Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.

abstract：:Metamaterials are artificial optical media composed of sub-wavelength metallic and dielectric building blocks that feature optical phenomena not present in naturally occurring materials. Although they can serve as the basis for unique optical devices that mould the flow of light in unconventional ways, three-dimension...

journal_title：Nature

authors： High AA,Devlin RC,Dibos A,Polking M,Wild DS,Perczel J,de Leon NP,Lukin MD,Park H

更新日期：2015-06-11 00:00:00

abstract：:Transport of calcium ions across membranes and against a thermodynamic gradient is essential to many biological processes, including muscle contraction, the citric acid cycle, glycogen metabolism, release of neurotransmitters, vision, biological signal transduction and immune response. Synthetic systems that transport...

journal_title：Nature

authors： Bennett IM,Farfano HM,Bogani F,Primak A,Liddell PA,Otero L,Sereno L,Silber JJ,Moore AL,Moore TA,Gust D

更新日期：2002-11-28 00:00:00

abstract：:The transcription factor NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB-family polypeptides, which include Rel-A, c-Rel, Rel-B, NF-kappaB/p50 and NF-kappaB2/p52 . The NF-kappaB1 gene encodes a larger precursor protein, p105, from which p50 is produced constitutively by proteasome-med...

journal_title：Nature

authors： Belich MP,Salmerón A,Johnston LH,Ley SC

更新日期：1999-01-28 00:00:00

abstract：:The ability to form integrated circuits on flexible sheets of plastic enables attributes (for example conformal and flexible formats and lightweight and shock resistant construction) in electronic devices that are difficult or impossible to achieve with technologies that use semiconductor wafers or glass plates as sub...

journal_title：Nature

authors： Cao Q,Kim HS,Pimparkar N,Kulkarni JP,Wang C,Shim M,Roy K,Alam MA,Rogers JA

更新日期：2008-07-24 00:00:00

abstract：:T200, a major cell-surface glycoprotein on lymphoid cells, exists in several forms with different electrophoretic mobilities. These forms have been correlated with different classes of lymphoid cell. The smaller forms, with molecular weights (MWs) of congruent to 170,000 and 180,000 are found predominantly on T cells ...

journal_title：Nature

authors： Coffman RL,Weissman IL

更新日期：1981-02-19 00:00:00

abstract：:Humans differ from other primates in their significantly lengthened growth period. The persistence of a fetal pattern of brain growth after birth is another important feature of human development. Here we present the results of an analysis of the 1.8-million-year-old Mojokerto child (Perning 1, Java), the only well pr...

journal_title：Nature

authors： Coqueugniot H,Hublin JJ,Veillon F,Houët F,Jacob T

更新日期：2004-09-16 00:00:00

abstract：: ...

journal_title：Nature

authors： Gewin V

更新日期：2018-12-01 00:00:00

abstract：:Single-stranded RNA viruses encompass broad classes of infectious agents and cause the common cold, cancer, AIDS and other serious health threats. Viral replication is regulated at many levels, including the use of conserved genomic RNA structures. Most potential regulatory elements in viral RNA genomes are uncharacte...

journal_title：Nature

authors： Watts JM,Dang KK,Gorelick RJ,Leonard CW,Bess JW Jr,Swanstrom R,Burch CL,Weeks KM

更新日期：2009-08-06 00:00:00

abstract：:Recently, a class of protein antigens of high relative molecular mass (Mt) which can induce protective immunity against blood-stage malaria has been identified. In Plasmodium falciparum the protein has a Mr of approximately 195,000 (P195). It is the precursor of three proteins of Mr 83,000 (83K), 42K and 19K which are...

journal_title：Nature

authors： Holder AA,Lockyer MJ,Odink KG,Sandhu JS,Riveros-Moreno V,Nicholls SC,Hillman Y,Davey LS,Tizard ML,Schwarz RT

更新日期：1985-09-19 00:00:00

abstract：:Most neurons of the mammalian central nervous system (CNS) lose the ability to regenerate severed axons in vivo after a certain point in development. At least part of this loss in regenerative potential is intrinsic to neurons. Although embryonic retinal ganglion cells (RGCs) can grow axons into tectum of any age, mos...

journal_title：Nature

authors： Chen DF,Schneider GE,Martinou JC,Tonegawa S

更新日期：1997-01-30 00:00:00

abstract：:Taubenberger et al. claim that the 1918 influenza virus was derived from an avian source and adapted to humans shortly before the pandemic. However, we do not believe that this conclusion, which has been widely disseminated in the popular press and in scientific journals, is supported by their phylogenetic evidence. ...

journal_title：Nature

authors： Antonovics J,Hood ME,Baker CH

更新日期：2006-04-27 00:00:00

abstract：:Microcrystals of the lipoprotein-phosphoprotein complex which are found in the oocytes of Xenopus laevis were examined using electron microscopy. Analysis of Fourier transforms of the images of the (010) and (001) projections showed the space group to be P2(1)22(1). Ten projections were combined to produce a map of th...

journal_title：Nature

authors： Ohlendorf DH,Wrenn RF,Banaszak LJ

更新日期：1978-03-02 00:00:00

abstract：:Quantum physics has remarkable distinguishing characteristics. For example, it gives only probabilistic predictions (non-determinism) and does not allow copying of unknown states (no-cloning). Quantum correlations may be stronger than any classical ones, but information cannot be transmitted faster than light (no-sign...

journal_title：Nature

authors： Pawłowski M,Paterek T,Kaszlikowski D,Scarani V,Winter A,Zukowski M

更新日期：2009-10-22 00:00:00

abstract：:Neurons in the developing rodent cortex are generated from radial glial cells that function as neural stem cells. These epithelial cells line the cerebral ventricles and generate intermediate progenitor cells that migrate into the subventricular zone (SVZ) and proliferate to increase neuronal number. The developing hu...

journal_title：Nature

authors： Hansen DV,Lui JH,Parker PR,Kriegstein AR

更新日期：2010-03-25 00:00:00

abstract：:Acetylcholine and dopamine are key neurotransmitters in the extrapyramidal motor system, where they are thought to lie in a 'functional balance' brought about by interactions between the terminals of the dopamine-containing nigrostriatal tract and the cholinergic interneurones of the striatum. The precise nature of th...

journal_title：Nature

authors： Graybiel AM,Baughman RW,Eckenstein F

更新日期：1986-10-16 00:00:00

abstract：:Mutations in the Schizosaccharomyces pombe cdc8 gene impair cytokinesis. Here we clone cdc8+ and find that it encodes a novel tropomyosin. Gene disruption results in lethal arrest of the cell cycle, but spore germination, cell growth, DNA replication and mitosis are all unaffected. Haploid cdc8 gene disruptants are re...

journal_title：Nature

authors： Balasubramanian MK,Helfman DM,Hemmingsen SM

更新日期：1992-11-05 00:00:00

abstract：:The steel of Damascus blades, which were first encountered by the Crusaders when fighting against Muslims, had features not found in European steels--a characteristic wavy banding pattern known as damask, extraordinary mechanical properties, and an exceptionally sharp cutting edge. Here we use high-resolution transmis...

journal_title：Nature

authors： Reibold M,Paufler P,Levin AA,Kochmann W,Pätzke N,Meyer DC

更新日期：2006-11-16 00:00:00

abstract：:The evolutionary biologist "studies the steps by which the miraculous adaptations so characteristic of every aspect of the organic world have evolved". But the general nature of such adaptive steps is still unclear. Evolution is often thought to be random and dependent on unpredictable events. In this light, one might...

journal_title：Nature

authors： Gerrish P

更新日期：2001-09-20 00:00:00

abstract：:This is an exciting time for scientific discovery that aims to reduce the frequency and impact of neurological, mental health and substance-use disorders. As it became increasingly clear that low- and middle-income countries have a disproportionate share of these disorders, and that many of the problems are best addre...

journal_title：Nature

authors： Silberberg D,Anand NP,Michels K,Kalaria RN

更新日期：2015-11-19 00:00:00

abstract：:Q beta replicase, in the absence of added template, will synthesize RNA autocatalytically. A variety of small RNa species, termed '6S RNAs' are generated. As this reaction purportedly occurs in the absence of template, it has been termed 'de novo' RNA synthesis. The question of whether Q beta replicase can polymerize ...

journal_title：Nature

authors： Hill D,Blumenthal T

更新日期：1983-01-27 00:00:00

abstract：:Multiple sclerosis is commonly associated with a local humoral immune response within the central nervous system. A hallmark of this intrathecal response is the presence of electrophoretically demonstrable oligoclonal bands of IgG in the cerebrospinal fluid (CSF) of up to 95% of patients. Observations indicating that ...

journal_title：Nature

authors： Vandvik B,Norrby E

更新日期：1989-04-27 00:00:00

abstract：:Antisense oligodeoxynucleotides (ODNs) have great promise as agents for the specific manipulation of gene expression. Until recently, nonspecific effects of ODNs often confounded the interpretation of antisense studies. Improvements in ODN chemistry and cellular delivery techniques now allow for more potent and specif...

journal_title：Nature

authors： Wagner RW

更新日期：1994-11-24 00:00:00

abstract：:Cpdm (chronic proliferative dermatitis) mice develop chronic dermatitis and an immunodeficiency with increased serum IgM, symptoms that resemble those of patients with X-linked hyper-IgM syndrome and hypohydrotic ectodermal dysplasia (XHM-ED), which is caused by mutations in NEMO (NF-κB essential modulator; also known...

journal_title：Nature

authors： Tokunaga F,Nakagawa T,Nakahara M,Saeki Y,Taniguchi M,Sakata S,Tanaka K,Nakano H,Iwai K

更新日期：2011-03-31 00:00:00

abstract：:Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioural functions1,2; however, the precise circuit computations remain unknown. One potentially unifying model by which dopamine may underlie a diversity of functions is by modulating the signal-to-noise ratio in subpopulations of mPFC ...

journal_title：Nature

authors： Vander Weele CM,Siciliano CA,Matthews GA,Namburi P,Izadmehr EM,Espinel IC,Nieh EH,Schut EHS,Padilla-Coreano N,Burgos-Robles A,Chang CJ,Kimchi EY,Beyeler A,Wichmann R,Wildes CP,Tye KM

更新日期：2018-11-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Nakar E

更新日期：2019-01-01 00:00:00

abstract：:Heterotrimeric G-proteins bind to cell-surface receptors and are integral in transmission of signals from outside the cell. Upon activation of the Galpha subunit by binding of GTP, the Galpha and Gbetagamma subunits dissociate and interact with effector proteins for signal transduction. Regulatory proteins with the 19...

journal_title：Nature

authors： Kimple RJ,Kimple ME,Betts L,Sondek J,Siderovski DP

更新日期：2002-04-25 00:00:00

abstract：:Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative analyses. Here we present a large-scale evolutionary study of lnc...

journal_title：Nature

authors： Necsulea A,Soumillon M,Warnefors M,Liechti A,Daish T,Zeller U,Baker JC,Grützner F,Kaessmann H

更新日期：2014-01-30 00:00:00

abstract：:Zygotic genome activation in metazoans typically occurs several hours to a day after fertilization, and thus maternal RNAs and proteins drive early animal embryo development. In plants, despite several molecular studies of post-fertilization transcriptional activation, the timing of zygotic genome activation remains a...

journal_title：Nature

authors： Del Toro-De León G,García-Aguilar M,Gillmor CS

更新日期：2014-10-30 00:00:00

abstract：:The mec-2 gene is required for the function of a set of six touch receptor neurons in the nematode Caenorhabditis elegans; mec-2 mutants, which are touch-insensitive, have touch cells that appear morphologically normal. Gene interaction studies suggest that mec-2 positively regulates the activity of the putative mecha...

journal_title：Nature

authors： Huang M,Gu G,Ferguson EL,Chalfie M

更新日期：1995-11-16 00:00:00

abstract：:Lung epithelial cells can influence immune responses to airway allergens. Airway epithelial cells also undergo apoptosis after encountering environmental allergens; yet, relatively little is known about how these are cleared, and their effect on airway inflammation. Here we show that airway epithelial cells efficientl...

journal_title：Nature

authors： Juncadella IJ,Kadl A,Sharma AK,Shim YM,Hochreiter-Hufford A,Borish L,Ravichandran KS

更新日期：2013-01-24 00:00:00