Publisher Correction: Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

abstract：:Human fibroblast cells produce beta-type interferon only in response to viral infection or treatment with an inducer such as poly(rI) X poly(rC); this event is most probably controlled at the transcriptional level (for review see ref. 1). To study the induction process, we inserted the human fibroblast interferon (IFN...

journal_title：Nature

authors： Tavernier J,Gheysen D,Duerinck F,Van der Heyden J,Fiers W

更新日期：1983-02-17 00:00:00

abstract：: ...

journal_title：Nature

authors： Venn K

更新日期：2018-11-01 00:00:00

abstract：:A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal s...

journal_title：Nature

authors： Saper CB,Scammell TE,Lu J

更新日期：2005-10-27 00:00:00

abstract：:Some beetles in the Namib Desert collect drinking water from fog-laden wind on their backs. We show here that these large droplets form by virtue of the insect's bumpy surface, which consists of alternating hydrophobic, wax-coated and hydrophilic, non-waxy regions. The design of this fog-collecting structure can be re...

journal_title：Nature

authors： Parker AR,Lawrence CR

更新日期：2001-11-01 00:00:00

abstract：:Calcium-dependent protease (calcium protease) is apparently involved in a variety of cellular processes. Here we have attempted to clarify the role and regulatory mechanism of calcium protease by analysing its structure. The complete primary structure of calcium protease (relative molecular mass (Mr) 80,000 (80K), 705...

journal_title：Nature

authors： Ohno S,Emori Y,Imajoh S,Kawasaki H,Kisaragi M,Suzuki K

更新日期：1984-12-06 00:00:00

abstract：:The search to understand the mechanisms regulating brain wiring has relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular cues and receptors for axon guidance. Here we describe a phenotype-based gene-trap screen in mice designed for the large-scale i...

journal_title：Nature

authors： Leighton PA,Mitchell KJ,Goodrich LV,Lu X,Pinson K,Scherz P,Skarnes WC,Tessier-Lavigne M

更新日期：2001-03-08 00:00:00

abstract：:Transmission of obligate bacterial symbionts between generations is vital for the survival of the host. Although the larvae of certain hydrothermal vent tubeworms (Vestimentifera, Siboglinidae) are symbiont-free and possess a transient digestive system, these structures are lost during development, resulting in adult ...

journal_title：Nature

authors： Nussbaumer AD,Fisher CR,Bright M

更新日期：2006-05-18 00:00:00

abstract：:Cutaneous malignant melanoma is a highly aggressive and frequently chemoresistant cancer, the incidence of which continues to rise. Epidemiological studies show that the major aetiological melanoma risk factor is ultraviolet (UV) solar radiation, with the highest risk associated with intermittent burning doses, especi...

journal_title：Nature

authors： Zaidi MR,Davis S,Noonan FP,Graff-Cherry C,Hawley TS,Walker RL,Feigenbaum L,Fuchs E,Lyakh L,Young HA,Hornyak TJ,Arnheiter H,Trinchieri G,Meltzer PS,De Fabo EC,Merlino G

更新日期：2011-01-27 00:00:00

abstract：:In the course of synaptic transmission in the brain and periphery, acetylcholine receptors (AChRs) rapidly transduce a chemical signal into an electrical impulse. The speed of transduction is facilitated by rapid ACh association and dissociation, suggesting a binding site relatively non-selective for small cations. Se...

journal_title：Nature

authors： Mukhtasimova N,Lee WY,Wang HL,Sine SM

更新日期：2009-05-21 00:00:00

abstract：:The inner ear is capable of highly selective frequency discrimination. This is achieved not only by the travelling wave of the basilar membrane in the cochlear partition, but also by the active participation of nonlinear and vulnerable elements that enhance frequency selectivity. It has been shown that isolated mammal...

journal_title：Nature

authors： Brundin L,Flock A,Canlon B

更新日期：1989-12-14 00:00:00

abstract：:The import of nuclear proteins proceeds through the nuclear pore complex and requires nuclear localization signals (NLSs), energy and soluble factors, namely importin-alpha (M(r) 60K), importin-beta (90K) and Ran. Importin-alpha is primarily responsible for NLS recognition and is a member of a protein family that incl...

journal_title：Nature

authors： Görlich D,Vogel F,Mills AD,Hartmann E,Laskey RA

更新日期：1995-09-21 00:00:00

abstract：:Circadian rhythms have evolved to anticipate and adapt animals to the constraints of the earth's 24-hour light cycle. Although the molecular processes that establish periodicity in clock neurons of the suprachiasmatic nucleus (SCN) are well understood, the mechanisms by which axonal projections from the central clock ...

journal_title：Nature

authors： Gizowski C,Zaelzer C,Bourque CW

更新日期：2016-09-29 00:00:00

abstract：:For life to be sustained, mistakes in DNA repair must be tolerated when damage obscures the genetic information. In bacteria such as Escherichia coli, DNA damage elicits the well regulated 'SOS response'. For the extreme case of damage that cannot be repaired by conventional enzymes, there are proteins that allow the ...

journal_title：Nature

authors： Peat TS,Frank EG,McDonald JP,Levine AS,Woodgate R,Hendrickson WA

更新日期：1996-04-25 00:00:00

abstract：:The interplay between magnetic fields and interacting particles can lead to exotic phases of matter that exhibit topological order and high degrees of spatial entanglement. Although these phases were discovered in a solid-state setting, recent innovations in systems of ultracold neutral atoms-uncharged atoms that do n...

journal_title：Nature

authors： Tai ME,Lukin A,Rispoli M,Schittko R,Menke T,Dan Borgnia,Preiss PM,Grusdt F,Kaufman AM,Greiner M

更新日期：2017-06-21 00:00:00

abstract：:Transplantation surgery, which is limited by the supply and short-term viability of fresh donor organs, would be revolutionized if these could survive freezing, but early claims of cryopreservation were never realized. Here we describe the successful transplantation in rats of ovaries, fallopian tubes and the upper se...

journal_title：Nature

authors： Wang X,Chen H,Yin H,Kim SS,Lin Tan S,Gosden RG

更新日期：2002-01-24 00:00:00

abstract：:The Arabidopsis thaliana protein UVR8 is a photoreceptor for ultraviolet-B. Upon ultraviolet-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, which triggers a signalling pathway for ultraviolet protection. The mechanism by which UVR8 senses ultraviolet-B remains largely unknown. Here we rep...

journal_title：Nature

authors： Wu D,Hu Q,Yan Z,Chen W,Yan C,Huang X,Zhang J,Yang P,Deng H,Wang J,Deng X,Shi Y

更新日期：2012-02-29 00:00:00

abstract：:Practice, with feedback, is a fundamental variable that influences the aquisition of motor skills: with it, everyone improves, but some improve more than others. This simple fact has led to frequent debate over the relative importance of genetic and environmental influences on motor learning. In principle these factor...

journal_title：Nature

authors： Fox PW,Hershberger SL,Bouchard TJ Jr

更新日期：1996-11-28 00:00:00

abstract：:A high degree of polymorphism for the length and copy number of rDNA spacers, in both the X and Y chromosome clusters, has been found in a wild population of Drosophila melanogaster. The genetic behaviour of rDNA structural variants in separate and mixed populations derived from isofemale lines suggest that they are n...

journal_title：Nature

authors： Coen ES,Thoday JM,Dover G

更新日期：1982-02-18 00:00:00

abstract：:High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets. Outside the cell, it binds with high affinity to RAGE (the receptor for advanced glycatio...

journal_title：Nature

authors： Scaffidi P,Misteli T,Bianchi ME

更新日期：2002-07-11 00:00:00

abstract：:S-100 protein, one of the unique proteins found in the nervous system, has recently been discovered unexpectedly in the rat anterior pituitary. Immunocytochemistry reveals that stellate, follicular and folliculostellate cells, and marginal cells of the rat anterior pituitary contain this protein; however, as far as we...

journal_title：Nature

authors： Ishikawa H,Nogami H,Shirasawa N

更新日期：1983-06-23 00:00:00

abstract：:MyoD1 and myogenin are muscle-specific proteins which can convert non-myogenic cells in culture to differentiated muscle fibres, implicating them in myogenic determination. The pattern of expression of MyoD1 and myogenin during the early stages of muscle formation in the mouse embryo in vivo and in limb-bud explants c...

journal_title：Nature

authors： Sassoon D,Lyons G,Wright WE,Lin V,Lassar A,Weintraub H,Buckingham M

更新日期：1989-09-28 00:00:00

abstract：:High-energy cosmic-ray electrons and positrons (CREs), which lose energy quickly during their propagation, provide a probe of Galactic high-energy processes and may enable the observation of phenomena such as dark-matter particle annihilation or decay. The CRE spectrum has been measured directly up to approximately 2 ...

journal_title：Nature

authors： DAMPE Collaboration.

更新日期：2017-12-07 00:00:00

abstract：:Many physiological events require transient increases in cytosolic Ca(2+) concentrations. Ryanodine receptors (RyRs) are ion channels that govern the release of Ca(2+) from the endoplasmic and sarcoplasmic reticulum. Mutations in RyRs can lead to severe genetic conditions that affect both cardiac and skeletal muscle, ...

journal_title：Nature

authors： Tung CC,Lobo PA,Kimlicka L,Van Petegem F

更新日期：2010-11-25 00:00:00

abstract：:Olefin chemistry, through pericyclic reactions, polymerizations, oxidations, or reductions, has an essential role in the manipulation of organic matter. Despite its importance, olefin synthesis still relies largely on chemistry introduced more than three decades ago, with metathesis being the most recent addition. Her...

journal_title：Nature

authors： Edwards JT,Merchant RR,McClymont KS,Knouse KW,Qin T,Malins LR,Vokits B,Shaw SA,Bao DH,Wei FL,Zhou T,Eastgate MD,Baran PS

更新日期：2017-05-11 00:00:00

abstract：:The global land and ocean carbon sinks have increased proportionally with increasing carbon dioxide emissions during the past decades1. It is thought that Northern Hemisphere lands make a dominant contribution to the global land carbon sink2-7; however, the long-term trend of the northern land sink remains uncertain. ...

journal_title：Nature

authors： Ciais P,Tan J,Wang X,Roedenbeck C,Chevallier F,Piao SL,Moriarty R,Broquet G,Le Quéré C,Canadell JG,Peng S,Poulter B,Liu Z,Tans P

更新日期：2019-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are endogenous approximately 22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression. Repression of these regulatory targets leads to decreased translational efficiency and/or decreased mRNA levels, but the relative ...

journal_title：Nature

authors： Guo H,Ingolia NT,Weissman JS,Bartel DP

更新日期：2010-08-12 00:00:00

abstract：:Stimuli-responsive hydrogels that undergo abrupt changes in volume in response to external stimuli such as pH, temperature and solvent composition have potential applications in biomedicine and the creation of 'intelligent' materials systems, for example as media for drug delivery, separation processes and protein imm...

journal_title：Nature

authors： Miyata T,Asami N,Uragami T

更新日期：1999-06-24 00:00:00

abstract：:Tumour cells become addicted to the expression of initiating oncogenes like Ras, such that loss of oncogene expression in established tumours leads to tumour regression. HRas, NRas or KRas are mutated to remain in the active GTP-bound oncogenic state in many cancers. Although Ras activates several proteins to initiate...

journal_title：Nature

authors： Lim KH,Ancrile BB,Kashatus DF,Counter CM

更新日期：2008-04-03 00:00:00

abstract：:IN 1969, Murozumi et al.1 demonstrated that the concentration of lead in Greenland snow had increased by a factor of 200 since ancient times, and concluded that most of this increase was a result of the use of alkyl-leaded petrol. Partly because of these findings, the United States and other western countries limited ...

journal_title：Nature

authors： Rosman KJR,Chisholm W,Boutron CF,Candelone JP,Görlach U

更新日期：1993-03-25 00:00:00

abstract：:Groundwater is a primary source of fresh water in many parts of the world. Some regions are becoming overly dependent on it, consuming groundwater faster than it is naturally replenished and causing water tables to decline unremittingly. Indirect evidence suggests that this is the case in northwest India, but there ha...

journal_title：Nature

authors： Rodell M,Velicogna I,Famiglietti JS

更新日期：2009-08-20 00:00:00