Cancer researcher defends immigrant scientists.

abstract：:When present in single-stranded DNA, palindromic or quasi-palindromic sequences have the potential to form complex secondary structures, including hairpins, which may facilitate interstrand misalignment of direct repeats and be responsible for diverse types of replication-based mutations, including deletions, addition...

journal_title：Nature

authors： Trinh TQ,Sinden RR

更新日期：1991-08-08 00:00:00

abstract：:Apoptosis (programmed cell death), an essential process in the development and homeostasis of metazoans, is carried out by caspases. The mitochondrial protein Smac/DIABLO performs a critical function in apoptosis by eliminating the inhibitory effect of IAPs (inhibitor of apoptosis proteins) on caspases. Here we show t...

journal_title：Nature

authors： Chai J,Du C,Wu JW,Kyin S,Wang X,Shi Y

更新日期：2000-08-24 00:00:00

abstract：:The ubiquity of tertiary alkylamines in pharmaceutical and agrochemical agents, natural products and small-molecule biological probes1,2 has stimulated efforts towards their streamlined synthesis3-9. Arguably the most robust method for the synthesis of tertiary alkylamines is carbonyl reductive amination3, which compr...

journal_title：Nature

authors： Kumar R,Flodén NJ,Whitehurst WG,Gaunt MJ

更新日期：2020-05-01 00:00:00

abstract：:Nerve growth factor (NGF) activity was not detected by bioassay in irides killed immediately after excision but NGF appeared within 24 h in living irides placed in culture or grafted to a host eye. Furthermore, sensory and, although less effective, sympathetic denervation of irides in situ led within 10 days to the ap...

journal_title：Nature

authors： Ebendal T,Olson L,Seiger A,Hedlund KO

更新日期：1980-07-03 00:00:00

abstract：:Ground- and aircraft-based measurements show that the seasonal amplitude of Northern Hemisphere atmospheric carbon dioxide (CO2) concentrations has increased by as much as 50 per cent over the past 50 years. This increase has been linked to changes in temperate, boreal and arctic ecosystem properties and processes suc...

journal_title：Nature

authors： Gray JM,Frolking S,Kort EA,Ray DK,Kucharik CJ,Ramankutty N,Friedl MA

更新日期：2014-11-20 00:00:00

abstract：:DEET (N,N-diethyl-meta-toluamide) is a synthetic chemical identified by the US Department of Agriculture in 1946 in a screen for repellents to protect soldiers from mosquito-borne diseases1,2. Since its discovery, DEET has become the world's most widely used arthropod repellent and is effective against invertebrates s...

journal_title：Nature

authors： Dennis EJ,Dobosiewicz M,Jin X,Duvall LB,Hartman PS,Bargmann CI,Vosshall LB

更新日期：2018-10-01 00:00:00

abstract：:The heat-shock protein Hsp90 supports diverse but specific signal transducers and lies at the interface of several developmental pathways. We report here that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is produced, with specific variants dep...

journal_title：Nature

authors： Rutherford SL,Lindquist S

更新日期：1998-11-26 00:00:00

abstract：:Experimental realization of a universal set of quantum logic gates is the central requirement for the implementation of a quantum computer. In an 'all-geometric' approach to quantum computation, the quantum gates are implemented using Berry phases and their non-Abelian extensions, holonomies, from geometric transforma...

journal_title：Nature

authors： Zu C,Wang WB,He L,Zhang WG,Dai CY,Wang F,Duan LM

更新日期：2014-10-02 00:00:00

abstract：:Observing and controlling macroscopic quantum systems has long been a driving force in quantum physics research. In particular, strong coupling between individual quantum systems and mechanical oscillators is being actively studied1-3. Whereas both read-out of mechanical motion using coherent control of spin systems4-...

journal_title：Nature

authors： Delord T,Huillery P,Nicolas L,Hétet G

更新日期：2020-04-01 00:00:00

abstract：:Since the original work on Bose-Einstein condensation1,2, the use of quantum degenerate gases of atoms has enabled the quantum emulation of important systems in condensed matter and nuclear physics, as well as the study of many-body states that have no analogue in other fields of physics3. Ultracold molecules in the m...

journal_title：Nature

authors： Son H,Park JJ,Ketterle W,Jamison AO

更新日期：2020-04-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a degenerative disorder of motor neurons in the cortex, brainstem and spinal cord. Its cause is unknown and it is uniformly fatal, typically within five years. About 10% of cases are inherited as an autosomal dominant trait, with high penetrance after the sixth decade. In most in...

journal_title：Nature

authors： Rosen DR,Siddique T,Patterson D,Figlewicz DA,Sapp P,Hentati A,Donaldson D,Goto J,O'Regan JP,Deng HX

更新日期：1993-03-04 00:00:00

abstract：:The human AIDS viruses human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) represent cross-species (zoonotic) infections. Although the primate reservoir of HIV-2 has been clearly identified as the sooty mangabey (Cercocebus atys), the origin of HIV-1 remains uncertain. Viruses related to HIV-1 have been iso...

journal_title：Nature

authors： Gao F,Bailes E,Robertson DL,Chen Y,Rodenburg CM,Michael SF,Cummins LB,Arthur LO,Peeters M,Shaw GM,Sharp PM,Hahn BH

更新日期：1999-02-04 00:00:00

abstract：:Advances in genetics and genomics have fuelled a revolution in discovery-based, or hypothesis-generating, research that provides a powerful complement to the more directly hypothesis-driven molecular, cellular and systems neuroscience. Genetic and functional genomic studies have already yielded important insights into...

journal_title：Nature

authors： Geschwind DH,Konopka G

更新日期：2009-10-15 00:00:00

abstract：:In Drosophila melanogaster, the rRNA genes (rDNA) are clustered at single sites on two non-homologous chromosomes, the X and Y. Examination of the structure of X and Y rDNAs with restriction endonucleases reveals that the X rDNA contains repeating units not present in the Y. Such observations, as well as genetic evide...

journal_title：Nature

authors： Tartof KD,Dawid IG

更新日期：1976-09-02 00:00:00

abstract：:P2Y receptors (P2YRs), a family of purinergic G-protein-coupled receptors (GPCRs), are activated by extracellular nucleotides. There are a total of eight distinct functional P2YRs expressed in human, which are subdivided into P2Y1-like receptors and P2Y12-like receptors. Their ligands are generally charged molecules w...

journal_title：Nature

authors： Zhang K,Zhang J,Gao ZG,Zhang D,Zhu L,Han GW,Moss SM,Paoletta S,Kiselev E,Lu W,Fenalti G,Zhang W,Müller CE,Yang H,Jiang H,Cherezov V,Katritch V,Jacobson KA,Stevens RC,Wu B,Zhao Q

更新日期：2014-05-01 00:00:00

abstract：:Although the regeneration of nervous tissue in the vertebrate is very limited, there are a few remarkable examples of this process. Understanding the factors that regulate CNS regeneration in those areas of the nervous system where it occurs, will doubtless provide generally applicable, essential information about the...

journal_title：Nature

authors： Reh TA,Nagy T,Gretton H

更新日期：1987-11-05 00:00:00

abstract：:As an approach to the study of the kind of chemical process that might have contributed to the origin of life, attempts have been made to develop purely chemical systems in which oligonucleotides self-replicate. Although performed oligonucleotides have been shown to facilitate the formation of their complements from a...

journal_title：Nature

authors： Zielinski WS,Orgel LE

更新日期：1987-05-28 00:00:00

abstract：:Most of the 470-million-year history of plants on land belongs to bryophytes, pteridophytes and gymnosperms, which eventually yielded to the ecological dominance by angiosperms 90 Myr ago. Our knowledge of angiosperm phylogeny, particularly the branching order of the earliest lineages, has recently been increased by t...

journal_title：Nature

authors： Pryer KM,Schneider H,Smith AR,Cranfill R,Wolf PG,Hunt JS,Sipes SD

更新日期：2001-02-01 00:00:00

abstract：:Aquaporin (AQP) water-channel proteins are freely permeated by water but not by ions or charged solutes. Although mammalian aquaporins were believed to be located in plasma membranes, rat AQP6 is restricted to intracellular vesicles in renal epithelia. Here we show that AQP6 is functionally distinct from other known a...

journal_title：Nature

authors： Yasui M,Hazama A,Kwon TH,Nielsen S,Guggino WB,Agre P

更新日期：1999-11-11 00:00:00

abstract：:A pathological hallmark of Alzheimer's disease is the deposition of amyloid fibrils in the brain. The principal component of amyloid fibrils is beta/A4 amyloid protein, which can be generated by the aberrant processing of a large membrane-bound glycoprotein, the beta/A4 amyloid protein precursor (APP)3. To test whethe...

journal_title：Nature

authors： Yoshikawa K,Aizawa T,Hayashi Y

更新日期：1992-09-03 00:00:00

abstract：:The T-cell receptor (TCR) repertoire is selected in the thymus after rearrangement of genes encoding TCR alpha and beta chains. Selection is based on the recognition by newly emergent T cells of self-ligands associated with molecules of the major histocompatibility complex: some combinations result in positive selecti...

journal_title：Nature

authors： Dyson PJ,Knight AM,Fairchild S,Simpson E,Tomonari K

更新日期：1991-02-07 00:00:00

abstract：:Chemokines are chemotactic cytokines that activate and direct the migration of leukocytes. There are two subfamilies, the CXC and the CC chemokines. We recently found that the CXC-chemokine stromal cell-derived factor-1 (SDF-1) is a highly efficacious lymphocyte chemoattractant. Chemokines act on responsive leukocyte ...

journal_title：Nature

authors： Bleul CC,Farzan M,Choe H,Parolin C,Clark-Lewis I,Sodroski J,Springer TA

更新日期：1996-08-29 00:00:00

abstract：:The beta, gamma-crystallins form a class of homologous proteins in the eye lens. Each gamma-crystallin comprises four topologically equivalent, Greek key motifs; pairs of motifs are organized around a local dyad to give domains and two similar domains are in turn related by a further local dyad. Sequence comparisons a...

journal_title：Nature

authors： Bax B,Lapatto R,Nalini V,Driessen H,Lindley PF,Mahadevan D,Blundell TL,Slingsby C

更新日期：1990-10-25 00:00:00

abstract：:oop RNA, which is initiated at the po promoter and is 81 nucleotides long, can function as a leader sequence for the lambda immunity establishment transcription, previously believed to originate at a special promoter pre located in the y region. Thus, oop RNA seems to have a dual role, either favouring the lytic cycle...

journal_title：Nature

authors： Honigman A,Hu SL,Chase R,Szybalski W

更新日期：1976-07-08 00:00:00

abstract：:Bacterial adhesion pili are designed to bind specifically and maintain attachment of bacteria to target cells. Uropathogenic P-pili are sufficiently mechanically resilient to resist the cleansing action of urine flow that removes most other bacteria. P-pili are 68 A in diameter and approximately 1 micron long, and are...

journal_title：Nature

authors： Bullitt E,Makowski L

更新日期：1995-01-12 00:00:00

abstract：:Mitogen-activated protein kinases, MAP kinases or ERKs (extracellular signal-regulated kinases) are rapidly stimulated by growth-promoting factors acting on a variety of cell-surface receptors. In turn, ERKs phosphorylate and regulate key intracellular enzymes and transcription factors involved in the control of cellu...

journal_title：Nature

authors： Crespo P,Xu N,Simonds WF,Gutkind JS

更新日期：1994-06-02 00:00:00

abstract：:The ability to form integrated circuits on flexible sheets of plastic enables attributes (for example conformal and flexible formats and lightweight and shock resistant construction) in electronic devices that are difficult or impossible to achieve with technologies that use semiconductor wafers or glass plates as sub...

journal_title：Nature

authors： Cao Q,Kim HS,Pimparkar N,Kulkarni JP,Wang C,Shim M,Roy K,Alam MA,Rogers JA

更新日期：2008-07-24 00:00:00

abstract：:G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with downstream signalling transducers, including the hetrotrimeric G proteins Gs (stimulatory) and Gi (inhibitory) and several arrestin proteins. The structural mechanisms ...

journal_title：Nature

authors： Kang Y,Kuybeda O,de Waal PW,Mukherjee S,Van Eps N,Dutka P,Zhou XE,Bartesaghi A,Erramilli S,Morizumi T,Gu X,Yin Y,Liu P,Jiang Y,Meng X,Zhao G,Melcher K,Ernst OP,Kossiakoff AA,Subramaniam S,Xu HE

更新日期：2018-06-01 00:00:00

abstract：:Periodic somite segmentation in vertebrate embryos is controlled by the 'segmentation clock', which consists of numerous cellular oscillators. Although the properties of a single oscillator, driven by a hairy negative-feedback loop, have been investigated, the system-level properties of the segmentation clock remain l...

journal_title：Nature

authors： Horikawa K,Ishimatsu K,Yoshimoto E,Kondo S,Takeda H

更新日期：2006-06-08 00:00:00

abstract：:Temperature is a key factor in controlling the distribution of marine organisms and is particularly important at hydrothermal vents, where steep thermal gradients are present over a scale of centimetres. The thermophilic worm Alvinella pompejana, which is found at the vents of the East Pacific Rise (2,500-m depth), ha...

journal_title：Nature

authors： Pradillon F,Shillito B,Young CM,Gaill F

更新日期：2001-10-18 00:00:00