Abstract:
:A short exposure of primary cultures of mouse mammary tumour cells to glucocorticoids results in at least a three-fold stimulation of mammary tumour virus (MTV) production. Specific interaction of glucocorticoids with the cytoplasmic and nuclear receptors can also be demonstrated. The biological potency of various steroids to stimulate MTV is related directly to the retention of the steroid-receptor complex in the nuclei. Progesterone has a high affinity for the cytoplasmic receptor, is not retained by the nuclei and does not stimulate or block the basal level of MTV production. It is, however, quite effective in abolishing the glucocorticoid-mediated stimulation of MTV and thus behaves as an antagonist of glucocorticoid.
journal_name
Naturejournal_title
Natureauthors
Shyamala G,Dickson Cdoi
10.1038/262107a0subject
Has Abstractpub_date
1976-07-08 00:00:00pages
107-12issue
5564eissn
0028-0836issn
1476-4687journal_volume
262pub_type
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