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NATURE文献大全abstract::A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms a protein-conducting channel, allowing polypeptides to be transferred across or integrated into membranes. We report the crystal structure of the complex from Methanococcus jannaschii at a resolution of 3.2 A. The structure suggests ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02218
更新日期:2004-01-01 00:00:00
abstract::Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision1,2. Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss; however, the generation of sensory neuronal subtypes such as photore...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2201-4
更新日期:2020-05-01 00:00:00
abstract::Macroscopic mechanical objects and electromagnetic degrees of freedom can couple to each other through radiation pressure. Optomechanical systems in which this coupling is sufficiently strong are predicted to show quantum effects and are a topic of considerable interest. Devices in this regime would offer new types of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06715
更新日期:2008-03-06 00:00:00
abstract::Melanocytes are phenotypically prominent but histologically inconspicuous skin cells. They are responsible for the pigmentation of skin and hair, and thereby contribute to the appearance of skin and provide protection from damage by ultraviolet radiation. Pigmentation mutants in various species are highly informative ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature05660
更新日期:2007-02-22 00:00:00
abstract::Depleted uranium is a mildly radioactive waste product that is stockpiled worldwide. The chemical reactivity of uranium complexes is well documented, including the stoichiometric activation of small molecules of biological and industrial interest such as H2O, CO2, CO, or N2 (refs 1 - 11), but catalytic transformations...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16530
更新日期:2016-02-18 00:00:00
abstract::Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with comprehensive identification and relative quantification of cellular proteomes have so far appeared to be insurmountable. Here, using advances in computational proteom...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07341
更新日期:2008-10-30 00:00:00
abstract::Large mammals, including humans, save much of the energy needed for running by means of elastic structures in their legs and feet. Kinetic and potential energy removed from the body in the first half of the stance phase is stored briefly as elastic strain energy and then returned in the second half by elastic recoil. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/325147a0
更新日期:1987-01-08 00:00:00
abstract::What limits the rate at which sensory information can be transmitted across synaptic connections in the brain? High-frequency signalling is restricted to brief bursts at many central excitatory synapses, whereas graded ribbon-type synapses can sustain release and transmit information at high rates. Here we investigate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04509
更新日期:2006-02-23 00:00:00
abstract::The key behavioural, physiological and anatomical components of a magnetite-based magnetic sense have been demonstrated in rainbow trout (Oncorhynchus mykiss). Candidate receptor cells located within a discrete sub-layer of the olfactory lamellae contained iron-rich crystals that were similar in size and shape to magn...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35018561
更新日期:2000-07-20 00:00:00
abstract::The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/282623a0
更新日期:1979-12-06 00:00:00
abstract::Epithelial organs undergo steady-state turnover throughout adult life, with old cells being continually replaced by the progeny of stem cell divisions. To avoid hyperplasia or atrophy, organ turnover demands strict equilibration of cell production and loss. However, the mechanistic basis of this equilibrium is unknown...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23678
更新日期:2017-08-31 00:00:00
abstract::Myeloid precursors can be grown in vitro in the presence of specific growth factors; however, their expansion is limited by a competing process of terminal differentiation. Proto-oncogenes seem to be involved in cellular proliferation and/or differentiation and may also play a role in the myelopoietic process. Murine ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/318667a0
更新日期:1985-12-19 00:00:00
abstract::The rat hippocampus receives a strong cholinergic innervation from the medial septum; information about the development and function of this pathway could help to elucidate the mechanisms of memory functions. Previous electrophysiological studies have shown that septal stimulation in vivo facilitates commissural and p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/313577a0
更新日期:1985-02-14 00:00:00
abstract::The remarkable compositional diversity of volatile ices within comets can plausibly be attributed to several factors, including differences in the chemical, thermal and radiation environments in comet-forming regions, chemical evolution during their long storage in reservoirs far from the Sun, and thermal processing b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05908
更新日期:2007-07-12 00:00:00
abstract::Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and ep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15756
更新日期:2015-11-19 00:00:00
abstract::Nitrogen (N) limits the productivity of many ecosystems worldwide, thereby restricting the ability of terrestrial ecosystems to offset the effects of rising atmospheric CO(2) emissions naturally. Understanding input pathways of bioavailable N is therefore paramount for predicting carbon (C) storage on land, particular...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10415
更新日期:2011-08-31 00:00:00
abstract::Cytotoxic T cells lyse only those virus infected target cells in vitro which express, in addition to the viral antigen(s), those K or D region products of the major histocompatibility complex (MHC) which were present during anti-viral sensitisation in vivo. This 'associative recognition' by cytotoxic T cells could ref...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/267160a0
更新日期:1977-05-12 00:00:00
abstract::Two main forms of long-term potentiation (LTP)-a prominent model for the cellular mechanism of learning and memory-have been distinguished in the mammalian brain. One requires activation of postsynaptic NMDA (N-methyl d-aspartate) receptors, whereas the other, called mossy fibre LTP, has a principal presynaptic compon...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415327a
更新日期:2002-01-17 00:00:00
abstract::Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a hybrid protein susceptible to proteolysis at mitosis. During the course of degradation, both cyclin and the hybrid form conjugates...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/349132a0
更新日期:1991-01-10 00:00:00
abstract::Helium-neon lasers emitting at 632.8 nm can influence the phytochrome controlled growth and development of plants more than a quarter of a mile away. It may therefore be possible to control the growth of crops using lasers to activate the phytochrome system. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/228970a0
更新日期:1970-12-05 00:00:00
abstract::In the present-day climate, surface water salinities are low in the western tropical Pacific Ocean and increase towards the eastern part of the basin. The salinity of surface waters in the tropical Pacific Ocean is thought to be controlled by a combination of atmospheric convection, precipitation, evaporation and ocea...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02903
更新日期:2004-09-02 00:00:00
abstract::Low-resolution intensity spectra of Earth's atmosphere obtained from space reveal strong signatures of life ('biosignatures'), such as molecular oxygen and methane with abundances far from chemical equilibrium, as well as the presence of a 'red edge' (a sharp increase of albedo for wavelengths longer than 700 nm) caus...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10778
更新日期:2012-02-29 00:00:00
abstract::The Gamburtsev Subglacial Mountains are the least understood tectonic feature on Earth, because they are completely hidden beneath the East Antarctic Ice Sheet. Their high elevation and youthful Alpine topography, combined with their location on the East Antarctic craton, creates a paradox that has puzzled researchers...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10566
更新日期:2011-11-16 00:00:00
abstract::TMV RNA is not an efficient template for translation of the viral coat protein, in spite of containing nucleotide sequences coding for the protein. Efficient translation requires the prior synthesis within infected cells of a smaller RNA carrying only a portion of the information encoded in the whole genome. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/260759a0
更新日期:1976-04-29 00:00:00
abstract::Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal diffe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11661
更新日期:2013-01-10 00:00:00
abstract::Mesolimbic dopamine-releasing neurons appear to be important in the brain reward system. One behavioural paradigm that supports this hypothesis is intracranial self-stimulation (ICS), during which animals repeatedly press a lever to stimulate their own dopamine-releasing neurons electrically. Here we study dopamine re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/18019
更新日期:1999-03-04 00:00:00
abstract::Defects in the architecture or integrity of the nuclear envelope are associated with a variety of human diseases1. Micronuclei, one common nuclear aberration, are an origin for chromothripsis2, a catastrophic mutational process that is commonly observed in cancer3-5. Chromothripsis occurs after micronuclei spontaneous...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0534-z
更新日期:2018-09-01 00:00:00
abstract::High-harmonic generation is a well-known method of producing coherent extreme-ultraviolet (EUV) light, with photon energies up to about 0.5 keV (refs 1, 2). This is achieved by focusing a femtosecond laser into a gas, and high harmonics of the fundamental laser frequency are radiated in the forward direction. However,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01222
更新日期:2003-01-02 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 信件
doi:10.1038/d41586-019-00549-4
更新日期:2019-02-01 00:00:00
abstract::During endocytosis, clathrin and the clathrin adaptor protein AP-2, assisted by a variety of accessory factors, help to generate an invaginated bud at the cell membrane. One of these factors is Eps15, a clathrin-coat-associated protein that binds the alpha-adaptin subunit of AP-2. Here we investigate the function of E...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/29555
更新日期:1998-08-20 00:00:00