The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.

Abstract:

:A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes. The structure shows that the CLIP fragment binds to DR3 in a way almost identical to that in which antigenic peptides bind class II histocompatibility glycoproteins. The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM.

journal_name

Nature

journal_title

Nature

authors

Ghosh P,Amaya M,Mellins E,Wiley DC

doi

10.1038/378457a0

subject

Has Abstract

pub_date

1995-11-30 00:00:00

pages

457-62

issue

6556

eissn

0028-0836

issn

1476-4687

journal_volume

378

pub_type

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