Abstract:
:A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes. The structure shows that the CLIP fragment binds to DR3 in a way almost identical to that in which antigenic peptides bind class II histocompatibility glycoproteins. The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM.
journal_name
Naturejournal_title
Natureauthors
Ghosh P,Amaya M,Mellins E,Wiley DCdoi
10.1038/378457a0subject
Has Abstractpub_date
1995-11-30 00:00:00pages
457-62issue
6556eissn
0028-0836issn
1476-4687journal_volume
378pub_type
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