Preferential expression of the T-cell receptor V beta 3 gene by Mlsc reactive T cells.


:The precursor frequency of T cells specific for any given foreign antigen is, in general, extremely low. Prominent exceptions to this rule are the T cells that are specific for foreign major histocompatibility complex (MHC) products or for products of the minor lymphocyte stimulatory (Mls) genes in the mouse which are present at high frequencies. Here, we report a striking overlap or cross-reactivity between the T cells specific for the protein antigen pigeon cytochrome c in association with Ek alpha Ek beta and the set of T cells specific for Mlsc products. In addition, we demonstrate that the basis for this overlap is the predominant expression of one T-cell receptor (TCR) V beta gene, V beta 3, by T cells that recognize Mlsc products. These results indicate the importance of specific TCR alpha beta dimers in the recognition of Mlsc products and that positive or negative selection of T cells specific for Mls self-determinants may selectively alter the repertoire of T cells available for MHC-restricted recognition of foreign antigens.






Abe R,Vacchio MS,Fox B,Hodes RJ




Has Abstract


1988-10-27 00:00:00














  • Science without borders: 4 big questions.

    abstract:: ...


    pub_type: 社论


    authors: Hodson R

    更新日期:2018-10-01 00:00:00

  • Peripheral deletion of self-reactive B cells.

    abstract::B LYMPHOCYTES are key participants in the immune response because of their specificity, their ability to take up and present antigens to T cells, and their capacity to differentiate into antibody-secreting cells. To limit reactivity to self antigens, autospecific B cells can be functionally inactivated or deleted. Dev...


    pub_type: 杂志文章


    authors: Russell DM,Dembić Z,Morahan G,Miller JF,Bürki K,Nemazee D

    更新日期:1991-11-28 00:00:00

  • Tumour exosome integrins determine organotropic metastasis.

    abstract::Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and ep...


    pub_type: 杂志文章


    authors: Hoshino A,Costa-Silva B,Shen TL,Rodrigues G,Hashimoto A,Tesic Mark M,Molina H,Kohsaka S,Di Giannatale A,Ceder S,Singh S,Williams C,Soplop N,Uryu K,Pharmer L,King T,Bojmar L,Davies AE,Ararso Y,Zhang T,Zhang H,Her

    更新日期:2015-11-19 00:00:00

  • Exploring biology with small organic molecules.

    abstract::Small organic molecules have proven to be invaluable tools for investigating biological systems, but there is still much to learn from their use. To discover and to use more effectively new chemical tools to understand biology, strategies are needed that allow us to systematically explore 'biological-activity space'. ...


    pub_type: 杂志文章,评审


    authors: Stockwell BR

    更新日期:2004-12-16 00:00:00

  • Dynamical transition of myoglobin revealed by inelastic neutron scattering.

    abstract::Structural fluctuations in proteins on the picosecond timescale have been studied in considerable detail by theoretical methods such as molecular dynamics simulation, but there exist very few experimental data with which to test the conclusions. We have used the technique of inelastic neutron scattering to investigate...


    pub_type: 杂志文章


    authors: Doster W,Cusack S,Petry W

    更新日期:1989-02-23 00:00:00

  • Conservation charities top citation charts.

    abstract:: ...


    pub_type: 信件


    authors: Butchart SHM,Clements A,Gibbons DW

    更新日期:2019-02-01 00:00:00

  • Dual nature of the adaptive immune system in lampreys.

    abstract::Jawless vertebrates use variable lymphocyte receptors (VLR) comprised of leucine-rich-repeat (LRR) segments as counterparts of the immunoglobulin-based receptors that jawed vertebrates use for antigen recognition. Highly diverse VLR genes are somatically assembled by the insertion of variable LRR sequences into incomp...


    pub_type: 杂志文章


    authors: Guo P,Hirano M,Herrin BR,Li J,Yu C,Sadlonova A,Cooper MD

    更新日期:2009-06-11 00:00:00

  • X-ray analysis of Co-C bond cleavage in the crystalline state.

    abstract::During serial structure analysis of cobaloxime derivatives, aimed at interpreting the catalytic capability of the asymmetric hydrogenation, we have found that the crystal of R-alpha-cyanoethyl (S-alpha-methylbenzylamine)-cobaloxime changes its unit cell dimensions by X-ray exposure without degradation of a single crys...


    pub_type: 杂志文章


    authors: Ohashi Y,Sasada Y

    更新日期:1977-05-12 00:00:00

  • Jamming phase diagram for attractive particles.

    abstract::A wide variety of systems, including granular media, colloidal suspensions and molecular systems, exhibit non-equilibrium transitions from a fluid-like to a solid-like state, characterized solely by the sudden arrest of their dynamics. Crowding or jamming of the constituent particles traps them kinetically, precluding...


    pub_type: 杂志文章


    authors: Trappe V,Prasad V,Cipelletti L,Segre PN,Weitz DA

    更新日期:2001-06-14 00:00:00

  • Interaction between CD4 and class II MHC molecules mediates cell adhesion.

    abstract::The CD4 glycoprotein is expressed on T-helper and cytotoxic lymphocytes which are restricted to class II major histocompatibility complex (MHC) antigens on target cells. Antibody inhibition studies imply that CD4 acts to increase the avidity of effector-target cell interactions. These observations have led to the spec...


    pub_type: 杂志文章


    authors: Doyle C,Strominger JL

    更新日期:1987-11-19 00:00:00

  • Induction of cell death by endogenous nerve growth factor through its p75 receptor.

    abstract::During development, neuronal survival is regulated by the limited availability of neurotrophins, which are proteins of the nerve growth factor (NGF) family. Activation of specific trk tyrosine kinase receptors by the neurotrophins blocks programmed cell death. The trkA-specific ligand NGF has also been shown to activa...


    pub_type: 杂志文章


    authors: Frade JM,Rodríguez-Tébar A,Barde YA

    更新日期:1996-09-12 00:00:00

  • Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion.

    abstract::SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) and Rab-GTPases, together with their cofactors, mediate the attachment step in the membrane fusion of vesicles. But how bilayer mixing--the subsequent core process of fusion--is catalysed remains unclear. Ca2+/calmodulin controls this term...


    pub_type: 杂志文章


    authors: Peters C,Bayer MJ,Bühler S,Andersen JS,Mann M,Mayer A

    更新日期:2001-02-01 00:00:00

  • Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor.

    abstract::Excitation-contraction coupling in skeletal muscle involves a voltage sensor in the plasma membrane which, in response to depolarization, causes an intracellular calcium-release channel to open. The skeletal isoform of the ryanodine receptor (RyR-1) functions as the Ca2+-release channel and the dihydropyridine recepto...


    pub_type: 杂志文章


    authors: Nakai J,Dirksen RT,Nguyen HT,Pessah IN,Beam KG,Allen PD

    更新日期:1996-03-07 00:00:00

  • The developmental transcriptome of Drosophila melanogaster.

    abstract::Drosophila melanogaster is one of the most well studied genetic model organisms; nonetheless, its genome still contains unannotated coding and non-coding genes, transcripts, exons and RNA editing sites. Full discovery and annotation are pre-requisites for understanding how the regulation of transcription, splicing and...


    pub_type: 杂志文章


    authors: Graveley BR,Brooks AN,Carlson JW,Duff MO,Landolin JM,Yang L,Artieri CG,van Baren MJ,Boley N,Booth BW,Brown JB,Cherbas L,Davis CA,Dobin A,Li R,Lin W,Malone JH,Mattiuzzo NR,Miller D,Sturgill D,Tuch BB,Zaleski C,

    更新日期:2011-03-24 00:00:00

  • Impaired cell fate through gain-of-function mutations in a chromatin reader.

    abstract::Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by 'reader' proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood....


    pub_type: 杂志文章


    authors: Wan L,Chong S,Xuan F,Liang A,Cui X,Gates L,Carroll TS,Li Y,Feng L,Chen G,Wang SP,Ortiz MV,Daley SK,Wang X,Xuan H,Kentsis A,Muir TW,Roeder RG,Li H,Li W,Tjian R,Wen H,Allis CD

    更新日期:2020-01-01 00:00:00

  • The lipid phosphatase SHIP2 controls insulin sensitivity.

    abstract::Insulin is the primary hormone involved in glucose homeostasis, and impairment of insulin action and/or secretion has a critical role in the pathogenesis of diabetes mellitus. Type-II SH2-domain-containing inositol 5-phosphatase, or 'SHIP2', is a member of the inositol polyphosphate 5-phosphatase family. In vitro stud...


    pub_type: 杂志文章


    authors: Clément S,Krause U,Desmedt F,Tanti JF,Behrends J,Pesesse X,Sasaki T,Penninger J,Doherty M,Malaisse W,Dumont JE,Le Marchand-Brustel Y,Erneux C,Hue L,Schurmans S

    更新日期:2001-01-04 00:00:00

  • Preferential inhibition of omega-conotoxin-sensitive presynaptic Ca2+ channels by adenosine autoreceptors.

    abstract::Adenosine is a potent modulator of transmitter release at a variety of synapses. The adenosine A1 receptor is assumed to reside in presynaptic terminals and to function as a negative autoreceptor. How adenosine reduces transmitter release is uncertain; it may reduce the calcium influx during nerve terminal depolarizat...


    pub_type: 杂志文章


    authors: Yawo H,Chuhma N

    更新日期:1993-09-16 00:00:00

  • An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.

    abstract::Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment. Most people infected with M. tuberculosis remain asymptomatic, termed latent TB, with a 10% lifetim...


    pub_type: 杂志文章


    authors: Berry MP,Graham CM,McNab FW,Xu Z,Bloch SA,Oni T,Wilkinson KA,Banchereau R,Skinner J,Wilkinson RJ,Quinn C,Blankenship D,Dhawan R,Cush JJ,Mejias A,Ramilo O,Kon OM,Pascual V,Banchereau J,Chaussabel D,O'Garra A

    更新日期:2010-08-19 00:00:00

  • Structures of protein-protein complexes involved in electron transfer.

    abstract::Electron transfer reactions are essential for life because they underpin oxidative phosphorylation and photosynthesis, processes leading to the generation of ATP, and are involved in many reactions of intermediary metabolism. Key to these roles is the formation of transient inter-protein electron transfer complexes. T...


    pub_type: 杂志文章


    authors: Antonyuk SV,Han C,Eady RR,Hasnain SS

    更新日期:2013-04-04 00:00:00

  • m6A RNA methylation regulates the fate of endogenous retroviruses.

    abstract::Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and neurodegenerative diseases2,3. Here, using an...


    pub_type: 杂志文章


    authors: Chelmicki T,Roger E,Teissandier A,Dura M,Bonneville L,Rucli S,Dossin F,Fouassier C,Lameiras S,Bourc'his D

    更新日期:2021-01-13 00:00:00

  • A new tropomyosin essential for cytokinesis in the fission yeast S. pombe.

    abstract::Mutations in the Schizosaccharomyces pombe cdc8 gene impair cytokinesis. Here we clone cdc8+ and find that it encodes a novel tropomyosin. Gene disruption results in lethal arrest of the cell cycle, but spore germination, cell growth, DNA replication and mitosis are all unaffected. Haploid cdc8 gene disruptants are re...


    pub_type: 杂志文章


    authors: Balasubramanian MK,Helfman DM,Hemmingsen SM

    更新日期:1992-11-05 00:00:00

  • Patterns of colonization in a metapopulation of grey seals.

    abstract::The colonization of a new habitat is a fundamental process in metapopulation biology, but it is difficult to study. The emigration of colonists from established populations might be induced by resource competition owing to high local population density. Migration distances are also important because they determine the...


    pub_type: 杂志文章


    authors: Gaggiotti OE,Jones F,Lee WM,Amos W,Harwood J,Nichols RA

    更新日期:2002-03-28 00:00:00

  • A molecular chaperone from a thermophilic archaebacterium is related to the eukaryotic protein t-complex polypeptide-1.

    abstract::There is evidence to suggest that components of archaebacteria are evolutionarily related to cognates in the eukaryotic cytosol. We postulated that the major heat-shock protein of the thermophilic archaebacterium, Sulfolobus shibatae, is a molecular chaperone and that it is related to an as-yet unidentified chaperone ...


    pub_type: 杂志文章


    authors: Trent JD,Nimmesgern E,Wall JS,Hartl FU,Horwich AL

    更新日期:1991-12-12 00:00:00

  • Vasopressin alters female sexual behaviour by acting on the brain independently of alterations in blood pressure.

    abstract::Subcutaneous (s.c.) administration of Arg-vasopressin (AVP) prolongs retention of a learned behaviour and elevates arterial blood pressure. Intracerebroventricular (i.c.v.) injection of a thousandfold lower dose of AVP than needed with s.c. injection produces the same behavioural effect, suggesting that AVP acts on th...


    pub_type: 杂志文章


    authors: Södersten P,Henning M,Melin P,Ludin S

    更新日期:1983-02-17 00:00:00

  • Regulated progression of a cultured pre-B-cell line to the B-cell stage.

    abstract::The variable (V) regions of heavy and light immunoglobulin chains are encoded by multiple germline DNA elements which are assembled into complete variable-region genes in precursor(pre-) B lymphocytes. The heavy-chain V region (VH) is assembled from three separate germline DNA elements, the variable (VH), diversity (D...


    pub_type: 杂志文章


    authors: Reth MG,Ammirati P,Jackson S,Alt FW

    更新日期:1985-09-26 00:00:00

  • Cloning, sequence and expression of human interleukin-2 receptor.

    abstract::T lymphocytes, essential for the generation of a normal immune response, require the presence of the lymphokine interleukin-2 (IL-2) in order to proliferate. Cells that respond to IL-2 possess a surface receptor glycoprotein specific for this lymphokine. We have recently purified and chemically characterized the IL-2 ...


    pub_type: 杂志文章


    authors: Cosman D,Cerretti DP,Larsen A,Park L,March C,Dower S,Gillis S,Urdal D

    更新日期:1984-12-20 00:00:00

  • Dynamical age differences among coeval star clusters as revealed by blue stragglers.

    abstract::Globular star clusters that formed at the same cosmic time may have evolved rather differently from the dynamical point of view (because that evolution depends on the internal environment) through a variety of processes that tend progressively to segregate stars more massive than the average towards the cluster centre...


    pub_type: 杂志文章


    authors: Ferraro FR,Lanzoni B,Dalessandro E,Beccari G,Pasquato M,Miocchi P,Rood RT,Sigurdsson S,Sills A,Vesperini E,Mapelli M,Contreras R,Sanna N,Mucciarelli A

    更新日期:2012-12-20 00:00:00

  • ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.

    abstract::The ATM (ataxia-telangiectasia mutated) protein kinase mediates early cellular responses to DNA double-strand breaks (DSBs) generated during metabolic processes or by DNA-damaging agents. ATM deficiency leads to ataxia-telangiectasia, a disease marked by lymphopenia, genomic instability and an increased predisposition...


    pub_type: 杂志文章


    authors: Bredemeyer AL,Sharma GG,Huang CY,Helmink BA,Walker LM,Khor KC,Nuskey B,Sullivan KE,Pandita TK,Bassing CH,Sleckman BP

    更新日期:2006-07-27 00:00:00

  • Ultraviolet emissions from the magnetic footprints of Io, Ganymede and Europa on Jupiter.

    abstract::Io leaves a magnetic footprint on Jupiter's upper atmosphere that appears as a spot of ultraviolet emission that remains fixed underneath Io as Jupiter rotates. The specific physical mechanisms responsible for generating those emissions are not well understood, but in general the spot seems to arise because of an elec...


    pub_type: 杂志文章


    authors: Clarke JT,Ajello J,Ballester G,Ben Jaffel L,Connerney J,Gérard JC,Gladstone GR,Grodent D,Pryor W,Trauger J,Waite JH Jr

    更新日期:2002-02-28 00:00:00

  • Complex mammalian-like haematopoietic system found in a colonial chordate.

    abstract::Haematopoiesis is an essential process that evolved in multicellular animals. At the heart of this process are haematopoietic stem cells (HSCs), which are multipotent and self-renewing, and generate the entire repertoire of blood and immune cells throughout an animal's life1. Although there have been comprehensive stu...


    pub_type: 杂志文章


    authors: Rosental B,Kowarsky M,Seita J,Corey DM,Ishizuka KJ,Palmeri KJ,Chen SY,Sinha R,Okamoto J,Mantalas G,Manni L,Raveh T,Clarke DN,Tsai JM,Newman AM,Neff NF,Nolan GP,Quake SR,Weissman IL,Voskoboynik A

    更新日期:2018-12-01 00:00:00