Abstract:
:Periodic somite segmentation in vertebrate embryos is controlled by the 'segmentation clock', which consists of numerous cellular oscillators. Although the properties of a single oscillator, driven by a hairy negative-feedback loop, have been investigated, the system-level properties of the segmentation clock remain largely unknown. To explore these characteristics, we have examined the response of a normally oscillating clock in zebrafish to experimental stimuli using in vivo mosaic experiments and mathematical simulation. We demonstrate that the segmentation clock behaves as a coupled oscillator, by showing that Notch-dependent intercellular communication, the activity of which is regulated by the internal hairy oscillator, couples neighbouring cells to facilitate synchronized oscillation. Furthermore, the oscillation phase of individual oscillators fluctuates due to developmental noise such as stochastic gene expression and active cell proliferation. The intercellular coupling was found to have a crucial role in minimizing the effects of this noise to maintain coherent oscillation.
journal_name
Naturejournal_title
Natureauthors
Horikawa K,Ishimatsu K,Yoshimoto E,Kondo S,Takeda Hdoi
10.1038/nature04861subject
Has Abstractpub_date
2006-06-08 00:00:00pages
719-23issue
7094eissn
0028-0836issn
1476-4687pii
nature04861journal_volume
441pub_type
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