Abstract:
:DNA double-strand breaks are generated by genotoxic agents and by cellular endonucleases as intermediates of several important physiological processes. The cellular response to genotoxic DNA breaks includes the activation of transcriptional programs known primarily to regulate cell-cycle checkpoints and cell survival. DNA double-strand breaks are generated in all developing lymphocytes during the assembly of antigen receptor genes, a process that is essential for normal lymphocyte development. Here we show that in murine lymphocytes these physiological DNA breaks activate a broad transcriptional program. This program transcends the canonical DNA double-strand break response and includes many genes that regulate diverse cellular processes important for lymphocyte development. Moreover, the expression of several of these genes is regulated similarly in response to genotoxic DNA damage. Thus, physiological DNA double-strand breaks provide cues that can regulate cell-type-specific processes not directly involved in maintaining the integrity of the genome, and genotoxic DNA breaks could disrupt normal cellular functions by corrupting these processes.
journal_name
Naturejournal_title
Natureauthors
Bredemeyer AL,Helmink BA,Innes CL,Calderon B,McGinnis LM,Mahowald GK,Gapud EJ,Walker LM,Collins JB,Weaver BK,Mandik-Nayak L,Schreiber RD,Allen PM,May MJ,Paules RS,Bassing CH,Sleckman BPdoi
10.1038/nature07392subject
Has Abstractpub_date
2008-12-11 00:00:00pages
819-23issue
7223eissn
0028-0836issn
1476-4687pii
nature07392journal_volume
456pub_type
杂志文章相关文献
NATURE文献大全abstract::Aberrant regulation of RNA stability has an important role in many disease states. Deregulated post-transcriptional modulation, such as that governed by microRNAs targeting linear sequence elements in messenger RNAs, has been implicated in the progression of many cancer types. A defining feature of RNA is its ability ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13466
更新日期:2014-09-11 00:00:00
abstract::Receptor tyrosine kinases (RTKs) are cell-surface molecules that transduce signals for cell growth and differentiation. The RTK encoded by the c-ret proto-oncogene is rearranged and constitutively activated in a large proportion of thyroid papillary carcinomas, and germ-line point mutations in c-ret seem to be respons...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/367380a0
更新日期:1994-01-27 00:00:00
abstract::Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital disorders. As part of the International Mouse Phenotyping Consortium effort to generate and phenotypically characterize 5,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19356
更新日期:2016-09-22 00:00:00
abstract::Butterflies rely extensively on colour vision to adapt to the natural world. Most species express a broad range of colour-sensitive Rhodopsin proteins in three types of ommatidia (unit eyes), which are distributed stochastically across the retina. The retinas of Drosophila melanogaster use just two main types, in whic...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature18616
更新日期:2016-07-14 00:00:00
abstract::Hydrolysis of the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) produces two prospective intracellular messengers: inositol 1,4,5-trisphosphate (InsP3), which releases Ca2+ from intracellular stores; and diacylglycerol (DG), which activates protein kinase C. Here we show how the formation...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323333a0
更新日期:1986-09-25 00:00:00
abstract::The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial com...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01262
更新日期:2002-12-05 00:00:00
abstract::Estimates of the total number of bacterial species indicate that existing DNA sequence databases carry only a tiny fraction of the total amount of DNA sequence space represented by this division of life. Indeed, environmental DNA samples have been shown to encode many previously unknown classes of proteins and RNAs. B...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08586
更新日期:2009-12-03 00:00:00
abstract::The study of bacterial ion channels has provided fundamental insights into the structural basis of neuronal signalling; however, the native role of ion channels in bacteria has remained elusive. Here we show that ion channels conduct long-range electrical signals within bacterial biofilm communities through spatially ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15709
更新日期:2015-11-05 00:00:00
abstract::Some bacteria are capable of extracellular electron transfer, thereby enabling them to use electron acceptors and donors without direct cell contact. Beyond the micrometre scale, however, no firm evidence has previously existed that spatially segregated biogeochemical processes can be coupled by electric currents in n...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08790
更新日期:2010-02-25 00:00:00
abstract::A brief account is provided of a meeting between federal officials and representatives of the Industrial Biotechnology Association (IBA), a consortium of companies concerned about the regulatory outlook for their industry. Current regulatory interest is focused on the Environmental Protection Agency, which has declar...
journal_title:Nature
pub_type: 新闻
doi:10.1038/305755a0
更新日期:1983-10-27 00:00:00
abstract::The effect of ions on the light-sensitive current of retinal rods was studied by sucking the inner segment into a tightly fitting capillary with the outer segment projecting into a flowing solution. This new method showed that the light-sensitive pathway, in which Na+ is the normal carrier of current, has an ionic sel...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/292502a0
更新日期:1981-08-06 00:00:00
abstract::Neuropeptide Y (NPY) has a number of functions in mammalian physiology. Here we identify a role for NPY in promoting proliferation of postnatal neuronal precursor cells. NPY is synthesized in the postnatal olfactory epithelium by sustentacular cells, previously proposed to function only in structural support. Mice wit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35073601
更新日期:2001-04-19 00:00:00
abstract::The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis methods to identify somatic variants across thousands of tumours. Here we present data and analytical results for point mutations and small insertions/deletions from 3,281 tumours across 12 tumour types as part of the TCGA Pan-Cancer effort. We...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12634
更新日期:2013-10-17 00:00:00
abstract::A long-standing hypothesis on tumorigenesis is that cell division failure, generating genetically unstable tetraploid cells, facilitates the development of aneuploid malignancies. Here we test this idea by transiently blocking cytokinesis in p53-null (p53-/-) mouse mammary epithelial cells (MMECs), enabling the isolat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04217
更新日期:2005-10-13 00:00:00
abstract::The ice-rich surface of the jovian satellite Europa is sparsely cratered, suggesting that this moon might be geologically active today. Moreover, models of the satellite's interior indicate that tidal interactions with Jupiter might produce enough heat to maintain a subsurface liquid water layer. But the mechanisms of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/34862
更新日期:1998-01-22 00:00:00
abstract::The skin of mice contains dendritic epidermal cells carrying the Thy-1 antigen (Thy-1+ dEC) which express antigen receptors composed of the T-cell antigen receptor (TCR) gamma- and delta-chains. Although the role of the thymus in the generation of most T cells is well established, the involvement of the thymus in the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344068a0
更新日期:1990-03-01 00:00:00
abstract::Elongation factor Tu is present in a fourfold excess over the amount seemingly involved in protein synthesis. It is identical to a major protein which we have found associated with the plasma membrane. The possibility of a specific role in that location is considered. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/261023a0
更新日期:1976-05-06 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-020-2064-8
更新日期:2020-03-01 00:00:00
abstract::Overfishing of large-bodied benthic fishes and their subsequent population collapses on the Scotian Shelf of Canada's east coast and elsewhere resulted in restructuring of entire food webs now dominated by planktivorous, forage fish species and macroinvertebrates. Despite the imposition of strict management measures i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10285
更新日期:2011-07-27 00:00:00
abstract::For cells of the innate immune system to mount a host defence response to infection, they must recognize products of microbial pathogens such as lipopolysaccharide (LPS), the endotoxin secreted by Gram-negative bacteria. These cellular responses require intracellular signalling pathways, such as the four MAP kinase (M...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386296a0
更新日期:1997-03-20 00:00:00
abstract::The global burden of malaria has been substantially reduced over the past two decades. Future efforts to reduce malaria further will require moving beyond the treatment of clinical infections to targeting malaria transmission more broadly in the community. As such, the accurate identification of asymptomatic human inf...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16039
更新日期:2015-12-03 00:00:00
abstract::Nuclear import of the NF-AT transcription factors during T-cell activation requires the calcium-activated phosphatase calcineurin, which unmasks nuclear-location signals on NF-AT. We show here that the nuclear import of NF-ATs is not sufficient to activate NF-AT target genes, as NF-ATs are subject to a futile cycling ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/18473
更新日期:1999-03-18 00:00:00
abstract::Multicomponent reactions are relied on in both academic and industrial synthetic organic chemistry owing to their step- and atom-economy advantages over traditional synthetic sequences1. Recently, bicyclo[1.1.1]pentane (BCP) motifs have become valuable as pharmaceutical bioisosteres of benzene rings, and in particular...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2060-z
更新日期:2020-04-01 00:00:00
abstract::Scientific fraud, much in the news recently, is not a new phenomenon. What follows is a personal account of a particular case. ...
journal_title:Nature
pub_type: 传,历史文章,杂志文章
doi:10.1038/357434a0
更新日期:1992-06-11 00:00:00
abstract::Atlantic tropical cyclone activity, as measured by annual storm counts, reached anomalous levels over the past decade. The short nature of the historical record and potential issues with its reliability in earlier decades, however, has prompted an ongoing debate regarding the reality and significance of the recent ris...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08219
更新日期:2009-08-13 00:00:00
abstract::The recognition and localization of sound signals is fundamental to acoustic communication. Complex neural mechanisms are thought to underlie the processing of species-specific sound patterns even in animals with simple auditory pathways. In female crickets, which orient towards the male's calling song, current models...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02787
更新日期:2004-08-12 00:00:00
abstract::Drosophila cells contain virus-like particles (VLPs) containing 5 kilobases (kb) of RNA (VLP H-RNA) homologous to the transposable element copia. The identity between VLP H-RNA and copia DNA has previously been confirmed at the nucleotide sequence level and reverse transcriptase activity is also detected in the VLPs. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323824a0
更新日期:1986-10-30 00:00:00
abstract::Although parasite-host co-speciation is a long-held hypothesis, convincing evidence for long-term co-speciation remains elusive, largely because of small numbers of hosts and parasites studied and uncertainty over rates of evolutionary change. Co-speciation is especially rare in RNA viruses, in which cross-species tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03341
更新日期:2005-03-17 00:00:00
abstract::In this Letter, the received date should have been 23 March 2017 instead of 13 April 2018. Authors R.M.K. and O.D.K. were incorrectly denoted as 'equally contributing' authors. The labels for 'control' and 'IFNγ' in Extended Data Fig. 4g were reversed. These have been corrected online. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0370-1
更新日期:2018-10-01 00:00:00
abstract::The brain cholecystokinin-B/gastrin receptor (CCK-B/gastrin) has been implicated in mediating anxiety, panic attacks, satiety, and the perception of pain. The canine and human CCK-B/gastrin receptors share 90% amino-acid identity and have similar agonist affinities. These receptors can be selectively blocked by the no...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/362348a0
更新日期:1993-03-25 00:00:00