Nickel and copper accumplation as essential elements in 10-A manganite of deep-sea manganese nodules.

abstract：:Intraplate magmatic provinces found away from plate boundaries provide direct sampling of the composition and heterogeneity of the Earth's mantle. The chemical heterogeneities that have been observed in the mantle are usually attributed to recycling during subduction1-3, which allows for the addition of volatiles and ...

journal_title：Nature

authors： Mazza SE,Gazel E,Bizimis M,Moucha R,Béguelin P,Johnson EA,McAleer RJ,Sobolev AV

更新日期：2019-05-01 00:00:00

abstract：:The structure of poly(dA).poly(dT) currently arouses great interest, mainly because dAn.dTn stretches are associated with considerable DNA bending. Until recently the heteronomous DNA described by Arnott et al., with the poly(dA) and poly(dT) chains in A and B conformations respectively, was the only detailed model of...

journal_title：Nature

authors： Alexeev DG,Lipanov AA,Skuratovskii IYa

更新日期：1987-02-26 00:00:00

abstract：:B LYMPHOCYTES are key participants in the immune response because of their specificity, their ability to take up and present antigens to T cells, and their capacity to differentiate into antibody-secreting cells. To limit reactivity to self antigens, autospecific B cells can be functionally inactivated or deleted. Dev...

journal_title：Nature

authors： Russell DM,Dembić Z,Morahan G,Miller JF,Bürki K,Nemazee D

更新日期：1991-11-28 00:00:00

abstract：:Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to distinct cargoes. Here we use electron microscopy and single-molecule studies to show that adaptors can recruit a second dynein to dynactin...

journal_title：Nature

authors： Urnavicius L,Lau CK,Elshenawy MM,Morales-Rios E,Motz C,Yildiz A,Carter AP

更新日期：2018-02-07 00:00:00

abstract：:The elevation history of the Tibetan plateau provides direct insight into the tectonic processes associated with continent-continent collisions. Here we present oxygen-isotope-based estimates of the palaeo-altimetry of late Eocene and younger deposits of the Lunpola basin in the centre of the plateau, which indicate t...

journal_title：Nature

authors： Rowley DB,Currie BS

更新日期：2006-02-09 00:00:00

abstract：:Treatments that target immune checkpoints, such as the one mediated by programmed cell death protein 1 (PD-1) and its ligand PD-L1, have been approved for treating human cancers with durable clinical benefit. However, many patients with cancer fail to respond to compounds that target the PD-1 and PD-L1 interaction, an...

journal_title：Nature

authors： Zhang J,Bu X,Wang H,Zhu Y,Geng Y,Nihira NT,Tan Y,Ci Y,Wu F,Dai X,Guo J,Huang YH,Fan C,Ren S,Sun Y,Freeman GJ,Sicinski P,Wei W

更新日期：2018-01-04 00:00:00

abstract：:Ice flow along land-terminating margins of the Greenland Ice Sheet (GIS) varies considerably in response to fluctuating inputs of surface meltwater to the bed of the ice sheet. Such inputs lubricate the ice-bed interface, transiently speeding up the flow of ice. Greater melting results in faster ice motion during summ...

journal_title：Nature

authors： Tedstone AJ,Nienow PW,Gourmelen N,Dehecq A,Goldberg D,Hanna E

更新日期：2015-10-29 00:00:00

abstract：:The enzyme complex nitrogenase, which reduces N2 to NH+4, involves two redox proteins, both irreversibly damaged by O2 (ref. 1). Enzyme activity therefore requires anaerobic conditions, a source of reductant and a large amount of ATP (approximately 16 ATPs per N2). In both aerobic and facultative anaerobic N2-fixing b...

journal_title：Nature

authors： Hill S,Kennedy C,Kavanagh E,Goldberg RB,Hanau R

更新日期：1981-04-02 00:00:00

abstract：:Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers1-3, and disease-specific screening and preventative strategies have reduced cancer mortality in affected patients4,5. These classical tumour-suppressor genes have tumorigenic effects associated with somatic biallelic inactivation, although haploins...

journal_title：Nature

authors： Jonsson P,Bandlamudi C,Cheng ML,Srinivasan P,Chavan SS,Friedman ND,Rosen EY,Richards AL,Bouvier N,Selcuklu SD,Bielski CM,Abida W,Mandelker D,Birsoy O,Zhang L,Zehir A,Donoghue MTA,Baselga J,Offit K,Scher HI,O'Reill

更新日期：2019-07-01 00:00:00

abstract：:The glyceraldehyde 3-phosphate dehydogenase holoenzyme of Bacillus stearothermophilus possesses precise 222 symmetry: in this respect it differs from the reported structure of the lobster muscle enzyme. Pairs of active sites are linked through a flexible polypeptide loop which probably mediates the structural changes ...

journal_title：Nature

authors： Biesecker G,Harris JI,Thierry JC,Walker JE,Wonacott AJ

更新日期：1977-03-24 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) is a dipeptidyl carboxy-peptidase that generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating peptide bradykinin. The gene encoding ACE is composed of two homologous regions and codes for both a somatic and testis isoenzyme. Experiments with hypertens...

journal_title：Nature

authors： Krege JH,John SW,Langenbach LL,Hodgin JB,Hagaman JR,Bachman ES,Jennette JC,O'Brien DA,Smithies O

更新日期：1995-05-11 00:00:00

abstract：:Neurotransmitters modulate the activity of ion channels through a variety of second messengers, including cyclic AMP, cyclic GMP and the products of phosphatidylinositol breakdown. Little is known about how different transmitters acting through different second-messenger systems interact within a cell to regulate sing...

journal_title：Nature

authors： Belardetti F,Kandel ER,Siegelbaum SA

更新日期：1987-01-08 00:00:00

abstract：:Retrospective epidemiological data have indicated that cutaneous malignant melanoma may arise as a consequence of intense, intermittent exposure of the skin to ultraviolet radiation, particularly in children, rather than from the cumulative lifetime exposure that is associated with other forms of skin cancer. Here we ...

journal_title：Nature

authors： Noonan FP,Recio JA,Takayama H,Duray P,Anver MR,Rush WL,De Fabo EC,Merlino G

更新日期：2001-09-20 00:00:00

abstract：:A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant ch...

journal_title：Nature

authors： Ghosh P,Amaya M,Mellins E,Wiley DC

更新日期：1995-11-30 00:00:00

abstract：:Leprosy is a spectral disease in which immune responses to Mycobacterium leprae correlate with the clinical, bacteriological and histopathological manifestations of disease, so study of its pathology provides insights into immunoregulatory mechanisms in man. At the tuberculoid pole, patients have few lesions in the sk...

journal_title：Nature

authors： Modlin RL,Kato H,Mehra V,Nelson EE,Fan XD,Rea TH,Pattengale PK,Bloom BR

更新日期：1986-07-31 00:00:00

abstract：:The lysis of murine sarcoma virus-murine leukaemia virus (MSV-MuLV)-induced tumour cells by cytotoxic T lymphocytes (CTL) appears to require that an antigen specified by MSV-MuLV, or induced by the infection, be presented in association with class I major histocompatibility complex antigens. The viral proteins of the ...

journal_title：Nature

authors： Flyer DC,Burakoff SJ,Faller DV

更新日期：1983-10-27 00:00:00

abstract：:Thrombin is a coagulation protease that activates platelets, leukocytes, endothelial and mesenchymal cells at sites of vascular injury, acting partly through an unusual proteolytically activated G-protein-coupled receptor. Knockout of the gene encoding this receptor provided definitive evidence for a second thrombin r...

journal_title：Nature

authors： Ishihara H,Connolly AJ,Zeng D,Kahn ML,Zheng YW,Timmons C,Tram T,Coughlin SR

更新日期：1997-04-03 00:00:00

abstract：:Recent computational and psychological theories of human texture vision assert that texture discrimination is based on first-order differences in geometric and luminance attributes of texture elements, called 'textons'. Significant differences in the density, orientation, size, or contrast of line segments or other sm...

journal_title：Nature

authors： Voorhees H,Poggio T

更新日期：1988-05-26 00:00:00

abstract：:5-hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily. Neurotransmitter binding in these proteins triggers the opening (gating) of an ion channel by means of an as-yet-uncharacterized conformational change. Here we show that a specific proline (Pro 8*), located at the apex of th...

journal_title：Nature

authors： Lummis SC,Beene DL,Lee LW,Lester HA,Broadhurst RW,Dougherty DA

更新日期：2005-11-10 00:00:00

abstract：:The response of the terrestrial carbon cycle to climate change is among the largest uncertainties affecting future climate change projections. The feedback between the terrestrial carbon cycle and climate is partly determined by changes in the turnover time of carbon in land ecosystems, which in turn is an ecosystem p...

journal_title：Nature

authors： Carvalhais N,Forkel M,Khomik M,Bellarby J,Jung M,Migliavacca M,Mu M,Saatchi S,Santoro M,Thurner M,Weber U,Ahrens B,Beer C,Cescatti A,Randerson JT,Reichstein M

更新日期：2014-10-09 00:00:00

abstract：:To understand the complex physics of a system with strong electron-electron interactions, the ideal is to control and monitor its properties while tuning an external electric field applied to the system (the electric-field effect). Indeed, complete electric-field control of many-body states in strongly correlated elec...

journal_title：Nature

authors： Li LJ,O'Farrell EC,Loh KP,Eda G,Özyilmaz B,Castro Neto AH

更新日期：2016-01-14 00:00:00

abstract：:The folding of newly synthesized proteins to the native state is a major challenge within the crowded cellular environment, as non-productive interactions can lead to misfolding, aggregation and degradation1. Cells cope with this challenge by coupling synthesis with polypeptide folding and by using molecular chaperone...

journal_title：Nature

authors： Shiber A,Döring K,Friedrich U,Klann K,Merker D,Zedan M,Tippmann F,Kramer G,Bukau B

更新日期：2018-09-01 00:00:00

abstract：:Anomalies in temperature and precipitation in northern Russia over the past few years have been viewed as manifestations of anthropogenic climate change, prompting suggestions that this may also account for exceptional forest fires in the region. Here we examine the number of forest-fire events across the boreal Russi...

journal_title：Nature

authors： Mollicone D,Eva HD,Achard F

更新日期：2006-03-23 00:00:00

abstract：:MyoD1 and myogenin are muscle-specific proteins which can convert non-myogenic cells in culture to differentiated muscle fibres, implicating them in myogenic determination. The pattern of expression of MyoD1 and myogenin during the early stages of muscle formation in the mouse embryo in vivo and in limb-bud explants c...

journal_title：Nature

authors： Sassoon D,Lyons G,Wright WE,Lin V,Lassar A,Weintraub H,Buckingham M

更新日期：1989-09-28 00:00:00

abstract：:Zygotic genome activation (ZGA) is the first transcription event in life1. However, it is unclear how RNA polymerase is engaged in initiating ZGA in mammals. Here, by developing small-scale Tn5-assisted chromatin cleavage with sequencing (Stacc-seq), we investigated the landscapes of RNA polymerase II (Pol II) binding...

journal_title：Nature

authors： Liu B,Xu Q,Wang Q,Feng S,Lai F,Wang P,Zheng F,Xiang Y,Wu J,Nie J,Qiu C,Xia W,Li L,Yu G,Lin Z,Xu K,Xiong Z,Kong F,Liu L,Huang C,Yu Y,Na J,Xie W

更新日期：2020-11-01 00:00:00

abstract：:Although many animals use the Earth's magnetic field for orientation and navigation, the precise biophysical mechanisms underlying magnetic sensing have been elusive. One theoretical model proposes that geomagnetic fields are perceived by chemical reactions involving specialized photoreceptors. However, the specific p...

journal_title：Nature

authors： Gegear RJ,Casselman A,Waddell S,Reppert SM

更新日期：2008-08-21 00:00:00

abstract：:Aberrant activation of the canonical WNT/beta-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated beta-catenin activity drives colon tumorigenesis, further genetic perturbations are required to elaborate full malignant transformation. To...

journal_title：Nature

authors： Firestein R,Bass AJ,Kim SY,Dunn IF,Silver SJ,Guney I,Freed E,Ligon AH,Vena N,Ogino S,Chheda MG,Tamayo P,Finn S,Shrestha Y,Boehm JS,Jain S,Bojarski E,Mermel C,Barretina J,Chan JA,Baselga J,Tabernero J,Root DE,

更新日期：2008-09-25 00:00:00

abstract：:Ferroptosis-an iron-dependent, non-apoptotic cell death process-is involved in various degenerative diseases and represents a targetable susceptibility in certain cancers1. The ferroptosis-susceptible cell state can either pre-exist in cells that arise from certain lineages or be acquired during cell-state transitions...

journal_title：Nature

authors： Zou Y,Henry WS,Ricq EL,Graham ET,Phadnis VV,Maretich P,Paradkar S,Boehnke N,Deik AA,Reinhardt F,Eaton JK,Ferguson B,Wang W,Fairman J,Keys HR,Dančík V,Clish CB,Clemons PA,Hammond PT,Boyer LA,Weinberg RA,Schreiber

更新日期：2020-09-01 00:00:00

abstract：:Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal diffe...

journal_title：Nature

authors： Kretz M,Siprashvili Z,Chu C,Webster DE,Zehnder A,Qu K,Lee CS,Flockhart RJ,Groff AF,Chow J,Johnston D,Kim GE,Spitale RC,Flynn RA,Zheng GX,Aiyer S,Raj A,Rinn JL,Chang HY,Khavari PA

更新日期：2013-01-10 00:00:00

abstract：:For more than four decades, transistors have been shrinking exponentially in size, and therefore the number of transistors in a single microelectronic chip has been increasing exponentially. Such an increase in packing density was made possible by continually shrinking the metal-oxide-semiconductor field-effect transi...

journal_title：Nature

authors： Ferain I,Colinge CA,Colinge JP

更新日期：2011-11-16 00:00:00