当前位置： SCI文献检索 > NATURE期刊下所有文献 > Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.

Abstract：

:Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells (CSCs), which co-opt stem cell properties. For most tumours, the cellular origin of these CSCs and regulatory pathways essential for sustaining stemness have not been identified. In murine skin, follicular morphogenesis is driven by bulge stem cells that specifically express CD34. Here we identify a population of cells in early epidermal tumours characterized by phenotypic and functional similarities to normal bulge skin stem cells. This population contains CSCs, which are the only cells with tumour initiation properties. Transplants derived from these CSCs preserve the hierarchical organization of the primary tumour. We describe beta-catenin signalling as being essential in sustaining the CSC phenotype. Ablation of the beta-catenin gene results in the loss of CSCs and complete tumour regression. In addition, we provide evidence for the involvement of increased beta-catenin signalling in malignant human squamous cell carcinomas. Because Wnt/beta-catenin signalling is not essential for normal epidermal homeostasis, such a mechanistic difference may thus be targeted to eliminate CSCs and consequently eradicate squamous cell carcinomas.

journal_name

Nature

journal_title

Nature

authors

Malanchi I,Peinado H,Kassen D,Hussenet T,Metzger D,Chambon P,Huber M,Hohl D,Cano A,Birchmeier W,Huelsken J

doi

10.1038/nature06835

subject

Has Abstract

pub_date

2008-04-03 00:00:00

pages

650-3

issue

7187

eissn

0028-0836

issn

1476-4687

pii

nature06835

journal_volume

452

pub_type

杂志文章

相关文献

NATURE文献大全
  • Structural basis of ultraviolet-B perception by UVR8.

    abstract：:The Arabidopsis thaliana protein UVR8 is a photoreceptor for ultraviolet-B. Upon ultraviolet-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, which triggers a signalling pathway for ultraviolet protection. The mechanism by which UVR8 senses ultraviolet-B remains largely unknown. Here we rep...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature10931

    authors： Wu D,Hu Q,Yan Z,Chen W,Yan C,Huang X,Zhang J,Yang P,Deng H,Wang J,Deng X,Shi Y

    更新日期：2012-02-29 00:00:00

  • Extracellular domains mediating epsilon subunit interactions of muscle acetylcholine receptor.

    abstract：:Ligand-gated ion channels, a major class of cell-surface proteins, have a pseudosymmetric structure with five highly homologous subunits arranged around a central ion pore. The correct assembly of each channel, whose subunit composition varies with cell type and stage of development, requires specific recognition betw...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/352064a0

    authors： Yu XM,Hall ZW

    更新日期：1991-07-04 00:00:00

  • Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor.

    abstract：:Excitation-contraction coupling in skeletal muscle involves a voltage sensor in the plasma membrane which, in response to depolarization, causes an intracellular calcium-release channel to open. The skeletal isoform of the ryanodine receptor (RyR-1) functions as the Ca2+-release channel and the dihydropyridine recepto...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/380072a0

    authors： Nakai J,Dirksen RT,Nguyen HT,Pessah IN,Beam KG,Allen PD

    更新日期：1996-03-07 00:00:00

  • Experimental realization of universal geometric quantum gates with solid-state spins.

    abstract：:Experimental realization of a universal set of quantum logic gates is the central requirement for the implementation of a quantum computer. In an 'all-geometric' approach to quantum computation, the quantum gates are implemented using Berry phases and their non-Abelian extensions, holonomies, from geometric transforma...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature13729

    authors： Zu C,Wang WB,He L,Zhang WG,Dai CY,Wang F,Duan LM

    更新日期：2014-10-02 00:00:00

  • An optical-frequency synthesizer using integrated photonics.

    abstract：:Optical-frequency synthesizers, which generate frequency-stable light from a single microwave-frequency reference, are revolutionizing ultrafast science and metrology, but their size, power requirement and cost need to be reduced if they are to be more widely used. Integrated-photonics microchips can be used in high-c...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-018-0065-7

    authors： Spencer DT,Drake T,Briles TC,Stone J,Sinclair LC,Fredrick C,Li Q,Westly D,Ilic BR,Bluestone A,Volet N,Komljenovic T,Chang L,Lee SH,Oh DY,Suh MG,Yang KY,Pfeiffer MHP,Kippenberg TJ,Norberg E,Theogarajan L,Vahala K

    更新日期：2018-05-01 00:00:00

  • Endangered plants persist under phosphorus limitation.

    abstract：:Nitrogen enrichment is widely thought to be responsible for the loss of plant species from temperate terrestrial ecosystems. This view is based on field surveys and controlled experiments showing that species richness correlates negatively with high productivity and nitrogen enrichment. However, as the type of nutrien...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature03950

    authors： Wassen MJ,Venterink HO,Lapshina ED,Tanneberger F

    更新日期：2005-09-22 00:00:00

  • Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid.

    abstract：:Endophilin I is a presynaptic protein of unknown function that binds to dynamin, a GTPase that is implicated in endocytosis and recycling of synaptic vesicles. Here we show that endophilin I is essential for the formation of synaptic-like microvesicles (SLMVs) from the plasma membrane. Endophilin I exhibits lysophosph...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/43613

    authors： Schmidt A,Wolde M,Thiele C,Fest W,Kratzin H,Podtelejnikov AV,Witke W,Huttner WB,Söling HD

    更新日期：1999-09-09 00:00:00

  • CpG motifs in bacterial DNA trigger direct B-cell activation.

    abstract：:Unmethylated CpG dinucleotides are more frequent in the genomes of bacteria and viruses than of vertebrates. We report here that bacterial DNA and synthetic oligodeoxynucleotides containing unmethylated CpG dinucleotides induce murine B cells to proliferate and secrete immunoglobulin in vitro and in vivo. This activat...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/374546a0

    authors： Krieg AM,Yi AK,Matson S,Waldschmidt TJ,Bishop GA,Teasdale R,Koretzky GA,Klinman DM

    更新日期：1995-04-06 00:00:00

  • Association between GTPase activators for Rho and Ras families.

    abstract：:The ras-related low-molecular-mass GTPases participate in signal transduction involving a variety of cellular functions, including cell-cycle progression, cellular differentiation, cytoskeletal organization, protein transport and secretion. The cycling of these proteins between GTP-bound and GDP-bound states is partia...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/359153a0

    authors： Settleman J,Albright CF,Foster LC,Weinberg RA

    更新日期：1992-09-10 00:00:00

  • Respiration as the main determinant of carbon balance in European forests.

    abstract：:Carbon exchange between the terrestrial biosphere and the atmosphere is one of the key processes that need to be assessed in the context of the Kyoto Protocol. Several studies suggest that the terrestrial biosphere is gaining carbon, but these estimates are obtained primarily by indirect methods, and the factors that ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35009084

    authors： Valentini R,Matteucci G,Dolman AJ,Schulze ED,Rebmann C,Moors EJ,Granier A,Gross P,Jensen NO,Pilegaard K,Lindroth A,Grelle A,Bernhofer C,Grünwald T,Aubinet M,Ceulemans R,Kowalski AS,Vesala T,Rannik U,Berbigier P,Lo

    更新日期：2000-04-20 00:00:00

  • The open pore conformation of potassium channels.

    abstract：:Living cells regulate the activity of their ion channels through a process known as gating. To open the pore, protein conformational changes must occur within a channel's membrane-spanning ion pathway. KcsA and MthK, closed and opened K(+) channels, respectively, reveal how such gating transitions occur. Pore-lining '...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/417523a

    authors： Jiang Y,Lee A,Chen J,Cadene M,Chait BT,MacKinnon R

    更新日期：2002-05-30 00:00:00

  • A circuit mechanism for differentiating positive and negative associations.

    abstract：:The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral amygdala complex (BLA) mediates the acquisition of associative memories, both positive and n...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature14366

    authors： Namburi P,Beyeler A,Yorozu S,Calhoon GG,Halbert SA,Wichmann R,Holden SS,Mertens KL,Anahtar M,Felix-Ortiz AC,Wickersham IR,Gray JM,Tye KM

    更新日期：2015-04-30 00:00:00

  • Crystal structure of a streptococcal protein G domain bound to an Fab fragment.

    abstract：:Protein G is a cell-surface protein from Streptococcus which binds to IgG molecules from a wide range of species with an affinity comparable to that of antigen. The high affinity of protein G for the Fab portion of IgG poses a particular challenge in molecular recognition, given the variability of heavy chain subclass...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/359752a0

    authors： Derrick JP,Wigley DB

    更新日期：1992-10-22 00:00:00

  • Monoclonal antibodies which recognize different cell types in the rat retina.

    abstract：:Seven monoclonal antibodies have been produced against a membrane preparation from adult rat retina. Three antibodies reacted with particular regions of rat photoreceptor cell surfaces: RET-P1 labelled the cell bodies, outer and inner segments (rods but not cones), RET-P2 labelled only outer segments and RET-P3 labell...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/286231a0

    authors： Barnstable CJ

    更新日期：1980-07-17 00:00:00

  • Ecological opportunity and sexual selection together predict adaptive radiation.

    abstract：:A fundamental challenge to our understanding of biodiversity is to explain why some groups of species undergo adaptive radiations, diversifying extensively into many and varied species, whereas others do not. Both extrinsic environmental factors (for example, resource availability, climate) and intrinsic lineage-speci...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature11144

    authors： Wagner CE,Harmon LJ,Seehausen O

    更新日期：2012-07-19 00:00:00

  • Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.

    abstract：:In this Letter, Supplementary Fig. 1 was missing. This error has been corrected online. ...

    journal_title：Nature

    pub_type： 已发布勘误

    doi：10.1038/s41586-019-1207-2

    authors： Eaglesham JB,Pan Y,Kupper TS,Kranzusch PJ

    更新日期：2019-05-01 00:00:00

  • Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.

    abstract：:Many cellular functions involve multi-domain proteins, which are composed of structurally independent modules connected by flexible linkers. Although it is often well understood how a given domain recognizes a cognate oligonucleotide or peptide motif, the dynamic interaction of multiple domains in the recognition of t...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature10171

    authors： Mackereth CD,Madl T,Bonnal S,Simon B,Zanier K,Gasch A,Rybin V,Valcárcel J,Sattler M

    更新日期：2011-07-13 00:00:00

  • A human neurodevelopmental model for Williams syndrome.

    abstract：:Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon hypersociability and a mosaic of retained and compromised linguistic and cognitive abilities. Nearly all clinically diagnosed individuals with Williams syndrome lack precisely the same set of genes, with breakpoints in chromosome b...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature19067

    authors： Chailangkarn T,Trujillo CA,Freitas BC,Hrvoj-Mihic B,Herai RH,Yu DX,Brown TT,Marchetto MC,Bardy C,McHenry L,Stefanacci L,Järvinen A,Searcy YM,DeWitt M,Wong W,Lai P,Ard MC,Hanson KL,Romero S,Jacobs B,Dale AM,Dai L

    更新日期：2016-08-18 00:00:00

  • GABAA receptor signalling mechanisms revealed by structural pharmacology.

    abstract：:Type-A γ-aminobutyric (GABAA) receptors are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs in clinical use and are common substances of abuse. Without reliable structural data, the mechanist...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-018-0832-5

    authors： Masiulis S,Desai R,Uchański T,Serna Martin I,Laverty D,Karia D,Malinauskas T,Zivanov J,Pardon E,Kotecha A,Steyaert J,Miller KW,Aricescu AR

    更新日期：2019-01-01 00:00:00

  • Regions of the skeletal muscle dihydropyridine receptor critical for excitation-contraction coupling.

    abstract：:It is thought that in skeletal muscle excitation-contraction (EC) coupling, the release of Ca2+ from the sarcoplasmic reticulum is controlled by the dihydropyridine (DHP) receptor in the transverse tubular membrane, where it serves as the voltage sensor. We have shown previously that injection of an expression plasmid...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/346567a0

    authors： Tanabe T,Beam KG,Adams BA,Niidome T,Numa S

    更新日期：1990-08-09 00:00:00

  • Dissecting the catalytic triad of a serine protease.

    abstract：:Serine proteases are present in virtually all organisms and function both inside and outside the cell; they exist as two families, the 'trypsin-like' and the 'subtilisin-like', that have independently evolved a similar catalytic device characterized by the Ser, His, Asp triad, an oxyanion binding site, and possibly ot...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/332564a0

    authors： Carter P,Wells JA

    更新日期：1988-04-07 00:00:00

  • Speech sounds learned by sleeping newborns.

    abstract：:It is not yet clear whether humans are able to learn while they are sleeping. Here we show that full-term human newborns can be taught to discriminate between similar vowel sounds when they are fast asleep. It is possible that such sleep training soon after birth could find application in clinical or educational situa...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/415599b

    authors： Cheour M,Martynova O,Näätänen R,Erkkola R,Sillanpää M,Kero P,Raz A,Kaipio ML,Hiltunen J,Aaltonen O,Savela J,Hämäläinen H

    更新日期：2002-02-07 00:00:00

  • The physical mechanisms of fast radio bursts.

    abstract：:Fast radio bursts are mysterious millisecond-duration transients prevalent in the radio sky. Rapid accumulation of data in recent years has facilitated an understanding of the underlying physical mechanisms of these events. Knowledge gained from the neighbouring fields of gamma-ray bursts and radio pulsars has also of...

    journal_title：Nature

    pub_type： 杂志文章,评审

    doi：10.1038/s41586-020-2828-1

    authors： Zhang B

    更新日期：2020-11-01 00:00:00

  • Induction of apoptosis by the Bcl-2 homologue Bak.

    abstract：:Cells are eliminated in a variety of physiological settings by apoptosis, a genetically encoded process of cellular suicide. Apoptosis comprises an intrinsic cellular defence against tumorigenesis, which, when suppressed, may contribute to the development of malignancies. The bcl-2 oncogene, which is activated in foll...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/374733a0

    authors： Chittenden T,Harrington EA,O'Connor R,Flemington C,Lutz RJ,Evan GI,Guild BC

    更新日期：1995-04-20 00:00:00

  • Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides.

    abstract：:Molecular cloning and DNA sequencing have yielded considerable structural information about proenkephalin. All previously characterized intermediate peptides of the enkephalin pathways in bovine adrenal medulla have now been aligned into an unambiguous primary structure. Two basic amino acid residues serve as processi...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/295206a0

    authors： Gubler U,Seeburg P,Hoffman BJ,Gage LP,Udenfriend S

    更新日期：1982-01-21 00:00:00

  • Dynamics of a seafloor-spreading episode at the East Pacific Rise.

    abstract：:Seafloor spreading is largely unobserved because 98 per cent of the global mid-ocean-ridge system is below the ocean surface. Our understanding of the dynamic processes that control seafloor spreading is thus inferred largely from geophysical observations of spreading events on land at Afar in East Africa and Iceland....

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature20116

    authors： Tan YJ,Tolstoy M,Waldhauser F,Wilcock WS

    更新日期：2016-12-08 00:00:00

  • Grid cells without theta oscillations in the entorhinal cortex of bats.

    abstract：:Grid cells provide a neural representation of space, by discharging when an animal traverses through the vertices of a periodic hexagonal grid spanning the environment. Although grid cells have been characterized in detail in rats, the fundamental question of what neural dynamics give rise to the grid structure remain...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature10583

    authors： Yartsev MM,Witter MP,Ulanovsky N

    更新日期：2011-11-02 00:00:00

  • The genome of Tetranychus urticae reveals herbivorous pest adaptations.

    abstract：:The spider mite Tetranychus urticae is a cosmopolitan agricultural pest with an extensive host plant range and an extreme record of pesticide resistance. Here we present the completely sequenced and annotated spider mite genome, representing the first complete chelicerate genome. At 90 megabases T. urticae has the sma...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature10640

    authors： Grbić M,Van Leeuwen T,Clark RM,Rombauts S,Rouzé P,Grbić V,Osborne EJ,Dermauw W,Ngoc PC,Ortego F,Hernández-Crespo P,Diaz I,Martinez M,Navajas M,Sucena É,Magalhães S,Nagy L,Pace RM,Djuranović S,Smagghe G,Iga M,Chr

    更新日期：2011-11-23 00:00:00

  • Inhibition of bacterial ice nucleators by fish antifreeze glycoproteins.

    abstract：:Certain bacteria promote the formation of ice in super-cooled water by means of ice nucleators which contain a unique protein associated with the cell membrane. Ice nucleators in general are believed to act by mimicking the structure of an ice crystal surface, thus imposing an ice-like arrangement on the water molecul...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/333782a0

    authors： Parody-Morreale A,Murphy KP,Di Cera E,Fall R,DeVries AL,Gill SJ

    更新日期：1988-06-23 00:00:00

  • Cooperating with the future.

    abstract：:Overexploitation of renewable resources today has a high cost on the welfare of future generations. Unlike in other public goods games, however, future generations cannot reciprocate actions made today. What mechanisms can maintain cooperation with the future? To answer this question, we devise a new experimental para...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature13530

    authors： Hauser OP,Rand DG,Peysakhovich A,Nowak MA

    更新日期：2014-07-10 00:00:00