Stage-specific control of neuronal migration by somatostatin.

Abstract:

:Developing neurons transiently express somatostatin and its receptors, but little is known about their function at these early stages. As we thought that endogenous somatostatin might control the migratory behaviour of immature neurons, we have examined the effects of somatostatin in cerebellar granule cells of early postnatal mice, because these cells express all five types of somatostatin receptors before the initiation of their migration. Here we show that somatostatin has opposite and stage-specific effects on the migration of cerebellar granule cells. Activation of somatostatin receptors increases the rate of granule cell migration near their birthplace, but decreases the rate near their final destination. Furthermore, somatostatin enhances the size and frequency of spontaneous Ca2+ fluctuations in the early phase of migration, whereas it eliminates spike-like Ca2+ transients in the late phase. Somatostatin-induced changes at both early and late phases are reversed by a blockade of K+ channel activity. These results indicate that somatostatin may provide an essential cue for accelerating the movement of granule cells in the early phase and for terminating the movement in the late phase through altering intracellular Ca2+ concentrations and K+ channel activity.

journal_name

Nature

journal_title

Nature

authors

Yacubova E,Komuro H

doi

10.1038/415077a

keywords:

subject

Has Abstract

pub_date

2002-01-03 00:00:00

pages

77-81

issue

6867

eissn

0028-0836

issn

1476-4687

pii

415077a

journal_volume

415

pub_type

杂志文章

相关文献

NATURE文献大全
  • Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.

    abstract::Cutaneous melanoma is a type of cancer with an inherent potential for lymph node colonization, which is generally preceded by neolymphangiogenesis. However, sentinel lymph node removal does not necessarily extend the overall survival of patients with melanoma. Moreover, lymphatic vessels collapse and become dysfunctio...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature22977

    authors: Olmeda D,Cerezo-Wallis D,Riveiro-Falkenbach E,Pennacchi PC,Contreras-Alcalde M,Ibarz N,Cifdaloz M,Catena X,Calvo TG,Cañón E,Alonso-Curbelo D,Suarez J,Osterloh L,Graña O,Mulero F,Megías D,Cañamero M,Martínez-Torrecuadrad

    更新日期:2017-06-28 00:00:00

  • The primate amygdala represents the positive and negative value of visual stimuli during learning.

    abstract::Visual stimuli can acquire positive or negative value through their association with rewards and punishments, a process called reinforcement learning. Although we now know a great deal about how the brain analyses visual information, we know little about how visual representations become linked with values. To study t...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature04490

    authors: Paton JJ,Belova MA,Morrison SE,Salzman CD

    更新日期:2006-02-16 00:00:00

  • Genome-lamina interactions are established de novo in the early mouse embryo.

    abstract::In mammals, the emergence of totipotency after fertilization involves extensive rearrangements of the spatial positioning of the genome1,2. However, the contribution of spatial genome organization to the regulation of developmental programs is unclear3. Here we generate high-resolution maps of genomic interactions wit...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1233-0

    authors: Borsos M,Perricone SM,Schauer T,Pontabry J,de Luca KL,de Vries SS,Ruiz-Morales ER,Torres-Padilla ME,Kind J

    更新日期:2019-05-01 00:00:00

  • Rapid subtropical North Atlantic salinity oscillations across Dansgaard-Oeschger cycles.

    abstract::Geochemical and sedimentological evidence suggest that the rapid climate warming oscillations of the last ice age, the Dansgaard-Oeschger cycles, were coupled to fluctuations in North Atlantic meridional overturning circulation through its regulation of poleward heat flux. The balance between cold meltwater from the n...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature05121

    authors: Schmidt MW,Vautravers MJ,Spero HJ

    更新日期:2006-10-05 00:00:00

  • A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1.

    abstract::Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways1. Cleavage of human and mouse RIPK1 after residues D324 and D325, respectively, by caspase-8 separates the RIPK1 kinase domain from the intermediate and death domains. The D325A mutation in mouse RIPK1 leads to embryonic lethali...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1830-y

    authors: Tao P,Sun J,Wu Z,Wang S,Wang J,Li W,Pan H,Bai R,Zhang J,Wang Y,Lee PY,Ying W,Zhou Q,Hou J,Wang W,Sun B,Yang M,Liu D,Fang R,Han H,Yang Z,Huang X,Li H,Deuitch N,Zhang Y,Dissanayake D,Haude K,McWalter K

    更新日期:2020-01-01 00:00:00

  • The Caenorhabditis elegans genome sequencing project: first steps in automation.

    abstract::Novel biochemical processes using magnetic particles have been automated to provide a robotic system to perform processes for large-scale shotgun sequencing. ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/362569a0

    authors: Watson A,Smaldon N,Lucke R,Hawkins T

    更新日期:1993-04-08 00:00:00

  • Atomic structure of anthrax protective antigen pore elucidates toxin translocation.

    abstract::Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Protective antigen forms oligomeric prepores that undergo conversion to membrane-spanning pores by endosomal acidification, and...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature14247

    authors: Jiang J,Pentelute BL,Collier RJ,Zhou ZH

    更新日期:2015-05-28 00:00:00

  • Nanoscale architecture of integrin-based cell adhesions.

    abstract::Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity and wound healing. Focal adhesions are multifunctional organelles that mediate cell-ECM adhesion, force transmission, cytoskeletal regulation and signalling. Focal adhesions consist of a complex network of trans-plasma-membrane ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09621

    authors: Kanchanawong P,Shtengel G,Pasapera AM,Ramko EB,Davidson MW,Hess HF,Waterman CM

    更新日期:2010-11-25 00:00:00

  • Light-induced shape-memory polymers.

    abstract::Materials are said to show a shape-memory effect if they can be deformed and fixed into a temporary shape, and recover their original, permanent shape only on exposure to an external stimulus. Shape-memory polymers have received increasing attention because of their scientific and technological significance. In princi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature03496

    authors: Lendlein A,Jiang H,Jünger O,Langer R

    更新日期:2005-04-14 00:00:00

  • A per-cent-level determination of the nucleon axial coupling from quantum chromodynamics.

    abstract::The axial coupling of the nucleon, gA, is the strength of its coupling to the weak axial current of the standard model of particle physics, in much the same way as the electric charge is the strength of the coupling to the electromagnetic current. This axial coupling dictates the rate at which neutrons decay to proton...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0161-8

    authors: Chang CC,Nicholson AN,Rinaldi E,Berkowitz E,Garron N,Brantley DA,Monge-Camacho H,Monahan CJ,Bouchard C,Clark MA,Joó B,Kurth T,Orginos K,Vranas P,Walker-Loud A

    更新日期:2018-06-01 00:00:00

  • Palaeontological evidence for an Oligocene divergence between Old World monkeys and apes.

    abstract::Apes and Old World monkeys are prominent components of modern African and Asian ecosystems, yet the earliest phases of their evolutionary history have remained largely undocumented. The absence of crown catarrhine fossils older than ∼20 million years (Myr) has stood in stark contrast to molecular divergence estimates ...

    journal_title:Nature

    pub_type: 历史文章,杂志文章

    doi:10.1038/nature12161

    authors: Stevens NJ,Seiffert ER,O'Connor PM,Roberts EM,Schmitz MD,Krause C,Gorscak E,Ngasala S,Hieronymus TL,Temu J

    更新日期:2013-05-30 00:00:00

  • Ploughing the deep sea floor.

    abstract::Bottom trawling is a non-selective commercial fishing technique whereby heavy nets and gear are pulled along the sea floor. The direct impact of this technique on fish populations and benthic communities has received much attention, but trawling can also modify the physical properties of seafloor sediments, water–sedi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11410

    authors: Puig P,Canals M,Company JB,Martín J,Amblas D,Lastras G,Palanques A

    更新日期:2012-09-13 00:00:00

  • Structure of the multimodular endonuclease FokI bound to DNA.

    abstract::FokI is a member of an unusual class of bipartite restriction enzymes that recognize a specific DNA sequence and cleave DNA nonspecifically a short distance away from that sequence. Because of its unusual bipartite nature, FokI has been used to create artificial enzymes with new specificities. We have determined the c...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/40446

    authors: Wah DA,Hirsch JA,Dorner LF,Schildkraut I,Aggarwal AK

    更新日期:1997-07-03 00:00:00

  • Constraints on radiative forcing and future climate change from observations and climate model ensembles.

    abstract::The assessment of uncertainties in global warming projections is often based on expert judgement, because a number of key variables in climate change are poorly quantified. In particular, the sensitivity of climate to changing greenhouse-gas concentrations in the atmosphere and the radiative forcing effects by aerosol...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/416719a

    authors: Knutti R,Stocker TF,Joos F,Plattner GK

    更新日期:2002-04-18 00:00:00

  • Microperiodic structures: direct writing of three-dimensional webs.

    abstract::Applications are emerging that require the creation of fine-scale structures in three dimensions--examples include scaffolds for tissue engineering, micro-fluidic devices and photonic materials that control light propagation over a range of frequencies. But writing methods such as dip-pen nanolithography and ink-jet p...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/428386a

    authors: Gratson GM,Xu M,Lewis JA

    更新日期:2004-03-25 00:00:00

  • Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

    abstract::Volatile anaesthetics have historically been considered to act in a nonspecific manner on the central nervous system. More recent studies, however, have revealed that the receptors for inhibitory neurotransmitters such as gamma-aminobutyric acid (GABA) and glycine are sensitive to clinically relevant concentrations of...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/38738

    authors: Mihic SJ,Ye Q,Wick MJ,Koltchine VV,Krasowski MD,Finn SE,Mascia MP,Valenzuela CF,Hanson KK,Greenblatt EP,Harris RA,Harrison NL

    更新日期:1997-09-25 00:00:00

  • Architecture and secondary structure of an entire HIV-1 RNA genome.

    abstract::Single-stranded RNA viruses encompass broad classes of infectious agents and cause the common cold, cancer, AIDS and other serious health threats. Viral replication is regulated at many levels, including the use of conserved genomic RNA structures. Most potential regulatory elements in viral RNA genomes are uncharacte...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature08237

    authors: Watts JM,Dang KK,Gorelick RJ,Leonard CW,Bess JW Jr,Swanstrom R,Burch CL,Weeks KM

    更新日期:2009-08-06 00:00:00

  • Arbuscular mycorrhizal fungi: hyphal fusion and multigenomic structure.

    abstract::Arbuscular mycorrhizal (AM) fungi (Glomeromycota) reproduce asexually, are multinucleate, and have high genetic variation within single cells. Pawlowska and Taylor find that genetic variation within AM fungal cells is not lost as a result of segregation, and they interpret this as evidence that the variation is presen...

    journal_title:Nature

    pub_type: 评论,杂志文章

    doi:10.1038/nature03294

    authors: Bever JD,Wang M

    更新日期:2005-01-13 00:00:00

  • Receptor binding redefined by a structural switch in a mutant human insulin.

    abstract::Crystal structures of insulin have been determined in various distinct forms, the relevance of which to receptor recognition has long been the subject of speculation. Recently the crystal structure of an inactive insulin analogue has been determined and, surprisingly, found to have a conformation identical to native i...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/354238a0

    authors: Hua QX,Shoelson SE,Kochoyan M,Weiss MA

    更新日期:1991-11-21 00:00:00

  • Imperfect vaccines and the evolution of pathogen virulence.

    abstract::Vaccines rarely provide full protection from disease. Nevertheless, partially effective (imperfect) vaccines may be used to protect both individuals and whole populations. We studied the potential impact of different types of imperfect vaccines on the evolution of pathogen virulence (induced host mortality) and the co...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/414751a

    authors: Gandon S,Mackinnon MJ,Nee S,Read AF

    更新日期:2001-12-13 00:00:00

  • Continuous c-fos expression precedes programmed cell death in vivo.

    abstract::The development of a multicellular organism involves a delicate balance among the processes of proliferation, differentiation and death. Naturally occurring cell death aids tissue remodelling, eliminates supernumerary cell populations and provides structural elements such as hair and skin. In the nervous system, selec...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/363166a0

    authors: Smeyne RJ,Vendrell M,Hayward M,Baker SJ,Miao GG,Schilling K,Robertson LM,Curran T,Morgan JI

    更新日期:1993-05-13 00:00:00

  • Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of dense stroma are prominent features accounting for this aggressive biology1,2. The reciprocal interplay betwe...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1130-6

    authors: Shi Y,Gao W,Lytle NK,Huang P,Yuan X,Dann AM,Ridinger-Saison M,DelGiorno KE,Antal CE,Liang G,Atkins AR,Erikson G,Sun H,Meisenhelder J,Terenziani E,Woo G,Fang L,Santisakultarm TP,Manor U,Xu R,Becerra CR,Borazanci

    更新日期:2019-05-01 00:00:00

  • COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.

    abstract::Mutations in phosphatase and tensin homologue (PTEN) or genomic alterations in the phosphatidylinositol-3-OH kinase-signalling pathway are the most common genetic alterations reported in human prostate cancer. However, the precise mechanism underlying how indolent tumours with PTEN alterations acquire metastatic poten...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11674

    authors: Qin J,Wu SP,Creighton CJ,Dai F,Xie X,Cheng CM,Frolov A,Ayala G,Lin X,Feng XH,Ittmann MM,Tsai SJ,Tsai MJ,Tsai SY

    更新日期:2013-01-10 00:00:00

  • Simple RNA enzymes with new and highly specific endoribonuclease activities.

    abstract::In vitro mutagenesis of sequences required for the self-catalysed cleavage of a plant virus satellite RNA has allowed definition of an RNA segment with endoribonuclease activity. General rules have been deduced for the design of new RNA enzymes capable of highly specific RNA cleavage, and have been successfully tested...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/334585a0

    authors: Haseloff J,Gerlach WL

    更新日期:1988-08-18 00:00:00

  • Hundreds of variants clustered in genomic loci and biological pathways affect human height.

    abstract::Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variati...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09410

    authors: Lango Allen H,Estrada K,Lettre G,Berndt SI,Weedon MN,Rivadeneira F,Willer CJ,Jackson AU,Vedantam S,Raychaudhuri S,Ferreira T,Wood AR,Weyant RJ,Segrè AV,Speliotes EK,Wheeler E,Soranzo N,Park JH,Yang J,Gudbjartsson D

    更新日期:2010-10-14 00:00:00

  • Structural insights into electron transfer in caa3-type cytochrome oxidase.

    abstract::Cytochrome c oxidase is a member of the haem copper oxidase superfamily (HCO). HCOs function as the terminal enzymes in the respiratory chain of mitochondria and aerobic prokaryotes, coupling molecular oxygen reduction to transmembrane proton pumping. Integral to the enzyme's function is the transfer of electrons from...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11182

    authors: Lyons JA,Aragão D,Slattery O,Pisliakov AV,Soulimane T,Caffrey M

    更新日期:2012-07-26 00:00:00

  • High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.

    abstract::An increasing body of evidence points to mitochondrial dysfunction as a contributor to the molecular pathogenesis of neurodegenerative diseases such as Parkinson's disease. Recent studies of the Parkinson's disease associated genes PINK1 (ref. 2) and parkin (PARK2, ref. 3) indicate that they may act in a quality contr...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature12748

    authors: Hasson SA,Kane LA,Yamano K,Huang CH,Sliter DA,Buehler E,Wang C,Heman-Ackah SM,Hessa T,Guha R,Martin SE,Youle RJ

    更新日期:2013-12-12 00:00:00

  • Survival times of anomalous melt inclusions from element diffusion in olivine and chromite.

    abstract::The chemical composition of basaltic magma erupted at the Earth's surface is the end product of a complex series of processes, beginning with partial melting and melt extraction from a mantle source and ending with fractional crystallization and crustal assimilation at lower pressures. It has been proposed that studyi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature05759

    authors: Spandler C,O'Neill HS,Kamenetsky VS

    更新日期:2007-05-17 00:00:00

  • Increasing risk of Amazonian drought due to decreasing aerosol pollution.

    abstract::The Amazon rainforest plays a crucial role in the climate system, helping to drive atmospheric circulations in the tropics by absorbing energy and recycling about half of the rainfall that falls on it. This region (Amazonia) is also estimated to contain about one-tenth of the total carbon stored in land ecosystems, an...

    journal_title:Nature

    pub_type: 历史文章,杂志文章

    doi:10.1038/nature06960

    authors: Cox PM,Harris PP,Huntingford C,Betts RA,Collins M,Jones CD,Jupp TE,Marengo JA,Nobre CA

    更新日期:2008-05-08 00:00:00

  • Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor.

    abstract::The growth and differentiation of cytolytic T lymphocytes (CTL) is regulated by soluble growth hormones, of which interleukin-2 (IL-2) is considered to be of prime importance. Here we report that the lymphokine B-cell stimulatory factor (BSF-1 or interleukin-4) also has profound effects on the generation of these func...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/326795a0

    authors: Widmer MB,Grabstein KH

    更新日期:1987-04-23 00:00:00