Continuous single-cell imaging of blood generation from haemogenic endothelium.

abstract：:The North Atlantic Oscillation (NAO) is the major source of variability in winter atmospheric circulation in the Northern Hemisphere, with large impacts on temperature, precipitation and storm tracks, and therefore also on strategic sectors such as insurance, renewable energy production, crop yields and water manageme...

journal_title：Nature

authors： Ortega P,Lehner F,Swingedouw D,Masson-Delmotte V,Raible CC,Casado M,Yiou P

更新日期：2015-07-02 00:00:00

abstract：:The efficiency of generating electricity from heat using concentrated solar power plants (which use mirrors or lenses to concentrate sunlight in order to drive heat engines, usually involving turbines) may be appreciably increased by operating with higher turbine inlet temperatures, but this would require improved hea...

journal_title：Nature

authors： Caccia M,Tabandeh-Khorshid M,Itskos G,Strayer AR,Caldwell AS,Pidaparti S,Singnisai S,Rohskopf AD,Schroeder AM,Jarrahbashi D,Kang T,Sahoo S,Kadasala NR,Marquez-Rossy A,Anderson MH,Lara-Curzio E,Ranjan D,Henry A,Sandhag

更新日期：2018-10-01 00:00:00

abstract：:Double-stranded RNAs (dsRNAs) induce post-transcriptional gene silencing in several species of animal and plant. In plants, dsRNAs targeted to CpG islands within a promoter can also induce RNA-directed DNA methylation; however, it remains unclear whether gene silencing mediated by DNA methylation can be induced by dsR...

journal_title：Nature

authors： Kawasaki H,Taira K

更新日期：2004-09-09 00:00:00

abstract：:Formation of catalytically active RNA structures within the spliceosome requires the assistance of proteins. However, little is known about the number and nature of proteins needed to establish and maintain the spliceosome's active site. Here we affinity-purified human spliceosomal C complexes and show that they catal...

journal_title：Nature

authors： Bessonov S,Anokhina M,Will CL,Urlaub H,Lührmann R

更新日期：2008-04-17 00:00:00

abstract：:A long-standing hypothesis posits that natural selection can favour two female strategies when density cycles. At low density, females producing many smaller progeny are favoured when the intrinsic rate of increase, r, governs population growth. At peak density, females producing fewer, high-quality, progeny are favou...

journal_title：Nature

authors： Sinervo B,Svensson E,Comendant T

更新日期：2000-08-31 00:00:00

abstract：:Historical ecologists working in the Neotropics argue that the present natural environment is an historical product of human intentionality and ingenuity, a creation that is imposed, built, managed and maintained by the collective multigenerational knowledge and experience of Native Americans. In the past 12,000 years...

journal_title：Nature

authors： Erickson CL

更新日期：2000-11-09 00:00:00

abstract：:The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functio...

journal_title：Nature

authors： van Houten M,Posner BI

更新日期：1979-12-06 00:00:00

abstract：:The microtubule cytoskeleton is essential to cell morphogenesis. Growing microtubule plus ends have emerged as dynamic regulatory sites in which specialized proteins, called plus-end-binding proteins (+TIPs), bind and regulate the proper functioning of microtubules. However, the molecular mechanism of plus-end associa...

journal_title：Nature

authors： Bieling P,Laan L,Schek H,Munteanu EL,Sandblad L,Dogterom M,Brunner D,Surrey T

更新日期：2007-12-13 00:00:00

abstract：:Long-term potentiation of chemical synapses is closely related to memory and learning. Studies of this process have concentrated on chemically mediated excitatory synapses. By contrast, activity-dependent modification of gap junctions, which also widely exist in higher structures such as hippocampus and neocortex, has...

journal_title：Nature

authors： Yang XD,Korn H,Faber DS

更新日期：1990-12-06 00:00:00

abstract：:Anomalies in temperature and precipitation in northern Russia over the past few years have been viewed as manifestations of anthropogenic climate change, prompting suggestions that this may also account for exceptional forest fires in the region. Here we examine the number of forest-fire events across the boreal Russi...

journal_title：Nature

authors： Mollicone D,Eva HD,Achard F

更新日期：2006-03-23 00:00:00

abstract：: ...

journal_title：Nature

authors： Narayan A

更新日期：2019-03-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but this restriction seems to break down in human autoimmune disease by an as yet poorly understood mechanism. Here we identify the antimicrob...

journal_title：Nature

authors： Lande R,Gregorio J,Facchinetti V,Chatterjee B,Wang YH,Homey B,Cao W,Wang YH,Su B,Nestle FO,Zal T,Mellman I,Schröder JM,Liu YJ,Gilliet M

更新日期：2007-10-04 00:00:00

abstract：:The sensitivity of soil carbon to warming is a major uncertainty in projections of carbon dioxide concentration and climate. Experimental studies overwhelmingly indicate increased soil organic carbon (SOC) decomposition at higher temperatures, resulting in increased carbon dioxide emissions from soils. However, recent...

journal_title：Nature

authors： Knorr W,Prentice IC,House JI,Holland EA

更新日期：2005-01-20 00:00:00

abstract：:The cellular oncogene c-Ki-ras is amplified 30- to 60-fold in cells of the mouse adrenocortical tumour Y1. The amplified oncogene is located in double minute chromosomes and in a homogeneously staining chromosomal region, common karyotypical anomalies of tumour cells. The amounts of c-Ki-ras specific mRNA and of the p...

journal_title：Nature

authors： Schwab M,Alitalo K,Varmus HE,Bishop JM,George D

更新日期：1983-06-09 00:00:00

abstract：:Sensory systems can adapt to the conditions imposed on them. In the visual system, adapting to a pattern increases the threshold of the ability to see that pattern, and reduces the perceived contrast of the pattern above threshold. Most neurons of the striate cortex reduce their responsiveness after being stimulated f...

journal_title：Nature

authors： Snowden RJ,Hammett ST

更新日期：1992-01-16 00:00:00

abstract：:We have used in vitro mutagenesis to identify a DNA sequence that is required for glucose regulation of the ADR2 locus of Saccharomyces cerevisiae. This region, located between 200 and 1,000 base pairs upstream of the structural gene for ADH II, has been identified by genetic and biochemical analysis as the site of AD...

journal_title：Nature

authors： Beier DR,Young ET

更新日期：1982-12-23 00:00:00

abstract：:Most normal mammalian cells have a finite lifespan, thought to constitute a protective mechanism against unlimited proliferation. This phenomenon, called senescence, is driven by telomere attrition, which triggers the induction of tumour suppressors including p16(INK4a) (ref. 5). In cultured cells, senescence can be e...

journal_title：Nature

authors： Michaloglou C,Vredeveld LC,Soengas MS,Denoyelle C,Kuilman T,van der Horst CM,Majoor DM,Shay JW,Mooi WJ,Peeper DS

更新日期：2005-08-04 00:00:00

abstract：:Hunter-Schreger bands (HSB) are seen in teeth that are composed of crossed sets of enamel prisms. They are present in the teeth of man and many other mammals, but absent in most insectivores and multituberculates. It has been suggested that the presence of HSB makes the tooth enamel less likely to split and is associa...

journal_title：Nature

authors： von Koenigswald W,Rensberger JM,Pretzschner HU

更新日期：1987-07-09 00:00:00

abstract：:Spectacular fossils from the Early Cretaceous Jehol Group of northeastern China have greatly expanded our knowledge of the diversity and palaeobiology of dinosaurs and early birds, and contributed to our understanding of the origin of birds, of flight, and of feathers. Pennaceous (vaned) feathers and integumentary fil...

journal_title：Nature

authors： Zhang F,Kearns SL,Orr PJ,Benton MJ,Zhou Z,Johnson D,Xu X,Wang X

更新日期：2010-02-25 00:00:00

abstract：:Epidermal growth factor (EGF) and transforming growth factor type I (TGF) are polypeptides of 53 and 50 amino acid residues, respectively. Both bind to EGF receptor, a 1,200-residue transmembranous glycoprotein, leading to phosphorylation of the receptor, enhancement of its tyrosine-specific kinase activity and ultima...

journal_title：Nature

authors： Brown JP,Twardzik DR,Marquardt H,Todaro GJ

更新日期：1985-02-07 00:00:00

abstract：:The antigen CD10 (common acute lymphoblastic leukaemia antigen), which is the zinc metalloprotease, neutral endopeptidase 24.11 (also known as NEP or 'enkephalinase'), is expressed by acute lymphoblastic leukaemias, normal lymphoid progenitors, mature polymorphonuclear leukocytes and certain nonhaematopoietic cells. C...

journal_title：Nature

authors： Shipp MA,Stefano GB,D'Adamio L,Switzer SN,Howard FD,Sinisterra J,Scharrer B,Reinherz EL

更新日期：1990-09-27 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin disorder that affects approximately 2-3% of the population worldwide and has severe effects on patients' physical and psychological well-being. The discovery that psoriasis is an immune-mediated disease has led to more targeted, effective therapies; recent advances have focused...

journal_title：Nature

authors： Kopp T,Riedl E,Bangert C,Bowman EP,Greisenegger E,Horowitz A,Kittler H,Blumenschein WM,McClanahan TK,Marbury T,Zachariae C,Xu D,Hou XS,Mehta A,Zandvliet AS,Montgomery D,van Aarle F,Khalilieh S

更新日期：2015-05-14 00:00:00

abstract：:The development and maintenance of an epithelium requires finely balanced rates of growth and cell death. However, the mechanical and biochemical mechanisms that ensure proper feedback control of tissue growth, which when deregulated contribute to tumorigenesis, are poorly understood. Here we use the fly notum as a mo...

journal_title：Nature

authors： Marinari E,Mehonic A,Curran S,Gale J,Duke T,Baum B

更新日期：2012-04-15 00:00:00

abstract：:A set of restriction fragments cloned into phage lambda vectors has allowed us to locate a site necessary for full rpoBC expression. We find that these genes for the two large subunits of RNA polymerase and the genes, rplL and rplJ, for two ribosomal proteins, form a single operon. ...

journal_title：Nature

authors： Linn T,Scaife J

更新日期：1978-11-02 00:00:00

abstract：:The identification of novel metabolites and the characterization of their biological functions are major challenges in biology. X-ray crystallography can reveal unanticipated ligands that persist through purification and crystallization. These adventitious protein-ligand complexes provide insights into new activities,...

journal_title：Nature

authors： Kim J,Xiao H,Bonanno JB,Kalyanaraman C,Brown S,Tang X,Al-Obaidi NF,Patskovsky Y,Babbitt PC,Jacobson MP,Lee YS,Almo SC

更新日期：2013-06-06 00:00:00

abstract：:Haemoglobin is the prototype of an allosteric protein in which cooperative behaviour depends on interaction between unlike subunits. Here we present haematological and biochemical evidence that electrostatic interactions are an important determinant of haemoglobin assembly. Individuals heterozygous for positively char...

journal_title：Nature

authors： Bunn HF,McDonald MJ

更新日期：1983-12-01 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) are cell-surface molecules that transduce signals for cell growth and differentiation. The RTK encoded by the c-ret proto-oncogene is rearranged and constitutively activated in a large proportion of thyroid papillary carcinomas, and germ-line point mutations in c-ret seem to be respons...

journal_title：Nature

authors： Schuchardt A,D'Agati V,Larsson-Blomberg L,Costantini F,Pachnis V

更新日期：1994-01-27 00:00:00

abstract：:Deposits of beta-amyloid are one of the main pathological characteristics of Alzheimer's disease. The beta-amyloid peptide constituent (relative molecular mass 4,200) of the deposits is derived from the beta-amyloid precursor protein (beta-APP) which is expressed in several different isoforms. The two most prevalent b...

journal_title：Nature

authors： Quon D,Wang Y,Catalano R,Scardina JM,Murakami K,Cordell B

更新日期：1991-07-18 00:00:00

abstract：:In the era of precision cosmology, it is essential to determine the Hubble constant empirically with an accuracy of one per cent or better1. At present, the uncertainty on this constant is dominated by the uncertainty in the calibration of the Cepheid period-luminosity relationship2,3 (also known as the Leavitt law). ...

journal_title：Nature

authors： Pietrzyński G,Graczyk D,Gallenne A,Gieren W,Thompson IB,Pilecki B,Karczmarek P,Górski M,Suchomska K,Taormina M,Zgirski B,Wielgórski P,Kołaczkowski Z,Konorski P,Villanova S,Nardetto N,Kervella P,Bresolin F,Kudritzki RP

更新日期：2019-03-01 00:00:00

abstract：:The crystal structure of a solid controls the interactions between the electronically active units and thus its electronic properties. In the high-temperature superconducting copper oxides, only one spatial arrangement of the electronically active Cu(2+) units-a two-dimensional square lattice-is available to study the...

journal_title：Nature

authors： Ganin AY,Takabayashi Y,Jeglic P,Arcon D,Potocnik A,Baker PJ,Ohishi Y,McDonald MT,Tzirakis MD,McLennan A,Darling GR,Takata M,Rosseinsky MJ,Prassides K

更新日期：2010-07-08 00:00:00