Abstract:
:Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure. Bacteria comprising the Chlamydiales were thought to be one of the few exceptions. Chlamydia harbour genes for PG biosynthesis and exhibit susceptibility to 'anti-PG' antibiotics, yet attempts to detect PG in any chlamydial species have proven unsuccessful (the 'chlamydial anomaly'). We used a novel approach to metabolically label chlamydial PG using d-amino acid dipeptide probes and click chemistry. Replicating Chlamydia trachomatis were labelled with these probes throughout their biphasic developmental life cycle, and the results of differential probe incorporation experiments conducted in the presence of ampicillin are consistent with the presence of chlamydial PG-modifying enzymes. These findings culminate 50 years of speculation and debate concerning the chlamydial anomaly and are the strongest evidence so far that chlamydial species possess functional PG.
journal_name
Naturejournal_title
Natureauthors
Liechti GW,Kuru E,Hall E,Kalinda A,Brun YV,VanNieuwenhze M,Maurelli ATdoi
10.1038/nature12892subject
Has Abstractpub_date
2014-02-27 00:00:00pages
507-10issue
7489eissn
0028-0836issn
1476-4687pii
nature12892journal_volume
506pub_type
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