The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling.

abstract：:Targeting of proteins to appropriate subcellular compartments is a crucial process in all living cells. Secretory and membrane proteins usually contain an amino-terminal signal peptide, which is recognized by the signal recognition particle (SRP) when nascent polypeptide chains emerge from the ribosome. The SRP-riboso...

journal_title：Nature

authors： Janda CY,Li J,Oubridge C,Hernández H,Robinson CV,Nagai K

更新日期：2010-05-27 00:00:00

abstract：:HIV-1 protease processes the Gag and Gag-Pol polyproteins into mature structural and functional proteins, including itself, and is therefore indispensable for viral maturation. The mature protease is active only as a dimer with each subunit contributing catalytic residues. The full-length transframe region protease pr...

journal_title：Nature

authors： Tang C,Louis JM,Aniana A,Suh JY,Clore GM

更新日期：2008-10-02 00:00:00

abstract：:Classical crystallography can determine structures as complicated as multi-component ribosomal assemblies with atomic resolution, but is inadequate for disordered systems--even those as simple as water ice--that occupy the complex middle ground between liquid-like randomness and crystalline periodic order. Correlated ...

journal_title：Nature

authors： Keen DA,Goodwin AL

更新日期：2015-05-21 00:00:00

abstract：:Exploring visual illusions reveals fundamental principles of cortical processing. Illusory motion perception of non-moving stimuli was described almost a century ago by Gestalt psychologists. However, the underlying neuronal mechanisms remain unknown. To explore cortical mechanisms underlying the 'line-motion' illusio...

journal_title：Nature

authors： Jancke D,Chavane F,Naaman S,Grinvald A

更新日期：2004-03-25 00:00:00

abstract：:Nuclear import of the NF-AT transcription factors during T-cell activation requires the calcium-activated phosphatase calcineurin, which unmasks nuclear-location signals on NF-AT. We show here that the nuclear import of NF-ATs is not sufficient to activate NF-AT target genes, as NF-ATs are subject to a futile cycling ...

journal_title：Nature

authors： Zhu J,McKeon F

更新日期：1999-03-18 00:00:00

abstract：:Classical endocrine studies have shown that steroid hormones are required for the maintenance of pregnancy and placental viability. The oestrogen-receptor-related receptor beta (ERR-beta) is an orphan member of the superfamily of nuclear hormone receptors. Although ERR-beta is homologous to the oestrogen receptor and ...

journal_title：Nature

authors： Luo J,Sladek R,Bader JA,Matthyssen A,Rossant J,Giguère V

更新日期：1997-08-21 00:00:00

abstract：:Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variati...

journal_title：Nature

authors： Lango Allen H,Estrada K,Lettre G,Berndt SI,Weedon MN,Rivadeneira F,Willer CJ,Jackson AU,Vedantam S,Raychaudhuri S,Ferreira T,Wood AR,Weyant RJ,Segrè AV,Speliotes EK,Wheeler E,Soranzo N,Park JH,Yang J,Gudbjartsson D

更新日期：2010-10-14 00:00:00

abstract：:Transport of calcium ions across membranes and against a thermodynamic gradient is essential to many biological processes, including muscle contraction, the citric acid cycle, glycogen metabolism, release of neurotransmitters, vision, biological signal transduction and immune response. Synthetic systems that transport...

journal_title：Nature

authors： Bennett IM,Farfano HM,Bogani F,Primak A,Liddell PA,Otero L,Sereno L,Silber JJ,Moore AL,Moore TA,Gust D

更新日期：2002-11-28 00:00:00

abstract：:Mammal-like reptiles of the order Therapsida document the emergence of mammals from more primitive synapsids and are of unique zoological and palaeontological interest on that account. Therapsids, first appearing in the Early Permian, were thought to become extinct in the Middle Jurassic, soon after the Late Triassic ...

journal_title：Nature

authors： Fox RC,Youzwyshyn GP,Krause DW

更新日期：1992-07-16 00:00:00

abstract：:Analytical tools that have spatial resolution at the nanometre scale are indispensable for the life and physical sciences. It is desirable that these tools also permit elemental and chemical identification on a scale of 10 nm or less, with large penetration depths. A variety of techniques in X-ray imaging are currentl...

journal_title：Nature

authors： Chao W,Harteneck BD,Liddle JA,Anderson EH,Attwood DT

更新日期：2005-06-30 00:00:00

abstract：:Group I and II introns are mobile elements that propagate by insertion into different genes. Some introns of both types self-splice in vitro by transesterification reactions catalysed by the intron RNA. These transesterifications are reversible, and it has been suggested that reverse splicing followed by reverse trans...

journal_title：Nature

authors： Mohr G,Lambowitz AM

更新日期：1991-11-14 00:00:00

abstract：:Deaf children whose access to usable conventional linguistic input, signed or spoken, is severely limited nevertheless use gesture to communicate. These gestures resemble natural language in that they are structured at the level both of sentence and of word. Although the inclination to use gesture may be traceable to ...

journal_title：Nature

authors： Goldin-Meadow S,Mylander C

更新日期：1998-01-15 00:00:00

abstract：:A cholecystokinin (CCK)-inactivating peptidase was purified and identified as a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4.14.10), a cytosolic subtilisin-like peptidase of previously unknown functions. The peptidase was found in neurons responding to cholecystokinin, as well as in non-neuronal cells. B...

journal_title：Nature

authors： Rose C,Vargas F,Facchinetti P,Bourgeat P,Bambal RB,Bishop PB,Chan SM,Moore AN,Ganellin CR,Schwartz JC

更新日期：1996-04-04 00:00:00

abstract：:In the originally published version of this Article, the sequenced axolotl strain (the homozygous white mutant) was denoted as 'D/D' rather than 'd/d' in Fig. 1a and the accompanying legend, the main text and the Methods section. The original Article has been corrected online. ...

journal_title：Nature

authors： Nowoshilow S,Schloissnig S,Fei JF,Dahl A,Pang AWC,Pippel M,Winkler S,Hastie AR,Young G,Roscito JG,Falcon F,Knapp D,Powell S,Cruz A,Cao H,Habermann B,Hiller M,Tanaka EM,Myers EW

更新日期：2018-07-01 00:00:00

abstract：:The overexpression of defined transcription factors in somatic cells results in their reprogramming into induced pluripotent stem (iPS) cells. The extremely low efficiency and slow kinetics of in vitro reprogramming suggest that further rare events are required to generate iPS cells. The nature and identity of these e...

journal_title：Nature

authors： Utikal J,Polo JM,Stadtfeld M,Maherali N,Kulalert W,Walsh RM,Khalil A,Rheinwald JG,Hochedlinger K

更新日期：2009-08-27 00:00:00

abstract：:The three-dimensional structure of the 66-amino acid cro repressor protein of bacteriophage lambda suggests how it binds to its operator DNA. We propose that a dimer of cro protein is bound to the B-form of DNA with the 2-fold axis of the dimer coincident with the 2-fold axis of DNA. A pair of 2-fold-related alpha-hel...

journal_title：Nature

authors： Anderson WF,Ohlendorf DH,Takeda Y,Matthews BW

更新日期：1981-04-30 00:00:00

abstract：:The collagens represent an interesting example of a structurally related but genetically distinct family of proteins. Type I, the most abundant of the vertebrate collagens, comprises two pro alpha 1(I) chains and one pro alpha 2(I) chain, each containing terminal propeptides and a central domain of 338 (Gly, X, Y) rep...

journal_title：Nature

authors： Chu ML,de Wet W,Bernard M,Ding JF,Morabito M,Myers J,Williams C,Ramirez F

更新日期：1984-07-26 00:00:00

abstract：:Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory...

journal_title：Nature

authors： Dou Z,Ghosh K,Vizioli MG,Zhu J,Sen P,Wangensteen KJ,Simithy J,Lan Y,Lin Y,Zhou Z,Capell BC,Xu C,Xu M,Kieckhaefer JE,Jiang T,Shoshkes-Carmel M,Tanim KMAA,Barber GN,Seykora JT,Millar SE,Kaestner KH,Garcia BA,Ada

更新日期：2017-10-19 00:00:00

abstract：:The mechanism of transformation of the overtly similar cells of the neural plate into the numerous and diverse cell types of the mature vertebrate central nervous system (CNS) can better be understood by studying the clonal development of isolated CNS precursor cells. Here I describe a culture system in which blast ce...

journal_title：Nature

authors： Temple S

更新日期：1989-08-10 00:00:00

abstract：:Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell...

journal_title：Nature

authors： Rajewsky N,Almouzni G,Gorski SA,Aerts S,Amit I,Bertero MG,Bock C,Bredenoord AL,Cavalli G,Chiocca S,Clevers H,De Strooper B,Eggert A,Ellenberg J,Fernández XM,Figlerowicz M,Gasser SM,Hubner N,Kjems J,Knoblich JA,Kra

更新日期：2020-11-01 00:00:00

abstract：:Diffuse gliomas are the most common malignant brain tumours in adults and include glioblastomas and World Health Organization (WHO) grade II and grade III tumours (sometimes referred to as lower-grade gliomas). Genetic tumour profiling is used to classify disease and guide therapy1,2, but involves brain surgery for ti...

journal_title：Nature

authors： Miller AM,Shah RH,Pentsova EI,Pourmaleki M,Briggs S,Distefano N,Zheng Y,Skakodub A,Mehta SA,Campos C,Hsieh WY,Selcuklu SD,Ling L,Meng F,Jing X,Samoila A,Bale TA,Tsui DWY,Grommes C,Viale A,Souweidane MM,Tabar V,

更新日期：2019-01-01 00:00:00

abstract：:The Milankovitch theory states that global climate variability on orbital timescales from tens to hundreds of thousands of years is dominated by the summer insolation at high northern latitudes. The supporting evidence includes reconstructed air temperatures in Antarctica that are nearly in phase with boreal summer in...

journal_title：Nature

authors： Laepple T,Werner M,Lohmann G

更新日期：2011-03-03 00:00:00

abstract：:Information from the human genome sequence will eventually alter many aspects of clinical practice. It will increase through our understanding of disease mechanisms, and guide the development of new drugs and therapeutic procedures. In the short term, however, knowledge of the genome will have a profound clinical impa...

journal_title：Nature

authors： Bell J

更新日期：2004-05-27 00:00:00

abstract：:Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insight into the dynamics of human immunodeficiency virus type 1 (HIV-1). The concentration of HIV-1 in plasma drops by approximately 99% in the first two weeks of treatment owing to the rapid eli...

journal_title：Nature

authors： Perelson AS,Essunger P,Cao Y,Vesanen M,Hurley A,Saksela K,Markowitz M,Ho DD

更新日期：1997-05-08 00:00:00

abstract：:Taubenberger et al. claim that the 1918 influenza virus was derived from an avian source and adapted to humans shortly before the pandemic. However, we do not believe that this conclusion, which has been widely disseminated in the popular press and in scientific journals, is supported by their phylogenetic evidence. ...

journal_title：Nature

authors： Antonovics J,Hood ME,Baker CH

更新日期：2006-04-27 00:00:00

abstract：:The mariner transposable element is a small member of the short inverted terminal repeat class thought to transpose through a DNA intermediate. Originally described in Drosophila mauritiana, it is now known in several species of the family Drosophilidae, and in a moth Hyalophora cecropia. Here I use primers designed t...

journal_title：Nature

authors： Robertson HM

更新日期：1993-03-18 00:00:00

abstract：:Saturn's moon Titan has a nitrogen atmosphere comparable to Earth's, with a surface pressure of 1.4 bar. Numerical models reproduce the tropospheric conditions very well but have trouble explaining the observed middle-atmosphere temperatures, composition and winds. The top of the middle-atmosphere circulation has been...

journal_title：Nature

authors： Teanby NA,Irwin PG,Nixon CA,de Kok R,Vinatier S,Coustenis A,Sefton-Nash E,Calcutt SB,Flasar FM

更新日期：2012-11-29 00:00:00

abstract：:The thymus is the major, if not the sole site of maturation of T lymphocytes from their haematopoietic precursors. During embryonic life (at a few well-defined intervals, at least in birds) the thymus receives thymus-homing haematopoietic precursors that give rise to antigen-specific functional T lymphocytes. Although...

journal_title：Nature

authors： Ezine S,Weissman IL,Rouse RV

更新日期：1984-06-14 00:00:00

abstract：:Binocular coordination of eye movements is essential for stereopsis (depth perception) and to prevent double vision. More than a century ago, Hering and Helmholtz debated the neural basis of binocular coordination. Helmholtz believed that each eye is controlled independently and that binocular coordination is learned....

journal_title：Nature

authors： Zhou W,King WM

更新日期：1998-06-18 00:00:00

abstract：:Expression of Ets2, a proto-oncogene and transcription factor, occurs in a variety of cell types. During murine development it is highly expressed in newly forming cartilage, including in the skull precursor cells and vertebral primordia. Ets2 is located on human chromosome 21 (ref. 8) and is overexpressed in Down's s...

journal_title：Nature

authors： Sumarsono SH,Wilson TJ,Tymms MJ,Venter DJ,Corrick CM,Kola R,Lahoud MH,Papas TS,Seth A,Kola I

更新日期：1996-02-08 00:00:00