Decadal slowdown of a land-terminating sector of the Greenland Ice Sheet despite warming.


:Ice flow along land-terminating margins of the Greenland Ice Sheet (GIS) varies considerably in response to fluctuating inputs of surface meltwater to the bed of the ice sheet. Such inputs lubricate the ice-bed interface, transiently speeding up the flow of ice. Greater melting results in faster ice motion during summer, but slower motion over the subsequent winter, owing to the evolution of an efficient drainage system that enables water to drain from regions of the ice-sheet bed that have a high basal water pressure. However, the impact of hydrodynamic coupling on ice motion over decadal timescales remains poorly constrained. Here we show that annual ice motion across an 8,000-km(2) land-terminating region of the west GIS margin, extending to 1,100 m above sea level, was 12% slower in 2007-14 compared with 1985-94, despite a 50% increase in surface meltwater production. Our findings suggest that, over these three decades, hydrodynamic coupling in this section of the ablation zone resulted in a net slowdown of ice motion (not a speed-up, as previously postulated). Increases in meltwater production from projected climate warming may therefore further reduce the motion of land-terminating margins of the GIS. Our findings suggest that these sectors of the ice sheet are more resilient to the dynamic impacts of enhanced meltwater production than previously thought.






Tedstone AJ,Nienow PW,Gourmelen N,Dehecq A,Goldberg D,Hanna E




Has Abstract


2015-10-29 00:00:00
















  • A self-renewing multipotential stem cell in embryonic rat cerebral cortex.

    abstract::Neuroectoderm cells in the cortical ventricular zone generate many diverse cell types, maintain the ventricular zone during embryonic life and create another germinal layer, the subventricular zone, which persists into adulthood. In other vertebrate tissues, including skin, intestine, blood and neural crest, stem cell...


    pub_type: 杂志文章


    authors: Davis AA,Temple S

    更新日期:1994-11-17 00:00:00

  • Multiple spike-initiation zones in single neurons revealed by voltage-sensitive dyes.

    abstract::The primary function of the nerve cell is to process electrical signals. Over the past fifteen years there has been renewed interest in the detailed spatial analysis of signalling in individual neurons owing to experimental evidence that the regional electrical properties of neurons are complex. Thus the behaviour of ...


    pub_type: 杂志文章


    authors: Zecević D

    更新日期:1996-05-23 00:00:00

  • Nanotechnology: 'buckypaper' from coaxial nanotubes.

    abstract::Double-walled carbon nanotubes are needed in a pure, highly crystalline form before features such as their electronic properties, thermal transport and mechanical behaviour can be investigated. Here we fabricate a paper-like material that consists of hexagonally packed bundles of clean, coaxial carbon nanotubes whose ...


    pub_type: 杂志文章


    authors: Endo M,Muramatsu H,Hayashi T,Kim YA,Terrones M,Dresselhaus MS

    更新日期:2005-02-03 00:00:00

  • Topoisomerases facilitate transcription of long genes linked to autism.

    abstract::Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expr...


    pub_type: 杂志文章


    authors: King IF,Yandava CN,Mabb AM,Hsiao JS,Huang HS,Pearson BL,Calabrese JM,Starmer J,Parker JS,Magnuson T,Chamberlain SJ,Philpot BD,Zylka MJ

    更新日期:2013-09-05 00:00:00

  • Fructose-1,6-bisphosphatase opposes renal carcinoma progression.

    abstract::Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is characterized by elevated glycogen levels and fat deposition. These consistent metabolic alterations are associated with normoxic stabilization of hypoxia-inducible factors (HIFs) secondary to von Hippel-Lindau (VHL) mutations that occu...


    pub_type: 杂志文章


    authors: Li B,Qiu B,Lee DS,Walton ZE,Ochocki JD,Mathew LK,Mancuso A,Gade TP,Keith B,Nissim I,Simon MC

    更新日期:2014-09-11 00:00:00

  • Messenger RNA from human brain induces drug- and voltage-operated channels in Xenopus oocytes.

    abstract::Sodium channels and receptors to serotonin and kainate were 'transplanted' from human brain into frog oocytes, by isolating messenger RNA from a fetal brain, and injecting it into Xenopus laevis oocytes. The mRNA was translated by the oocyte and induced the appearance of functional receptors and channels in its membra...


    pub_type: 杂志文章


    authors: Gundersen CB,Miledi R,Parker I

    更新日期:1984-03-29 00:00:00

  • Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2.

    abstract::Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in the gastrointestinal tract1-4. The protective effects of IL-2 involve the generation, maintenance and function of regulatory T (Treg) cells4-8, and the use of low doses of IL-2 has emerged as a potential therapeutic strat...


    pub_type: 杂志文章


    authors: Zhou L,Chu C,Teng F,Bessman NJ,Goc J,Santosa EK,Putzel GG,Kabata H,Kelsen JR,Baldassano RN,Shah MA,Sockolow RE,Vivier E,Eberl G,Smith KA,Sonnenberg GF

    更新日期:2019-04-01 00:00:00

  • A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.

    abstract::An essential feature of the bacterial pathogen Salmonella spp. is its ability to enter cells that are normally non-phagocytic, such as those of the intestinal epithelium. The bacterium achieves entry by delivering effector proteins into the host-cell cytosol by means of a specialized protein-secretion system (termed t...


    pub_type: 杂志文章


    authors: Fu Y,Galán JE

    更新日期:1999-09-16 00:00:00

  • Journal blacklists: show your working.

    abstract:: ...


    pub_type: 社论



    更新日期:2018-10-01 00:00:00

  • The effect of energy feedbacks on continental strength.

    abstract::The classical strength profile of continents is derived from a quasi-static view of their rheological response to stress--one that does not consider dynamic interactions between brittle and ductile layers. Such interactions result in complexities of failure in the brittle-ductile transition and the need to couple ener...


    pub_type: 杂志文章


    authors: Regenauer-Lieb K,Weinberg RF,Rosenbaum G

    更新日期:2006-07-06 00:00:00

  • MicroRNAs 103 and 107 regulate insulin sensitivity.

    abstract::Defects in insulin signalling are among the most common and earliest defects that predispose an individual to the development of type 2 diabetes. MicroRNAs have been identified as a new class of regulatory molecules that influence many biological functions, including metabolism. However, the direct regulation of insul...


    pub_type: 杂志文章


    authors: Trajkovski M,Hausser J,Soutschek J,Bhat B,Akin A,Zavolan M,Heim MH,Stoffel M

    更新日期:2011-06-08 00:00:00

  • Structure of the cro repressor from bacteriophage lambda and its interaction with DNA.

    abstract::The three-dimensional structure of the 66-amino acid cro repressor protein of bacteriophage lambda suggests how it binds to its operator DNA. We propose that a dimer of cro protein is bound to the B-form of DNA with the 2-fold axis of the dimer coincident with the 2-fold axis of DNA. A pair of 2-fold-related alpha-hel...


    pub_type: 杂志文章


    authors: Anderson WF,Ohlendorf DH,Takeda Y,Matthews BW

    更新日期:1981-04-30 00:00:00

  • Origins and functional evolution of Y chromosomes across mammals.

    abstract::Y chromosomes underlie sex determination in mammals, but their repeat-rich nature has hampered sequencing and associated evolutionary studies. Here we trace Y evolution across 15 representative mammals on the basis of high-throughput genome and transcriptome sequencing. We uncover three independent sex chromosome orig...


    pub_type: 杂志文章


    authors: Cortez D,Marin R,Toledo-Flores D,Froidevaux L,Liechti A,Waters PD,Grützner F,Kaessmann H

    更新日期:2014-04-24 00:00:00

  • The Wnt/beta-catenin pathway regulates cardiac valve formation.

    abstract::Truncation of the tumour suppressor adenomatous polyposis coli (Apc) constitutively activates the Wnt/beta-catenin signalling pathway. Apc has a role in development: for example, embryos of mice with truncated Apc do not complete gastrulation. To understand this role more fully, we examined the effect of truncated Apc...


    pub_type: 杂志文章


    authors: Hurlstone AF,Haramis AP,Wienholds E,Begthel H,Korving J,Van Eeden F,Cuppen E,Zivkovic D,Plasterk RH,Clevers H

    更新日期:2003-10-09 00:00:00

  • New cell lines from mouse epiblast share defining features with human embryonic stem cells.

    abstract::The application of human embryonic stem (ES) cells in medicine and biology has an inherent reliance on understanding the starting cell population. Human ES cells differ from mouse ES cells and the specific embryonic origin of both cell types is unclear. Previous work suggested that mouse ES cells could only be obtaine...


    pub_type: 杂志文章


    authors: Tesar PJ,Chenoweth JG,Brook FA,Davies TJ,Evans EP,Mack DL,Gardner RL,McKay RD

    更新日期:2007-07-12 00:00:00

  • Requirement for monocytes in the spontaneous cytotoxic effects of human lymphocytes against non-lymphoid target cells.

    abstract::Human lymphocytes have been shown to lyse in vitro a large variety of target cells derived from tumour as well as normal tissues. The effector cells involved in this spontaneous cell-mediated cytotoxicity (SCMC) have generally been characterised as lymphocytes which lack surface membrane immunoglobulin (sIg) and lack ...


    pub_type: 杂志文章


    authors: de Vries JE,Mendelsohn J,Bont WS

    更新日期:1980-02-07 00:00:00

  • Antibody-dependent cell-mediated antibacterial activity of intestinal lymphocytes with secretory IgA.

    abstract::Secretory antibodies of the IgA class (sIgA) are thought to have an important role in the defence against bacteria at mucosal surfaces--the level at which the infectious agents first come into contact with the host. However, the mechanism by which sIgA exert their antibacterial activity is still a matter of debate. Af...


    pub_type: 杂志文章


    authors: Tagliabue A,Nencioni L,Villa L,Keren DF,Lowell GH,Boraschi D

    更新日期:1983-11-10 00:00:00

  • A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells.

    abstract::The c-myc gene product is a nuclear protein expressed in a wide variety of cell types. It has been implicated in the control of normal cell growth as well as transformation, but its exact function is unknown. When the human promyelocytic leukaemia cell line HL60 is treated with retinoic acid, the cells differentiate i...


    pub_type: 杂志文章


    authors: Bentley DL,Groudine M

    更新日期:1986-06-12 00:00:00

  • Decreased rate of DNA-chain growth in human basal cell carcinoma.

    abstract::The DNA synthetic (S) phase of cell division is about twice as long in human basal cell carcinoma (BCC) as the normal epidermis and several non-malignant skin diseases. A similar increase in S phase duration seems to occur in tumours of the human oesophagus, larynx and recto-colon. At the molecular level, the overall ...


    pub_type: 杂志文章


    authors: Heenen M,Galand P

    更新日期:1980-05-22 00:00:00

  • Enhancing the potential of enantioselective organocatalysis with light.

    abstract::Organocatalysis-catalysis mediated by small chiral organic molecules-is a powerful technology for enantioselective synthesis, and has extensive applications in traditional ionic, two-electron-pair reactivity domains. Recently, organocatalysis has been successfully combined with photochemical reactivity to unlock previ...


    pub_type: 杂志文章,评审


    authors: Silvi M,Melchiorre P

    更新日期:2018-01-31 00:00:00

  • How broken sleep promotes cardiovascular disease.

    abstract:: ...


    pub_type: 评论,新闻


    authors: Tall AR,Jelic S

    更新日期:2019-02-01 00:00:00

  • Change in pattern of ongoing cortical activity with auditory category learning.

    abstract::Humans are able to classify novel items correctly by category; some other animals have also been shown to do this. During category learning, humans group perceptual stimuli by abstracting qualities from similarity relationships of their physical properties. Forming categories is fundamental to cognition and can be ind...


    pub_type: 杂志文章


    authors: Ohl FW,Scheich H,Freeman WJ

    更新日期:2001-08-16 00:00:00

  • A network that learns to recognize three-dimensional objects.

    abstract::The visual recognition of three-dimensional (3-D) objects on the basis of their shape poses at least two difficult problems. First, there is the problem of variable illumination, which can be addressed by working with relatively stable features such as intensity edges rather than the raw intensity images. Second, ther...


    pub_type: 杂志文章


    authors: Poggio T,Edelman S

    更新日期:1990-01-18 00:00:00

  • From the archive.

    abstract:: ...


    pub_type: 新闻



    更新日期:2019-01-01 00:00:00

  • IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.

    abstract::Pro-inflammatory cytokines activate the transcription factor NF-kappaB by stimulating the activity of a protein kinase that phosphorylates IkappaB, an inhibitor of NF-kappaB, at sites that trigger its ubiquitination and degradation. This results in the nuclear translocation of freed NF-kappaB dimers and the activation...


    pub_type: 杂志文章


    authors: Rothwarf DM,Zandi E,Natoli G,Karin M

    更新日期:1998-09-17 00:00:00

  • Peripheral modulation of mechano-sensitivity in primary afferent neurons.

    abstract::Considerable attention has centered recently on the changes in neuron excitability and synaptic efficacy caused by certain biogenic amines and neuropeptides. These neuromodulators act at a wide variety of both central and peripheral targets, and bring about diverse biological results. In sensory pathways, modulation o...


    pub_type: 杂志文章


    authors: Pasztor VM,Bush BM

    更新日期:1987-04-23 00:00:00

  • Structural details of an adenine tract that does not cause DNA to bend.

    abstract::Runs of adenines (adenine tracts) have been implicated as the main determinant of sequence-directed DNA bending. The most widely used experimental test for bending relies on the observation that bent DNA migrates more slowly than straight DNA on a polyacrylamide electrophoresis gel. It was shown recently that the poly...


    pub_type: 杂志文章


    authors: Burkhoff AM,Tullius TD

    更新日期:1988-02-04 00:00:00

  • A second source of repeating fast radio bursts.

    abstract::The discovery of a repeating fast radio burst (FRB) source1,2, FRB 121102, eliminated models involving cataclysmic events for this source. No other repeating FRB has hitherto been detected despite many recent discoveries and follow-ups3-5, suggesting that repeaters may be rare in the FRB population. Here we report the...


    pub_type: 杂志文章


    authors: CHIME\/FRB Collaboration.

    更新日期:2019-02-01 00:00:00

  • Major histocompatibility complex class I molecules internalized via coated pits in T lymphocytes.

    abstract::Endocytosis of the major histocompatibility complex (MHC)-encoded class I and class II molecules has been the subject of recent investigations. Class I molecules, which are key elements in T cell-mediated cytotoxicity, are differentially endocytosed by different cell types. Fibroblasts internalize their class I molecu...


    pub_type: 杂志文章


    authors: Machy P,Truneh A,Gennaro D,Hoffstein S

    更新日期:1987-08-20 00:00:00

  • Directional guidance of neuronal migration in the olfactory system by the protein Slit.

    abstract::Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a di...


    pub_type: 杂志文章


    authors: Wu W,Wong K,Chen J,Jiang Z,Dupuis S,Wu JY,Rao Y

    更新日期:1999-07-22 00:00:00