Abstract：
:Calcium influx through voltage-sensitive Ca2+ channels is the normal physiological stimulus for the activity-dependent release of neurotransmitters at synaptic contacts. It has been postulated that presynaptic inhibition of transmitter release is due to a reduction in Ca2+ influx at the nerve terminal, which could result from the direct inhibition of Ca2+ channels. Neuropeptide Y and noradrenaline act as cotransmitters at many sympathetic synapses. Both of these substances produce presynaptic inhibition and can inhibit Ca2+ currents in the soma of sympathetic neurons. Here we provide direct evidence that presynaptic inhibition produced by neuropeptide Y at sympathetic nerve terminals is associated with a reduction in Ca2+ influx and that this is due to the selective inhibition of neuronal N-type Ca2+ channels.
journal_name
Naturejournal_title
Natureauthors
Toth PT,Bindokas VP,Bleakman D,Colmers WF,Miller RJdoi
10.1038/364635a0subject
Has Abstractpub_date
1993-08-12 00:00:00pages
635-9issue
6438eissn
0028-0836issn
1476-4687journal_volume
364pub_type
杂志文章相关文献
NATURE文献大全abstract：:The split promoter sequences of a tRNALeuCUG gene of Xenopus laevis have been mapped to nucleotides 13-20 and 51-64 of the tRNALeu coding sequences. The sequences closely coincide with two conserved sequence blocks present in all eukaryotic tRNA genes. The two conserved sequence blocks were found to be exchangeable be...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/294626a0
更新日期：1981-12-17 00:00:00
abstract：:Protein modification by the conjugation of ubiquitin moieties--ubiquitination--plays a major part in many biological processes, including cell cycle and apoptosis. The enzymes that mediate ubiquitin-conjugation have been well-studied, but much less is known about the ubiquitin-specific proteases that mediate de-ubiqui...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01811
更新日期：2003-08-14 00:00:00
abstract：:Most mitochondrial proteins are synthesized on cytoplasmic ribosomes and imported into mitochondria. The imported proteins are directed to one of four submitochondrial compartments--the outer mitochondrial membrane, the inner mitochondrial membrane, the intramembraneous space, or the matrix--where the protein then fun...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/417087a
更新日期：2002-05-02 00:00:00
abstract：:During puberty, the mouse mammary gland develops into a highly branched epithelial network. Owing to the absence of exclusive stem cell markers, the location, multiplicity, dynamics and fate of mammary stem cells (MaSCs), which drive branching morphogenesis, are unknown. Here we show that morphogenesis is driven by pr...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature21046
更新日期：2017-02-16 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 评论,新闻
doi：10.1038/d41586-018-07328-7
更新日期：2018-11-01 00:00:00
abstract：:Osteoarthritis-the most common form of age-related degenerative whole-joint disease1-is primarily characterized by cartilage destruction, as well as by synovial inflammation, osteophyte formation and subchondral bone remodelling2,3. However, the molecular mechanisms that underlie the pathogenesis of osteoarthritis are...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-0920-1
更新日期：2019-02-01 00:00:00
abstract：:The evolution of animal personalities is a topic of primary importance in behavioural ecology. An intriguing empirical fact is the consistency of animal responses to repeated stresses or threats. Wolf et al. propose an evolutionary model to explain the emergence of consistent personalities. They show that a population...
journal_title：Nature
pub_type： 评论,杂志文章
doi：10.1038/nature06743
更新日期：2008-02-28 00:00:00
abstract：:Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature24050
更新日期：2017-10-19 00:00:00
abstract：:The CD4 subset of cells displays helper/inducer activity and recognizes class II antigens of the major histocompatibility complex (MHC), while the CD8 subset recognizes class I MHC antigens and exhibits cytotoxic or suppressor function. Considerable functional as well as corresponding phenotypic heterogeneity exists w...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/330479a0
更新日期：1987-12-03 00:00:00
abstract：:The generation of reprogrammed induced pluripotent stem cells (iPSCs) from patients with defined genetic disorders holds the promise of increased understanding of the aetiologies of complex diseases and may also facilitate the development of novel therapeutic interventions. We have generated iPSCs from patients with L...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09005
更新日期：2010-06-10 00:00:00
abstract：:First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biol...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature09783
更新日期：2011-01-20 00:00:00
abstract：:Receptors for dopamine have been classified into two functional types, D1 and D2. They belong to the family of receptors acting through G (or guanine nucleotide-binding) proteins. D2 receptors inhibit adenylyl cyclase, but D1 receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases. Dopam...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/347080a0
更新日期：1990-09-06 00:00:00
abstract：:Guanine-nucleotide-exchange factors (GEFs) promote the exchange of GDP for GTP in Ras GTPases, and thereby positively regulate their functions. Members of the Sec4/Ypt1/Rab branch of the Ras superfamily are essential for vesicular transport. A GEF for a subset of Rab proteins, termed mammalian suppressor of Sec4 (Mss4...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/376788a0
更新日期：1995-08-31 00:00:00
abstract：:Leks have traditionally been considered as arenas where males compete to attract females and secure matings. Thus, direct fitness benefits mediated through competition between males to fertilize females have been considered to be the primary force driving the evolution of lekking behaviour. Inclusive fitness benefits ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35042562
更新日期：2000-11-16 00:00:00
abstract：:Neurons in the visual cortex respond preferentially to edge-like stimuli of a particular orientation. It is a long-standing hypothesis that orientation selectivity arises during development through the activity-dependent refinement of cortical circuitry. Unambiguous evidence for such a process has, however, remained e...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/25736
更新日期：1998-09-03 00:00:00
abstract：:The extension of growing season at high northern latitudes seems increasingly clear from satellite observations of vegetation extent and duration. This extension is also thought to explain the observed increase in amplitude of seasonal variations in atmospheric CO2 concentration. Increased plant respiration and photos...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35015049
更新日期：2000-06-08 00:00:00
abstract：:Acquired drug resistance is a major problem in the treatment of cancer. Of the more than 500,000 annual deaths from cancer in the United States, many follow the development of resistance to chemotherapy. The emergence of resistance depends in part on the genetic instability, heterogeneity and high mutational rate of t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/37126
更新日期：1997-11-27 00:00:00
abstract：:The enzyme Cu, Zn superoxide dismutase (SOD) protects against oxidative damage by dismuting the superoxide radical O2-. to molecular oxygen and hydrogen peroxide at the active-site Cu ion in a reaction that is rate-limited by diffusion and enhanced by electrostatic guidance. SOD has evolved to be one of the fastest en...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/358347a0
更新日期：1992-07-23 00:00:00
abstract：:Transcription factors recognize specific genomic sequences to regulate complex gene-expression programs. Although it is well-established that transcription factors bind to specific DNA sequences using a combination of base readout and shape recognition, some fundamental aspects of protein-DNA binding remain poorly und...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2843-2
更新日期：2020-11-01 00:00:00
abstract：:Activity-dependent change in the efficacy of transmission is a basic feature of many excitatory synapses in the central nervous system. The best understood postsynaptic modification involves a change in responsiveness of AMPAR (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor)-mediated currents follo...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35013064
更新日期：2000-05-25 00:00:00
abstract：:A nuclear protein, CREB, has been isolated from rat brain and shown to stimulate transcription of the cyclic AMP-responsive gene somatostatin as a dimer. Biochemical analysis suggests that dimerization and transcriptional efficacy of CREB protein in vitro are regulated by phosphorylation. These findings demonstrate th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/334494a0
更新日期：1988-08-11 00:00:00
abstract：:Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers hyperactive neurological disorders such as insomnia, anxiety and epilepsy. Here we present the first three-dimensional structure of a GABAAR, ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature13293
更新日期：2014-08-21 00:00:00
abstract：:Bax (Bcl2-associated X protein) is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases. Bax resides in an inactive state in the cytosol of many cells. In response to death stimuli, Bax protein undergoes conformational changes that expose membrane-targeting do...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01627
更新日期：2003-05-22 00:00:00
abstract：:All of the DNA synthesis genes of budding yeast examined so far are periodically expressed and hence under cell-cycle control (Table 1). Expression occurs near the G1/S phase boundary and the genes seem to be coordinately regulated (reviewed in ref. 4). The upstream promoter sequences of these genes have only a hexame...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/350247a0
更新日期：1991-03-21 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 新闻
doi：10.1038/d41586-018-07109-2
更新日期：2018-10-01 00:00:00
abstract：:Mating and egg laying are tightly cooordinated events in the reproductive life of all oviparous females. Oviposition is typically rare in virgin females but is initiated after copulation. Here we identify the neural circuitry that links egg laying to mating status in Drosophila melanogaster. Activation of female-speci...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2055-9
更新日期：2020-03-01 00:00:00
abstract：:Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols3,4. Ferroptosis has previously been implica...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1705-2
更新日期：2019-11-01 00:00:00
abstract：:Reported widespread declines of wild and managed insect pollinators have serious consequences for global ecosystem services and agricultural production. Bees contribute approximately 80% of insect pollination, so it is important to understand and mitigate the causes of current declines in bee populations . Recent stud...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11585
更新日期：2012-11-01 00:00:00
abstract：:Thewissen et al. describe new fossils from India that apparently support a phylogeny that places Cetacea (that is, whales, dolphins, porpoises) as the sister group to the extinct family Raoellidae, and Hippopotamidae as more closely related to pigs and peccaries (that is, Suina) than to cetaceans. However, our reanaly...
journal_title：Nature
pub_type： 评论,杂志文章
doi：10.1038/nature07776
更新日期：2009-03-19 00:00:00
abstract：:Ciliary neurotrophic factor (CNTF) promotes the survival of several populations of neurons, including sensory and motor neurons. Although CNTF is abundant in adult sciatic nerve, the mature protein lacks a signal sequence and is not secreted; therefore, it has been proposed to act as a lesion factor. The identificatio...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/365253a0
更新日期：1993-09-16 00:00:00
