Tumour exosome integrins determine organotropic metastasis.


:Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics revealed distinct integrin expression patterns, in which the exosomal integrins α6β4 and α6β1 were associated with lung metastasis, while exosomal integrin αvβ5 was linked to liver metastasis. Targeting the integrins α6β4 and αvβ5 decreased exosome uptake, as well as lung and liver metastasis, respectively. We demonstrate that exosome integrin uptake by resident cells activates Src phosphorylation and pro-inflammatory S100 gene expression. Finally, our clinical data indicate that exosomal integrins could be used to predict organ-specific metastasis.






Hoshino A,Costa-Silva B,Shen TL,Rodrigues G,Hashimoto A,Tesic Mark M,Molina H,Kohsaka S,Di Giannatale A,Ceder S,Singh S,Williams C,Soplop N,Uryu K,Pharmer L,King T,Bojmar L,Davies AE,Ararso Y,Zhang T,Zhang H,Her




Has Abstract


2015-11-19 00:00:00
















  • Satellite-based estimates of groundwater depletion in India.

    abstract::Groundwater is a primary source of fresh water in many parts of the world. Some regions are becoming overly dependent on it, consuming groundwater faster than it is naturally replenished and causing water tables to decline unremittingly. Indirect evidence suggests that this is the case in northwest India, but there ha...


    pub_type: 杂志文章


    authors: Rodell M,Velicogna I,Famiglietti JS

    更新日期:2009-08-20 00:00:00

  • More than one bad apple.

    abstract::A congressional investigation alleges that some researchers have failed to report all the drug-company money that they have received--and that universities may have been too slow to police them. ...


    pub_type: 社论



    更新日期:2008-10-16 00:00:00

  • Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel.

    abstract::In cardiac muscle, where Ca2+ influx across the sarcolemma is essential for contraction, the dihydropyridine (DHP)-sensitive L-type calcium channel represents the major entry pathway of extracellular Ca2+. We have previously elucidated the primary structure of the rabbit skeletal muscle DHP receptor by cloning and seq...


    pub_type: 杂志文章


    authors: Mikami A,Imoto K,Tanabe T,Niidome T,Mori Y,Takeshima H,Narumiya S,Numa S

    更新日期:1989-07-20 00:00:00

  • A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells.

    abstract::Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppre...


    pub_type: 杂志文章


    authors: Png KJ,Halberg N,Yoshida M,Tavazoie SF

    更新日期:2011-12-14 00:00:00

  • Structure of transcribing mammalian RNA polymerase II.

    abstract::RNA polymerase (Pol) II produces messenger RNA during transcription of protein-coding genes in all eukaryotic cells. The Pol II structure is known at high resolution from X-ray crystallography for two yeast species. Structural studies of mammalian Pol II, however, remain limited to low-resolution electron microscopy a...


    pub_type: 杂志文章


    authors: Bernecky C,Herzog F,Baumeister W,Plitzko JM,Cramer P

    更新日期:2016-01-28 00:00:00

  • X-ray analysis of beta B2-crystallin and evolution of oligomeric lens proteins.

    abstract::The beta, gamma-crystallins form a class of homologous proteins in the eye lens. Each gamma-crystallin comprises four topologically equivalent, Greek key motifs; pairs of motifs are organized around a local dyad to give domains and two similar domains are in turn related by a further local dyad. Sequence comparisons a...


    pub_type: 杂志文章


    authors: Bax B,Lapatto R,Nalini V,Driessen H,Lindley PF,Mahadevan D,Blundell TL,Slingsby C

    更新日期:1990-10-25 00:00:00

  • B220: a B cell-specific member of th T200 glycoprotein family.

    abstract::T200, a major cell-surface glycoprotein on lymphoid cells, exists in several forms with different electrophoretic mobilities. These forms have been correlated with different classes of lymphoid cell. The smaller forms, with molecular weights (MWs) of congruent to 170,000 and 180,000 are found predominantly on T cells ...


    pub_type: 杂志文章


    authors: Coffman RL,Weissman IL

    更新日期:1981-02-19 00:00:00

  • Meet the space researcher smoothing the path for women in science across Africa.

    abstract:: ...


    pub_type: 面试


    authors: Dance A

    更新日期:2018-11-01 00:00:00

  • Structure of the cro repressor from bacteriophage lambda and its interaction with DNA.

    abstract::The three-dimensional structure of the 66-amino acid cro repressor protein of bacteriophage lambda suggests how it binds to its operator DNA. We propose that a dimer of cro protein is bound to the B-form of DNA with the 2-fold axis of the dimer coincident with the 2-fold axis of DNA. A pair of 2-fold-related alpha-hel...


    pub_type: 杂志文章


    authors: Anderson WF,Ohlendorf DH,Takeda Y,Matthews BW

    更新日期:1981-04-30 00:00:00

  • A new orang-utan relative from the Late Miocene of Thailand.

    abstract::The fossil record of the living great apes is poor. New fossils from undocumented areas, particularly the equatorial forested habitats of extant hominoids, are therefore crucial for understanding their origins and evolution. Two main competing hypotheses have been proposed for orang-utan origins: dental similarities s...


    pub_type: 杂志文章


    authors: Chaimanee Y,Suteethorn V,Jintasakul P,Vidthayanon C,Marandat B,Jaeger JJ

    更新日期:2004-01-29 00:00:00

  • A visual motion detection circuit suggested by Drosophila connectomics.

    abstract::Animal behaviour arises from computations in neuronal circuits, but our understanding of these computations has been frustrated by the lack of detailed synaptic connection maps, or connectomes. For example, despite intensive investigations over half a century, the neuronal implementation of local motion detection in t...


    pub_type: 杂志文章


    authors: Takemura SY,Bharioke A,Lu Z,Nern A,Vitaladevuni S,Rivlin PK,Katz WT,Olbris DJ,Plaza SM,Winston P,Zhao T,Horne JA,Fetter RD,Takemura S,Blazek K,Chang LA,Ogundeyi O,Saunders MA,Shapiro V,Sigmund C,Rubin GM,Scheffe

    更新日期:2013-08-08 00:00:00

  • Deformation cycles of subduction earthquakes in a viscoelastic Earth.

    abstract::Subduction zones produce the largest earthquakes. Over the past two decades, space geodesy has revolutionized our view of crustal deformation between consecutive earthquakes. The short time span of modern measurements necessitates comparative studies of subduction zones that are at different stages of the deformation ...


    pub_type: 杂志文章


    authors: Wang K,Hu Y,He J

    更新日期:2012-04-18 00:00:00

  • Peripheral deletion of antigen-reactive T cells in oral tolerance.

    abstract::Oral administration of antigen is used to induce antigen-specific peripheral immune tolerance. As well as preventing systemic immune responses to ingested proteins, oral tolerance to autoantigens has also been used to suppress autoimmune diseases in animals and humans. Both active suppression and clonal anergy are sug...


    pub_type: 杂志文章


    authors: Chen Y,Inobe J,Marks R,Gonnella P,Kuchroo VK,Weiner HL

    更新日期:1995-07-13 00:00:00

  • Quantum tomography of an electron.

    abstract::The complete knowledge of a quantum state allows the prediction of the probability of all possible measurement outcomes, a crucial step in quantum mechanics. It can be provided by tomographic methods which have been applied to atomic, molecular, spin and photonic states. For optical or microwave photons, standard tomo...


    pub_type: 杂志文章


    authors: Jullien T,Roulleau P,Roche B,Cavanna A,Jin Y,Glattli DC

    更新日期:2014-10-30 00:00:00

  • Differential inhibition of neurone-neurone, neurone-astrocyte and astrocyte-astrocyte adhesion by L1, L2 and N-CAM antibodies.

    abstract::The cell adhesion molecules L1, N-CAM and Ng-CAM have been implicated in cell-cell interactions among developing neural cells. L1 and N-CAM are structurally and functionally distinct molecular entities and act synergistically in mediating Ca2+-independent adhesion between re-aggregating early postnatal cerebellar cell...


    pub_type: 杂志文章


    authors: Keilhauer G,Faissner A,Schachner M

    更新日期:1985-08-22 00:00:00

  • Tissue-specific activation of a cloned alpha-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line.

    abstract::To identify cis-acting DNA elements involved in the activation of the alpha-fetoprotein gene during differentiation, modified copies of the gene were introduced into murine F9 embryonal carcinoma cells. The differentiation of the transformants to either parietal or visceral endoderm was accompanied by induction of the...


    pub_type: 杂志文章


    authors: Scott RW,Vogt TF,Croke ME,Tilghman SM

    更新日期:1984-08-16 00:00:00

  • Transposon tagging of a male sterility gene in Arabidopsis.

    abstract::Transformation of the well-studied maize transposable elements into other plant species should enable transposon tagging methodology to be used for the isolation of interesting genes in the heterologous host. Here we describe the isolation of a transposon-tagged male sterile mutant in Arabidopsis thaliana using the ma...


    pub_type: 杂志文章


    authors: Aarts MG,Dirkse WG,Stiekema WJ,Pereira A

    更新日期:1993-06-24 00:00:00

  • Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.

    abstract::Metformin is considered to be one of the most effective therapeutics for treating type 2 diabetes because it specifically reduces hepatic gluconeogenesis without increasing insulin secretion, inducing weight gain or posing a risk of hypoglycaemia. For over half a century, this agent has been prescribed to patients wit...


    pub_type: 杂志文章


    authors: Madiraju AK,Erion DM,Rahimi Y,Zhang XM,Braddock DT,Albright RA,Prigaro BJ,Wood JL,Bhanot S,MacDonald MJ,Jurczak MJ,Camporez JP,Lee HY,Cline GW,Samuel VT,Kibbey RG,Shulman GI

    更新日期:2014-06-26 00:00:00

  • Glutamate induces de novo growth of functional spines in developing cortex.

    abstract::Mature cortical pyramidal neurons receive excitatory inputs onto small protrusions emanating from their dendrites called spines. Spines undergo activity-dependent remodelling, stabilization and pruning during development, and similar structural changes can be triggered by learning and changes in sensory experiences. H...


    pub_type: 杂志文章


    authors: Kwon HB,Sabatini BL

    更新日期:2011-06-02 00:00:00

  • Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.

    abstract::The eight catalytic subunits of the mammalian phosphoinositide-3-OH kinase (PI(3)K) family form the backbone of an evolutionarily conserved signalling pathway; however, the roles of most PI(3)K isoforms in organismal physiology and disease are unknown. To delineate the role of p110alpha, a ubiquitously expressed PI(3)...


    pub_type: 杂志文章


    authors: Foukas LC,Claret M,Pearce W,Okkenhaug K,Meek S,Peskett E,Sancho S,Smith AJ,Withers DJ,Vanhaesebroeck B

    更新日期:2006-05-18 00:00:00

  • Preferential DNA secondary structure mutagenesis in the lagging strand of replication in E. coli.

    abstract::When present in single-stranded DNA, palindromic or quasi-palindromic sequences have the potential to form complex secondary structures, including hairpins, which may facilitate interstrand misalignment of direct repeats and be responsible for diverse types of replication-based mutations, including deletions, addition...


    pub_type: 杂志文章


    authors: Trinh TQ,Sinden RR

    更新日期:1991-08-08 00:00:00

  • Novel thioether bond revealed by a 1.7 A crystal structure of galactose oxidase.

    abstract::Galactose oxidase is an extracellular enzyme secreted by the fungus Dactylium dendroides. It is monomeric, with a relative molecular mass of 68,000, catalyses the stereospecific oxidation of a broad range of primary alcohol substrates and possesses a unique mononuclear copper site essential for catalysing a two-electr...


    pub_type: 杂志文章


    authors: Ito N,Phillips SE,Stevens C,Ogel ZB,McPherson MJ,Keen JN,Yadav KD,Knowles PF

    更新日期:1991-03-07 00:00:00

  • Subtractive and divisive adaptation in the human visual system.

    abstract::Sensory systems can adapt to the conditions imposed on them. In the visual system, adapting to a pattern increases the threshold of the ability to see that pattern, and reduces the perceived contrast of the pattern above threshold. Most neurons of the striate cortex reduce their responsiveness after being stimulated f...


    pub_type: 杂志文章


    authors: Snowden RJ,Hammett ST

    更新日期:1992-01-16 00:00:00

  • Separate body- and world-referenced representations of visual space in parietal cortex.

    abstract::In order to direct a movement towards a visual stimulus, visual spatial information must be combined with postural information. For example, directing gaze (eye plus head) towards a visible target requires the combination of retinal image location with eye and head position to determine the location of the target rela...


    pub_type: 杂志文章


    authors: Snyder LH,Grieve KL,Brotchie P,Andersen RA

    更新日期:1998-08-27 00:00:00

  • A disintegrating minor planet transiting a white dwarf.

    abstract::Most stars become white dwarfs after they have exhausted their nuclear fuel (the Sun will be one such). Between one-quarter and one-half of white dwarfs have elements heavier than helium in their atmospheres, even though these elements ought to sink rapidly into the stellar interiors (unless they are occasionally repl...


    pub_type: 杂志文章


    authors: Vanderburg A,Johnson JA,Rappaport S,Bieryla A,Irwin J,Lewis JA,Kipping D,Brown WR,Dufour P,Ciardi DR,Angus R,Schaefer L,Latham DW,Charbonneau D,Beichman C,Eastman J,McCrady N,Wittenmyer RA,Wright JT

    更新日期:2015-10-22 00:00:00

  • Long-term proliferation of mouse primordial germ cells in culture.

    abstract::Primordial germ cells (PGCs) are first identifiable as a population of about eight alkaline phosphatase-positive cells in the 7.0 days postcoitum mouse embryo. During the next 6 days of development they proliferate to give rise to the 25,000 cells that will establish the meiotic population. Steel factor is required fo...


    pub_type: 杂志文章


    authors: Resnick JL,Bixler LS,Cheng L,Donovan PJ

    更新日期:1992-10-08 00:00:00

  • High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.

    abstract::An increasing body of evidence points to mitochondrial dysfunction as a contributor to the molecular pathogenesis of neurodegenerative diseases such as Parkinson's disease. Recent studies of the Parkinson's disease associated genes PINK1 (ref. 2) and parkin (PARK2, ref. 3) indicate that they may act in a quality contr...


    pub_type: 杂志文章


    authors: Hasson SA,Kane LA,Yamano K,Huang CH,Sliter DA,Buehler E,Wang C,Heman-Ackah SM,Hessa T,Guha R,Martin SE,Youle RJ

    更新日期:2013-12-12 00:00:00

  • Mechanical milling assisted by electrical discharge.

    abstract::Mechanical milling is an effective technique for the preparation of fine metallic and ceramic powders and can also be used to drive a wide range of chemical reactions. Milling devices include planetary machines, attritors and vibrational mills; products include amorphous, nanocrystalline and quasicrystalline materials...


    pub_type: 杂志文章


    authors: Calka A,Wexler D

    更新日期:2002-09-12 00:00:00

  • Isolation of a replication-defective murine leukaemia virus from cultured AKR leukaemia cells.

    abstract::Mice of the AKR strain are characterised by a high incidence of spontaneous thymic lymphomas. AKR chromosomes contain the genomes of ecotropic murine leukaemia virus (MuLV) at two loci, termed Akv-1 and Akv-2 (refs 2-6). Shortly after birth, the normal tissues of AKR mice begin to produce high levels of this XC-positi...


    pub_type: 杂志文章


    authors: Rein A,Athan E,Benjers BM,Bassin RH,Gerwin BI,Slocum DR

    更新日期:1979-12-13 00:00:00

  • Poly(dA).poly(dT) is a B-type double helix with a distinctively narrow minor groove.

    abstract::The structure of poly(dA).poly(dT) currently arouses great interest, mainly because dAn.dTn stretches are associated with considerable DNA bending. Until recently the heteronomous DNA described by Arnott et al., with the poly(dA) and poly(dT) chains in A and B conformations respectively, was the only detailed model of...


    pub_type: 杂志文章


    authors: Alexeev DG,Lipanov AA,Skuratovskii IYa

    更新日期:1987-02-26 00:00:00