Abstract：
:We have identified a cell type in 7-day-old rat optic nerve that differentiates into a fibrous astrocyte if cultured in the presence of fetal calf serum and into an oligodendrocyte if cultured in the absence of serum. In certain culture conditions some of these cells acquire a mixed phenotype, displaying properties of both astrocytes and oligodendrocytes. These observations suggest that fibrous astrocytes and oligodendrocytes develop from a common progenitor cell and provide a striking example of developmental plasticity and environmental influence in the differentiation of CNS glial cells.
journal_name
Naturejournal_title
Natureauthors
Raff MC,Miller RH,Noble Mdoi
10.1038/303390a0subject
Has Abstractpub_date
1983-06-02 00:00:00pages
390-6issue
5916eissn
0028-0836issn
1476-4687journal_volume
303pub_type
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