Abstract:
:Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation specifically affects the migration of the heart precursors to the midline. We found that mutant cells transplanted into a wild-type embryo migrate normally and that wild-type cells in a mutant embryo fail to migrate, suggesting that mil may be involved in generating an environment permissive for migration. We isolated mil by positional cloning and show that it encodes a member of the lysosphingolipid G-protein-coupled receptor family. We also show that sphingosine-1-phosphate is a ligand for Mil, and that it activates several downstream signalling events that are not activated by the mutant alleles. These data reveal a new role for lysosphingolipids in regulating cell migration during vertebrate development and provide the first molecular clues into the fusion of the bilateral heart primordia during organogenesis of the heart.
journal_name
Naturejournal_title
Natureauthors
Kupperman E,An S,Osborne N,Waldron S,Stainier DYdoi
10.1038/35018092keywords:
subject
Has Abstractpub_date
2000-07-13 00:00:00pages
192-5issue
6792eissn
0028-0836issn
1476-4687journal_volume
406pub_type
杂志文章相关文献
NATURE文献大全abstract::Large panels of comprehensively characterized human cancer models, including the Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study genetic variants, candidate targets, and small-molecule and biological therapeutics and to identify new marker-driven cancer dependencies. To imp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1186-3
更新日期:2019-05-01 00:00:00
abstract::Recent studies have shown that normal cellular sequences on chromosome 13 are lost during the development of retinoblastomas and that sequences on chromosome 11 are similarly lost during the development of Wilms' kidney tumours and embryonal tumours. Cells from these tumors have been found to contain either the patern...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/318377a0
更新日期:1985-11-28 00:00:00
abstract::Models and simulations of the epoch of reionization predict that spectra of the 21-centimetre transition of atomic hydrogen will show a clear fluctuation peak, at a redshift and scale, respectively, that mark the central stage of reionization and the characteristic size of ionized bubbles. This is based on the assumpt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12999
更新日期:2014-02-13 00:00:00
abstract::Mammalian circadian clocks consist of complex integrated feedback loops that cannot be elucidated without comprehensive measurement of system dynamics and determination of network structures. To dissect such a complicated system, we took a systems-biological approach based on genomic, molecular and cell biological tec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00906
更新日期:2002-08-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-020-2789-4
更新日期:2020-10-01 00:00:00
abstract::During the biosynthesis of selenoproteins in both prokaryotes and eukaryotes, selenocysteine is cotranslationally incorporated into the nascent polypeptide chain through a process directed by a UGA codon that normally functions as a stop codon. Recently, four genes have been identified whose products are required for ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/342453a0
更新日期:1989-11-23 00:00:00
abstract::DNA repair by homologous recombination is highly suppressed in G1 cells to ensure that mitotic recombination occurs solely between sister chromatids. Although many homologous recombination factors are cell-cycle regulated, the identity of the events that are both necessary and sufficient to suppress recombination in G...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16142
更新日期:2015-12-17 00:00:00
abstract::Contact inhibition of locomotion was discovered by Abercrombie more than 50 years ago and describes the behaviour of fibroblast cells confronting each other in vitro, where they retract their protrusions and change direction on contact. Its failure was suggested to contribute to malignant invasion. However, the molecu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07441
更新日期:2008-12-18 00:00:00
abstract::Alzheimer's disease (AD) affects more than 30% of people over 80 years of age. The aetiology and pathogenesis of this progressive dementia is poorly understood, but symptomatic disease is associated histopathologically with amyloid plaques, neurofibrillary tangles and neuronal loss primarily in the temporal lobe and n...
journal_title:Nature
pub_type: 杂志文章,收录出版
doi:10.1038/354476a0
更新日期:1991-12-12 00:00:00
abstract::Neurons develop a highly polarized morphology consisting of dendrites and a long axon. Both axons and dendrites contain microtubules and microtubule-associated proteins (MAPs) with characteristic structures. Among MAPs, MAP2 is specifically expressed in dendrites whereas MAP2C and tau are abundant in the axon. But the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/360674a0
更新日期:1992-12-17 00:00:00
abstract::Living organisms rely on simultaneous reactions catalysed by mutually compatible and selective enzymes to synthesize complex natural products and other metabolites. To combine the advantages of these biological systems with the reactivity of artificial chemical catalysts, chemists have devised sequential, concurrent, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0413-7
更新日期:2018-08-01 00:00:00
abstract::The ability to excise (repair) UV-induced pyrimidine dimers in Escherichia coli is not related to its ability to remove N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced O6-methylguanine (O6-MeG) from DNA. It was therefore surprising that certain xeroderma pigmentosum cell lines, deficient in dimer excision, were al...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289417a0
更新日期:1981-01-29 00:00:00
abstract::At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength. Rapid frequency-dependent changes in synaptic strength have key roles in sensory adaptation, gain control and many other neural computations. However, some auditory, vestibular and cerebellar synapses maintain constant streng...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24474
更新日期:2017-11-23 00:00:00
abstract::DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization, followed by passive loss that reaches a minimum at the blastocyst stage. However, this model is based on limited data, and so far no base-resoluti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10960
更新日期:2012-03-28 00:00:00
abstract::Environmental change has altered the phenology, morphological traits and population dynamics of many species. However, the links underlying these joint responses remain largely unknown owing to a paucity of long-term data and the lack of an appropriate analytical framework. Here we investigate the link between phenoty...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09210
更新日期:2010-07-22 00:00:00
abstract::How black holes accrete surrounding matter is a fundamental yet unsolved question in astrophysics. It is generally believed that matter is absorbed into black holes via accretion disks, the state of which depends primarily on the mass-accretion rate. When this rate approaches the critical rate (the Eddington limit), t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16452
更新日期:2016-01-07 00:00:00
abstract::In vitro mutagenesis of sequences required for the self-catalysed cleavage of a plant virus satellite RNA has allowed definition of an RNA segment with endoribonuclease activity. General rules have been deduced for the design of new RNA enzymes capable of highly specific RNA cleavage, and have been successfully tested...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/334585a0
更新日期:1988-08-18 00:00:00
abstract::Electrons in a single sheet of graphene behave quite differently from those in traditional two-dimensional electron systems. Like massless relativistic particles, they have linear dispersion and chiral eigenstates. Furthermore, two sets of electrons centred at different points in reciprocal space ('valleys') have this...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09330
更新日期:2010-09-09 00:00:00
abstract::The superposition principle is a fundamental tenet of quantum mechanics. It allows a quantum system to be 'in two places at the same time', because the quantum state of a physical system can simultaneously include measurably different physical states. The preparation and use of such superposed states forms the basis o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08005
更新日期:2009-05-28 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0796-5
更新日期:2018-12-01 00:00:00
abstract::The global land and ocean carbon sinks have increased proportionally with increasing carbon dioxide emissions during the past decades1. It is thought that Northern Hemisphere lands make a dominant contribution to the global land carbon sink2-7; however, the long-term trend of the northern land sink remains uncertain. ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/s41586-019-1078-6
更新日期:2019-04-01 00:00:00
abstract::The evolution of self-fertilization in hermaphrodites is opposed by costs that decrease the value of self progeny relative to that of outcross progeny. However, self-fertilization is common in plants; 20% are highly selfing and 33% are intermediate between selfing and outcrossing. Darwin proposed an adaptive benefit o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02776
更新日期:2004-08-19 00:00:00
abstract::The biochemical and morphological differentiation of actinomycetes makes them academically and economically interesting. Their secondary metabolites provide the majority of medically and agriculturally important antibiotics (streptomycete genes may also be the primary source of clinically important antibiotic resistan...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/286525a0
更新日期:1980-07-31 00:00:00
abstract::Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumour progression. Angiostatin, a proteolytic fragment of plasminogen that was first isolated from the serum and urine of tumour-bearing mice, inhibits angiogenesis and thereby growth of primary and metastatic tumours. Radiothe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/28412
更新日期:1998-07-16 00:00:00
abstract::The vasa gene product of Drosophila melanogaster is required only in the female germ line. Progeny of females homozygous for vasa mutations lack posterior structures and pole cells. Isolation and characterization of vasa genomic and complementary DNA clones show that the transcript is abundant in the female germ line ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335611a0
更新日期:1988-10-13 00:00:00
abstract::The human AIDS viruses human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) represent cross-species (zoonotic) infections. Although the primate reservoir of HIV-2 has been clearly identified as the sooty mangabey (Cercocebus atys), the origin of HIV-1 remains uncertain. Viruses related to HIV-1 have been iso...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/17130
更新日期:1999-02-04 00:00:00
abstract::Time-of-flight mass spectrometry-most notably matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) spectrometry-is an important class of techniques for the study of proteins and other biomolecules. Although these techniques provide excellent performance for masses up to about 20,000 daltons, there ha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35582
更新日期:1998-02-12 00:00:00
abstract::Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12504
更新日期:2013-09-05 00:00:00
abstract::Membrane-bound receptors often form large assemblies resulting from binding to soluble ligands, cell-surface molecules on other cells and extracellular matrix proteins. For example, the association of membrane proteins with proteins on different cells (trans-interactions) can drive the oligomerization of proteins on t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10183
更新日期:2011-07-27 00:00:00
abstract::The role of adaptive immunity in early cancer development is controversial. Here we show that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver disease is accompanied by accumulation of liver-resident immunoglobulin-A-producing (IgA+) cells. These cells also express programmed death l...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24302
更新日期:2017-11-16 00:00:00