Abstract：
:Collagen fibrils have been extensively studied by electron microscopy, but only scant evidence has yet been obtained about their transverse structure. A transverse pediodicity of about 40 or 80 A might be expected if the microfibril model (until recently the common preference) is correct, but little direct evidence for such a periodicity has been obtained so far. We have studied electron micrographs of longitudinal cryosections of rat tail tendon. These appear very fibrous when studied by eye, but they produce at best only diffuse equatorial peaks in optical diffraction patterns. Nevertheless, we show here that like other fibrous protein structures, they do possess a strong transverse periodicity as revealed by their self-convolution functions (or auto-correlation functions). The observed periodicity is consistent with the presence of an 80 A structural unit in collagen fibrils in vivo.
journal_name
Naturejournal_title
Natureauthors
Squire JM,Freundlich Adoi
10.1038/288410a0subject
Has Abstractpub_date
1980-11-27 00:00:00pages
410-3issue
5789eissn
0028-0836issn
1476-4687journal_volume
288pub_type
杂志文章相关文献
NATURE文献大全abstract：:beta Pictoris (beta Pic) is a main-sequence star with an edge-on dust disk that might represent a state of the early Solar System. The dust does not seem to be a remnant from the original protoplanetary disk, but rather is thought to have been generated from large bodies like planetesimals and/or comets. The history a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02948
更新日期：2004-10-07 00:00:00
abstract：:Magnetic fields play a part in almost all stages of stellar evolution. Most low-mass stars, including the Sun, show surface fields that are generated by dynamo processes in their convective envelopes. Intermediate-mass stars do not have deep convective envelopes, although 10 per cent exhibit strong surface fields that...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature16171
更新日期：2016-01-21 00:00:00
abstract：:During lymphocyte development, cellular proliferation and positive and negative selection events ensure the production of T and B lymphocytes bearing highly diverse, but self-tolerant, repertoires of antigen receptors. These processes are initiated when engagement of growth-factor receptors, or the T and B lymphocyte ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/374474a0
更新日期：1995-03-30 00:00:00
abstract：:The most severe excursions in the Earth's climatic history are thought to be associated with Proterozoic glaciations. According to the 'Snowball Earth' hypothesis, the Marinoan glaciation, which ended about 635 million years ago, involved global or nearly global ice cover. At the termination of this glacial period, ra...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03176
更新日期：2005-01-13 00:00:00
abstract：:During development, cells become progressively restricted, until they reach their final phenotype. Differentiation was originally thought to be irreversible, but phenotypic plasticity has been observed in a variety of cell types, for example sympathetic neurones, the limb blastema and some glial cell types. A detailed...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/324569a0
更新日期：1986-12-11 00:00:00
abstract：:The GAL4 protein activates transcription of the genes required for galactose utilization in Saccharomyces cerevisiae. The protein, consisting of 881 amino acids, is dimeric when bound to one of the approximately twofold symmetrical DNA sites present in the galactose upstream activating sequence (UASG). Here we use two...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/356450a0
更新日期：1992-04-02 00:00:00
abstract：:With only a few exceptions that are well understood, conventional superconductivity does not coexist with long-range magnetic order (for example, ref. 1). Unconventional superconductivity, on the other hand, develops near a phase boundary separating magnetically ordered and magnetically disordered phases. A maximum in...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04571
更新日期：2006-03-02 00:00:00
abstract：:Atrial extracts contain factors which induce potent natriuresis changes in renal haemodynamics, and relax pre-contracted vascular smooth muscle. Low-molecular-weight peptides which mimic these actions have now been purified by several groups, including ours (see accompanying paper), and higher-molecular-weight protein...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/309719a0
更新日期：1984-06-21 00:00:00
abstract：:In Drosophila, Decapentaplegic (Dpp) and Wingless (Wg) are two secreted signalling proteins of the transforming growth factor (TGF)-beta and Wnt families, respectively. Although both are often required during development, only a few downstream components of these signalling pathways have been described. Here we presen...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/383630a0
更新日期：1996-10-17 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 评论,信件
doi：10.1038/d41586-019-00232-8
更新日期：2019-01-01 00:00:00
abstract：:In double-stranded-RNA (dsRNA) viruses found in animals, bacteria and yeast, the genome is transcribed within the structurally intact core of the virion with extraordinary efficiency. The structural organization of the genome and the enzymes involved in the transcription inside any of these viruses, critical for under...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/382471a0
更新日期：1996-08-01 00:00:00
abstract：:The abundance of chlorine in the Earth's atmosphere increased considerably during the 1970s to 1990s, following large emissions of anthropogenic long-lived chlorine-containing source gases, notably the chlorofluorocarbons. The chemical inertness of chlorofluorocarbons allows their transport and mixing throughout the t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature13857
更新日期：2014-11-06 00:00:00
abstract：:Metabolic phenotypes are the products of interactions among a variety of factors-dietary, other lifestyle/environmental, gut microbial and genetic. We use a large-scale exploratory analytical approach to investigate metabolic phenotype variation across and within four human populations, based on 1H NMR spectroscopy. M...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06882
更新日期：2008-05-15 00:00:00
abstract：:The neocortex of the adult brain consists of neurons and glia that are generated by precursor cells of the embryonic ventricular zone. In general, glia are generated after neurons during development, but radial glia are an exception to this rule. Radial glia are generated before neurogenesis and guide neuronal migrati...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35055553
更新日期：2001-02-08 00:00:00
abstract：:p60src, the transforming protein of Rous sarcoma virus (RSV), is a protein kinase that has a strict specificity for tyrosine. The phosphorylation of cellular proteins by p60src (ref. 4) results in transformation. Recently, Barker and Dayhoff discovered that residues 259-485 of p60src have 22% sequence identity with re...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/310589a0
更新日期：1984-08-16 00:00:00
abstract：:The neutron superfluid in most neutron stars should be in a highly turbulent state. If so, this turbulence drastically alters its rotational properties. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/227791a0
更新日期：1970-08-22 00:00:00
abstract：:A short exposure of primary cultures of mouse mammary tumour cells to glucocorticoids results in at least a three-fold stimulation of mammary tumour virus (MTV) production. Specific interaction of glucocorticoids with the cytoplasmic and nuclear receptors can also be demonstrated. The biological potency of various ste...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/262107a0
更新日期：1976-07-08 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 面试
doi：10.1038/d41586-018-07047-z
更新日期：2018-10-01 00:00:00
abstract：:The RNA polymerase II large subunit contains an essential carboxy-terminal domain (CTD) believed to be involved in the response to regulators during transcription initiation. The CTD is phosphorylated on a portion of RNA polymerase II molecules in vivo and it can be phosphorylated by the general transcription factor T...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/374280a0
更新日期：1995-03-16 00:00:00
abstract：:Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35018092
更新日期：2000-07-13 00:00:00
abstract：:The existence in the ocean of deep western boundary currents, which connect the high-latitude regions where deep water is formed with upwelling regions as part of the global ocean circulation, was postulated more than 40 years ago. These ocean currents have been found adjacent to the continental slopes of all ocean ba...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03134
更新日期：2004-12-23 00:00:00
abstract：:Evolutionary relationships among the eight major lineages of Mollusca have remained unresolved despite their diversity and importance. Previous investigations of molluscan phylogeny, based primarily on nuclear ribosomal gene sequences or morphological data, have been unsuccessful at elucidating these relationships. Re...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10382
更新日期：2011-09-04 00:00:00
abstract：:Non-impulsive seismic radiation or 'tremor' has long been observed at volcanoes and more recently around subduction zones. Although the number of observations of non-volcanic tremor is steadily increasing, the causative mechanism remains unclear. Some have attributed non-volcanic tremor to the movement of fluids, whil...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06017
更新日期：2007-08-02 00:00:00
abstract：:The promoter for a weakly expressed constitutive gene, the lactose repressor gene (lacI), has been sequenced, along with an 'up' promoter mutation Iq. The 10-fold enhancement in I expression found in Iq is the result of a single base change at position -35. To facilitate the sequencing, the lacI gene was cloned in a s...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/274762a0
更新日期：1978-08-24 00:00:00
abstract：:The cyanobacterium Prochlorococcus is the dominant oxygenic phototroph in the tropical and subtropical regions of the world's oceans. It can grow at a range of depths over which light intensities can vary by up to 4 orders of magnitude. This broad depth distribution has been hypothesized to stem from the coexistence o...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/30965
更新日期：1998-06-04 00:00:00
abstract：:Organ-specific metastasis is governed, in part, by interactions between chemokine receptors on cancer cells and matching chemokines in target organs. For example, malignant breast cancer cells express the chemokine receptor CXCR4 and commonly metastasize to organs that are an abundant source of the CXCR4-specific liga...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01874
更新日期：2003-09-18 00:00:00
abstract：:Pluto's tenuous nitrogen atmosphere was first detected by the imprint left on the light curve of a star that was occulted by the planet in 1985 (ref. 1), and studied more extensively during a second occultation event in 1988 (refs 2-6). These events are, however, quite rare and Pluto's atmosphere remains poorly unders...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01766
更新日期：2003-07-10 00:00:00
abstract：:Fluorine is the thirteenth most abundant element in the earth's crust, but fluoride concentrations in surface water are low and fluorinated metabolites are extremely rare. The fluoride ion is a potent nucleophile in its desolvated state, but is tightly hydrated in water and effectively inert. Low availability and a la...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02280
更新日期：2004-02-05 00:00:00
abstract：:Crystal structures of insulin have been determined in various distinct forms, the relevance of which to receptor recognition has long been the subject of speculation. Recently the crystal structure of an inactive insulin analogue has been determined and, surprisingly, found to have a conformation identical to native i...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/354238a0
更新日期：1991-11-21 00:00:00
abstract：:Ecological and societal disruptions by modern climate change are critically determined by the time frame over which climates shift beyond historical analogues. Here we present a new index of the year when the projected mean climate of a given location moves to a state continuously outside the bounds of historical vari...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12540
更新日期：2013-10-10 00:00:00
