi T,Wright JD,Humbles AA,Gerard CJ,Ogura Y,Pan Y,S

更新日期：2009-07-09 00:00:00

abstract：:Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes, but also with gain-of-function mutations of proto-oncogenes. Here we show unique gain-of-function mutations of the C-CBL (...

journal_title：Nature

authors： Sanada M,Suzuki T,Shih LY,Otsu M,Kato M,Yamazaki S,Tamura A,Honda H,Sakata-Yanagimoto M,Kumano K,Oda H,Yamagata T,Takita J,Gotoh N,Nakazaki K,Kawamata N,Onodera M,Nobuyoshi M,Hayashi Y,Harada H,Kurokawa M,Chiba

更新日期：2009-08-13 00:00:00

abstract：:Haematopoiesis is a developmental cascade that generates all blood cell lineages in health and disease. This process relies on quiescent haematopoietic stem cells capable of differentiating, self renewing and expanding upon physiological demand. However, the mechanisms that regulate haematopoietic stem cell homeostasi...

journal_title：Nature

authors： Fonseca-Pereira D,Arroz-Madeira S,Rodrigues-Campos M,Barbosa IA,Domingues RG,Bento T,Almeida AR,Ribeiro H,Potocnik AJ,Enomoto H,Veiga-Fernandes H

更新日期：2014-10-02 00:00:00

abstract：:Transport of fermions, particles with half-integer spin, is central to many fields of physics. Electron transport runs modern technology, defining states of matter such as superconductors and insulators, and electron spin is being explored as a new carrier of information. Neutrino transport energizes supernova explosi...

journal_title：Nature

authors： Sommer A,Ku M,Roati G,Zwierlein MW

更新日期：2011-04-14 00:00:00

abstract：:The study of the extent and basis of gene-enzyme variation has long been a principal concern of population genetics. Numerous surveys have indicated considerable amounts of genetic variation detectable in natural populations, with few exceptions. The variances of average heterozygosities (H) between species and among ...

journal_title：Nature

authors： O'Brien SJ,Gail MH,Levin DL

更新日期：1980-12-11 00:00:00

abstract：:Integration of information between tyrosine kinase and G-protein-mediated pathways is necessary, but remains poorly understood. Here we use cells from transgenic mice harbouring inducible expression of RNA antisense to the gene encoding G ialpha2 to show that G ialpha2 is critical for insulin action. G ialpha2 deficie...

journal_title：Nature

authors： Moxham CM,Malbon CC

更新日期：1996-02-29 00:00:00

abstract：: ...

journal_title：Nature

authors： Mallapaty S

更新日期：2018-12-01 00:00:00

abstract：:Ice flow along land-terminating margins of the Greenland Ice Sheet (GIS) varies considerably in response to fluctuating inputs of surface meltwater to the bed of the ice sheet. Such inputs lubricate the ice-bed interface, transiently speeding up the flow of ice. Greater melting results in faster ice motion during summ...

journal_title：Nature

authors： Tedstone AJ,Nienow PW,Gourmelen N,Dehecq A,Goldberg D,Hanna E

更新日期：2015-10-29 00:00:00

abstract：:The first zygotic genes to be expressed during early Drosophila development are the gap genes. Their role is to read and interpret coarse positional information deposited in the egg by the mother and to refine it by cross-regulatory interactions and by controlling a class of pair-rule genes. Little is known about the ...

journal_title：Nature

authors： Treisman J,Desplan C

更新日期：1989-09-28 00:00:00

abstract：:Mesenchymal cells contribute to the 'stroma' of most normal and malignant tissues, with specific mesenchymal cells participating in the regulatory niches of stem cells. By examining how mesenchymal osteolineage cells modulate haematopoiesis, here we show that deletion of Dicer1 specifically in mouse osteoprogenitors, ...

journal_title：Nature

authors： Raaijmakers MH,Mukherjee S,Guo S,Zhang S,Kobayashi T,Schoonmaker JA,Ebert BL,Al-Shahrour F,Hasserjian RP,Scadden EO,Aung Z,Matza M,Merkenschlager M,Lin C,Rommens JM,Scadden DT

更新日期：2010-04-08 00:00:00

abstract：:Noradrenaline releases prostaglandins in the kidney, and in rats these augment rather than reduce vasoconstriction produced by the amine. Homogenates of kidneys of New Zealand rats inbred for hypertension exhibit lower prostaglandin inactivation by 15-hydroxydehydrogenase than controls. At the same time, augmentation ...

journal_title：Nature

authors： Armstrong JM,Blackwell GJ,Flower RJ,McGiff JC,Mullane KM,Vane JR

更新日期：1976-04-15 00:00:00

abstract：:THE mouse H19 gene encodes one of the most abundant RNAs in the developing mouse embryo. It is expressed at the blastocyst stage of development, and accumulates to high levels in tissues of endodermal and mesodermal origin (H. Kim, unpublished result). After birth the gene is expressed in all tissues except skeletal m...

journal_title：Nature

authors： Bartolomei MS,Zemel S,Tilghman SM

更新日期：1991-05-09 00:00:00

abstract：:Topoisomerases relieve the torsional strain in DNA that is built up during replication and transcription. They are vital for cell proliferation and are a target for poisoning by anti-cancer drugs. Type IB topoisomerase (TopIB) forms a protein clamp around the DNA duplex and creates a transient nick that permits remova...

journal_title：Nature

authors： Koster DA,Croquette V,Dekker C,Shuman S,Dekker NH

更新日期：2005-03-31 00:00:00

abstract：:The identification of novel metabolites and the characterization of their biological functions are major challenges in biology. X-ray crystallography can reveal unanticipated ligands that persist through purification and crystallization. These adventitious protein-ligand complexes provide insights into new activities,...

journal_title：Nature

authors： Kim J,Xiao H,Bonanno JB,Kalyanaraman C,Brown S,Tang X,Al-Obaidi NF,Patskovsky Y,Babbitt PC,Jacobson MP,Lee YS,Almo SC

更新日期：2013-06-06 00:00:00

abstract：:The four R-spondin secreted ligands (RSPO1-RSPO4) act via their cognate LGR4, LGR5 and LGR6 receptors to amplify WNT signalling1-3. Here we report an allelic series of recessive RSPO2 mutations in humans that cause tetra-amelia syndrome, which is characterized by lung aplasia and a total absence of the four limbs. Fun...

journal_title：Nature

authors： Szenker-Ravi E,Altunoglu U,Leushacke M,Bosso-Lefèvre C,Khatoo M,Thi Tran H,Naert T,Noelanders R,Hajamohideen A,Beneteau C,de Sousa SB,Karaman B,Latypova X,Başaran S,Yücel EB,Tan TT,Vlaminck L,Nayak SS,Shukla A,Giris

更新日期：2018-05-01 00:00:00

abstract：:Mitochondria, organelles specialized in energy conservation reactions in eukaryotic cells, have evolved from eubacteria-like endosymbionts whose closest known relatives are the rickettsial group of alpha-proteobacteria. Because characterized mitochondrial genomes vary markedly in structure, it has been impossible to i...

journal_title：Nature

authors： Lang BF,Burger G,O'Kelly CJ,Cedergren R,Golding GB,Lemieux C,Sankoff D,Turmel M,Gray MW

更新日期：1997-05-29 00:00:00

abstract：:HIV has advanced from high-risk groups such as intravenous drug users to some in the general population, according to comprehensive new data from the south of China. What needs to be done to halt its spread? ...

journal_title：Nature

authors： Lu L,Jia M,Ma Y,Yang L,Chen Z,Ho DD,Jiang Y,Zhang L

更新日期：2008-10-02 00:00:00

abstract：:The thymus has two important roles in controlling the specificity of T lymphocytes. First, T cells differentiating in the thymus are rendered tolerant of 'self' antigens, particularly antigens encoded by the major histocompatibility complex, the H-2 complex in mice. Second, the thymus imbues T cells with the property ...

journal_title：Nature

authors： Lo D,Sprent J

更新日期：1986-02-20 00:00:00

abstract：:The T-cell immune response is directed against antigenic peptide fragments generated in intracellular compartments, the cytosol or the endocytic system. Peptides derived from cytosolic proteins, usually of biosynthetic origin, are presented efficiently to T-cell receptors by major histocompatibility complex (MHC) clas...

journal_title：Nature

authors： Deverson EV,Gow IR,Coadwell WJ,Monaco JJ,Butcher GW,Howard JC

更新日期：1990-12-20 00:00:00

abstract：:Precipitation and atmospheric circulation are the coupled processes through which tropical ocean surface temperatures drive global weather and climate1-5. Local sea surface warming tends to increase precipitation, but this local control is difficult to disentangle from remote effects of conditions elsewhere. As an exa...

journal_title：Nature

authors： Good P,Chadwick R,Holloway CE,Kennedy J,Lowe JA,Roehrig R,Rushley SS

更新日期：2021-01-01 00:00:00

abstract：:N-glycosylation of proteins in the endoplasmic reticulum (ER) has a central role in protein quality control. Here we report that N-glycan serves as a signal for degradation by the Skp1-Cullin1-Fbx2-Roc1 (SCF(Fbx2)) ubiquitin ligase complex. The F-box protein Fbx2 (ref. 4) binds specifically to proteins attached to N-l...

journal_title：Nature

authors： Yoshida Y,Chiba T,Tokunaga F,Kawasaki H,Iwai K,Suzuki T,Ito Y,Matsuoka K,Yoshida M,Tanaka K,Tai T

更新日期：2002-07-25 00:00:00

abstract：:The degradation of cytosolic proteins is carried out predominantly by the proteasome, which generates peptides of 7-9 amino acids long. These products need further processing. Recently, a proteolytic system was identified in the model organism Thermoplasma acidophilum that performs this processing. The hexameric core ...

journal_title：Nature

authors： Brandstetter H,Kim JS,Groll M,Huber R

更新日期：2001-11-22 00:00:00

abstract：:Serious concerns have been raised about the ecological effects of industrialized fishing, spurring a United Nations resolution on restoring fisheries and marine ecosystems to healthy levels. However, a prerequisite for restoration is a general understanding of the composition and abundance of unexploited fish communit...

journal_title：Nature

authors： Myers RA,Worm B

更新日期：2003-05-15 00:00:00