Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.

abstract：:Microbiome-wide association studies have established that numerous diseases are associated with changes in the microbiota. These studies typically generate a long list of commensals implicated as biomarkers of disease, with no clear relevance to disease pathogenesis. If the field is to move beyond correlations and beg...

journal_title：Nature

authors： Surana NK,Kasper DL

更新日期：2017-12-14 00:00:00

abstract：:Multistranded DNA structures based upon guanine association have been proposed to be important in the structure of chromosome telomeres and in immunoglobulin class switching. Nucleic acids containing runs of guanine bases form a number of structures in vitro, including fold-back structures (Fig. 1a) and parallel-stran...

journal_title：Nature

authors： Aboul-ela F,Murchie AI,Lilley DM

更新日期：1992-11-19 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is characterized by elevated glycogen levels and fat deposition. These consistent metabolic alterations are associated with normoxic stabilization of hypoxia-inducible factors (HIFs) secondary to von Hippel-Lindau (VHL) mutations that occu...

journal_title：Nature

authors： Li B,Qiu B,Lee DS,Walton ZE,Ochocki JD,Mathew LK,Mancuso A,Gade TP,Keith B,Nissim I,Simon MC

更新日期：2014-09-11 00:00:00

abstract：:Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription ...

journal_title：Nature

authors： Anneser L,Alcantara IC,Gemmer A,Mirkes K,Ryu S,Schuman EM

更新日期：2020-12-01 00:00:00

abstract：:Despite decades of research, the identity of the cells generating the first haematopoietic cells in mammalian embryos is unknown. Indeed, whether blood cells arise from mesodermal cells, mesenchymal progenitors, bipotent endothelial-haematopoietic precursors or haemogenic endothelial cells remains controversial. Proxi...

journal_title：Nature

authors： Eilken HM,Nishikawa S,Schroeder T

更新日期：2009-02-12 00:00:00

abstract：:Established infections with the human and simian immunodeficiency viruses (HIV and SIV, respectively) are thought to be permanent with even the most effective immune responses and antiretroviral therapies only able to control, but not clear, these infections. Whether the residual virus that maintains these infections ...

journal_title：Nature

authors： Hansen SG,Piatak M Jr,Ventura AB,Hughes CM,Gilbride RM,Ford JC,Oswald K,Shoemaker R,Li Y,Lewis MS,Gilliam AN,Xu G,Whizin N,Burwitz BJ,Planer SL,Turner JM,Legasse AW,Axthelm MK,Nelson JA,Früh K,Sacha JB,Estes JD

更新日期：2013-10-03 00:00:00

abstract：:Genetic studies, using floral homeotic mutants, have led to the ABC model of flower development. This model proposes that the combinatorial action of three sets of genes, the A, B and C function genes, specify the four floral organs (sepals, petals, stamens and carpels) in the concentric floral whorls. However, attemp...

journal_title：Nature

authors： Honma T,Goto K

更新日期：2001-01-25 00:00:00

abstract：:The formation and guidance of specialized endothelial tip cells is essential for both developmental and pathological angiogenesis. Notch-1 signalling regulates the generation of tip cells, which respond to gradients of vascular endothelial growth factor (VEGF-A). The molecular cues and signalling pathways that control...

journal_title：Nature

authors： Sawamiphak S,Seidel S,Essmann CL,Wilkinson GA,Pitulescu ME,Acker T,Acker-Palmer A

更新日期：2010-05-27 00:00:00

abstract：:ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP occurs in the mitochondrial matrix, ATP is exported into the cytoplasm while ADP is imported into the matrix. The exchange is accomplished by...

journal_title：Nature

authors： Pebay-Peyroula E,Dahout-Gonzalez C,Kahn R,Trézéguet V,Lauquin GJ,Brandolin G

更新日期：2003-11-06 00:00:00

abstract：:There is still no universally accepted theory of high-temperature superconductivity. Most models assume that doping creates 'holes' in the valence band of an insulating, antiferromagnetic 'parent' compound, and that antiferromagnetism and high-temperature superconductivity are intimately related. If their respective e...

journal_title：Nature

authors： Bozovic I,Logvenov G,Verhoeven MA,Caputo P,Goldobin E,Geballe TH

更新日期：2003-04-24 00:00:00

abstract：:Type Ia supernovae are thought to result from thermonuclear explosions of carbon-oxygen white dwarf stars. Existing models generally explain the observed properties, with the exception of the sub-luminous 1991bg-like supernovae. It has long been suspected that the merger of two white dwarfs could give rise to a type I...

journal_title：Nature

authors： Pakmor R,Kromer M,Röpke FK,Sim SA,Ruiter AJ,Hillebrandt W

更新日期：2010-01-07 00:00:00

abstract：:Although phytoalexins have long been inferred to be important in the defence of plants against fungal infection, there are few reports showing that they provide resistance to infection. Several plants, including grapevine, synthesize the stilbene-type phytoalexin resveratrol when attacked by pathogens. Stilbenes with ...

journal_title：Nature

authors： Hain R,Reif HJ,Krause E,Langebartels R,Kindl H,Vornam B,Wiese W,Schmelzer E,Schreier PH,Stöcker RH

更新日期：1993-01-14 00:00:00

abstract：:Growth of neurite processes from the cell body is the critical step in neuronal development and involves a large increase in cell membrane surface area. Arachidonic-acid-releasing phospholipases are highly enriched in nerve growth cones and have previously been implicated in neurite outgrowth. Cell membrane expansion ...

journal_title：Nature

authors： Darios F,Davletov B

更新日期：2006-04-06 00:00:00

abstract：:The formation of disulphide bonds is essential to the structure and function of proteins. These bonds rapidly form either cotranslationally or immediately post-translationally in the lumen of the endoplasmic reticulum. Native disulphide pairing for such proteins has been achieved in vitro; however, the rates of reasse...

journal_title：Nature

authors： Edman JC,Ellis L,Blacher RW,Roth RA,Rutter WJ

更新日期：1985-09-19 00:00:00

abstract：:The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer and chronic circadian rhythm disruption predisposes individuals to tumour development. This raises the hypothesis that pharmacological modulation o...

journal_title：Nature

authors： Sulli G,Rommel A,Wang X,Kolar MJ,Puca F,Saghatelian A,Plikus MV,Verma IM,Panda S

更新日期：2018-01-18 00:00:00

abstract：:Fast radio bursts (FRBs) are millisecond-duration radio transients1,2 of unknown origin. Two possible mechanisms that could generate extremely coherent emission from FRBs invoke neutron star magnetospheres3-5 or relativistic shocks far from the central energy source6-8. Detailed polarization observations may help us t...

journal_title：Nature

authors： Luo R,Wang BJ,Men YP,Zhang CF,Jiang JC,Xu H,Wang WY,Lee KJ,Han JL,Zhang B,Caballero RN,Chen MZ,Chen XL,Gan HQ,Guo YJ,Hao LF,Huang YX,Jiang P,Li H,Li J,Li ZX,Luo JT,Pan J,Pei X,Qian L,Sun JH,Wang M,Wa

更新日期：2020-10-01 00:00:00

abstract：:The TGF-beta/activin/BMP cytokine family signals through serine/threonine kinase receptors, but how the receptors transduce the signal is unknown. The Mad (Mothers against decapentaplegic) gene from Drosophila and the related Sma genes from Caenorhabditis elegans have been genetically implicated in signalling by membe...

journal_title：Nature

authors： Liu F,Hata A,Baker JC,Doody J,Cárcamo J,Harland RM,Massagué J

更新日期：1996-06-13 00:00:00

abstract：:The resemblance of the orbitally filtered isotope signal from the past 340 kyr in Antarctic ice cores to Northern Hemisphere summer insolation intensity has been used to suggest that the northern hemisphere may drive orbital-scale global climate changes. A recent Letter by Laepple et al. suggests that, contrary to thi...

journal_title：Nature

authors： Sime LC,Wolff EW

更新日期：2011-11-09 00:00:00

abstract：:Macroscopic mechanical oscillators have been coaxed into a regime of quantum behaviour by direct refrigeration or a combination of refrigeration and laser-like cooling. This result supports the idea that mechanical oscillators may perform useful functions in the processing of quantum information with superconducting c...

journal_title：Nature

authors： Palomaki TA,Harlow JW,Teufel JD,Simmonds RW,Lehnert KW

更新日期：2013-03-14 00:00:00

abstract：:The human nose is often considered something of a luxury, but in the rest of the animal world, from bacteria to mammals, detecting chemicals in the environment has been critical to the successful organism. An indication of the importance of olfactory systems is the significant proportion - as much as 4% - of the genom...

journal_title：Nature

authors： Firestein S

更新日期：2001-09-13 00:00:00

abstract：:Life implies movement. Most forms of movement in the living world are powered by tiny protein machines known as molecular motors. Among the best known are motors that use sophisticated intramolecular amplification mechanisms to take nanometre steps along protein tracks in the cytoplasm. These motors transport a wide v...

journal_title：Nature

authors： Schliwa M,Woehlke G

更新日期：2003-04-17 00:00:00

abstract：:The 3-dimethylsulphoniopropionate (DMSP) produced by marine algae is the main biogenic precursor of atmospheric dimethylsulphide (DMS). This biogenic DMS, formed by bacterial and algal degradation of DMSP, contributes about 1.5 x 10(13) g of sulphur to the atmosphere annually, and plays a major part in the global sulp...

journal_title：Nature

authors： Gage DA,Rhodes D,Nolte KD,Hicks WA,Leustek T,Cooper AJ,Hanson AD

更新日期：1997-06-26 00:00:00

abstract：:Cytotoxic T cells lyse only those virus infected target cells in vitro which express, in addition to the viral antigen(s), those K or D region products of the major histocompatibility complex (MHC) which were present during anti-viral sensitisation in vivo. This 'associative recognition' by cytotoxic T cells could ref...

journal_title：Nature

authors： Koszinowski U,Gething MJ,Waterfield M

更新日期：1977-05-12 00:00:00

abstract：:Environmental change has altered the phenology, morphological traits and population dynamics of many species. However, the links underlying these joint responses remain largely unknown owing to a paucity of long-term data and the lack of an appropriate analytical framework. Here we investigate the link between phenoty...

journal_title：Nature

authors： Ozgul A,Childs DZ,Oli MK,Armitage KB,Blumstein DT,Olson LE,Tuljapurkar S,Coulson T

更新日期：2010-07-22 00:00:00

abstract：:Appropriate repair of DNA lesions and the inhibition of DNA repair activities at telomeres are crucial to prevent genomic instability. By fuelling the generation of genetic alterations and by compromising cell viability, genomic instability is a driving force in cancer and ageing. Here we identify MAD2L2 (also known a...

journal_title：Nature

authors： Boersma V,Moatti N,Segura-Bayona S,Peuscher MH,van der Torre J,Wevers BA,Orthwein A,Durocher D,Jacobs JJL

更新日期：2015-05-28 00:00:00

abstract：:Many eukaryotic cellular and viral proteins have a covalently attached myristoyl group at the amino terminus. One such protein is recoverin, a calcium sensor in retinal rod cells, which controls the lifetime of photoexcited rhodopsin by inhibiting rhodopsin kinase. Recoverin has a relative molecular mass of 23,000 (M[...

journal_title：Nature

authors： Ames JB,Ishima R,Tanaka T,Gordon JI,Stryer L,Ikura M

更新日期：1997-09-11 00:00:00

abstract：:Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest tha...

journal_title：Nature

authors： Canter RG,Penney J,Tsai LH

更新日期：2016-11-10 00:00:00

abstract：:Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to the control of hunger. They are activated by caloric deficiency and, when naturally or artificially stimulated, they potently in...

journal_title：Nature

authors： Krashes MJ,Shah BP,Madara JC,Olson DP,Strochlic DE,Garfield AS,Vong L,Pei H,Watabe-Uchida M,Uchida N,Liberles SD,Lowell BB

更新日期：2014-03-13 00:00:00

abstract：:Activity in the motor cortex predicts movements, seconds before they are initiated. This preparatory activity has been observed across cortical layers, including in descending pyramidal tract neurons in layer 5. A key question is how preparatory activity is maintained without causing movement, and is ultimately conver...

journal_title：Nature

authors： Economo MN,Viswanathan S,Tasic B,Bas E,Winnubst J,Menon V,Graybuck LT,Nguyen TN,Smith KA,Yao Z,Wang L,Gerfen CR,Chandrashekar J,Zeng H,Looger LL,Svoboda K

更新日期：2018-11-01 00:00:00

abstract：:Transport of calcium ions across membranes and against a thermodynamic gradient is essential to many biological processes, including muscle contraction, the citric acid cycle, glycogen metabolism, release of neurotransmitters, vision, biological signal transduction and immune response. Synthetic systems that transport...

journal_title：Nature

authors： Bennett IM,Farfano HM,Bogani F,Primak A,Liddell PA,Otero L,Sereno L,Silber JJ,Moore AL,Moore TA,Gust D

更新日期：2002-11-28 00:00:00