Decadal slowdown of a land-terminating sector of the Greenland Ice Sheet despite warming.


:Ice flow along land-terminating margins of the Greenland Ice Sheet (GIS) varies considerably in response to fluctuating inputs of surface meltwater to the bed of the ice sheet. Such inputs lubricate the ice-bed interface, transiently speeding up the flow of ice. Greater melting results in faster ice motion during summer, but slower motion over the subsequent winter, owing to the evolution of an efficient drainage system that enables water to drain from regions of the ice-sheet bed that have a high basal water pressure. However, the impact of hydrodynamic coupling on ice motion over decadal timescales remains poorly constrained. Here we show that annual ice motion across an 8,000-km(2) land-terminating region of the west GIS margin, extending to 1,100 m above sea level, was 12% slower in 2007-14 compared with 1985-94, despite a 50% increase in surface meltwater production. Our findings suggest that, over these three decades, hydrodynamic coupling in this section of the ablation zone resulted in a net slowdown of ice motion (not a speed-up, as previously postulated). Increases in meltwater production from projected climate warming may therefore further reduce the motion of land-terminating margins of the GIS. Our findings suggest that these sectors of the ice sheet are more resilient to the dynamic impacts of enhanced meltwater production than previously thought.






Tedstone AJ,Nienow PW,Gourmelen N,Dehecq A,Goldberg D,Hanna E




Has Abstract


2015-10-29 00:00:00
















  • Schwann cells induce morphological transformation of sensory neurones in vitro.

    abstract::Cell-cell interactions are thought to play a crucial part in determining the developmental fate of vertebrate cells and regulating their subsequent differentiation. In the peripheral nervous system, for example, signals from neuronal axons determine whether or not some Schwann cells wrap their plasma membrane concentr...


    pub_type: 杂志文章


    authors: Mudge AW

    更新日期:1984-05-24 00:00:00

  • Potent antitumour activity of a new class of tumour-specific killer cells.

    abstract::Two approaches to the antibody-directed targeting of toxic or cytolytic activity and augmentation of cellular immune responses have been explored for tumour immunotherapy, but so far success has been limited. Obstacles facing immunotherapy are the limited accessibility of antibodies or antibody conjugates to solid tum...


    pub_type: 杂志文章


    authors: Chen SY,Yang AG,Chen JD,Kute T,King CR,Collier J,Cong Y,Yao C,Huang XF

    更新日期:1997-01-02 00:00:00

  • Genome sequencing and analysis of Aspergillus oryzae.

    abstract::The genome of Aspergillus oryzae, a fungus important for the production of traditional fermented foods and beverages in Japan, has been sequenced. The ability to secrete large amounts of proteins and the development of a transformation system have facilitated the use of A. oryzae in modern biotechnology. Although both...


    pub_type: 杂志文章


    authors: Machida M,Asai K,Sano M,Tanaka T,Kumagai T,Terai G,Kusumoto K,Arima T,Akita O,Kashiwagi Y,Abe K,Gomi K,Horiuchi H,Kitamoto K,Kobayashi T,Takeuchi M,Denning DW,Galagan JE,Nierman WC,Yu J,Archer DB,Bennett JW,Bh

    更新日期:2005-12-22 00:00:00

  • Fetal bovine serum alternatives.

    abstract::With the current shortage in fetal bovine serum, researchers are turning to a variety of options for cell and tissue culture. ...


    pub_type: 杂志文章


    authors: Jayme DW,Epstein DA,Conrad DR

    更新日期:1988-08-11 00:00:00

  • P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1.

    abstract::The factors determining disease severity in malaria are complex and include host polymorphisms, acquired immunity and parasite virulence. Studies in Africa have shown that severe malaria is associated with the ability of erythrocytes infected with the parasite Plasmodium falciparum to bind uninfected erythrocytes and ...


    pub_type: 杂志文章


    authors: Rowe JA,Moulds JM,Newbold CI,Miller LH

    更新日期:1997-07-17 00:00:00

  • Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site.

    abstract::Neurotransmitter/sodium symporters (NSSs) couple the uptake of neurotransmitter with one or more sodium ions, removing neurotransmitter from the synaptic cleft. NSSs are essential to the function of chemical synapses, are associated with multiple neurological diseases and disorders, and are the targets of therapeutic ...


    pub_type: 杂志文章


    authors: Piscitelli CL,Krishnamurthy H,Gouaux E

    更新日期:2010-12-23 00:00:00

  • Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture.

    abstract::The inner ear contains sensory epithelia that detect head movements, gravity and sound. It is unclear how to develop these sensory epithelia from pluripotent stem cells, a process that will be critical for modelling inner ear disorders or developing cell-based therapies for profound hearing loss and balance disorders....


    pub_type: 杂志文章


    authors: Koehler KR,Mikosz AM,Molosh AI,Patel D,Hashino E

    更新日期:2013-08-08 00:00:00

  • Adherens junction protein nectin-4 is the epithelial receptor for measles virus.

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    pub_type: 杂志文章


    authors: Mühlebach MD,Mateo M,Sinn PL,Prüfer S,Uhlig KM,Leonard VH,Navaratnarajah CK,Frenzke M,Wong XX,Sawatsky B,Ramachandran S,McCray PB Jr,Cichutek K,von Messling V,Lopez M,Cattaneo R

    更新日期:2011-11-02 00:00:00

  • Citrullination regulates pluripotency and histone H1 binding to chromatin.

    abstract::Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline. This modification leads to the loss of a positive charge and reduction in hydrogen-bonding ability. It is carried out by a small family of tissue-specific vertebrate enzymes called peptid...


    pub_type: 杂志文章


    authors: Christophorou MA,Castelo-Branco G,Halley-Stott RP,Oliveira CS,Loos R,Radzisheuskaya A,Mowen KA,Bertone P,Silva JC,Zernicka-Goetz M,Nielsen ML,Gurdon JB,Kouzarides T

    更新日期:2014-03-06 00:00:00

  • Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.

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    pub_type: 杂志文章


    authors: Kim S,Kim H,Yim YS,Ha S,Atarashi K,Tan TG,Longman RS,Honda K,Littman DR,Choi GB,Huh JR

    更新日期:2017-09-28 00:00:00

  • Peptide growth factors are multifunctional.

    abstract::The actions of many peptide growth factors include both stimulation and inhibition of cell proliferation, as well as effects unrelated to the control of cell growth. One peptide can have both stimulatory and inhibitory activity in a single cell, depending on the context of the other signal molecules present. ...


    pub_type: 杂志文章,评审


    authors: Sporn MB,Roberts AB

    更新日期:1988-03-17 00:00:00

  • Selective neuroanatomical plasticity and division of labour in the honeybee.

    abstract::The mushroom bodies in the protocerebrum are believed to be the structures of the insect brain most closely associated with higher-order sensory integration and learning. Drosophila melanogaster mutants with olfactory learning deficits have anatomically abnormal mushroom bodies or altered patterns of gene expression i...


    pub_type: 杂志文章


    authors: Withers GS,Fahrbach SE,Robinson GE

    更新日期:1993-07-15 00:00:00

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    pub_type: 杂志文章


    authors: International HapMap Consortium.

    更新日期:2005-10-27 00:00:00

  • Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.

    abstract::The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneous...


    pub_type: 杂志文章


    authors: Hilbert P,Lindpaintner K,Beckmann JS,Serikawa T,Soubrier F,Dubay C,Cartwright P,De Gouyon B,Julier C,Takahasi S

    更新日期:1991-10-10 00:00:00

  • Author Correction: Neutrophils support lung colonization of metastasis-initiating breast cancer cells.

    abstract::Change history: In this Letter, the final two pages of the Supplementary Information, which included two tables listing primer and antibodies, respectively, were missing; see accompanying Amendment for the missing Supplementary Tables. This Letter has not been corrected online. ...


    pub_type: 已发布勘误


    authors: Wculek SK,Malanchi I

    更新日期:2019-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Kalil RE,Dubin MW,Scott G,Stark LA

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    pub_type: 杂志文章,评审


    authors: Bell J

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    pub_type: 杂志文章


    authors: Lenski RE,Ofria C,Collier TC,Adami C

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    pub_type: 杂志文章


    authors: Chen J,Chen ZJ

    更新日期:2018-12-01 00:00:00

  • A high-performance brain-computer interface.

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    pub_type: 杂志文章


    authors: Santhanam G,Ryu SI,Yu BM,Afshar A,Shenoy KV

    更新日期:2006-07-13 00:00:00

  • Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons.

    abstract::Cation-selective P2X receptor channels were first described in sensory neurons where they are important for primary afferent neurotransmission and nociception. Here we report the cloning of a complementary DNA (P2X3) from rat dorsal root ganglia that had properties dissimilar to those of sensory neurons. We also found...


    pub_type: 杂志文章


    authors: Lewis C,Neidhart S,Holy C,North RA,Buell G,Surprenant A

    更新日期:1995-10-05 00:00:00

  • Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

    abstract::Activated oncogenes and anticancer chemotherapy induce cellular senescence, a terminal growth arrest of viable cells characterized by S-phase entry-blocking histone 3 lysine 9 trimethylation (H3K9me3). Although therapy-induced senescence (TIS) improves long-term outcomes, potentially harmful properties of senescent tu...


    pub_type: 杂志文章


    authors: Dörr JR,Yu Y,Milanovic M,Beuster G,Zasada C,Däbritz JH,Lisec J,Lenze D,Gerhardt A,Schleicher K,Kratzat S,Purfürst B,Walenta S,Mueller-Klieser W,Gräler M,Hummel M,Keller U,Buck AK,Dörken B,Willmitzer L,Reimann M,

    更新日期:2013-09-19 00:00:00

  • Brain and other nervous system disorders across the lifespan - global challenges and opportunities.

    abstract::This is an exciting time for scientific discovery that aims to reduce the frequency and impact of neurological, mental health and substance-use disorders. As it became increasingly clear that low- and middle-income countries have a disproportionate share of these disorders, and that many of the problems are best addre...


    pub_type: 杂志文章


    authors: Silberberg D,Anand NP,Michels K,Kalaria RN

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  • Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function.

    abstract::'Pioneer' transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prominent pioneer factor that is essential for pluripotency and self-re...


    pub_type: 杂志文章


    authors: Dodonova SO,Zhu F,Dienemann C,Taipale J,Cramer P

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    pub_type: 杂志文章


    authors: Darrah PA,Zeppa JJ,Maiello P,Hackney JA,Wadsworth MH 2nd,Hughes TK,Pokkali S,Swanson PA 2nd,Grant NL,Rodgers MA,Kamath M,Causgrove CM,Laddy DJ,Bonavia A,Casimiro D,Lin PL,Klein E,White AG,Scanga CA,Shalek AK,Roede

    更新日期:2020-01-01 00:00:00

  • Sharply increased mass loss from glaciers and ice caps in the Canadian Arctic Archipelago.

    abstract::Mountain glaciers and ice caps are contributing significantly to present rates of sea level rise and will continue to do so over the next century and beyond. The Canadian Arctic Archipelago, located off the northwestern shore of Greenland, contains one-third of the global volume of land ice outside the ice sheets, but...


    pub_type: 杂志文章


    authors: Gardner AS,Moholdt G,Wouters B,Wolken GJ,Burgess DO,Sharp MJ,Cogley JG,Braun C,Labine C

    更新日期:2011-05-19 00:00:00

  • Sparse whole-genome sequencing identifies two loci for major depressive disorder.

    abstract::Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified, despite analysis of more than 9,000 cases. Here, using low-coverag...


    pub_type: 杂志文章


    authors: CONVERGE consortium.

    更新日期:2015-07-30 00:00:00

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    abstract::How left/right functional asymmetry is layered on top of an anatomically symmetrical nervous system is poorly understood. In the nematode Caenorhabditis elegans, two morphologically bilateral taste receptor neurons, ASE left (ASEL) and ASE right (ASER), display a left/right asymmetrical expression pattern of putative ...


    pub_type: 杂志文章


    authors: Johnston RJ,Hobert O

    更新日期:2003-12-18 00:00:00

  • The Polycomb group protein EZH2 directly controls DNA methylation.

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    pub_type: 杂志文章


    authors: Viré E,Brenner C,Deplus R,Blanchon L,Fraga M,Didelot C,Morey L,Van Eynde A,Bernard D,Vanderwinden JM,Bollen M,Esteller M,Di Croce L,de Launoit Y,Fuks F

    更新日期:2006-02-16 00:00:00

  • Abrasion-set limits on Himalayan gravel flux.

    abstract::Rivers sourced in the Himalayan mountain range carry some of the largest sediment loads on the planet, yet coarse gravel in these rivers vanishes within approximately 10-40 kilometres on entering the Ganga Plain (the part of the North Indian River Plain containing the Ganges River). Understanding the fate of gravel is...


    pub_type: 杂志文章


    authors: Dingle EH,Attal M,Sinclair HD

    更新日期:2017-04-26 00:00:00