Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

abstract：:The isolation of a mutant adenovirus carrying an insertion of cellular DNA has led to the identification of a new family of human repetitive sequences, which are found tandemly arranged in the genome. The sequence of the viral insert resembles that of eukaryotic transposable elements. ...

journal_title：Nature

authors： Shimizu Y,Yoshida K,Ren CS,Fujinaga K,Rajagopalan S,Chinnadurai G

更新日期：1983-04-14 00:00:00

abstract：:The classical view of fast chemical synaptic transmission is that released neurotransmitter acts locally on postsynaptic receptors and is cleared from the synaptic cleft within a few milliseconds by diffusion and by specific reuptake mechanisms. This rapid clearance restricts the spread of neurotransmitter and, combin...

journal_title：Nature

authors： Scanziani M,Salin PA,Vogt KE,Malenka RC,Nicoll RA

更新日期：1997-02-13 00:00:00

abstract：:Data collected at approximately 60 Global Positioning System (GPS) sites in southeast Asia show the crustal deformation caused by the 26 December 2004 Sumatra-Andaman earthquake at an unprecedented large scale. Small but significant co-seismic jumps are clearly detected more than 3,000 km from the earthquake epicentre...

journal_title：Nature

authors： Vigny C,Simons WJ,Abu S,Bamphenyu R,Satirapod C,Choosakul N,Subarya C,Socquet A,Omar K,Abidin HZ,Ambrosius BA

更新日期：2005-07-14 00:00:00

abstract：:Type Ia supernovae are thought to result from thermonuclear explosions of carbon-oxygen white dwarf stars. Existing models generally explain the observed properties, with the exception of the sub-luminous 1991bg-like supernovae. It has long been suspected that the merger of two white dwarfs could give rise to a type I...

journal_title：Nature

authors： Pakmor R,Kromer M,Röpke FK,Sim SA,Ruiter AJ,Hillebrandt W

更新日期：2010-01-07 00:00:00

abstract：:The effect of anthropogenic aerosols on cloud droplet concentrations and radiative properties is the source of one of the largest uncertainties in the radiative forcing of climate over the industrial period. This uncertainty affects our ability to estimate how sensitive the climate is to greenhouse gas emissions. Here...

journal_title：Nature

authors： Carslaw KS,Lee LA,Reddington CL,Pringle KJ,Rap A,Forster PM,Mann GW,Spracklen DV,Woodhouse MT,Regayre LA,Pierce JR

更新日期：2013-11-07 00:00:00

abstract：:The largest products of magmatic activity on Earth, the great bodies of granite and their corresponding large eruptions, have a dual nature: homogeneity at the large scale and spatial and temporal heterogeneity at the small scale. This duality calls for a mechanism that selectively removes the large-scale heterogeneit...

journal_title：Nature

authors： Burgisser A,Bergantz GW

更新日期：2011-03-10 00:00:00

abstract：:Interstellar dust is responsible, through surface reactions, for the creation of molecular hydrogen, the main component of the interstellar clouds in which new stars form. Intermediate between small, gas-phase molecules and dust are the polycyclic aromatic hydrocarbons (PAHs). Such molecules could account for 2-30% of...

journal_title：Nature

authors： Cook DJ,Schlemmer S,Balucani N,Wagner DR,Steiner B,Saykally RJ

更新日期：1996-03-21 00:00:00

abstract：:The superposition principle is a fundamental tenet of quantum mechanics. It allows a quantum system to be 'in two places at the same time', because the quantum state of a physical system can simultaneously include measurably different physical states. The preparation and use of such superposed states forms the basis o...

journal_title：Nature

authors： Hofheinz M,Wang H,Ansmann M,Bialczak RC,Lucero E,Neeley M,O'Connell AD,Sank D,Wenner J,Martinis JM,Cleland AN

更新日期：2009-05-28 00:00:00

abstract：:The injection of Rous sarcoma virus (RSV) into the wing web of newly hatched chicks causes a rapidly growing sarcomatous tumour which is palpable within 1 week of inoculation; and cultures of fibroblasts derived from chick embryos (CEF) and infected with RSV become rapidly transformed. Genetic studies have determined ...

journal_title：Nature

authors： Dolberg DS,Bissell MJ

更新日期：1984-06-07 00:00:00

abstract：:This is an exciting time for scientific discovery that aims to reduce the frequency and impact of neurological, mental health and substance-use disorders. As it became increasingly clear that low- and middle-income countries have a disproportionate share of these disorders, and that many of the problems are best addre...

journal_title：Nature

authors： Silberberg D,Anand NP,Michels K,Kalaria RN

更新日期：2015-11-19 00:00:00

abstract：:Type II DNA topoisomerases are ubiquitous ATP-dependent enzymes capable of transporting a DNA through a transient double-strand break in a second DNA segment. This enables them to untangle DNA and relax the interwound supercoils (plectonemes) that arise in twisted DNA. In vivo, they are responsible for untangling repl...

journal_title：Nature

authors： Strick TR,Croquette V,Bensimon D

更新日期：2000-04-20 00:00:00

abstract：:Insulin binding to its receptor leads to negatively cooperative interactions among the receptor sites. Studies with 29 insulin analogues (animal insulins and proinsulin, insulin-like growth factor and chemically modified insulins) which vary 1,000-fold in their affinity for the receptor and in their biological potency...

journal_title：Nature

authors： De Meyts P,Van Obberghen E,Roth J

更新日期：1978-06-15 00:00:00

abstract：:Hereditary persistance of fetal haemoglobin (HPFH) is a benign condition characterized by the production in adulthood of more than 1% fetal haemoglobin (HbF, alpha 2 gamma 2) in the absence of erythropoietic stress. Several genetic types have been discerned based on the level of HbF produced, the relative contribution...

journal_title：Nature

authors： Collins FS,Metherall JE,Yamakawa M,Pan J,Weissman SM,Forget BG

更新日期：1985-01-24 00:00:00

abstract：:The University of California at Berkeley has announced the postponement of a planned experiment involving the field testing of bacteria genetically engineered to reduce frost damage to crops. The action came after Jeremy Rifkin, who had earlier filed suit against the National Institutes of Health after its Recombinan...

journal_title：Nature

authors： Budiansky S

更新日期：1983-10-13 00:00:00

abstract：:Classically, there is a direct correlation between the lipophilic nature of a molecule and its rate of permeation across a biological membrane, so cell membranes should be more permeable to small, neutral molecules than they are to charged molecular species of similar size. Consequently, the distribution of NH+4 in bi...

journal_title：Nature

authors： Kikeri D,Sun A,Zeidel ML,Hebert SC

更新日期：1989-06-08 00:00:00

abstract：:The human AIDS viruses human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) represent cross-species (zoonotic) infections. Although the primate reservoir of HIV-2 has been clearly identified as the sooty mangabey (Cercocebus atys), the origin of HIV-1 remains uncertain. Viruses related to HIV-1 have been iso...

journal_title：Nature

authors： Gao F,Bailes E,Robertson DL,Chen Y,Rodenburg CM,Michael SF,Cummins LB,Arthur LO,Peeters M,Shaw GM,Sharp PM,Hahn BH

更新日期：1999-02-04 00:00:00

abstract：:The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic and inactive heterochromatic regions of the genome1,2. In conventional nuclei, microscopy shows that euchromatin is localized in the nuclear interior and heterochromatin at the nuclear periphery1,2. Genome-wide chromosome conf...

journal_title：Nature

authors： Falk M,Feodorova Y,Naumova N,Imakaev M,Lajoie BR,Leonhardt H,Joffe B,Dekker J,Fudenberg G,Solovei I,Mirny LA

更新日期：2019-06-01 00:00:00

abstract：:Establishing the age at death of individuals is an important step in their identification and can be done with high precision up to adolescence by analysis of dentition, but it is more difficult in adults. Here we show that the amount of radiocarbon present in tooth enamel as a result of nuclear bomb testing during 19...

journal_title：Nature

authors： Spalding KL,Buchholz BA,Bergman LE,Druid H,Frisén J

更新日期：2005-09-15 00:00:00

abstract：:Monoclonal antibodies can now be genetically engineered and endowed with new properties. In the future, gene technology could enable antigen-binding fragments to be made by exploiting repertoires of variable domain genes derived from immunized animals and expressed in bacteria. How readily can this approach be extende...

journal_title：Nature

authors： Winter G,Milstein C

更新日期：1991-01-24 00:00:00

abstract：:A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The ge...

journal_title：Nature

authors： Kuro-o M,Matsumura Y,Aizawa H,Kawaguchi H,Suga T,Utsugi T,Ohyama Y,Kurabayashi M,Kaname T,Kume E,Iwasaki H,Iida A,Shiraki-Iida T,Nishikawa S,Nagai R,Nabeshima YI

更新日期：1997-11-06 00:00:00

abstract：:Protein G is a cell-surface protein from Streptococcus which binds to IgG molecules from a wide range of species with an affinity comparable to that of antigen. The high affinity of protein G for the Fab portion of IgG poses a particular challenge in molecular recognition, given the variability of heavy chain subclass...

journal_title：Nature

authors： Derrick JP,Wigley DB

更新日期：1992-10-22 00:00:00

abstract：:Environmental change is rapidly accelerating, and many species will need to adapt to survive1. Ensuring that protected areas cover populations across a broad range of environmental conditions could safeguard the processes that lead to such adaptations1-3. However, international conservation policies have largely negle...

journal_title：Nature

authors： Hanson JO,Rhodes JR,Butchart SHM,Buchanan GM,Rondinini C,Ficetola GF,Fuller RA

更新日期：2020-04-01 00:00:00

abstract：:It is generally accepted that the specific function of a gene depends on its coding sequence. The three paired-box and homeobox genes paired (prd), gooseberry (gsb) and gooseberry neuro (gsbn) have distinct developmental functions in Drosophila embryogenesis. During the syncytial blastoderm stage, the pair-rule gene p...

journal_title：Nature

authors： Li X,Noll M

更新日期：1994-01-06 00:00:00

abstract：:Regulatory T cells (Treg cells), a distinct subset of CD4+ T cells, are necessary for the maintenance of immune self-tolerance and homeostasis1,2. Recent studies have demonstrated that Treg cells exhibit a unique metabolic profile, characterized by an increase in mitochondrial metabolism relative to other CD4+ effecto...

journal_title：Nature

authors： Weinberg SE,Singer BD,Steinert EM,Martinez CA,Mehta MM,Martínez-Reyes I,Gao P,Helmin KA,Abdala-Valencia H,Sena LA,Schumacker PT,Turka LA,Chandel NS

更新日期：2019-01-01 00:00:00

abstract：:Considerable attention has centered recently on the changes in neuron excitability and synaptic efficacy caused by certain biogenic amines and neuropeptides. These neuromodulators act at a wide variety of both central and peripheral targets, and bring about diverse biological results. In sensory pathways, modulation o...

journal_title：Nature

authors： Pasztor VM,Bush BM

更新日期：1987-04-23 00:00:00

abstract：:Elongation factor Tu is present in a fourfold excess over the amount seemingly involved in protein synthesis. It is identical to a major protein which we have found associated with the plasma membrane. The possibility of a specific role in that location is considered. ...

journal_title：Nature

authors： Jacobson GR,Rosenbusch JP

更新日期：1976-05-06 00:00:00

abstract：:Neurotransmitter/sodium symporters (NSSs) couple the uptake of neurotransmitter with one or more sodium ions, removing neurotransmitter from the synaptic cleft. NSSs are essential to the function of chemical synapses, are associated with multiple neurological diseases and disorders, and are the targets of therapeutic ...

journal_title：Nature

authors： Piscitelli CL,Krishnamurthy H,Gouaux E

更新日期：2010-12-23 00:00:00

abstract：:Jupiter's aurora is the most powerful in the Solar System. It is powered largely by energy extracted from planetary rotation, although there seems also to be a contribution from the solar wind. This contrasts with Earth's aurora, which is generated through the interaction of the solar wind with the magnetosphere. The ...

journal_title：Nature

authors： Waite JH Jr,Gladstone GR,Lewis WS,Goldstein R,McComas DJ,Riley P,Walker RJ,Robertson P,Desai S,Clarke JT,Young DT

更新日期：2001-04-12 00:00:00

abstract：:Functional studies seem now to confirm, as first suggested by E. Geoffroy Saint-Hilaire in 1822, that there was an inversion of the dorsoventral axis during animal evolution. A conserved system of extracellular signals provides positional information for the allocation of embryonic cells to specific tissue types both ...

journal_title：Nature

authors： De Robertis EM,Sasai Y

更新日期：1996-03-07 00:00:00

abstract：:Collagen fibrils have been extensively studied by electron microscopy, but only scant evidence has yet been obtained about their transverse structure. A transverse pediodicity of about 40 or 80 A might be expected if the microfibril model (until recently the common preference) is correct, but little direct evidence fo...

journal_title：Nature

authors： Squire JM,Freundlich A

更新日期：1980-11-27 00:00:00