Functional innervation of cultured hippocampal neurones by cholinergic afferents from co-cultured septal explants.

abstract：:Evolutionary relationships among the eight major lineages of Mollusca have remained unresolved despite their diversity and importance. Previous investigations of molluscan phylogeny, based primarily on nuclear ribosomal gene sequences or morphological data, have been unsuccessful at elucidating these relationships. Re...

journal_title：Nature

authors： Kocot KM,Cannon JT,Todt C,Citarella MR,Kohn AB,Meyer A,Santos SR,Schander C,Moroz LL,Lieb B,Halanych KM

更新日期：2011-09-04 00:00:00

abstract：:The visual recognition of three-dimensional (3-D) objects on the basis of their shape poses at least two difficult problems. First, there is the problem of variable illumination, which can be addressed by working with relatively stable features such as intensity edges rather than the raw intensity images. Second, ther...

journal_title：Nature

authors： Poggio T,Edelman S

更新日期：1990-01-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Grishin E,Malamud U,Perets HB,Wandel O,Schäfer CM

更新日期：2020-06-01 00:00:00

abstract：:A new system has been developed for measuring the forces produced by a small number (less than 5-150) of myosin molecules interacting with a single actin filament in vitro. The technique can resolve forces of less than a piconewton and has a time resolution in the submillisecond range. It can thus detect fluctuations ...

journal_title：Nature

authors： Ishijima A,Doi T,Sakurada K,Yanagida T

更新日期：1991-07-25 00:00:00

abstract：:Numerous studies have suggested that biodiversity reduces variability in ecosystem productivity through compensatory effects; that is, a species increases in its abundance in response to the reduction of another in a fluctuating environment. But this view has been challenged on several grounds. Because most studies ha...

journal_title：Nature

authors： Bai Y,Han X,Wu J,Chen Z,Li L

更新日期：2004-09-09 00:00:00

abstract：:The collagens represent an interesting example of a structurally related but genetically distinct family of proteins. Type I, the most abundant of the vertebrate collagens, comprises two pro alpha 1(I) chains and one pro alpha 2(I) chain, each containing terminal propeptides and a central domain of 338 (Gly, X, Y) rep...

journal_title：Nature

authors： Chu ML,de Wet W,Bernard M,Ding JF,Morabito M,Myers J,Williams C,Ramirez F

更新日期：1984-07-26 00:00:00

abstract：:In the chick embryo hindbrain, morphological segmentation into rhombomeres is matched by metameric patterns of early neuronal differentiation and axonogenesis. Boundaries between rhombomeres coincide with boundaries of expression of murine regulatory genes. By clonal analysis using intracellular marking, we show here ...

journal_title：Nature

authors： Fraser S,Keynes R,Lumsden A

更新日期：1990-03-29 00:00:00

abstract：:Oocytes arrested in the G2 phase of the cell cycle contain a p34cdc2/cyclin B complex which is kept in an inactive form by phosphorylation of its p34cdc2 subunit on tyrosine, threonine and perhaps serine residues. The phosphatase(s) involved in p34cdc2 dephosphorylation is unknown, but the product of the fission yeast...

journal_title：Nature

authors： Strausfeld U,Labbé JC,Fesquet D,Cavadore JC,Picard A,Sadhu K,Russell P,Dorée M

更新日期：1991-05-16 00:00:00

abstract：:Oxygen consumption by carnivorous reptiles increases enormously after they have eaten a large meal in order to meet metabolic demands, and this places an extra load on the cardiovascular system. Here we show that there is an extraordinarily rapid 40% increase in ventricular muscle mass in Burmese pythons (Python molur...

journal_title：Nature

authors： Andersen JB,Rourke BC,Caiozzo VJ,Bennett AF,Hicks JW

更新日期：2005-03-03 00:00:00

abstract：:Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1 are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) pandemic and ultimately bring it to an end. Studies in animal models and acute HIV-1 infection reviewed here reveal potential viral vulnerabili...

journal_title：Nature

authors： Haase AT

更新日期：2010-03-11 00:00:00

abstract：:Transport of calcium ions across membranes and against a thermodynamic gradient is essential to many biological processes, including muscle contraction, the citric acid cycle, glycogen metabolism, release of neurotransmitters, vision, biological signal transduction and immune response. Synthetic systems that transport...

journal_title：Nature

authors： Bennett IM,Farfano HM,Bogani F,Primak A,Liddell PA,Otero L,Sereno L,Silber JJ,Moore AL,Moore TA,Gust D

更新日期：2002-11-28 00:00:00

abstract：:The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods...

journal_title：Nature

authors： Bakken TE,Miller JA,Ding SL,Sunkin SM,Smith KA,Ng L,Szafer A,Dalley RA,Royall JJ,Lemon T,Shapouri S,Aiona K,Arnold J,Bennett JL,Bertagnolli D,Bickley K,Boe A,Brouner K,Butler S,Byrnes E,Caldejon S,Carey A,Cate

更新日期：2016-07-21 00:00:00

abstract：:Little is known about virus-host cell interactions that regulate the lytic potential of viruses during productive replication. Sindbis virus (SV), a single-stranded positive-sense RNA virus in the alphavirus genus (family Togaviridae), results in lytic infection in most vertebrate cell lines, but persistent productive...

journal_title：Nature

authors： Levine B,Huang Q,Isaacs JT,Reed JC,Griffin DE,Hardwick JM

更新日期：1993-02-25 00:00:00

abstract：:Capacitors are a mainstay of electronic integrated circuits and devices, where they perform essential functions such as storing electrical charge, and blocking direct current while allowing alternating currents to propagate. Because they are often the largest components in circuits, extensive efforts are directed at r...

journal_title：Nature

authors： Stengel M,Spaldin NA

更新日期：2006-10-12 00:00:00

abstract：:The selection and design of modern high-performance structural engineering materials is driven by optimizing combinations of mechanical properties such as strength, ductility, toughness, elasticity and requirements for predictable and graceful (non-catastrophic) failure in service. Highly processable bulk metallic gla...

journal_title：Nature

authors： Hofmann DC,Suh JY,Wiest A,Duan G,Lind ML,Demetriou MD,Johnson WL

更新日期：2008-02-28 00:00:00

abstract：:Practice, with feedback, is a fundamental variable that influences the aquisition of motor skills: with it, everyone improves, but some improve more than others. This simple fact has led to frequent debate over the relative importance of genetic and environmental influences on motor learning. In principle these factor...

journal_title：Nature

authors： Fox PW,Hershberger SL,Bouchard TJ Jr

更新日期：1996-11-28 00:00:00

abstract：:The quantum-level interplay between geometry, topology and correlation is at the forefront of fundamental physics1-15. Kagome magnets are predicted to support intrinsic Chern quantum phases owing to their unusual lattice geometry and breaking of time-reversal symmetry14,15. However, quantum materials hosting ideal spi...

journal_title：Nature

authors： Yin JX,Ma W,Cochran TA,Xu X,Zhang SS,Tien HJ,Shumiya N,Cheng G,Jiang K,Lian B,Song Z,Chang G,Belopolski I,Multer D,Litskevich M,Cheng ZJ,Yang XP,Swidler B,Zhou H,Lin H,Neupert T,Wang Z,Yao N,Chang TR,Jia S

更新日期：2020-07-01 00:00:00

abstract：:The Tharsis region is the largest volcanic complex on Mars and in the Solar System. Young lava flows cover its surface (from the Amazonian period, less than 3 billion years ago) but its growth started during the Noachian era (more than 3.7 billion years ago). Its position has induced a reorientation of the planet with...

journal_title：Nature

authors： Bouley S,Baratoux D,Matsuyama I,Forget F,Séjourné A,Turbet M,Costard F

更新日期：2016-03-17 00:00:00

abstract：:Framework cavities are the largest but least explored coral reef habitat. Previous dive studies of caverns, spaces below plate corals, rubble and artificial cavities suggest that cavity-dwelling (coelobite) filter-feeders are important in the trophodynamics of reefs. Quantitative community data are lacking, however, a...

journal_title：Nature

authors： Richter C,Wunsch M,Rasheed M,Kötter I,Badran MI

更新日期：2001-10-18 00:00:00

abstract：:Surgical sectioning of the corpus callosum in epileptic patients has provided a unique opportunity to study separately the competence and processing capacities of the two cerebral hemispheres, each of which is able to perceive, think, memorize and learn independently and essentially outside the realm of awareness of t...

journal_title：Nature

authors： Sergent J

更新日期：1983-10-27 00:00:00

abstract：:We describe here a new view of primary visual cortex (V1) based on measurements of neural responses in V1 to patterns called 'illusory contours' (Fig. 1a, b). Detection of an object's boundary contours is a fundamental visual task. Boundary contours are defined by discontinuities not only in luminance and colour, but ...

journal_title：Nature

authors： Grosof DH,Shapley RM,Hawken MJ

更新日期：1993-10-07 00:00:00

abstract：:The creation of neural circuits depends on the formation of synapses between specific sets of neurons. Little is known, however, of the molecular mechanisms governing synaptic choice. A mutation in the unc-4 gene alters the pattern of synaptic input to one class of motor neurons in the Caenorhabditis elegans ventral n...

journal_title：Nature

authors： Miller DM,Shen MM,Shamu CE,Bürglin TR,Ruvkun G,Dubois ML,Ghee M,Wilson L

更新日期：1992-02-27 00:00:00

abstract：:Human B cell stimulatory factor 2 (BSF-2) was originally characterized and isolated as a T cell-derived factor that caused the terminal maturation of activated B cells to immunoglobulin-producing cells. Molecular cloning of the complementary DNA predicts that BSF-2 is a protein of relative molecular mass (Mr) 26,000 s...

journal_title：Nature

authors： Kawano M,Hirano T,Matsuda T,Taga T,Horii Y,Iwato K,Asaoku H,Tang B,Tanabe O,Tanaka H

更新日期：1988-03-03 00:00:00

abstract：:Aberrant activation of the canonical WNT/beta-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated beta-catenin activity drives colon tumorigenesis, further genetic perturbations are required to elaborate full malignant transformation. To...

journal_title：Nature

authors： Firestein R,Bass AJ,Kim SY,Dunn IF,Silver SJ,Guney I,Freed E,Ligon AH,Vena N,Ogino S,Chheda MG,Tamayo P,Finn S,Shrestha Y,Boehm JS,Jain S,Bojarski E,Mermel C,Barretina J,Chan JA,Baselga J,Tabernero J,Root DE,

更新日期：2008-09-25 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Gundem G,Van Loo P,Kremeyer B,Alexandrov LB,Tubio JMC,Papaemmanuil E,Brewer DS,Kallio HML,Hägnäs G,Annala M,Kivinummi K,Goody V,Latimer C,O'Meara S,Dawson KJ,Isaacs W,Emmert-Buck MR,Nykter M,Foster C,Kote-Jarai Z,

更新日期：2020-08-01 00:00:00

abstract：:There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined approxima...

journal_title：Nature

authors： Wellcome Trust Case Control Consortium.

更新日期：2007-06-07 00:00:00

abstract：:Phase and antigenic variation of pilin expression in Neisseria gonorrhoeae result from recombination events in which variant sequences from one of the silent loci (pilS) are transferred to the expression locus (pilE). Such rearrangements were originally thought to be gene conversions, but findings showing that phase v...

journal_title：Nature

authors： Gibbs CP,Reimann BY,Schultz E,Kaufmann A,Haas R,Meyer TF

更新日期：1989-04-20 00:00:00

abstract：:The variable regions of mouse kappa (kappa) chains are coded for by multiple variable (V) gene segments and multiple joining (J) gene segments. The V kappa gene segments code for residues 1 to 95; the J kappa gene segments code for residues 96 to 108 (refs 1-3). This gene organisation is similar to that encoding the V...

journal_title：Nature

authors： Weigert M,Perry R,Kelley D,Hunkapiller T,Schilling J,Hood L

更新日期：1980-01-31 00:00:00

abstract：:Truncation of the tumour suppressor adenomatous polyposis coli (Apc) constitutively activates the Wnt/beta-catenin signalling pathway. Apc has a role in development: for example, embryos of mice with truncated Apc do not complete gastrulation. To understand this role more fully, we examined the effect of truncated Apc...

journal_title：Nature

authors： Hurlstone AF,Haramis AP,Wienholds E,Begthel H,Korving J,Van Eeden F,Cuppen E,Zivkovic D,Plasterk RH,Clevers H

更新日期：2003-10-09 00:00:00

abstract：:The interneuronal messenger nitric oxide (NO) may play a central role in the processing of olfactory information. Several circuit elements in the mammalian olfactory bulb contain NO synthase or its functional equivalent, NADPH diaphorase. The effects of NO on cellular excitability or circuit dynamics in the olfactory ...

journal_title：Nature

authors： Gelperin A

更新日期：1994-05-05 00:00:00