Association between GTPase activators for Rho and Ras families.

abstract：:Protein synthesis takes place on the ribosome, where genetic information carried by messenger RNA is translated into a sequence of amino acids. This process is terminated when a stop codon moves into the ribosomal decoding centre (DC) and is recognized by a class-1 release factor (RF). RFs have a conserved GGQ amino-a...

journal_title：Nature

authors： Rawat UB,Zavialov AV,Sengupta J,Valle M,Grassucci RA,Linde J,Vestergaard B,Ehrenberg M,Frank J

更新日期：2003-01-02 00:00:00

abstract：:Insect eyes have an anti-reflective coating, owing to nanostructures on the corneal surface creating a gradient of refractive index between that of air and that of the lens material1,2. These nanocoatings have also been shown to provide anti-adhesive functionality3. The morphology of corneal nanocoatings are very dive...

journal_title：Nature

authors： Kryuchkov M,Bilousov O,Lehmann J,Fiebig M,Katanaev VL

更新日期：2020-09-01 00:00:00

abstract：:DNA methylation has a profound impact on genome stability, transcription and development. Although enzymes that catalyse DNA methylation have been well characterized, those that are involved in methyl group removal have remained elusive, until recently. The transformative discovery that ten-eleven translocation (TET) ...

journal_title：Nature

authors： Kohli RM,Zhang Y

更新日期：2013-10-24 00:00:00

abstract：:The DNA sequences of the alcohol dehydrogenase (Adh) genes of four very closely related species of Drosophila show that the rates of nucleotide change vary greatly in different functional domains of this gene. A phylogeny of these species based on the Adh sequence data is consistent with that based on polytene chromos...

journal_title：Nature

authors： Bodmer M,Ashburner M

更新日期：1984-05-31 00:00:00

abstract：:The carbothermal reduction of silica into silicon requires the use of temperatures well above the silicon melting point (> or =2,000 degrees C). Solid silicon has recently been generated directly from silica at much lower temperatures (< or =850 degrees C) via electrochemical reduction in molten salts. However, the si...

journal_title：Nature

authors： Bao Z,Weatherspoon MR,Shian S,Cai Y,Graham PD,Allan SM,Ahmad G,Dickerson MB,Church BC,Kang Z,Abernathy HW 3rd,Summers CJ,Liu M,Sandhage KH

更新日期：2007-03-08 00:00:00

abstract：:Neptune has five narrow ring arcs, spanning about 40 degrees in longitude, which are apparently confined against the rapid azimuthal and radial spreading that normally results from inter-particle collisions. A gravitational resonance based on the vertical motion of the nearby neptunian moon Galatea was proposed to exp...

journal_title：Nature

authors： Namouni F,Porco C

更新日期：2002-05-02 00:00:00

abstract：:When present in single-stranded DNA, palindromic or quasi-palindromic sequences have the potential to form complex secondary structures, including hairpins, which may facilitate interstrand misalignment of direct repeats and be responsible for diverse types of replication-based mutations, including deletions, addition...

journal_title：Nature

authors： Trinh TQ,Sinden RR

更新日期：1991-08-08 00:00:00

abstract：:Locomotion relies on neural networks called central pattern generators (CPGs) that generate periodic motor commands for rhythmic movements. In vertebrates, the excitatory synaptic drive for inducing the spinal CPG can originate from either supraspinal glutamatergic inputs or from within the spinal cord. Here we identi...

journal_title：Nature

authors： Wyart C,Del Bene F,Warp E,Scott EK,Trauner D,Baier H,Isacoff EY

更新日期：2009-09-17 00:00:00

abstract：:Many natural habitats exist on privately owned land outside protected areas, but few governments can afford to enforce or subsidize conservation of this biodiversity. Even in some developed countries, conservation subsidy schemes have only achieved limited success. Fortunately, some landowners may be willing to accept...

journal_title：Nature

authors： Oldfield TE,Smith RJ,Harrop SR,Leader-Williams N

更新日期：2003-05-29 00:00:00

abstract：:An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Momcilovic M,Jones A,Bailey ST,Waldmann CM,Li R,Lee JT,Abdelhady G,Gomez A,Holloway T,Schmid E,Stout D,Fishbein MC,Stiles L,Dabir DV,Dubinett SM,Christofk H,Shirihai O,Koehler CM,Sadeghi S,Shackelford DB

更新日期：2020-01-01 00:00:00

abstract：:The study of the extent and basis of gene-enzyme variation has long been a principal concern of population genetics. Numerous surveys have indicated considerable amounts of genetic variation detectable in natural populations, with few exceptions. The variances of average heterozygosities (H) between species and among ...

journal_title：Nature

authors： O'Brien SJ,Gail MH,Levin DL

更新日期：1980-12-11 00:00:00

abstract：:Common fragile sites have long been identified by cytogeneticists as chromosomal regions prone to breakage upon replication stress. They are increasingly recognized to be preferential targets for oncogene-induced DNA damage in pre-neoplastic lesions and hotspots for chromosomal rearrangements in various cancers. Commo...

journal_title：Nature

authors： Letessier A,Millot GA,Koundrioukoff S,Lachagès AM,Vogt N,Hansen RS,Malfoy B,Brison O,Debatisse M

更新日期：2011-02-03 00:00:00

abstract：:The GAL4 protein activates transcription of the genes required for galactose utilization in Saccharomyces cerevisiae. The protein, consisting of 881 amino acids, is dimeric when bound to one of the approximately twofold symmetrical DNA sites present in the galactose upstream activating sequence (UASG). Here we use two...

journal_title：Nature

authors： Baleja JD,Marmorstein R,Harrison SC,Wagner G

更新日期：1992-04-02 00:00:00

abstract：:Developing neurons transiently express somatostatin and its receptors, but little is known about their function at these early stages. As we thought that endogenous somatostatin might control the migratory behaviour of immature neurons, we have examined the effects of somatostatin in cerebellar granule cells of early ...

journal_title：Nature

authors： Yacubova E,Komuro H

更新日期：2002-01-03 00:00:00

abstract：:Many corals bleach as a result of increased seawater temperature, which causes them to lose their vital symbiotic algae (Symbiodinium spp.) - unless these symbioses are able to adapt to global warming, bleaching threatens coral reefs worldwide. Here I show that some corals have adapted to higher temperatures, at least...

journal_title：Nature

authors： Rowan R

更新日期：2004-08-12 00:00:00

abstract：:Called the "mystery of mysteries" by Darwin, speciation is still a little-understood area of evolution. Genetic analysis, however, has yielded new generalizations about speciation and suggests promising avenues of research. ...

journal_title：Nature

authors： Coyne JA

更新日期：1992-02-06 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Growth of neurite processes from the cell body is the critical step in neuronal development and involves a large increase in cell membrane surface area. Arachidonic-acid-releasing phospholipases are highly enriched in nerve growth cones and have previously been implicated in neurite outgrowth. Cell membrane expansion ...

journal_title：Nature

authors： Darios F,Davletov B

更新日期：2006-04-06 00:00:00

abstract：:The recent decades-long decline in East African rainfall suggests that multidecadal variability is an important component of the climate of this vulnerable region. Prior work based on analysing the instrumental record implicates both Indian and Pacific ocean sea surface temperatures (SSTs) as possible drivers of East ...

journal_title：Nature

authors： Tierney JE,Smerdon JE,Anchukaitis KJ,Seager R

更新日期：2013-01-17 00:00:00

abstract：:Fluids and melts liberated from subducting oceanic crust recycle lithophile elements back into the mantle wedge, facilitate melting and ultimately lead to prolific subduction-zone arc volcanism. The nature and composition of the mobile phases generated in the subducting slab at high pressures have, however, remained l...

journal_title：Nature

authors： Kessel R,Schmidt MW,Ulmer P,Pettke T

更新日期：2005-09-29 00:00:00

abstract：:Reinforcement learning models postulate that neurons that release dopamine encode information about action and action outcome, and provide a teaching signal to striatal spiny projection neurons in the form of dopamine release1. Dopamine is thought to guide learning via dynamic and differential modulation of protein ki...

journal_title：Nature

authors： Lee SJ,Lodder B,Chen Y,Patriarchi T,Tian L,Sabatini BL

更新日期：2020-12-23 00:00:00

abstract：:Cells sense the context in which they grow to adapt their phenotype and allow multicellular patterning by mechanisms of autocrine and paracrine signalling. However, patterns also form in cell populations exposed to the same signalling molecules and substratum, which often correlate with specific features of the popula...

journal_title：Nature

authors： Frechin M,Stoeger T,Daetwyler S,Gehin C,Battich N,Damm EM,Stergiou L,Riezman H,Pelkmans L

更新日期：2015-07-02 00:00:00

abstract：:The microtubule cytoskeleton is essential to cell morphogenesis. Growing microtubule plus ends have emerged as dynamic regulatory sites in which specialized proteins, called plus-end-binding proteins (+TIPs), bind and regulate the proper functioning of microtubules. However, the molecular mechanism of plus-end associa...

journal_title：Nature

authors： Bieling P,Laan L,Schek H,Munteanu EL,Sandblad L,Dogterom M,Brunner D,Surrey T

更新日期：2007-12-13 00:00:00

abstract：:The neurohypophysial hormone vasopressin exerts antidiuretic, vasopressor and behavioural effects (for example, facilitation of memory processes). Vasopressin may alter animal behaviour via direct effect on brain processes. Recently, however, it has been suggested that vasopressin acts mainly at peripheral receptor sy...

journal_title：Nature

authors： de Wied D,Gaffori O,van Ree JM,de Jong W

更新日期：1984-03-15 00:00:00

abstract：:Manic depression is a severe cyclic mental illness that can be unipolar or bipolar and has a lifetime risk of approximately 7 per 1,000 in most populations. Families with multiple cases of manic depression have been described that are compatible with both autosomal dominant and X-linked modes of genetic transmission. ...

journal_title：Nature

authors： Hodgkinson S,Sherrington R,Gurling H,Marchbanks R,Reeders S,Mallet J,McInnis M,Petursson H,Brynjolfsson J

更新日期：1987-02-26 00:00:00

abstract：:Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in about 10-15% of human cancers. How DNA damage induces assembly and execution of a DNA replication complex (brea...

journal_title：Nature

authors： Dilley RL,Verma P,Cho NW,Winters HD,Wondisford AR,Greenberg RA

更新日期：2016-11-03 00:00:00

abstract：:Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self. In the settings of infection and cancer, microbes and tumours can exploit DCs to evade immunity, but DCs also can generate resistance, a capacity that is readily enhanced with...

journal_title：Nature

authors： Steinman RM,Banchereau J

更新日期：2007-09-27 00:00:00

abstract：:A family of G-protein-coupled chemoattractant receptors is known to mediate the transport and activation of neutrophils and macrophages This family includes receptors for chemokines, such as interleukin-8, bacterial formylated peptides, platelet-activating factor, leukotriene B4, and the complement anaphylatoxins. The...

journal_title：Nature

authors： Höpken UE,Lu B,Gerard NP,Gerard C

更新日期：1996-09-05 00:00:00

abstract：:Although individuals age and die with time, an animal species can continue indefinitely, because of its immortal germ-cell lineage. How the germline avoids transmitting damage from one generation to the next remains a fundamental question in biology. Here we identify a lysosomal switch that enhances germline proteosta...

journal_title：Nature

authors： Bohnert KA,Kenyon C

更新日期：2017-11-30 00:00:00

abstract：:The wavelength of light represents a fundamental technological barrier to the production of increasingly smaller features on integrated circuits. New technologies that allow the replication of patterns on scales less than 100 nm need to be developed if increases in computing power are to continue at the present rate. ...

journal_title：Nature

authors： Schaffer E,Thurn-Albrecht T,Russell TP,Steiner U

更新日期：2000-02-24 00:00:00