A human neurodevelopmental model for Williams syndrome.

abstract：:Touch and mechanical pain are first detected at our largest sensory surface, the skin. The cell bodies of sensory neurons that detect such stimuli are located in the dorsal root ganglia, and subtypes of these neurons are specialized to detect specific modalities of mechanical stimuli. Molecules have been identified th...

journal_title：Nature

authors： Wetzel C,Hu J,Riethmacher D,Benckendorff A,Harder L,Eilers A,Moshourab R,Kozlenkov A,Labuz D,Caspani O,Erdmann B,Machelska H,Heppenstall PA,Lewin GR

更新日期：2007-01-11 00:00:00

abstract：:Human fibroblast cells produce beta-type interferon only in response to viral infection or treatment with an inducer such as poly(rI) X poly(rC); this event is most probably controlled at the transcriptional level (for review see ref. 1). To study the induction process, we inserted the human fibroblast interferon (IFN...

journal_title：Nature

authors： Tavernier J,Gheysen D,Duerinck F,Van der Heyden J,Fiers W

更新日期：1983-02-17 00:00:00

abstract：:Diminishing fossil fuel reserves and growing concerns about global warming indicate that sustainable sources of energy are needed in the near future. For fuels to be useful in the transportation sector, they must have specific physical properties that allow for efficient distribution, storage and combustion; these pro...

journal_title：Nature

authors： Román-Leshkov Y,Barrett CJ,Liu ZY,Dumesic JA

更新日期：2007-06-21 00:00:00

abstract：:Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK) signalling cascade in melanoma-an observation that has bee...

journal_title：Nature

authors： Johannessen CM,Boehm JS,Kim SY,Thomas SR,Wardwell L,Johnson LA,Emery CM,Stransky N,Cogdill AP,Barretina J,Caponigro G,Hieronymus H,Murray RR,Salehi-Ashtiani K,Hill DE,Vidal M,Zhao JJ,Yang X,Alkan O,Kim S,Harris JL

更新日期：2010-12-16 00:00:00

abstract：:Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at severa...

journal_title：Nature

authors： Adams JM,Harris AW,Pinkert CA,Corcoran LM,Alexander WS,Cory S,Palmiter RD,Brinster RL

更新日期：1985-12-12 00:00:00

abstract：:Sea-level histories during the two most recent deglacial-interglacial intervals show substantial differences1-3 despite both periods undergoing similar changes in global mean temperature4,5 and forcing from greenhouse gases6. Although the last interglaciation (LIG) experienced stronger boreal summer insolation forcing...

journal_title：Nature

authors： Clark PU,He F,Golledge NR,Mitrovica JX,Dutton A,Hoffman JS,Dendy S

更新日期：2020-01-01 00:00:00

abstract：:Concentrating urine is mandatory for most mammals to prevent water loss from the body. Concentrated urine is produced in response to vasopressin by the transepithelial recovery of water from the lumen of the kidney collecting tubule through highly water-permeable membranes. In this nephron segment, vasopressin regulat...

journal_title：Nature

authors： Fushimi K,Uchida S,Hara Y,Hirata Y,Marumo F,Sasaki S

更新日期：1993-02-11 00:00:00

abstract：:In mammalian somatic-cell cycles, progression through the G1-phase restriction point and initiation of DNA replication are controlled by the ability of the retinoblastoma tumour-suppressor protein (pRb) family to regulate the E2F/DP transcription factors. Continuing transcription of E2F target genes beyond the G1/S tr...

journal_title：Nature

authors： Lukas C,Sørensen CS,Kramer E,Santoni-Rugiu E,Lindeneg C,Peters JM,Bartek J,Lukas J

更新日期：1999-10-21 00:00:00

abstract：:Although the link between long gamma-ray bursts (GRBs) and supernovae has been established, hitherto there have been no observations of the beginning of a supernova explosion and its intimate link to a GRB. In particular, we do not know how the jet that defines a gamma-ray burst emerges from the star's surface, nor ho...

journal_title：Nature

authors： Campana S,Mangano V,Blustin AJ,Brown P,Burrows DN,Chincarini G,Cummings JR,Cusumano G,Della Valle M,Malesani D,Mészáros P,Nousek JA,Page M,Sakamoto T,Waxman E,Zhang B,Dai ZG,Gehrels N,Immler S,Marshall FE,Mason KO

更新日期：2006-08-31 00:00:00

abstract：:Zika virus (ZIKV) is a flavivirus that is responsible for the current epidemic in Brazil and the Americas. ZIKV has been causally associated with fetal microcephaly, intrauterine growth restriction, and other birth defects in both humans and mice. The rapid development of a safe and effective ZIKV vaccine is a global ...

journal_title：Nature

authors： Larocca RA,Abbink P,Peron JP,Zanotto PM,Iampietro MJ,Badamchi-Zadeh A,Boyd M,Ng'ang'a D,Kirilova M,Nityanandam R,Mercado NB,Li Z,Moseley ET,Bricault CA,Borducchi EN,Giglio PB,Jetton D,Neubauer G,Nkolola JP,Maxfield

更新日期：2016-08-25 00:00:00

abstract：:'Hot Jupiter' extrasolar planets are expected to be tidally locked because they are close (<0.05 astronomical units, where 1 au is the average Sun-Earth distance) to their parent stars, resulting in permanent daysides and nightsides. By observing systems where the planet and star periodically eclipse each other, sever...

journal_title：Nature

authors： Knutson HA,Charbonneau D,Allen LE,Fortney JJ,Agol E,Cowan NB,Showman AP,Cooper CS,Megeath ST

更新日期：2007-05-10 00:00:00

abstract：:Collagen fibrils have been extensively studied by electron microscopy, but only scant evidence has yet been obtained about their transverse structure. A transverse pediodicity of about 40 or 80 A might be expected if the microfibril model (until recently the common preference) is correct, but little direct evidence fo...

journal_title：Nature

authors： Squire JM,Freundlich A

更新日期：1980-11-27 00:00:00

abstract：:DNA double-strand breaks are generated by genotoxic agents and by cellular endonucleases as intermediates of several important physiological processes. The cellular response to genotoxic DNA breaks includes the activation of transcriptional programs known primarily to regulate cell-cycle checkpoints and cell survival....

journal_title：Nature

authors： Bredemeyer AL,Helmink BA,Innes CL,Calderon B,McGinnis LM,Mahowald GK,Gapud EJ,Walker LM,Collins JB,Weaver BK,Mandik-Nayak L,Schreiber RD,Allen PM,May MJ,Paules RS,Bassing CH,Sleckman BP

更新日期：2008-12-11 00:00:00

abstract：:Alternative splicing of pre-messenger RNAs diversifies gene products in eukaryotes and is guided by factors that enable spliceosomes to recognize particular splice sites. Here we report that alternative splicing of Saccharomyces cerevisiae SRC1 pre-mRNA is promoted by the conserved ubiquitin-like protein Hub1. Structu...

journal_title：Nature

authors： Mishra SK,Ammon T,Popowicz GM,Krajewski M,Nagel RJ,Ares M Jr,Holak TA,Jentsch S

更新日期：2011-05-25 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:A statute banning nuclear weapons research in Cambridge, Massachusetts, is scheduled for a referendum vote in November 1983. If passed, the act would require the city to fine or imprison violators after the ban takes effect in October 1985, and could have an impact on work done at Harvard University and the Massachus...

journal_title：Nature

authors： David P

更新日期：1983-09-15 00:00:00

abstract：:Magnetic reconnection is the process by which magnetic field lines of opposite polarity reconfigure to a lower-energy state, with the release of magnetic energy to the surroundings. Reconnection at the Earth's dayside magnetopause and in the magnetotail allows the solar wind into the magnetosphere. It begins in a smal...

journal_title：Nature

authors： Oieroset M,Phan TD,Fujimoto M,Lin RP,Lepping RP

更新日期：2001-07-26 00:00:00

abstract：:The expression of immunodeficiency in patients with specific purine enzyme defects indicates a crucial role of the purine salvage pathway in the acquisition and expression of normal immune function. One current hypothesis links the failure of normal lymphocyte development in these diseases to the accumulation of deoxy...

journal_title：Nature

authors： Dosch HM,Mansour A,Cohen A,Shore A,Gelfand EW

更新日期：1980-06-12 00:00:00

abstract：:The manner in which phase transformations occur in solids determines important structural and physical properties of many materials. The main problem in characterizing the kinetic processes that occur during phase transformations is the difficulty of observing directly, in real time, the growth of one phase at the exp...

journal_title：Nature

authors： Hannon JB,Hibino H,Bartelt NC,Swartzentruber BS,Ogino T,Kellogg GL

更新日期：2000-06-01 00:00:00

abstract：:Ice sheets are currently ignored in global methane budgets1,2. Although ice sheets have been proposed to contain large reserves of methane that may contribute to a rise in atmospheric methane concentration if released during periods of rapid ice retreat3,4, no data exist on the current methane footprint of ice sheets....

journal_title：Nature

authors： Lamarche-Gagnon G,Wadham JL,Sherwood Lollar B,Arndt S,Fietzek P,Beaton AD,Tedstone AJ,Telling J,Bagshaw EA,Hawkings JR,Kohler TJ,Zarsky JD,Mowlem MC,Anesio AM,Stibal M

更新日期：2019-01-01 00:00:00

abstract：:Trophic control over the expression and membrane distribution of voltage-dependent ion channels is one of the principal organizing events underlying the maturation of excitable cells. The myelin sheath is a major structural determinant of regional ion channel topography in central axons, but the exact molecular signal...

journal_title：Nature

authors： Noebels JL,Marcom PK,Jalilian-Tehrani MH

更新日期：1991-08-01 00:00:00

abstract：:Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes, but also with gain-of-function mutations of proto-oncogenes. Here we show unique gain-of-function mutations of the C-CBL (...

journal_title：Nature

authors： Sanada M,Suzuki T,Shih LY,Otsu M,Kato M,Yamazaki S,Tamura A,Honda H,Sakata-Yanagimoto M,Kumano K,Oda H,Yamagata T,Takita J,Gotoh N,Nakazaki K,Kawamata N,Onodera M,Nobuyoshi M,Hayashi Y,Harada H,Kurokawa M,Chiba

更新日期：2009-08-13 00:00:00

abstract：:Among the pathological effects in man following infection with Mycoplasma pneumoniae is a transient autoimmune disorder characterized by the presence of high-titre erythrocyte autoantibodies (cold agglutinins). These autoantibodies are usually directed against the carbohydrate antigen termed I (ref. 3) which consists ...

journal_title：Nature

authors： Loomes LM,Uemura K,Childs RA,Paulson JC,Rogers GN,Scudder PR,Michalski JC,Hounsell EF,Taylor-Robinson D,Feizi T

更新日期：1984-02-09 00:00:00

abstract：:Gram-negative bacteria, such as Escherichia coli, expel toxic chemicals through tripartite efflux pumps that span both the inner and outer membrane. The three parts are an inner membrane, substrate-binding transporter; a membrane fusion protein; and an outer-membrane-anchored channel. The fusion protein connects the t...

journal_title：Nature

authors： Su CC,Long F,Zimmermann MT,Rajashankar KR,Jernigan RL,Yu EW

更新日期：2011-02-24 00:00:00

abstract：:Five new double-mutant haemoglobins composed of betaS chains and alpha chains with different substitutions, which are located at the surface of the tetramer, have been prepared. Although all the hybrids are more soluble than deoxyhaemoglobin S, the individual differences between these molecules make it possible to eva...

journal_title：Nature

authors： Benesch RE,Yung S,Benesch R,Mack J,Schneider RG

更新日期：1976-03-18 00:00:00

abstract：:The kidney has been widely exploited as a model system for the study of tissue inductions regulating vertebrate organogenesis. Kidney development is initiated by the ingrowth of the Wolfian duct-derived ureteric bud into the presumptive kidney mesenchyme. In response to a signal from the ureter, mesenchymal cells cond...

journal_title：Nature

authors： Stark K,Vainio S,Vassileva G,McMahon AP

更新日期：1994-12-15 00:00:00

abstract：:Autism spectrum disorder (ASD) is an early-onset developmental disorder characterized by deficits in communication and social interaction and restrictive or repetitive behaviours1,2. Family studies demonstrate that ASD has a substantial genetic basis with contributions both from inherited and de novo variants3,4. It h...

journal_title：Nature

authors： Mitra I,Huang B,Mousavi N,Ma N,Lamkin M,Yanicky R,Shleizer-Burko S,Lohmueller KE,Gymrek M

更新日期：2021-01-01 00:00:00

abstract：:Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot branching. SL signalling requires the hormone-dependent interaction of DWARF 14 (D14), a probable candidate SL receptor, with DWARF 3 (D3), an F-box component of the Skp-Cullin-F-box (SCF) E3 ubiquitin ligase complex. Here we ...

journal_title：Nature

authors： Jiang L,Liu X,Xiong G,Liu H,Chen F,Wang L,Meng X,Liu G,Yu H,Yuan Y,Yi W,Zhao L,Ma H,He Y,Wu Z,Melcher K,Qian Q,Xu HE,Wang Y,Li J

更新日期：2013-12-19 00:00:00

abstract：:This corrects the article DOI: 10.1038/nature24295. ...

journal_title：Nature

authors： Waldron A,Miller DC,Redding D,Mooers A,Kuhn TS,Nibbelink N,Roberts JT,Tobias JA,Gittleman JL

更新日期：2018-01-25 00:00:00

abstract：:Interstellar dust plays a crucial role in the evolution of the Universe by assisting the formation of molecules, by triggering the formation of the first low-mass stars, and by absorbing stellar ultraviolet-optical light and subsequently re-emitting it at infrared/millimetre wavelengths. Dust is thought to be produced...

journal_title：Nature

authors： Maiolino R,Schneider R,Oliva E,Bianchi S,Ferrara A,Mannucci F,Pedani M,Sogorb MR

更新日期：2004-09-30 00:00:00