A 'don't eat me' immune signal protects neuronal connections.

abstract：:The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has impor...

journal_title：Nature

authors： Acharya R,Fry E,Stuart D,Fox G,Rowlands D,Brown F

更新日期：1989-02-23 00:00:00

abstract：: ...

journal_title：Nature

authors： Else H

更新日期：2018-11-01 00:00:00

abstract：:The Pax-6 transcription-factor gene, containing a paired domain and a paired-type homeodomain, is conserved in structure and ubiquitously present among Metazoa. It is required for development of the central nervous system, and is mutated in human aniridia, mouse and rat small eye and Drosophila eyeless. We identified ...

journal_title：Nature

authors： Zhang Y,Emmons SW

更新日期：1995-09-07 00:00:00

abstract：:Regulatory T (T(reg)) cells are a critical sub-population of CD4+ T cells that are essential for maintaining self tolerance and preventing autoimmunity, for limiting chronic inflammatory diseases, such as asthma and inflammatory bowel disease, and for regulating homeostatic lymphocyte expansion. However, they also sup...

journal_title：Nature

authors： Collison LW,Workman CJ,Kuo TT,Boyd K,Wang Y,Vignali KM,Cross R,Sehy D,Blumberg RS,Vignali DA

更新日期：2007-11-22 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:The chemical evolution of the Earth and the terrestrial planets is largely controlled by the density of silicate melts. If melt density is higher than that of the surrounding solid, incompatible elements dissolved in the melt will be sequestered in the deep mantle. Previous studies on dry (water-free) melts showed tha...

journal_title：Nature

authors： Matsukage KN,Jing Z,Karato S

更新日期：2005-11-24 00:00:00

abstract：:Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure. Bacteria comprising the Chlamydiales were thought to be one of the few exceptions. Chlamydia harbour genes for PG biosynthesis and exhibit suscept...

journal_title：Nature

authors： Liechti GW,Kuru E,Hall E,Kalinda A,Brun YV,VanNieuwenhze M,Maurelli AT

更新日期：2014-02-27 00:00:00

abstract：:Many biomolecules are characterized by surfaces containing extended nonpolar regions, and the aggregation and subsequent removal of such surfaces from water is believed to play a critical role in the biomolecular assembly in cells. A better understanding of the hydrophobic hydration of biomolecules may therefore yield...

journal_title：Nature

authors： Cheng YK,Rossky PJ

更新日期：1998-04-16 00:00:00

abstract：:Blood coagulation can be initiated when factor VII or VIIa, a plasma protease, binds to its essential cofactor, tissue factor (TF), and proteolytically activates factors IX and X, triggering a cascade of events which eventually leads to the formation of thrombin and a fibrin clot. Plasma contains a lipoprotein-associa...

journal_title：Nature

authors： Girard TJ,Warren LA,Novotny WF,Likert KM,Brown SG,Miletich JP,Broze GJ Jr

更新日期：1989-04-06 00:00:00

abstract：:In this Letter, the statement 'I.I. and A.B. performed computations at the NCI Australia' was missing from the Acknowledgements section. This has been corrected online. ...

journal_title：Nature

authors： Sainadh US,Xu H,Wang X,Atia-Tul-Noor A,Wallace WC,Douguet N,Bray A,Ivanov I,Bartschat K,Kheifets A,Sang RT,Litvinyuk IV

更新日期：2019-05-01 00:00:00

abstract：:The geometry and dimensions of branched structures such as blood vessels or airways are important factors in determining the efficiency of physiological processes. It has been shown that fractal trees can be space filling and can ensure minimal dissipation. The bronchial tree of most mammalian lungs is a good example ...

journal_title：Nature

authors： Mauroy B,Filoche M,Weibel ER,Sapoval B

更新日期：2004-02-12 00:00:00

abstract：:Strong interactions between electrons in a solid material can lead to surprising properties. A prime example is the Mott insulator, in which suppression of conductivity occurs as a result of interactions rather than a filled Bloch band. Proximity to the Mott insulating phase in fermionic systems is the origin of many ...

journal_title：Nature

authors： Jördens R,Strohmaier N,Günter K,Moritz H,Esslinger T

更新日期：2008-09-11 00:00:00

abstract：:High pressure is known to influence electronic structure and crystal packing, and can in some cases even induce compound formation between elements that do not bond under ambient conditions. Here we present a computational study showing that high pressure fundamentally alters the reactivity of the light elements lithi...

journal_title：Nature

authors： Feng J,Hennig RG,Ashcroft NW,Hoffmann R

更新日期：2008-01-24 00:00:00

abstract：:The establishment and maintenance of epigenetic gene silencing is fundamental to cell determination and function. The essential epigenetic systems involved in heritable repression of gene activity are the Polycomb group (PcG) proteins and the DNA methylation systems. Here we show that the corresponding silencing pathw...

journal_title：Nature

authors： Viré E,Brenner C,Deplus R,Blanchon L,Fraga M,Didelot C,Morey L,Van Eynde A,Bernard D,Vanderwinden JM,Bollen M,Esteller M,Di Croce L,de Launoit Y,Fuks F

更新日期：2006-02-16 00:00:00

abstract：:Generation of a diverse and self-tolerant T-cell repertoire requires appropriate interpretation of T-cell antigen receptor (TCR) signals by CD4(+ ) CD8(+) double-positive thymocytes. Thymocyte cell fate is dictated by the nature of TCR-major-histocompatibility-complex (MHC)-peptide interactions, with signals of higher...

journal_title：Nature

authors： Staton TL,Lazarevic V,Jones DC,Lanser AJ,Takagi T,Ishii S,Glimcher LH

更新日期：2011-04-07 00:00:00

abstract：:Chronic myeloid leukaemia (CML) is caused by a defined genetic abnormality that generates BCR-ABL, a constitutively active tyrosine kinase. It is widely believed that BCR-ABL activates Akt signalling that suppresses the forkhead O transcription factors (FOXO), supporting the proliferation or inhibiting the apoptosis o...

journal_title：Nature

authors： Naka K,Hoshii T,Muraguchi T,Tadokoro Y,Ooshio T,Kondo Y,Nakao S,Motoyama N,Hirao A

更新日期：2010-02-04 00:00:00

abstract：:CD4 and CD8 antigens are simultaneously expressed on most of the cortical thymocytes, that weakly express the T-cell antigen receptor(TCR)/CD3 complex. Mature peripheral T cells, however, strongly express the TCR complex and are positive for either CD4 or CD8. Nevertheless, a small percentage of peripheral CD3+ T cell...

journal_title：Nature

authors： Paliard X,Malefijt RW,de Vries JE,Spits H

更新日期：1988-10-13 00:00:00

abstract：:Relative to the present day, meridional temperature gradients in the Early Eocene age ( approximately 56-53 Myr ago) were unusually low, with slightly warmer equatorial regions but with much warmer subtropical Arctic and mid-latitude climates. By the end of the Eocene epoch ( approximately 34 Myr ago), the first major...

journal_title：Nature

authors： Bijl PK,Schouten S,Sluijs A,Reichart GJ,Zachos JC,Brinkhuis H

更新日期：2009-10-08 00:00:00

abstract：:The multi-disciplinary role of intermediate energy proton accelerators in pure and applied nuclear physics is discussed with particular reference to the experimental programmes at LAMPF (Los Alamos Meson Physics Facility) and SIN (Swiss Institute for Nuclear Research, Zurich). ...

journal_title：Nature

authors： Davies JD,Batty CJ,Green K

更新日期：1977-12-22 00:00:00

abstract：:Multiple sclerosis is commonly associated with a local humoral immune response within the central nervous system. A hallmark of this intrathecal response is the presence of electrophoretically demonstrable oligoclonal bands of IgG in the cerebrospinal fluid (CSF) of up to 95% of patients. Observations indicating that ...

journal_title：Nature

authors： Vandvik B,Norrby E

更新日期：1989-04-27 00:00:00

abstract：:The neocortex of the adult brain consists of neurons and glia that are generated by precursor cells of the embryonic ventricular zone. In general, glia are generated after neurons during development, but radial glia are an exception to this rule. Radial glia are generated before neurogenesis and guide neuronal migrati...

journal_title：Nature

authors： Noctor SC,Flint AC,Weissman TA,Dammerman RS,Kriegstein AR

更新日期：2001-02-08 00:00:00

abstract：:The first nerve cells to appear in the limb buds of embryonic grasshoppers are a pair which lie at the distal tip and project axons along the length of the limb to the central nervous system (CNS). The stereotyped route navigated by these 'pioneer' axons is followed by other neurones and eventually becomes that of a m...

journal_title：Nature

authors： Bentley D,Caudy M

更新日期：1983-07-07 00:00:00

abstract：:Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription ...

journal_title：Nature

authors： Anneser L,Alcantara IC,Gemmer A,Mirkes K,Ryu S,Schuman EM

更新日期：2020-12-01 00:00:00

abstract：:RecBCD enzyme is a processive DNA helicase and nuclease that participates in the repair of chromosomal DNA through homologous recombination. We have visualized directly the movement of individual RecBCD enzymes on single molecules of double-stranded DNA (dsDNA). Detection involves the optical trapping of solitary, flu...

journal_title：Nature

authors： Bianco PR,Brewer LR,Corzett M,Balhorn R,Yeh Y,Kowalczykowski SC,Baskin RJ

更新日期：2001-01-18 00:00:00

abstract：:The TE1 family of transposable elements (TEs) of Drosophila consists of unusually large transposons, cytologically visible in larval polytene chromosomes as one or more bands. They are composite elements, as their termini consist of foldback (FB) sequences which are themselves transposable. The location of FB elements...

journal_title：Nature

authors： Chia W,McGill S,Karp R,Gubb D,Ashburner M

更新日期：1985-07-04 00:00:00

abstract：:Eukaryotes and archaea use a protease called the proteasome that has an integral role in maintaining cellular function through the selective degradation of proteins. Proteolysis occurs in a barrel-shaped 20S core particle, which in Thermoplasma acidophilum is built from four stacked homoheptameric rings of subunits, α...

journal_title：Nature

authors： Ruschak AM,Religa TL,Breuer S,Witt S,Kay LE

更新日期：2010-10-14 00:00:00

abstract：:Complementary DNA cloning of the transcripts of the Drosophila clock gene period reveals three distinct transcripts. These result from unusual splicing pathways, one involving a CG 3' splice site and one resulting in the use of two different reading frames in one exon, and they predict three separate proteins. Two of ...

journal_title：Nature

authors： Citri Y,Colot HV,Jacquier AC,Yu Q,Hall JC,Baltimore D,Rosbash M

更新日期：1987-03-05 00:00:00

abstract：:Halobacterium halobium is an obligately halophilic archaebacterium of interest to molecular biologists for many reasons, one of which is the unexplained high frequency (10(-4)-10(-2) mutants per cell plated) at which it yields readily identifiable and unstable mutants. We showed previously that the genome of H. halobi...

journal_title：Nature

authors： Sapienza C,Rose MR,Doolittle WF

更新日期：1982-09-09 00:00:00

abstract：:Piwi-associated RNAs (piRNAs), a specific class of 24- to 30-nucleotide-long RNAs produced by the Piwi-type of Argonaute proteins, have a specific germline function in repressing transposable elements. This repression is thought to involve heterochromatin formation and transcriptional and post-transcriptional silencin...

journal_title：Nature

authors： Rouget C,Papin C,Boureux A,Meunier AC,Franco B,Robine N,Lai EC,Pelisson A,Simonelig M

更新日期：2010-10-28 00:00:00

abstract：:High-harmonic generation by focusing a femtosecond laser onto a gas is a well-known method of producing coherent extreme-ultraviolet (EUV) light. This nonlinear conversion process requires high pulse intensities, greater than 10(13) W cm(-2), which are not directly attainable using only the output power of a femtoseco...

journal_title：Nature

authors： Kim S,Jin J,Kim YJ,Park IY,Kim Y,Kim SW

更新日期：2008-06-05 00:00:00