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NATURE文献大全abstract::One of the main unanswered questions in solar physics is why the Sun's outer atmosphere is hotter than its surface. Theory predicts abundant production of high-frequency (10-50 mHz) acoustic waves in subsurface layers of the Sun, and such waves are believed by many to constitute the dominant heating mechanism of the c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03695
更新日期:2005-06-16 00:00:00
abstract::The neuronal structure and connectivity underlying receptive field organisation of cells in the cat visual cortex have been investigated. Intracellular recordings were made using a micropipette filled with a histochemical marker, which was injected into the cells after their receptive fields had been characterised. Th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/280120a0
更新日期:1979-07-12 00:00:00
abstract::Adenylyl cyclase is the prototypical second messenger generator. Nearly all of the eight cloned adenylyl cyclases are regulated by one or other arm of the phospholipase C pathway. Functional and ultrastructural investigations have shown that adenylyl cyclases are intimately associated with sites of calcium ion entry i...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/374421a0
更新日期:1995-03-30 00:00:00
abstract::In double-stranded-RNA (dsRNA) viruses found in animals, bacteria and yeast, the genome is transcribed within the structurally intact core of the virion with extraordinary efficiency. The structural organization of the genome and the enzymes involved in the transcription inside any of these viruses, critical for under...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/382471a0
更新日期:1996-08-01 00:00:00
abstract::Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon hypersociability and a mosaic of retained and compromised linguistic and cognitive abilities. Nearly all clinically diagnosed individuals with Williams syndrome lack precisely the same set of genes, with breakpoints in chromosome b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19067
更新日期:2016-08-18 00:00:00
abstract::Electromagnetically induced transparency is a quantum interference effect that permits the propagation of light through an otherwise opaque atomic medium; a 'coupling' laser is used to create the interference necessary to allow the transmission of resonant pulses from a 'probe' laser. This technique has been used to s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35054017
更新日期:2001-01-25 00:00:00
abstract::Change history: In this Letter, the bottom blot in Fig. 2g (for 'IB: Myc') was missing. This has been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1360-7
更新日期:2019-07-01 00:00:00
abstract::Sex-determination genes are among the most fluid features of the genome in many groups of animals. In some taxa the master sex-determining gene moves frequently between chromosomes, whereas in other taxa different genes have been recruited to determine the sex of the zygotes. There is a well developed theory for the o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06178
更新日期:2007-10-18 00:00:00
abstract::Human cytomegalovirus (HCMV) is a major pathogen in immunosuppressed individuals, including patients with acquired immune deficiency syndrome. The nucleoside analogue ganciclovir (9-(1,3-dihydroxy-2-propoxymethyl)-guanine) is one of the few drugs available to treat HCMV infections, but resistant virus is a growing pro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/358162a0
更新日期:1992-07-09 00:00:00
abstract::Excitatory amino acids mediate fast synaptic transmission in the central nervous system through the activation of at least three distinct ionotropic receptors: N-methyl-D-aspartate (NMDA), the alpha-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/quisqualate (QUIS) and the kainate subtypes (for reviews, see ref...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347765a0
更新日期:1990-10-25 00:00:00
abstract::Positive selection allows thymocytes that recognize an individual's own major histocompatibility complex (self-MHC) molecules to survive and differentiate, whereas negative selection removes overtly self-reactive thymocytes. Although both forms of thymic selection are mediated by the alphabeta T-cell receptor (TCR) an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35019094
更新日期:2000-07-27 00:00:00
abstract::Analysis of the nucleotide sequence of the human retrovirus associated with AIDS in West Africa, HIV-2, shows that it is evolutionarily distant from the previously characterized HIV-1. We suggest that these viruses existed long before the current AIDS epidemics. Their biological properties are conserved in spite of li...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326662a0
更新日期:1987-04-16 00:00:00
abstract::Intracellular responses recorded in vitro from the cochleas of anaesthetized mammals have shown that the mechanoreceptive inner and outer hair cells are sharply tuned, accounting for many of the properties of the afferent fibres in the auditory nerve. However, in vivo it has not been possible to measure directly the e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/321517a0
更新日期:1986-05-29 00:00:00
abstract::Relative to the present day, meridional temperature gradients in the Early Eocene age ( approximately 56-53 Myr ago) were unusually low, with slightly warmer equatorial regions but with much warmer subtropical Arctic and mid-latitude climates. By the end of the Eocene epoch ( approximately 34 Myr ago), the first major...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature08399
更新日期:2009-10-08 00:00:00
abstract::The mechanistic Target of Rapamycin Complex 1 (mTORC1) is a major regulator of eukaryotic growth that coordinates anabolic and catabolic cellular processes with inputs such as growth factors and nutrients, including amino acids. In mammals arginine is particularly important, promoting diverse physiological effects suc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19079
更新日期:2016-08-11 00:00:00
abstract::Elucidation of the nature of the gene interactions that underly the sterility of interspecific hybrids is important in evolutionary biology. The interactions between the heterospecific X and Y (or Z and W) chromosomes are often used as an explanation for two reasons. First, the fertility of the hybrids of the heteroga...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/358751a0
更新日期:1992-08-27 00:00:00
abstract::Deviations from the universal genetic code have been reported for several microorganisms. Termination codons are used for coding some amino acids in Paramecium, Mycoplasma or Tetrahymena, and in Escherichia coli, the UGA termination codon is used to code for selenocysteine. In mitochondria, the changes of sense codons...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/341164a0
更新日期:1989-09-14 00:00:00
abstract::Aerobic methanotrophic bacteria consume methane as it diffuses away from methanogenic zones of soil and sediment. They act as a biofilter to reduce methane emissions to the atmosphere, and they are therefore targets in strategies to combat global climate change. No cultured methanotroph grows optimally below pH 5, but...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06411
更新日期:2007-12-06 00:00:00
abstract::The four R-spondin secreted ligands (RSPO1-RSPO4) act via their cognate LGR4, LGR5 and LGR6 receptors to amplify WNT signalling1-3. Here we report an allelic series of recessive RSPO2 mutations in humans that cause tetra-amelia syndrome, which is characterized by lung aplasia and a total absence of the four limbs. Fun...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0118-y
更新日期:2018-05-01 00:00:00
abstract::In this Letter, in Fig. 3c and f the Saccharomyces cerevisiae and Escherichia coli networks were subject to both weight loss and node deletion, a combination of two types of perturbation, as opposed to weight loss only (as the labelling incorrectly indicated). The collapse in Fig. 3h was also obtained from this combin...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1091-9
更新日期:2019-04-01 00:00:00
abstract::B cells are important in the pathogenesis of many, and perhaps all, immune-mediated diseases. Each B cell expresses a single B cell receptor (BCR)1, and the diverse range of BCRs expressed by the total B cell population of an individual is termed the 'BCR repertoire'. Our understanding of the BCR repertoire in the con...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1595-3
更新日期:2019-10-01 00:00:00
abstract::The optimal water transport system in plants should maximize hydraulic conductance (which is proportional to photosynthesis) for a given investment in transport tissue. To investigate how this optimum may be achieved, we have performed computer simulations of the hydraulic conductance of a branched transport system. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01444
更新日期:2003-02-27 00:00:00
abstract::The nuclear envelope defines a compartment boundary which is penetrated by pores that mediate a remarkable transport process. Precursor RNAs are retained in the nucleus, while processed messenger RNA, transfer RNA and ribosomal subunits are transported to the cytoplasm. Proteins destined for the nucleus become localiz...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322641a0
更新日期:1986-08-14 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07356-3
更新日期:2018-11-01 00:00:00
abstract::How bacteria regulate cell cycle progression at a molecular level is a fundamental but poorly understood problem. In Caulobacter crescentus, two-component signal transduction proteins are crucial for cell cycle regulation, but the connectivity of regulators involved has remained elusive and key factors are unidentifie...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05321
更新日期:2006-12-14 00:00:00
abstract::One simple, widely accepted mechanism for generating an aberrant chromosome number, or aneuploidy, is through nondisjunction--a chromosome distribution error that occurs during mitosis when both copies of a duplicated chromosome are deposited into one daughter cell and none into the other. Shi and King challenge this ...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature05139
更新日期:2006-08-17 00:00:00
abstract::Protein-tyrosine phosphatases (PTPs) are vital for regulating tryosine phosphorylation in many processes, including growth and differentiation. The regulation of receptor-like PTP (RPTP) activity remains poorly understood, but based on the crystal structure of RPTPalpha domain 1 we have proposed that dimerization can ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/44170
更新日期:1999-10-07 00:00:00
abstract::Excision of introns from nuclear precursors to messenger RNAs (pre-mRNAs) by the spliceosome requires two distinct phosphodiester transfer (transesterification) reactions: exchange of a 3'-5' for a 2'-5' bond in the first step (lariat formation) and exchange of one 3'-5' phosphodiester for another in the second step (...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/365364a0
更新日期:1993-09-23 00:00:00
abstract::We have shown previously that chemically skinned fibre bundles from scallop muscle can be desensitized to the action of calcium by the removal of the regulatory light chains of myosin and that sensitivity can be restored by the re-addition of scallop light chains. We have now confirmed these results and extended our o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/286626a0
更新日期:1980-08-07 00:00:00
abstract::The radio sky is relatively unexplored for transient signals, although the potential of radio-transient searches is high. This was demonstrated recently by the discovery of a previously unknown type of source, varying on timescales of minutes to hours. Here we report a search for radio sources that vary on much shorte...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04440
更新日期:2006-02-16 00:00:00