N-glycans as apical sorting signals in epithelial cells.

abstract：:Calcium influx through voltage-sensitive Ca2+ channels is the normal physiological stimulus for the activity-dependent release of neurotransmitters at synaptic contacts. It has been postulated that presynaptic inhibition of transmitter release is due to a reduction in Ca2+ influx at the nerve terminal, which could res...

journal_title：Nature

authors： Toth PT,Bindokas VP,Bleakman D,Colmers WF,Miller RJ

更新日期：1993-08-12 00:00:00

abstract：:Nitrogen (N) limits the productivity of many ecosystems worldwide, thereby restricting the ability of terrestrial ecosystems to offset the effects of rising atmospheric CO(2) emissions naturally. Understanding input pathways of bioavailable N is therefore paramount for predicting carbon (C) storage on land, particular...

journal_title：Nature

authors： Morford SL,Houlton BZ,Dahlgren RA

更新日期：2011-08-31 00:00:00

abstract：:Osteocalcin is the most abundant noncollagenous protein in bone, and its concentration in serum is closely linked to bone metabolism and serves as a biological marker for the clinical assessment of bone disease. Although its precise mechanism of action is unclear, osteocalcin influences bone mineralization, in part th...

journal_title：Nature

authors： Hoang QQ,Sicheri F,Howard AJ,Yang DS

更新日期：2003-10-30 00:00:00

abstract：:The actin cytoskeleton is regulated by GTP-hydrolysing proteins, the Rho GTPases, which act as molecular switches in diverse signal-transduction processes. Various bacterial toxins can inactivate Rho GTPases by ADP-ribosylation or glucosylation. Previous research has identified Rho proteins as putative targets for Esc...

journal_title：Nature

authors： Schmidt G,Sehr P,Wilm M,Selzer J,Mann M,Aktories K

更新日期：1997-06-12 00:00:00

abstract：:Cells are organized on length scales ranging from ångström to micrometres. However, the mechanisms by which ångström-scale molecular properties are translated to micrometre-scale macroscopic properties are not well understood. Here we show that interactions between diverse synthetic, multivalent macromolecules (includ...

journal_title：Nature

authors： Li P,Banjade S,Cheng HC,Kim S,Chen B,Guo L,Llaguno M,Hollingsworth JV,King DS,Banani SF,Russo PS,Jiang QX,Nixon BT,Rosen MK

更新日期：2012-03-07 00:00:00

abstract：:The highly conserved protein gamma-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified gamma-tubulin complex from Xenopus consisting of at least seven different proteins is seen to have an open ring structure. This complex acts as an active microtubule-nucl...

journal_title：Nature

authors： Zheng Y,Wong ML,Alberts B,Mitchison T

更新日期：1995-12-07 00:00:00

abstract：:Compartments in food webs are subgroups of taxa in which many strong interactions occur within the subgroups and few weak interactions occur between the subgroups. Theoretically, compartments increase the stability in networks, such as food webs. Compartments have been difficult to detect in empirical food webs becaus...

journal_title：Nature

authors： Krause AE,Frank KA,Mason DM,Ulanowicz RE,Taylor WW

更新日期：2003-11-20 00:00:00

abstract：: ...

journal_title：Nature

authors： Rivest S

更新日期：2018-11-01 00:00:00

abstract：:The hypothesis that animal population dynamics may be synchronized by climate is highly relevant in the context of climate change because it suggests that several populations might respond simultaneously to climatic trends if their dynamics are entrained by environmental correlation. The dynamics of many species throu...

journal_title：Nature

authors： Post E,Forchhammer MC

更新日期：2002-11-14 00:00:00

abstract：:Rho is the essential RNA helicase that sets the borders between transcription units and adjusts transcriptional yield to translational needs in bacteria. Although Rho was the first termination factor to be discovered, the actual mechanism by which it reaches and disrupts the elongation complex (EC) is unknown. Here we...

journal_title：Nature

authors： Epshtein V,Dutta D,Wade J,Nudler E

更新日期：2010-01-14 00:00:00

abstract：: ...

journal_title：Nature

authors： Narayan A

更新日期：2019-03-01 00:00:00

abstract：:Non-impulsive seismic radiation or 'tremor' has long been observed at volcanoes and more recently around subduction zones. Although the number of observations of non-volcanic tremor is steadily increasing, the causative mechanism remains unclear. Some have attributed non-volcanic tremor to the movement of fluids, whil...

journal_title：Nature

authors： Rubinstein JL,Vidale JE,Gomberg J,Bodin P,Creager KC,Malone SD

更新日期：2007-08-02 00:00:00

abstract：:Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell...

journal_title：Nature

authors： Rajewsky N,Almouzni G,Gorski SA,Aerts S,Amit I,Bertero MG,Bock C,Bredenoord AL,Cavalli G,Chiocca S,Clevers H,De Strooper B,Eggert A,Ellenberg J,Fernández XM,Figlerowicz M,Gasser SM,Hubner N,Kjems J,Knoblich JA,Kra

更新日期：2020-11-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Segal M

更新日期：2018-11-01 00:00:00

abstract：:In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferato...

journal_title：Nature

authors： Kersten S,Desvergne B,Wahli W

更新日期：2000-05-25 00:00:00

abstract：:Diapycnal mixing (across density surfaces) is an important process in the global ocean overturning circulation. Mixing in the interior of most of the ocean, however, is thought to have a magnitude just one-tenth of that required to close the global circulation by the downward mixing of less dense waters. Some of this ...

journal_title：Nature

authors： Watson AJ,Ledwell JR,Messias MJ,King BA,Mackay N,Meredith MP,Mills B,Naveira Garabato AC

更新日期：2013-09-19 00:00:00

abstract：:The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating reg...

journal_title：Nature

authors： Ptashne M,Gann A

更新日期：1997-04-10 00:00:00

abstract：:The innate immune defence of multicellular organisms against microbial pathogens requires cellular collaboration. Information exchange allowing immune cells to collaborate is generally attributed to soluble protein factors secreted by pathogen-sensing cells. Cytokines, such as type I interferons (IFNs), serve to alert...

journal_title：Nature

authors： Ablasser A,Schmid-Burgk JL,Hemmerling I,Horvath GL,Schmidt T,Latz E,Hornung V

更新日期：2013-11-28 00:00:00

abstract：:When an intense laser pulse is focused into a gas, the light-atom interaction that occurs as atoms are ionized results in an extremely nonlinear optical process--the generation of high harmonics of the driving laser frequency. Harmonics that extend up to orders of about 300 have been reported, some corresponding to ph...

journal_title：Nature

authors： Bartels R,Backus S,Zeek E,Misoguti L,Vdovin G,Christov IP,Murnane MM,Kapteyn HC

更新日期：2000-07-13 00:00:00

abstract：:In their investigation into whether female mate-choice drives male dispersal, Höner et al. argue that female spotted hyaenas (Crocuta crocuta) prefer mates whose tenure in the social group is less than the females' age, to avoid paternal incest, and suggest that male dispersal reflects this preference. However, we are...

journal_title：Nature

authors： Van Horn RC,Watts HE,Holekamp KE

更新日期：2008-07-10 00:00:00

abstract：:It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light thr...

journal_title：Nature

authors： Sonnenburg JL,Bäckhed F

更新日期：2016-07-07 00:00:00

abstract：:The initiation of plate tectonics on Earth is a critical event in our planet's history. The time lag between the first proto-subduction (about 4 billion years ago) and global tectonics (approximately 3 billion years ago) suggests that plates and plate boundaries became widespread over a period of 1 billion years. The ...

journal_title：Nature

authors： Bercovici D,Ricard Y

更新日期：2014-04-24 00:00:00

abstract：:Seven monoclonal antibodies have been produced against a membrane preparation from adult rat retina. Three antibodies reacted with particular regions of rat photoreceptor cell surfaces: RET-P1 labelled the cell bodies, outer and inner segments (rods but not cones), RET-P2 labelled only outer segments and RET-P3 labell...

journal_title：Nature

authors： Barnstable CJ

更新日期：1980-07-17 00:00:00

abstract：:On the basis of the anti-correlation of their palaeoclimatic proxy for the strength of the East Asian winter monsoon from Lake Huguang Maar, China, with stalagmite records of the strength of the summer monsoon, Yancheva et al. claim that the strengths of the summer and winter monsoons are anti-correlated on a decadal ...

journal_title：Nature

authors： Zhang D,Lu L

更新日期：2007-11-15 00:00:00

abstract：:Haematopoietic stem cells (HSCs) must achieve a balance between quiescence and activation that fulfils immediate demands for haematopoiesis without compromising long-term stem cell maintenance, yet little is known about the molecular events governing this balance. Phosphatase and tensin homologue (PTEN) functions as a...

journal_title：Nature

authors： Zhang J,Grindley JC,Yin T,Jayasinghe S,He XC,Ross JT,Haug JS,Rupp D,Porter-Westpfahl KS,Wiedemann LM,Wu H,Li L

更新日期：2006-05-25 00:00:00

abstract：:Increasing human populations around the global coastline have caused extensive loss, degradation and fragmentation of coastal ecosystems, threatening the delivery of important ecosystem services1. As a result, alarming losses of mangrove, coral reef, seagrass, kelp forest and coastal marsh ecosystems have occurred1-6....

journal_title：Nature

authors： Murray NJ,Phinn SR,DeWitt M,Ferrari R,Johnston R,Lyons MB,Clinton N,Thau D,Fuller RA

更新日期：2019-01-01 00:00:00

abstract：:Natural visual scenes are cluttered with multiple objects whose individual features must somehow be selectively linked (or 'bound') if perception is to coincide with reality. Recent neurophysiological evidence supports a 'binding-by-synchrony' hypothesis: neurons excited by features of the same object fire synchronous...

journal_title：Nature

authors： Thiele A,Stoner G

更新日期：2003-01-23 00:00:00

abstract：: ...

journal_title：Nature

authors： Rios Rojas C

更新日期：2018-12-01 00:00:00

abstract：:Somatic sexual differentiation in Drosophila melanogaster involves a cascade of regulated splicing events and provides an attractive model system for the analysis of alternative splicing mechanisms. The protein Sex-lethal (Sxl) activates a female-specific 3' splice site in the first intron of transformer (tra) pre-mRN...

journal_title：Nature

authors： Valcárcel J,Singh R,Zamore PD,Green MR

更新日期：1993-03-11 00:00:00

abstract：:Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells (CSCs), which co-opt stem cell properties. For most tumours, the cellular origin of these CSCs and regulatory pathways essential for sus...

journal_title：Nature

authors： Malanchi I,Peinado H,Kassen D,Hussenet T,Metzger D,Chambon P,Huber M,Hohl D,Cano A,Birchmeier W,Huelsken J

更新日期：2008-04-03 00:00:00