Abstract:
:Multiple sclerosis is commonly associated with a local humoral immune response within the central nervous system. A hallmark of this intrathecal response is the presence of electrophoretically demonstrable oligoclonal bands of IgG in the cerebrospinal fluid (CSF) of up to 95% of patients. Observations indicating that a major part of the CSF IgG in some patients may represent antibodies to SV5, a simian virus closely related to human parainfluenza type 2 virus, were recently reported by Goswami et al. We have studied thirty patients with multiple sclerosis, but although we find intrathecal synthesis of IgG antibodies reacting with SV5 in seven of these, the antibodies were not associated with oligoclonal CSF IgG bands and could in each case be explained as potentially cross-reacting antibodies to other paramyxoviruses known to be human pathogens. We have therefore been unable to confirm that SV5 may be a major intrathecal immunogen in multiple sclerosis.
journal_name
Naturejournal_title
Natureauthors
Vandvik B,Norrby Edoi
10.1038/338769a0subject
Has Abstractpub_date
1989-04-27 00:00:00pages
769-71issue
6218eissn
0028-0836issn
1476-4687journal_volume
338pub_type
杂志文章相关文献
NATURE文献大全abstract::Tissue-specific transcription factors regulate several important aspects of embryonic development. They must function in the context of DNA assembled into the higher-order structure of chromatin. Enzymatic complexes such as the Swi/Snf-like BAF complexes remodel chromatin to allow the transcriptional machinery access ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03071
更新日期:2004-11-04 00:00:00
abstract::Macrophages are pivotal constituents of the innate immune system, vital for recognition and elimination of microbial pathogens. Macrophages use Toll-like receptors (TLRs) to detect pathogen-associated molecular patterns--including bacterial cell wall components, such as lipopolysaccharide or lipoteichoic acid, and vir...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02405
更新日期:2004-03-18 00:00:00
abstract::Earth's climate history is often understood by breaking it down into constituent climatic epochs1. Over the Common Era (the past 2,000 years) these epochs, such as the Little Ice Age2-4, have been characterized as having occurred at the same time across extensive spatial scales5. Although the rapid global warming seen...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/s41586-019-1401-2
更新日期:2019-07-01 00:00:00
abstract::Molluscs (snails, octopuses, clams and their relatives) have a great disparity of body plans and, among the animals, only arthropods surpass them in species number. This diversity has made Mollusca one of the best-studied groups of animals, yet their evolutionary relationships remain poorly resolved. Open questions ha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10526
更新日期:2011-10-26 00:00:00
abstract::Glycosaminoglycans such as heparan sulphate and chondroitin sulphate are extracellular sugar chains involved in intercellular signalling. Disruptions of genes encoding enzymes that mediate glycosaminoglycan biosynthesis have severe consequences in Drosophila and mice. Mutations in the Drosophila gene sugarless, which ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01635
更新日期:2003-05-22 00:00:00
abstract::Calnexin, an endoplasmic reticulum transmembrane protein, represents a new type of molecular chaperone that selectively associates in a transient fashion with newly synthesized monomeric glycoproteins in HepG2 cells. Calnexin only recognizes glycoproteins when they are incompletely folded. Dissociation of glycoprotein...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/364771a0
更新日期:1993-08-26 00:00:00
abstract::Critical issues in the cognitive neuroscience of language are whether there are multiple systems for the representation of meaning, perhaps organized by processing system (such as vision or language), and whether further subsystems are distinguishable within these larger ones. We describe here a patient (K.R.) with ce...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359060a0
更新日期:1992-09-03 00:00:00
abstract::Lantibiotics are a class of peptide antibiotics that contain one or more thioether bonds. The lantibiotic nisin is an antimicrobial peptide that is widely used as a food preservative to combat food-borne pathogens. Nisin contains dehydroalanine and dehydrobutyrine residues that are formed by the dehydration of Ser/Thr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13888
更新日期:2015-01-22 00:00:00
abstract::Environmental change has altered the phenology, morphological traits and population dynamics of many species. However, the links underlying these joint responses remain largely unknown owing to a paucity of long-term data and the lack of an appropriate analytical framework. Here we investigate the link between phenoty...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09210
更新日期:2010-07-22 00:00:00
abstract::Prions are believed to be infectious, self-propagating polymers of otherwise soluble, host-encoded proteins. This concept is now strongly supported by the recent findings that amyloid fibrils of recombinant prion proteins from yeast, Podospora anserina and mammals can induce prion phenotypes in the corresponding hosts...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03793
更新日期:2005-06-09 00:00:00
abstract::When simian virus 40 (SV40) infects host cells, the viral genes are expressed in two phases. Early in infection, the virus genome is transcribed and translated to yield two related proteins, 'large T' and 'small t' antigens. Later the rate of synthesis of the early messenger RNA falls and the viral genes coding for th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289810a0
更新日期:1981-02-26 00:00:00
abstract::Bananas (Musa spp.), including dessert and cooking types, are giant perennial monocotyledonous herbs of the order Zingiberales, a sister group to the well-studied Poales, which include cereals. Bananas are vital for food security in many tropical and subtropical countries and the most popular fruit in industrialized c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11241
更新日期:2012-08-09 00:00:00
abstract::The collagens represent an interesting example of a structurally related but genetically distinct family of proteins. Type I, the most abundant of the vertebrate collagens, comprises two pro alpha 1(I) chains and one pro alpha 2(I) chain, each containing terminal propeptides and a central domain of 338 (Gly, X, Y) rep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310337a0
更新日期:1984-07-26 00:00:00
abstract::Growing concern about how loss of biodiversity will affect ecosystems has stimulated numerous studies. Although most studies have assumed that species go extinct randomly, species often go extinct in order of their sensitivity to a stress that intensifies through time (such as climate change). Here we show that the co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02515
更新日期:2004-05-13 00:00:00
abstract::The quantum-level interplay between geometry, topology and correlation is at the forefront of fundamental physics1-15. Kagome magnets are predicted to support intrinsic Chern quantum phases owing to their unusual lattice geometry and breaking of time-reversal symmetry14,15. However, quantum materials hosting ideal spi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2482-7
更新日期:2020-07-01 00:00:00
abstract::The death of massive stars produces a variety of supernovae, which are linked to the structure of the exploding stars. The detection of several precursor stars of type II supernovae has been reported (see, for example, ref. 3), but we do not yet have direct information on the progenitors of the hydrogen-deficient type...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05825
更新日期:2007-06-14 00:00:00
abstract::In epithelial Madin-Darby canine kidney (MDCK) cells newly synthesized molecules are sorted in the trans-Golgi network and directly delivered to their apical and basolateral surface destinations. Sorting is mediated by signals in the cytoplasmic domains of basolateral transmembrane proteins whereas glycosylphosphatidy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/378096a0
更新日期:1995-11-02 00:00:00
abstract::Copy number variants (CNVs) are major contributors to genetic disorders. We have dissected a region of the 16p11.2 chromosome--which encompasses 29 genes--that confers susceptibility to neurocognitive defects when deleted or duplicated. Overexpression of each human transcript in zebrafish embryos identified KCTD13 as ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11091
更新日期:2012-05-16 00:00:00
abstract::Germ cells must develop along distinct male or female paths to produce the sperm or eggs required for sexual reproduction. In both mouse and Drosophila, the sexual identity of germ cells is influenced by the sex of the surrounding somatic tissue (for example, refs 1, 2, reviewed in refs 3, 4); however, little is known...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03849
更新日期:2005-07-28 00:00:00
abstract::Meristems are distinctive regions of plants that have capacity for continuous growth. Their developmental activity generates the majority of plant organs. It is currently unknown how cell division and cell differentiation are orchestrated in meristems, although genetic studies have demonstrated the relevance of a prop...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/36856
更新日期:1997-11-20 00:00:00
abstract::Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35018092
更新日期:2000-07-13 00:00:00
abstract::Long-term potentiation of chemical synapses is closely related to memory and learning. Studies of this process have concentrated on chemically mediated excitatory synapses. By contrast, activity-dependent modification of gap junctions, which also widely exist in higher structures such as hippocampus and neocortex, has...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/348542a0
更新日期:1990-12-06 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,信件
doi:10.1038/d41586-019-00232-8
更新日期:2019-01-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-019-00676-y
更新日期:2019-02-01 00:00:00
abstract::Titan, the largest moon of Saturn, is the only satellite in the Solar System with a substantial atmosphere. The atmosphere is poorly understood and obscures the surface, leading to intense speculation about Titan's nature. Here we present observations of Titan from the imaging science experiment onboard the Cassini sp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03436
更新日期:2005-03-10 00:00:00
abstract::Among the pathological effects in man following infection with Mycoplasma pneumoniae is a transient autoimmune disorder characterized by the presence of high-titre erythrocyte autoantibodies (cold agglutinins). These autoantibodies are usually directed against the carbohydrate antigen termed I (ref. 3) which consists ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307560a0
更新日期:1984-02-09 00:00:00
abstract::A short exposure of primary cultures of mouse mammary tumour cells to glucocorticoids results in at least a three-fold stimulation of mammary tumour virus (MTV) production. Specific interaction of glucocorticoids with the cytoplasmic and nuclear receptors can also be demonstrated. The biological potency of various ste...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/262107a0
更新日期:1976-07-08 00:00:00
abstract::Microscopic diamond was recently discovered in oxidized acid residues from several carbonaceous chondrite meteorites (for example, the C delta component of the Allende meteorite). Some of the reported properties of C delta seem in conflict with those expected of diamond. Here we present high spatial resolution analy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332611a0
更新日期:1988-04-14 00:00:00
abstract::The amplitude and frequency of laser light can be routinely measured and controlled on a femtosecond (10(-15) s) timescale. However, in pulses comprising just a few wave cycles, the amplitude envelope and carrier frequency are not sufficient to characterize and control laser radiation, because evolution of the light f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01414
更新日期:2003-02-06 00:00:00
abstract::The mouse major transplantation antigens H-2K, H-2D and H-2L are highly polymorphic cell-surface glycoproteins which may serve as recognition elements in cell-cell interactions. Each antigen possesses a number of alloantigenic determinants defined by antisera of various specificities. Recently, monoclonal antibodies h...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/300755a0
更新日期:1982-12-23 00:00:00