A risk worth taking.

abstract：:Several functionally important genetic elements (such as the TATA box, mRNA splice sequences, poly(A) addition signal) were first detected as short segments of unexplained sequence homology within non-coding regions of different genes. A short region of unknown sequence in the intron between the human J kappa and C ka...

journal_title：Nature

authors： Emorine L,Kuehl M,Weir L,Leder P,Max EE

更新日期：1983-08-04 00:00:00

abstract：:Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellula...

journal_title：Nature

authors： Dustin ML,Springer TA

更新日期：1989-10-19 00:00:00

abstract：:The battle for survival between bacteria and the viruses that infect them (phages) has led to the evolution of many bacterial defence systems and phage-encoded antagonists of these systems. Clustered regularly interspaced short palindromic repeats (CRISPR) and the CRISPR-associated (cas) genes comprise an adaptive imm...

journal_title：Nature

authors： Bondy-Denomy J,Garcia B,Strum S,Du M,Rollins MF,Hidalgo-Reyes Y,Wiedenheft B,Maxwell KL,Davidson AR

更新日期：2015-10-01 00:00:00

abstract：:High biodiversity has been shown to enhance ecological stability on small spatial scales and over intervals of weeks to decades. It remains unclear, however, whether this diversity-stability relationship can be scaled up to regional scales, or to longer timescales. Without empirical validation at larger scales, the im...

journal_title：Nature

authors： Kiessling W

更新日期：2005-01-27 00:00:00

abstract：:The DNA synthetic (S) phase of cell division is about twice as long in human basal cell carcinoma (BCC) as the normal epidermis and several non-malignant skin diseases. A similar increase in S phase duration seems to occur in tumours of the human oesophagus, larynx and recto-colon. At the molecular level, the overall ...

journal_title：Nature

authors： Heenen M,Galand P

更新日期：1980-05-22 00:00:00

abstract：:Generation of a diverse and self-tolerant T-cell repertoire requires appropriate interpretation of T-cell antigen receptor (TCR) signals by CD4(+ ) CD8(+) double-positive thymocytes. Thymocyte cell fate is dictated by the nature of TCR-major-histocompatibility-complex (MHC)-peptide interactions, with signals of higher...

journal_title：Nature

authors： Staton TL,Lazarevic V,Jones DC,Lanser AJ,Takagi T,Ishii S,Glimcher LH

更新日期：2011-04-07 00:00:00

abstract：:Mammalian sex chromosomes share a small terminal region of homologous DNA sequences, which pair and recombine during male meiosis. Alleles in this region can be exchanged between X and Y chromosomes and are therefore inherited as if autosomal. Genes from this so-called pseudoautosomal region (PAR) are present in two d...

journal_title：Nature

authors： Gough NM,Gearing DP,Nicola NA,Baker E,Pritchard M,Callen DF,Sutherland GR

更新日期：1990-06-21 00:00:00

abstract：:Aquaporin (AQP) water-channel proteins are freely permeated by water but not by ions or charged solutes. Although mammalian aquaporins were believed to be located in plasma membranes, rat AQP6 is restricted to intracellular vesicles in renal epithelia. Here we show that AQP6 is functionally distinct from other known a...

journal_title：Nature

authors： Yasui M,Hazama A,Kwon TH,Nielsen S,Guggino WB,Agre P

更新日期：1999-11-11 00:00:00

abstract：:A large impact by a comet or meteorite releases an enormous amount of energy, which evaporates, melts and fractures the surrounding rocks. Distinctive features of such impacts are 'shatter cones', deformed rocks characterized by hierarchical striated features. Although such features have been used for decades as unequ...

journal_title：Nature

authors： Sagy A,Reches Z,Fineberg J

更新日期：2002-07-18 00:00:00

abstract：:Opsin, the ligand-free form of the G-protein-coupled receptor rhodopsin, at low pH adopts a conformationally distinct, active G-protein-binding state known as Ops*. A synthetic peptide derived from the main binding site of the heterotrimeric G protein-the carboxy terminus of the alpha-subunit (GalphaCT)-stabilizes Ops...

journal_title：Nature

authors： Scheerer P,Park JH,Hildebrand PW,Kim YJ,Krauss N,Choe HW,Hofmann KP,Ernst OP

更新日期：2008-09-25 00:00:00

abstract：:The E6 oncoprotein derived from tumour-associated human papillomaviruses (HPVs) binds to and induces the degradation of the cellular tumour-suppressor protein p53. A common polymorphism that occurs in the p53 amino-acid sequence results in the presence of either a proline or an arginine at position 72. The effect of t...

journal_title：Nature

authors： Storey A,Thomas M,Kalita A,Harwood C,Gardiol D,Mantovani F,Breuer J,Leigh IM,Matlashewski G,Banks L

更新日期：1998-05-21 00:00:00

abstract：:Limiting the increase of CO2 in the atmosphere is one of the largest challenges of our generation1. Because carbon capture and storage is one of the few viable technologies that can mitigate current CO2 emissions2, much effort is focused on developing solid adsorbents that can efficiently capture CO2 from flue gases e...

journal_title：Nature

authors： Boyd PG,Chidambaram A,García-Díez E,Ireland CP,Daff TD,Bounds R,Gładysiak A,Schouwink P,Moosavi SM,Maroto-Valer MM,Reimer JA,Navarro JAR,Woo TK,Garcia S,Stylianou KC,Smit B

更新日期：2019-12-01 00:00:00

abstract：:Periodic somite segmentation in vertebrate embryos is controlled by the 'segmentation clock', which consists of numerous cellular oscillators. Although the properties of a single oscillator, driven by a hairy negative-feedback loop, have been investigated, the system-level properties of the segmentation clock remain l...

journal_title：Nature

authors： Horikawa K,Ishimatsu K,Yoshimoto E,Kondo S,Takeda H

更新日期：2006-06-08 00:00:00

abstract：:The massive health problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco smoke and the limited success of current approaches to cessation of smoking. Yet little is known about the neuropharmacological actions of cigarette smoke that contribute to smoking behaviour, or why smok...

journal_title：Nature

authors： Fowler JS,Volkow ND,Wang GJ,Pappas N,Logan J,MacGregor R,Alexoff D,Shea C,Schlyer D,Wolf AP,Warner D,Zezulkova I,Cilento R

更新日期：1996-02-22 00:00:00

abstract：:The ability to design proteins with high affinity and selectivity for any given small molecule is a rigorous test of our understanding of the physiochemical principles that govern molecular recognition. Attempts to rationally design ligand-binding proteins have met with little success, however, and the computational d...

journal_title：Nature

authors： Tinberg CE,Khare SD,Dou J,Doyle L,Nelson JW,Schena A,Jankowski W,Kalodimos CG,Johnsson K,Stoddard BL,Baker D

更新日期：2013-09-12 00:00:00

abstract：:Oscillations in cyclin-dependent kinase (CDK) activity drive the somatic cell cycle. After entry into mitosis, CDKs activate the anaphase-promoting complex (APC), which then promotes cyclin degradation and mitotic exit. The re-accumulation of cyclin A causes the inactivation of APC and entry into S phase, but how cycl...

journal_title：Nature

authors： Rape M,Kirschner MW

更新日期：2004-12-02 00:00:00

abstract：:Protein chains coil into alpha-helices and beta-sheet structures. Knowing the timescales and mechanism of formation of these basic structural elements is essential for understanding how proteins fold. For the past 40 years, alpha-helix formation has been extensively investigated in synthetic and natural peptides, incl...

journal_title：Nature

authors： Muñoz V,Thompson PA,Hofrichter J,Eaton WA

更新日期：1997-11-13 00:00:00

abstract：:In their investigation into whether female mate-choice drives male dispersal, Höner et al. argue that female spotted hyaenas (Crocuta crocuta) prefer mates whose tenure in the social group is less than the females' age, to avoid paternal incest, and suggest that male dispersal reflects this preference. However, we are...

journal_title：Nature

authors： Van Horn RC,Watts HE,Holekamp KE

更新日期：2008-07-10 00:00:00

abstract：:Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure. Bacteria comprising the Chlamydiales were thought to be one of the few exceptions. Chlamydia harbour genes for PG biosynthesis and exhibit suscept...

journal_title：Nature

authors： Liechti GW,Kuru E,Hall E,Kalinda A,Brun YV,VanNieuwenhze M,Maurelli AT

更新日期：2014-02-27 00:00:00

abstract：:Optical irradiation accompanied by spontaneous anti-Stokes emission can lead to cooling of matter, in a phenomenon known as laser cooling, or optical refrigeration, which was proposed by Pringsheim in 1929. In gaseous matter, an extremely low temperature can be obtained in diluted atomic gases by Doppler cooling, and ...

journal_title：Nature

authors： Zhang J,Li D,Chen R,Xiong Q

更新日期：2013-01-24 00:00:00

abstract：:Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4. APOE4 is a major genetic risk factor for Alzheimer's disease and is associated with Down's syndrome dementia and poor neurological outcome after traumatic brain injury and haemorrhage. Neurovascular dysfunction is present in normal APOE4 carriers and i...

journal_title：Nature

authors： Bell RD,Winkler EA,Singh I,Sagare AP,Deane R,Wu Z,Holtzman DM,Betsholtz C,Armulik A,Sallstrom J,Berk BC,Zlokovic BV

更新日期：2012-05-16 00:00:00

abstract：:Ligand-induced allosteric changes in proteins are important in their cellular functions and regulation, and both concerted and sequential examples are known. The distinction has entailed elaborate analysis, however, and only a few systems have been unequivocally analysed. We have investigated the coupling between ATP ...

journal_title：Nature

authors： Lindsley JE,Wang JC

更新日期：1993-02-25 00:00:00

abstract：:Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein ...

journal_title：Nature

authors： de Brito OM,Scorrano L

更新日期：2008-12-04 00:00:00

abstract：:Jupiter's atmosphere is rotating differentially, with zones and belts rotating at speeds that differ by up to 100 metres per second. Whether this is also true of the gas giant's interior has been unknown, limiting our ability to probe the structure and composition of the planet. The discovery by the Juno spacecraft th...

journal_title：Nature

authors： Guillot T,Miguel Y,Militzer B,Hubbard WB,Kaspi Y,Galanti E,Cao H,Helled R,Wahl SM,Iess L,Folkner WM,Stevenson DJ,Lunine JI,Reese DR,Biekman A,Parisi M,Durante D,Connerney JEP,Levin SM,Bolton SJ

更新日期：2018-03-07 00:00:00

abstract：:Understanding how the brain constructs movements remains a fundamental challenge in neuroscience. The brain may control complex movements through flexible combination of motor primitives, where each primitive is an element of computation in the sensorimotor map that transforms desired limb trajectories into motor comm...

journal_title：Nature

authors： Thoroughman KA,Shadmehr R

更新日期：2000-10-12 00:00:00

abstract：:DNA double-strand breaks are generated by genotoxic agents and by cellular endonucleases as intermediates of several important physiological processes. The cellular response to genotoxic DNA breaks includes the activation of transcriptional programs known primarily to regulate cell-cycle checkpoints and cell survival....

journal_title：Nature

authors： Bredemeyer AL,Helmink BA,Innes CL,Calderon B,McGinnis LM,Mahowald GK,Gapud EJ,Walker LM,Collins JB,Weaver BK,Mandik-Nayak L,Schreiber RD,Allen PM,May MJ,Paules RS,Bassing CH,Sleckman BP

更新日期：2008-12-11 00:00:00

abstract：:In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy. Kinetochores are large protein complexes that, by assembling onto specialized Cenp-A nucleosomes1,2, function to connect centromeric chromatin to microtubules of the mitotic spindle3,4. Whereas the...

journal_title：Nature

authors： Yan K,Yang J,Zhang Z,McLaughlin SH,Chang L,Fasci D,Ehrenhofer-Murray AE,Heck AJR,Barford D

更新日期：2019-10-01 00:00:00

abstract：:Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid mechanisms. Here we show that an opioid-independent form of this phenomenon, termed stress-induced analgesia, is mediated by the release of endogenous marijuana-like (cannabinoid) compounds in the brain. Blockade of cannabinoid ...

journal_title：Nature

authors： Hohmann AG,Suplita RL,Bolton NM,Neely MH,Fegley D,Mangieri R,Krey JF,Walker JM,Holmes PV,Crystal JD,Duranti A,Tontini A,Mor M,Tarzia G,Piomelli D

更新日期：2005-06-23 00:00:00

abstract：:It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia. We find that a p...

journal_title：Nature

authors： Kuhlwilm M,Gronau I,Hubisz MJ,de Filippo C,Prado-Martinez J,Kircher M,Fu Q,Burbano HA,Lalueza-Fox C,de la Rasilla M,Rosas A,Rudan P,Brajkovic D,Kucan Ž,Gušic I,Marques-Bonet T,Andrés AM,Viola B,Pääbo S,Meyer M,Sie

更新日期：2016-02-25 00:00:00

abstract：:Valuable information about proto-oncogenes and their physiological function has been obtained by studying their expression in normal cells. However, expression of the c-mos gene, the cellular homologue of the transforming gene of Moloney murine sarcoma virus, has not been detected in normal mouse cells or tissues. The...

journal_title：Nature

authors： Propst F,Vande Woude GF

更新日期：1985-06-06 00:00:00