Abstract:
:The Arabidopsis thaliana protein UVR8 is a photoreceptor for ultraviolet-B. Upon ultraviolet-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, which triggers a signalling pathway for ultraviolet protection. The mechanism by which UVR8 senses ultraviolet-B remains largely unknown. Here we report the crystal structure of UVR8 at 1.8 Å resolution, revealing a symmetric homodimer of seven-bladed β-propeller that is devoid of any external cofactor as the chromophore. Arginine residues that stabilize the homodimeric interface, principally Arg 286 and Arg 338, make elaborate intramolecular cation-π interactions with surrounding tryptophan amino acids. Two of these tryptophans, Trp 285 and Trp 233, collectively serve as the ultraviolet-B chromophore. Our structural and biochemical analyses identify the molecular mechanism for UVR8-mediated ultraviolet-B perception, in which ultraviolet-B radiation results in destabilization of the intramolecular cation-π interactions, causing disruption of the critical intermolecular hydrogen bonds mediated by Arg 286 and Arg 338 and subsequent dissociation of the UVR8 homodimer.
journal_name
Naturejournal_title
Natureauthors
Wu D,Hu Q,Yan Z,Chen W,Yan C,Huang X,Zhang J,Yang P,Deng H,Wang J,Deng X,Shi Ydoi
10.1038/nature10931subject
Has Abstractpub_date
2012-02-29 00:00:00pages
214-9issue
7393eissn
0028-0836issn
1476-4687pii
nature10931journal_volume
484pub_type
杂志文章相关文献
NATURE文献大全abstract::5-hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily. Neurotransmitter binding in these proteins triggers the opening (gating) of an ion channel by means of an as-yet-uncharacterized conformational change. Here we show that a specific proline (Pro 8*), located at the apex of th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04130
更新日期:2005-11-10 00:00:00
abstract::Neurons in the visual cortex respond preferentially to edge-like stimuli of a particular orientation. It is a long-standing hypothesis that orientation selectivity arises during development through the activity-dependent refinement of cortical circuitry. Unambiguous evidence for such a process has, however, remained e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/25736
更新日期:1998-09-03 00:00:00
abstract::Geochemical data from ancient sedimentary successions provide evidence for the progressive evolution of Earth's atmosphere and oceans. Key stages in increasing oxygenation are postulated for the Palaeoproterozoic era (∼2.3 billion years ago, Gyr ago) and the late Proterozoic eon (about 0.8 Gyr ago), with the latter im...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature09538
更新日期:2010-11-11 00:00:00
abstract::Synapsin I is a neuron-specific phosphoprotein localized to the cytoplasmic surface of synaptic vesicles. This phosphoprotein is a major substrate for cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases. Its state of phosphorylation can be altered both in vivo and in vitro by a variety of physiologic...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326704a0
更新日期:1987-04-16 00:00:00
abstract::A variety of observations indicate that mid-ocean ridges produce less crust at spreading rates below 20 mm yr(-1) (refs 1-3), reflecting changes in fundamental ridge processes with decreasing spreading rate. The nature of these changes, however, remains uncertain, with end-member explanations being decreasing shallow ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03140
更新日期:2004-12-09 00:00:00
abstract::Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid mechanisms. Here we show that an opioid-independent form of this phenomenon, termed stress-induced analgesia, is mediated by the release of endogenous marijuana-like (cannabinoid) compounds in the brain. Blockade of cannabinoid ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03658
更新日期:2005-06-23 00:00:00
abstract::Change history: In this Letter, the final two pages of the Supplementary Information, which included two tables listing primer and antibodies, respectively, were missing; see accompanying Amendment for the missing Supplementary Tables. This Letter has not been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1328-7
更新日期:2019-07-01 00:00:00
abstract::The antigen CD10 (common acute lymphoblastic leukaemia antigen), which is the zinc metalloprotease, neutral endopeptidase 24.11 (also known as NEP or 'enkephalinase'), is expressed by acute lymphoblastic leukaemias, normal lymphoid progenitors, mature polymorphonuclear leukocytes and certain nonhaematopoietic cells. C...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347394a0
更新日期:1990-09-27 00:00:00
abstract::Long-term potentiation of chemical synapses is closely related to memory and learning. Studies of this process have concentrated on chemically mediated excitatory synapses. By contrast, activity-dependent modification of gap junctions, which also widely exist in higher structures such as hippocampus and neocortex, has...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/348542a0
更新日期:1990-12-06 00:00:00
abstract::Members of the Hedgehog family of secreted proteins control a number of important inductive interactions in the development of both vertebrates and Drosophila, but little is known about the ways in which their signalling activities are transduced. In Drosophila, hedgehog is one of the segment-polarity genes, mutations...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/382547a0
更新日期:1996-08-08 00:00:00
abstract::Humans are able to classify novel items correctly by category; some other animals have also been shown to do this. During category learning, humans group perceptual stimuli by abstracting qualities from similarity relationships of their physical properties. Forming categories is fundamental to cognition and can be ind...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35089076
更新日期:2001-08-16 00:00:00
abstract::Integration of information between tyrosine kinase and G-protein-mediated pathways is necessary, but remains poorly understood. Here we use cells from transgenic mice harbouring inducible expression of RNA antisense to the gene encoding G ialpha2 to show that G ialpha2 is critical for insulin action. G ialpha2 deficie...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/379840a0
更新日期:1996-02-29 00:00:00
abstract::Therapies for patients with cancer have changed gradually over the past decade, moving away from the administration of broadly acting cytotoxic drugs towards the use of more-specific therapies that are targeted to each tumour. To facilitate this shift, tests need to be developed to identify those individuals who requi...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature06915
更新日期:2008-04-03 00:00:00
abstract::What is it that defines an animal? The definition provided here, made on the basis of developmental biology, suggests methods for resolving phylogenetic problems. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/361490a0
更新日期:1993-02-11 00:00:00
abstract::G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with downstream signalling transducers, including the hetrotrimeric G proteins Gs (stimulatory) and Gi (inhibitory) and several arrestin proteins. The structural mechanisms ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0215-y
更新日期:2018-06-01 00:00:00
abstract::During the fission yeast cell cycle, the rate of polyadenylated messenger RNA synthesis doubles when the cell reaches a critical size. This size-related control maintains average mRNA content in balance with total cell mass during exponential growth, even in cells growing at different absolute growth rates per cell. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/271726a0
更新日期:1978-02-23 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07667-5
更新日期:2018-12-01 00:00:00
abstract::Recent studies have demonstrated that monkeys and humans can use signals from the brain to guide computer cursors. Brain-computer interfaces (BCIs) may one day assist patients suffering from neurological injury or disease, but relatively low system performance remains a major obstacle. In fact, the speed and accuracy ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04968
更新日期:2006-07-13 00:00:00
abstract::Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in the gastrointestinal tract1-4. The protective effects of IL-2 involve the generation, maintenance and function of regulatory T (Treg) cells4-8, and the use of low doses of IL-2 has emerged as a potential therapeutic strat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1082-x
更新日期:2019-04-01 00:00:00
abstract::The overexpression of defined transcription factors in somatic cells results in their reprogramming into induced pluripotent stem (iPS) cells. The extremely low efficiency and slow kinetics of in vitro reprogramming suggest that further rare events are required to generate iPS cells. The nature and identity of these e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08285
更新日期:2009-08-27 00:00:00
abstract::The stable isotope ratios of atmospheric CO(2) ((18)O/(16)O and (13)C/(12)C) have been monitored since 1977 to improve our understanding of the global carbon cycle, because biosphere-atmosphere exchange fluxes affect the different atomic masses in a measurable way. Interpreting the (18)O/(16)O variability has proved d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10421
更新日期:2011-09-28 00:00:00
abstract::The female germ line undergoes a unique sequence of differentiation processes that confers totipotency to the egg. The reconstitution of these events in vitro using pluripotent stem cells is a key achievement in reproductive biology and regenerative medicine. Here we report successful reconstitution in vitro of the en...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20104
更新日期:2016-11-10 00:00:00
abstract::Low-resolution intensity spectra of Earth's atmosphere obtained from space reveal strong signatures of life ('biosignatures'), such as molecular oxygen and methane with abundances far from chemical equilibrium, as well as the presence of a 'red edge' (a sharp increase of albedo for wavelengths longer than 700 nm) caus...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10778
更新日期:2012-02-29 00:00:00
abstract::Pollinators are declining worldwide and this has raised concerns for a parallel decline in the essential pollination service they provide to both crops and wild plants. Anthropogenic drivers linked to this decline include habitat changes, intensive agriculture, pesticides, invasive alien species, spread of pathogens a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23288
更新日期:2017-08-10 00:00:00
abstract::Calcium permeability of basophil and mast cell membranes is stimulated on allergen binding to its specific membrane-bound IgE. This entry of Ca2+ ions into the cell triggers the degranulation and secretion process. Disodium cromoglycate (cromolyn DSCG), the disodium salt of 1,3-bis(-2-carboxychromon-5-yloxy)-2-hydroxy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/286722a0
更新日期:1980-08-14 00:00:00
abstract::The annual cycle in the Earth's surface temperature is extremely large-comparable in magnitude to the glacial-interglacial cycles over most of the planet. Trends in the phase and the amplitude of the annual cycle have been observed, but the causes and significance of these changes remain poorly understood-in part beca...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07675
更新日期:2009-01-22 00:00:00
abstract::The colonization of a new habitat is a fundamental process in metapopulation biology, but it is difficult to study. The emigration of colonists from established populations might be induced by resource competition owing to high local population density. Migration distances are also important because they determine the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416424a
更新日期:2002-03-28 00:00:00
abstract::Jets of highly energized plasma with relativistic velocities are associated with black holes ranging in mass from a few times that of the Sun to the billion-solar-mass black holes at the centres of galaxies. A popular but unconfirmed hypothesis to explain how the plasma is energized is the 'internal shock model', in w...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14481
更新日期:2015-05-28 00:00:00
abstract::MANY ferromanganese minerals have been found in marine manganese deposits. There have been terminological and intrinsic problems in accurately defining the constituents of manganese nodules(1), but 10-A manganite and delta-MnO(2) which are often compared with todorokite and birnessite seem to be the only major constit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279411a0
更新日期:1979-05-31 00:00:00
abstract::Large seasonal and hemispheric asymmetries in the martian climate system are generally ascribed to variations in solar heating associated with orbital eccentricity. As the orbital elements slowly change (over a period of >104 years), characteristics of the climate such as dustiness and the vigour of atmospheric circul...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416298a
更新日期:2002-03-21 00:00:00